§ 792 14 who is responsible for responding to my request
Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... successfully used to perform chimera studies with rat CPT1A [16] Therefore, to highlight the role of the CPT1B N-terminal segment, we took advantage of this naturally occurring pig CPT1B enzyme to generate ... carnitine: mm (for standard comparison with other published data), and a concentration equal to the Km for carnitine of each enzyme (for comparison between mutants) In this article, we show that Glu17 ... the yeast P pastoris Mitochondria (10 lg of protein) were separated by 8% SDS ⁄ PAGE Lane 1: D28Pig Lane 2: D18Pig Lane 3: Pig wild-type (B) Isolated mitochondria were assayed for CPT1 activity...
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12 Principles for Responding to Negative Online Comments
... respon ded, fin d ways to en g ag e direct with th e customer in question on an on g oin g basis En courag in g deeper discussion on th e topic will sh ow you are willin g to listen an d learn , ... d customer service teams un derstan d wh en an d h ow to in teract with th em Th is is n ot to say you sh ould ig n ore th e rest of th e commun ity wh ich , clearly, must n ot be allowed to feel ... ereafter reg ularly Appear an xious to h elp, as opposed to desperate to please Backin g yourself in to a rh etorical corn er can prove awkward wh en you h ave to extricate yourself publicly Be...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... thromboplastin time discovered prior to a surgical procedure An appendectomy, adenoidectomy, and right-knee arthroscopy carried out previously had been without mishap Laboratory analysis revealed a ... ME, Kato H & Davie EW (1974) The mechanism of activation of bovine factor IX (Christmas factor) by bovine factor XIa (activated plasma thromboplastin antecedent) Biochemistry 13, 45084516 Saito ... at least in part, this discrepancy Evolutionary conservation analysis of serine protease sequences shows that the position corresponding to FXIVal371 is highly conserved For example, among serine...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... However, this proteolysis is much slower in vitro, because of a lack of chaperone machinery The in vitro proteolysis requires ATP [14] We examined the proteolysis of purified r32-C-his (1.2 lm) ... proteolysis of r32 by different concentrations of CIII or CIIIC The bands corresponding to r32-Chis (1.2 lM) remaining after proteolysis with GST–HflB (0.8 lM) for 40 in the presence of His6–CIII ... HflB-mediated proteolysis of r32 by CIII or CIIIC The bands corresponding to r32-C-his (1.2 lM) remaining after proteolysis with GST–HflB (0.8 lM) in the absence or presence of (A) His6–CIII (100 lM)...
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It is time for us to check in for our flight ppt
... từ đó) It is time for us to check in for our flight 2 Các bạn di chuột vào cụm từ để biết chức cụm câu: It is time for us to check in for our flight 3 Tại câu lại dịch vậy? - “It is time” – ... *It is time for us to check in for our flight Hình thức cấu trúc ngữ pháp: “It’s time (for somebody) to something” - đến lúc người làm việc Chúng ta ... đầu làm công việc Chúng ta dùng cấu trúc để phê phán hay phàn nàn Ví dụ "It is time for us checked in for our flight It is long after the checking time (Lẽ nên làm thủ tục cho chuyến bay Đã làm...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... sorting and cytoskeletal regulation [1–5] The fatty acid composition of this phospholipid is quite distinctive in living organisms because, in comparison with other phospholipids, PI is by far the ... biosynthetic pathway for PI synthesis is well documented [14] PI is synthesized from phosphatidic acid (PA), which is further used as substrate by a cytidine diphosphate-diacylglycerol synthase to produce ... strongly that PI is remodeled in microsomal membranes before being transferred to mitochondria or, in other words, that Psi1p is located in the microsomal membranes This finding is in agreement...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc
... The synthesis was performed according to the methodology described by Soroka [15] Acetyl chloride (0.05 mol) was added dropwise to a vigorously stirred mixture of 0.1 mol of acetamide dissolved ... obtained are not very precise (150 mV for Dopa and 195 mV for compound 1), but indicate that the formation of the phosphonic o-quinone is not favored Thus, two other factors drive the reaction: ... site for the hydroxylation reaction to occur The same seems to hold for the derivatives of mandelic acid: 3,4-dihydroxymandelic acid is oxidized by tyrosinase, whereas 4-hydroxymandelic acid is...
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Báo cáo y học: " JNK activation is responsible for mucus overproduction in smoke inhalation injury" potx
... contributions WIC was responsible for carrying out the experiments, for data analysis, and for drafted this manuscript; KYK was responsible for the analysis and design for the histologic study; OS ... into groups: wild-type, WS24; JNK-1-/-, JKOC24; and wild type administered the JNK inhibitor, JIS24 Each group was assigned mice, and a total of 63 mice were studied Western blot analysis For ... parenchymal tissues, 4) increased peribronchial and perivascular cuff area, and 5) alveolar atelectasis The total lung injury score was calculated as the sum of each variable (0 for none or normal to for...
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12 principles for responding to negative comments in social media
... Online issues management principles • Actively listen for turbulence • Think laterally and connect the dots • Assume guilty until proved innocent • Everyone is a gatekeeper • Language is no barrier ... conversations • Develop Online Response Manual • Identify & train teams • Initially… • Respond to misleading statements • Focus on your own channels QUESTIONS? CONNECT WITH ME: @cpownall charliepownall.com...
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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
... TA isoforms act similarly to p53, inducing apoptosis In comparison, ΔN isoforms have little transactivation activity and play a role blocking target genes of p53 and their respective TAp73 isoforms ... used to predict the prognosis of colorectal cancer and to guide treatment [8] P73 has long been recognized as central to the induction of apoptosis in response to DNA damage, a function thought to ... correlates with a poor prognosis [21-23] and is associated with lack of response to EGFR inhibitors such as cetuximab [24,25] Wild type K-Ras status is currently required to administer cetuximab in monotherapy,...
