TNU Journal of Science and Technology 227(10) 219 227 http //jst tnu edu vn 219 Email jst@tnu edu vn ANTIOXIDANT, ANTIHYPERGLYCAEMIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF DRIED EXTRACT FROM OF GRAPEFRU[.]
TNU Journal of Science and Technology 227(10): 219 - 227 ANTIOXIDANT, ANTIHYPERGLYCAEMIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF DRIED EXTRACT FROM OF GRAPEFRUIT (Citrus grandis (L.) Osbeck) PEEL IN ALLOXAN-INDUCED DIABETIC MICE Trinh Thi Hong Ngoc1, Tran Chi Linh2, Luu Thai Quan3, Ngo Anh Duc3 Phan Minh Tu3, Do Thi Hong Xuyen3, Nguyen Ngoc Quynh3* 1Bac Lieu City Medical Center, 2Can Tho University, 3Can Tho University of Medicine and Pharmacy ARTICLE INFO Received: 21/6/2022 Revised: 14/7/2022 Published: 14/7/2022 KEYWORDS Antidiabetic Antioxidant Antihyperlipidemic Blood glucose α-Glucosidase ABSTRACT The present study was aimed to evaluate the in vitro antidiabetic (αglucosidase inhibition assay) and antioxidant (DPPH scavenging and ferric reducing-antioxidant power) activities of dried extract from pomelo peel The in vivo antihyperglycaemic and antihyperlipidemic activities of dried extract from pomelo peel were performed in alloxan monohydrate-induced diabetic mice The dried extract from pomelo peel has the ability to inhibit the enzyme α-glucosidase, and possess the antioxidant activity Administrations of dried extract from pomelo peel at 100, 200 and 400 mg/kg doses to AM-induced diabetic mice resulted in significant decrease (p