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According to Ashley Buckle, Associate Professor in Monash University , said that PlyC is 100 times more effective at killing bacteria than any other lysin found.[r]
(1)(2)
Kháng sinh chất chuyển hóa từ vi sinh vật hay chất tương đồng tổng hợp, chất tổng hợp không liên quan đến chất thiên nhiên; ở liều nhỏ các chất nầy ức chế sự phát triển sống sót vi sinh vật mà khơng có độc tính trầm trọng ký chủ
kháng sinh kháng khuẩn kháng sinh kháng nấm
kháng sinh kháng ung thư
(3)Chỉ số trị liệu = TD50 / ED 50
Độc tính chọn lọc là điểm quan trọng để phân biệt thuốc kháng sinh (antibiotic) với thuốc sát khuẩn (antiseptic)
Độc tính chọn lọc = Chỉ số trị liệu (therapeutic index)
TD50 = Liều gây độc tính cho 50% dân số
(4)1930 (các sulfonamid) – Nobel 1938 (sử dụng sulfanilamid- Paul Ehrlich)
- Flemming (Anh) khám phá penicillin 1929
-12-2-1941 thử nghiệm lâm sàng với penicillin thô thành công
1940 (các penicillin)
1944 : Aminoglycoside 1947: Chloramphenicol 1948: Tetracyclin 1952: Macrolid 1955: Cephalosporin 1965: Quinolon ………
Peptid [dalbavancin, oritavancin (2014), teixobactin (2015)]
Oxazolidinone [linezolid (2000), tedizolid (2014)]
(5)(6)Viral protein could replace antibiotics in future
Researchers have found that antibacterial viral protein can be used as an alternative to antibiotics
This research has been published online in the Proceedings of the National
Academy of Sciences (PNAS) USA
Antibacterial viral protein, PlyC, is a bacteriophage lysin It was first discovered in
1925 After the potential research in antibiotics, research on this protein stopped
But recently The Rockefeller University, University of Maryland and Monash
University’s School of Biomedical Sciences have reported that PlyC could be an important thing in the times of rising antibiotic resistance
(7)Viral protein could replace antibiotics in future
Via: News Australia
PlyC has the ability to kill the bacteria that can cause infections ranging from pneumonia to streptococcal toxic shock syndrome
Researchers from Monash University have successfully identified the atomic structure of PlyC to understand its antibacterial properties
“Scientists have been trying to decipher the structure of PlyC for more than 40 years,” said Monash’s Dr Sheena McGowan
“Finally knowing what it looks like, and how it attacks bacteria, is a huge step forward.” She said, PlyC “operates by locking onto the bacterial surface using eight separate docking sites located on one face of the saucer The two warheads can then chew through the surface of the cell, rapidly killing the bacteria.”