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In order to become competent in a foreign language, it is important for language learners not only to acquire new vocabularies and a new set of phonological and syntactic rules but also to learn what Wilson (1986)
... ngữ to n dân đòa phương cụ thể với nét khác biệt so với ngôn ngữ to n dân hay với phương ngữ khác “[8; 24] Ở đây, thấy cần phân biệt ngôn ngữ to n dân phương ngữ Phương ngữ biến thể ngôn ngữ to n ... 13 1.1.1 Đặc điểm tự nhiên 14 1.1.1.1 Đòa hình, đất đai 14 1.1.1.2 Khí hậu, thuỷ văn 14 -3- 1.1.1.3 Sông rạch 15 1.1.1.4 Đảo, ... chỉnh riêng “một nhánh tách từ thân cây” [8; 54] ngôn ngữ to n dân Ngôn ngữ to n dân trừu tượng phương ngữ cụ thể “Phương ngữ ngôn ngữ to n dân có mặt trừu tượng mặt cụ thể ” [8; 54] 1.1.4.1.2...
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Software Design and Development (A guide) is help you how to managed IT Project. Especially for Design and Develop software project.
... is software ? Software is computer programs that provide instructions for individual machines to function and for combinations of machines to work together Day - Definitions & Overview What is ... Design Prototyping - its benefits Multiple prototyping tasks may be conducted to simultaneously to address various alternative design issues Can help resolve open issues ie Usercentred design issues, ... and design issues D Day - Software Design Analyzing the requirements To ensure that requirement is complete Obvious requirements are documented so that design decision is not left to the developer...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... binding affinity for [a32P]azido-ATP as KD = 201 ± 80 lm This affinity is similar to the value obtained for ATP binding to ABCB1 [29] The ability of nucleotides to displace binding is shown in Fig ... inference, therefore, the step in the catalytic cycle corresponding to the release of inorganic phosphate ([Pi]) is likely to correspond to the restoration of a high-affinity conformation for the transporter, ... evidence for an interaction between the two domains is the ability of numerous substrates and modulators of ABCG2 (and the R482G isoform) to stimulate the rate of ATP hydrolysis [21,24,25], albeit to...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... This is, to our knowledge, the first hypothesis of a genomic recombination event to account for genetic polymorphism at a locus encoding a milk protein MATERIALS AND METHODS Animals A total of 147 ... hydrolysis), corresponding to that expected for the F variant This result is the first evidence for the heterozygous status (M/F) of the individual goat milk analysed In addition to this, the ... 33-nucleotide exon Taken together, the exonic sequence data allowed us to construct a sequence corresponding to the complete cDNA of the M allele This sequence is given in Fig 6, where it is compared with...
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STRENGTHENING HEALTH SYSTEMS TO IMPROVE HEALTH OUTCOMES: WHO’S FRAMEWORK FOR ACTION pot
... e-mail: bookorders @who. int) Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above ... media WHO s tendency at present is to focus on the development of specific technical health policies This is important, but the added challenge for governments is to provide vision and direction for ... workforce asking questions that include: What strategic information is required to monitor the availability, distribution and performance of health workers? What are the regulatory mechanisms...
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Guidelines for Responsible Food Marketing to Children ppt
... Wilkenfeld Assistant Director for Advertising Practices Federal Trade Commission, 1981-95 Stefan Harvey and Harold Goldstein, Dr.P.H California Center for Public Health Advocacy Guidelines for Responsible ... marketed to kids Uniquely, the Guidelines for Responsible Food Marketing to Children set criteria for which foods are appropriate to market to children Other guidance regarding marketing to children ... and salt, and too low in fruits, vegetables, whole grains, and calcium This increases their risk of heart disease, cancer, diabetes, osteoporosis, and other serious and costly diseases Many children...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... particular importance for TfR1 interactions [16,17,20] The effect of HFE binding to TfR1 is to lower the affinity of the receptor for transferrin [15] This most likely reflects the existence of overlapping ... protein is unable to form a structurally important disulfide bridge required for HFE interactions with b2 microglobulin (b2M) [4,5,8–11] In the absence of b2M binding, the protein misfolds and is retained ... metabolism This includes hepcidin, a 25 amino acid antimicrobial peptide that is expressed in liver cells and is now recognized as a key regulator of iron homeostasis in the body Hepatocellular...
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Báo cáo khoa học: Passage through the Golgi is necessary for Shiga toxin B subunit to reach the endoplasmic reticulum pptx
... to this sequestration appears to have been to develop a mechanism to exploit retro- Shiga toxin in the Golgi grade transport out of the Golgi into the ER While this process is also slow, it is ... StxB to reach the ER in cytoplasts We wished to test directly if passage through the Golgi ⁄ TGN was required for StxB entry into the ER To accomplish this, we made use of subcellular surgery to ... Bound toxin is endocytosed via both clathrin-dependent and -independent mechanisms and is delivered to EEs [18–20] There is no known protein receptor for Stx B subunit (StxB), and the mechanism...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... from 0.5 to 12 h after transfection of Ku-80 IR gene is consistent with previous report that the stability of Ku-70 is compromised by the absence of Ku-80 [57] This is the first report to show ... factor in the regulation of WD promoter activity Comparison of WD promoter activity in Ku-deficient Xrs-5 cells to the activity in CHO cells To verify that Ku-80 is an essential regulatory factor ... was performed according to the Current Protocol method [35] Concentrated Ku proteins were digested with 50 lL 70% formic acid at 37 °C for 48 h The peptide fragments generated by the formic acid...
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