Nghiên ứu tổng hợp amantadin hydroclorid từ adamantyl bromid trên cơ sở phản ứng kiểu ritter

Tên gọi, công thức cấu tạoHình 1.. Phương pháp nghiên cứu khảo sát tổng hợp amantadin hydroclorid trên cơ sở công bố của Marvin P.. Quy trình tổng hợp amantadin hydroclorid theo Marvin P

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Ban co the xoa dong chu nay!!! 17057204843041000000   -    PHN NG KI RITTER                          Chuyên ngành:   CA170302    - -chng 3) - g web thành báo tham kh  -  trang 17) -  - Thê         -       Trang         1.1  1.1.1  1.1.2  1.2  1.3  amantadin hydroclorid theo 1.4 Tác  1.4.1    1.4.      10 1.5  1.6   10 10 10  11  11  12  12  13 p 13  13 1.6.9  14   2.1 15 15 2.1 15 2.1 16 2.2 16 2.2.1  16 2.2.2  17 2.2.3        18 Marvin P Watts J 2.2.4 22 Ad-Br CH3CONH2  2CHO 2.3 26  26 2.5  27 2.5. 27 2.5R) 28 2.5. 29 2.6 K  30 THC NGHIM  32          -NH2.HCl quy mơ phịng thí 32  J -Br CH3CN ntadin hydroclorid theo 32  2.HCl 33 Marvin P., Watts J 3.2 Nghiên   Ad-Br 40 CH3CONH  2CHO 3.2.1 Nghiên        Ad-Br -NH40 2.HCl  CH3CONH 3.2.2 Nghiên          48 2 NH2CHO K QU 59 4.1 K qu kh sát xây dng quy trình tng hp amantadin hydroclorid 59 c s phn ng ki Ritter 4.1.1         59  4.1.2  60   4.2 K qu nghiên c phng pháp m tng hp amantadin hydroclorid  62 adamantyl bromid  62   63  4.3  64  4.3.1  a 64 4.3.2  65 4.3.3  67                              2017 - 2018           GS.TSKH Phan Đình Châu, TS Nguyễn Hữu Tùng –     PGS.TS Vũ Bì góp ý t          NCS Nguyễn V Phạm Văn Hiển, anh Hồ Bá Ngọc Minh   -       ,     30 tháng 05 2018  Vân Trần Thị Vân        “Nghiên cứu tổng hợp amantadin hydroclorid từ adamantyl bromid sở phản ứng kiểu Ritter”  “Nghiên cứu xây dựng quy trình tổng hợp amantadin làm thuốc điều trị cúm A”   Ngày 30   Vân Trần Thị Vân  STT   Ad-NHCOCH3 Adamantyl acetamid Ad-Br Adamantyl bromid Ad-NHCHO Adamantyl formamid Ad-NH2 Amantadin Ad-NH2.HCl Amantadin hydroclorid 13 (Carbon 13 Nuclear Magnetic Resonance Spectroscopy) C  NMR 13C H  NMR (Proton Nuclear Magnetic Resonance Spectroscopy) 1H CTPT  EtOH Ethanol 10 DEG Diethylene glycol 11 h  12 HS   13 g Gam 14 IR  15 msp  16 mg Miligam 17 MeOH Methanol 18 MS  19 PG Propylen glycol 20 SKBM  21 SPTG  22 t°nc  23 t°  24 tR     Trang 2.1  15  3.1  35 1.1 -NHCOCH 3.2    Ad-Br  36 3CN    -NHCOCH 3.3       Ad -   37 SO4  AdNHCOCH 3.4  42 -NHCOCH 3.5      Ad-  44 3CONH Ad-NHCOCH 3.6        Ad-    45 2SO4 Ad-NHCOCH 3.7  47 -NH 2 3.8  50 -NHCHO 3.9      Ad-  51 2SO4 -NHCHO 3.10   2CHO Ad- 52 -NHCHO 3.11  55  2.HCl- 3.12  56 -NH 2.HCl 3.13  57 thành Ad-NH2.HCl 4.1 K qu kim nghim mu amantadin hydroclorid tng h 61