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- T GENE KRAS (CÔNG NGH SINH H ) : TS PGS TS T - 2013 17081779625878cca1030-7650-47a1-b6c6-99e1262206df 170817796258757f0e688-4f99-4b93-b6c3-6510a833c081 1708177962587f75ffb85-d193-474f-a89d-de6a8a381bca 10 11 14 14 14 14 15 17 17 18 .19 23 34 1.5 KRAS 37 2011 - 2013 GENE KRAS 40 .40 42 43 43 .43 2.1.2 Hóa ch 43 .44 2.2 45 45 .46 46 .48 2.2.5 -Dual Priming-Oligonucleotide) 49 52 56 56 6 56 2011 - 2013 KRAS 57 59 60 61 KRAS 62 64 67 68 69 2011 - 2013 Trung, khoa S t n l Tôi sinh-Vi - - Tôi B - tháng 09 2011 - 2013 do v 2011 - 2013 DAN APC: adenomatous polyposis coli EMEA:European Medicines Agenecy AKT: v-akt murine thymoma viral ESMO: European society for medical oncogene homolog oncology anti-EGFR mABs: anti-EGFR monoclonal ERBB: v-erb-b1 avian erythroblastic antibodies leukemia viral oncogene homolog BRAF: v-Raf murine sarcoma viral EDTA: Ethylene diamine tetraacetic acid oncogene CD: Crohn's disease CIN: Chromosomal instability CpG: Cytosine-phosphate-guanine CIMP: CpG Island Methylator Phenotype ERK: extracellular-signal regulated kinase FDA: Food and drug administration FAP: Familial Adenomatous Polyp FRZ: Frizzled GSK-e-3 GRB: growth factor receptor-bound CDK: cyclin dependent kinases protein DPO: Dual priming oligo GEFs: Guanine nucleotide exchange DCC: deleted in colorectal carcinoma DNA: Deoxyribonucleic acid DNMT: DNA methyltransferase DTCS: Dye terminating cycle sequencing ddNTP: dideoxynucleotide triphosphate factors GAPs: GTPase-activating proteins GTP: Guanosine-5'-triphosphate GDP: Guanosine diphosphate HNPCC: Hereditary non-polyposis colorectal cancer EGFR: Epidermal growth factor receptor 2011 - 2013 HER: human epidermal growth factor HLH1: hemophagocytic receptor lymphohistiocytosis HAT: Histon acetyltransferase mt: mutant HDAC: Histon deacetylase NST HRM: High Resolution Melting IBD: Inflammatory bowel disease IGF1R: insulin-like growth-factor-1 OD: Optical density p53: protein p53 p21: protein p21 receptors PI3K: Phosphoinositide 3-kinase IRS-1: insulin receptor substrate PDGFR: platelet-derived growth-factor JUN: jun proto-oncogene KRAS: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog LRP: lipoprotein receptor-related protein MEK: mitogene-activated protein kinase MAPK: mitogene activated protein kinase MMR: Mismatch repair enzymes MSH: mutS homolog receptor PIP2: phosphatidylinositol-4, 5bisphosphate PIP3: phosphatidylinositol-3,4,5trisphosphate PDK: phosphoinositide-dependent kinase PTEN: Phosphatase and tensin homologue PIK3CA: Phosphatidylinositol-4,5- MeCP2: methyl CpG binding protein bisphosphate 3-kinase MBD: methyl-CpG binding domain PBS: Phosphate buffer saline protein MLH1: mutL homolog PCR: Polymerase chain reaction pH: Hydrogene power 2011 - 2013 MSI: Microsatellite instability SFRPs: Secreted Frizzled-related proteins SOS: son of sevenless TGFBR: transforming growth factor beta receptor SHC: Src homology TP53: tumor protein p53 SDS: Sodium dodecyl sulfate UICC: Union for International Cancer TE: Tris-EDTA Control TGF-transforming growth factor beta TGFB:transforming growth factor beta mTOR: mammalian target of rapamycin RNA: Ribonucleic acid UC: Ulerative colitis WNT: Wingless-type wt: Wild type RTK: receptor tyrosine kinase bp Base pair mm minimetter Centigrade mM Millimolar Ct Threshold cycle mg Milligram h Hour nm Nanometer kDa KiloDaltons rpm Revolutions per mimute M Molar µg Microgram mL Milliliter Microliter C 2011 - 2013 39 KRAS 41 Realtime .51 KRAS máy Realtime PCR 52 53 (Stop Solution) .54 2 56 56 KRAS 63 Realtime .64 AS máy Realtime 65 10 2011 - 2013