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11 st GASTROENTEROLOGICAL CONGRESS OF SOUTHEAST ASEAN NATIONS 22 nd NATIONAL SCIENTIFIC CONGRESS ON GASTROENTEROLOGY Prevalence of Helicobacter pylori infectionpylori and gastroduodenal Prevalence of Helicobacter infection diseases in minor ethnic groups in Vietnam and gastroduodenal diseases in minority ethnic groups in Vietnam Vu Van Khien2, Ho Dang Quy Dung1, Tran Thanh Binh1, Tran Thi Huyen Trang2, Tran Dinh Tri1, Bui Chi Nam2, Yoshio Yamaoka3, et al 108 Military Central Hospital and Cho Ray Hospital –Vietnam1-2 Dept of Environmental & Prevention Medicine, Oita University, Japan3 Slide Library Introduction Vietnam is located in Southeast Asia, comprising of 54 ethnic groups Halong Bay Population: 90.493.352 (April, 2014) Ho Chi Minh Slide Library Laocai (27 ethnicities) Hanoi (Kinh people) The Vietnamese (called Kinh) people are a major ethnic group accounting for 87% of the Vietnamese population List of ethnic groups in Vietnam Hue (Kinh people) Daklak (47 ethnicities) Other ethnic groups living mountains or highlands HoChiMinh City (Kinh people) Helicobacter pylori in Vietnam Slide Library Prevalence of H.pylori infection was reportedly high in Vietnam H pylori infection is common among Kinh people Infected Non-infected Male Female Hochiminh Hanoi General 20 40 60 80 Prevelance of H.pylori infection: 65.6% 100 % Nguyen TL, Uchida T, Tsukamoto Y, et al Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a crosssectional, hospital-based study BMC Gastroenterol 2010;Slide 10: Library 114 Unresolved issue H pylori infection in Vietnam has been reported 1,2 (Focused on Kinh people) Prevalence of H pylori infection as well as Gastroduodenal diseases in minority ethnic groups in Vietnam have not been studies Nguyen TL, Uchida T, Yamaoka Y et al Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study BMC Gastroenterol, 2010; 10: 114-120 Hoang TT, Bengtsoon C, Phung DC et al (2005) Seroprevalence of Helicobacter pylor infection in urban and rural Vietnam Clin Diagn Lab Immunol, 2005: 2; 81-85 Slide Library We examine H pylori status in minor ethnic groups in provinces: Laocai (North) and Daklak (Central) Laocai Hanoi Dao Nung Daklak Tay Hochiminh Slide Library Aims H pylori infection in minority ethnic groups in Vietnam H pylori-related gastroduodenal diseases pylori Investigate H pylori- related histological finding H pylori virulence in minority ethnic groups in Vietnam Slide Library Research plan and Timeline 07/2012 ce tati ta on a n ce p le dat da sen n ere ing Pre f Con k Ma sam i rov vin ce le mp p ro g sa p cai ting g kin Ma le Col Lao n lecti Col la k Dak Slide Library 6/2016 2014 2015 07/2013 Methodology Subject -Patients: 494 - Laocai: 294 - Daklak: 200 -210 Males - 284 Females H pylori infection -Culture -Serum ELISA -Histology -Rapid urease test Diagnosis -Endoscopy -Histology: Updated Sydney System Operative Link on Gastritis Assessment (OLGA) system Slide Library Genotyping -Investigation of virulence factors: cagA, vacA by sequencing and PCR Strong correlation between H pylori infection and Peptic ulcer Gastroduodenal disease Gastritis Peptic ulcer Gastric cancer Reflux esophagitis Total H pylori infection: n (%) 167/446 (37.4%)a 17/28 (60.7%)a 0/1(0%) 4/19 (21.1%) 188/494 (38.0%) Gastric ulcer, duodenal ulcer: 16/494 (3.2%) & 12/494 (2.4%) respectively H pylori infection in Peptic ulcer higher than gastritis (p