TỔNG QUAN về THÀNH PHẦN hóa HỌC và tác DỤNG SINH HỌC của THUỐC cổ TRUYỀN có CÔNG NĂNG THANH NHIỆT GIẢI độc KHÓA LUẬN tốt NGHIỆP dược sĩ hà nội 2022

BỘ Y TẾ TRƯỜNG ĐẠI HỌC DƯỢC HÀ NỘI LÊ NGỌC THÙY LINH TỔNG QUAN VỀ THÀNH PHẦN HÓA HỌC VÀ TÁC DỤNG SINH HỌC CỦA THUỐC CỔ TRUYỀN CÓ CƠNG NĂNG THANH NHIỆT GIẢI ĐỢC KHĨA LUẬN TỐT NGHIỆP DƯỢC SĨ HÀ NỘI - 2022 BỘ Y TẾ TRƯỜNG ĐẠI HỌC DƯỢC HÀ NỘI LÊ NGỌC THÙY LINH Mã sinh viên: 1701311 TỔNG QUAN VỀ THÀNH PHẦN HÓA HỌC VÀ TÁC DỤNG SINH HỌC CỦA THUỐC CỔ TRUYỀN CÓ CƠNG NĂNG THANH NHIỆT GIẢI ĐỢC KHĨA LUẬN TỐT NGHIỆP DƯỢC SĨ Người hướng dẫn: PGS TS Bùi Hồng Cường Nơi thực hiện: Bộ môn Dược học cổ truyền HÀ NỘI - 2022 LỜI CẢM ƠN Trước tiên, em xin chân thành cảm ơn thầy cô cùng bộ môn Dược học cổ truyền trường Đại học Dược Hà Nội, đặc biệt PGS TS Bùi Hồng Cường người tận tình hướng dẫn, giúp đỡ và đợng viên em, cho em bảo quý báu suốt thời gian thực khóa luận Xin chân thành cảm ơn thầy, cô anh chị kỹ thuật viên Bộ môn Dược học cổ truyền giúp đỡ tạo điều kiện cho em trình nghiên cứu, hồn thiện khóa luận Đồng thời em xin chân thành cảm ơn cán bộ thư viện Đại học Dược Hà Nợi, cán bợ phịng đào tạo, bợ mơn, phịng ban khác trường Đại học Dược Hà Nợi tạo điều kiện cho em suốt trình nghiên cứu hồn thành khóa luận Cuối em xin cảm ơn gia đình bạn bè ln giúp đỡ, đợng viên đóng góp ý kiến cho em hồn thành khóa luận Hà Nội, ngày 28 tháng năm 2022 Sinh viên Lê Ngọc Thùy Linh MỤC LỤC LỜI CẢM ƠN MỤC LỤC DANH MỤC CÁC CHỮ VIẾT TẮT DANH MỤC CÁC BẢNG ĐẶT VẤN ĐỀ CHƯƠNG ĐỐI TƯỢNG VÀ PHƯƠNG PHÁP THU THẬP THÔNG TIN 1 ĐỐI TƯỢNG 2 PHƯƠNG PHÁP NGHIÊN CỨU 2 Phương pháp thu thập thông tin 2 Phương pháp xử lý thơng tin CHƯƠNG TỞNG QUAN VỀ THUỐC CĨ CƠNG NĂNG THANH NHIỆT GIẢI ĐỢC 2.1 Mợt số khái niệm nhiệt độc danh mục vị thuốc có cơng nhiệt giải đợc 1 Khái niệm nhiệt 2 Thuốc nhiệt giải độc 2 Tổng quan thành phần hóa học tác dụng sinh học vị thuốc có cơng nhiệt giải đợc 11 2 Bạch đồng nữ (Folium Clerodendri chinense) 11 2 Bạch hoa xà thiệt thảo (Herba Hedyotidis diffusae) 13 2 Bạch tiễn bì (Cortex Dictamni) 19 2 Bán chi liên (Herba Scutellariae barbatae) 25 2 Bảy một hoa (Rhizoma Paridis) 29 2 Bồ công anh (Herba Lactucae indicae) 34 2 Diếp cá (Herba Hottuyniae cordatae) 37 2 Diệp hạ châu (Herba Phyllanthi urinariae) 45 2 Diệp hạ châu đắng (Herba Phyllanthus amarus) 52 2 10 Đơn đỏ (Herba Excoecariae cochinchinensis) 57 2 11 Đơn kim (Herba Bidensis pilosae) 60 2 12 Giảo cổ lam (Herba Gynostemmae pentaphylli) 65 2 13 Hạ khô thảo (Spica Prunellae) 70 2 14 Kim ngân hoa (Flos Lonicerae) 74 2 15 Liên kiều (Fructus Forsythiae) 84 2 16 Mã tiên thảo (Herba Verbenae) 92 2 17 Mần tưới (Herba Eupatorii) 94 2 18 Rau sam (Herba Portulacae oleraceae) 98 2 19 Ráy gai (Rhizoma Lasiae spinosae) 104 2 20 Sài đất (Herba Wedelia) 108 2 21 Thổ phục linh (Rhizoma Smilacis glabrae) 113 2 22 Trinh nữ hoàng cung (Folium Crini latifolii) 118 2 23 Xạ can (Rhizoma Belamcandae) 121 2 24 Xích đồng nam (Radix Clerodendri japonica) 129 2 25 Xuyên tâm liên (Herba Andrographitis paniculatae) 133 CHƯƠNG BÀN LUẬN CHUNG 143 Thành phần hóa học vị thuốc có cơng nhiệt giải độc 143 1 Bàn luận tác dụng flavonid vị thuốc có công nhiệt giải độc 150 Bàn luận tác dụng polysaccharid vị thuốc có cơng nhiệt giải đợc 150 3 Bàn luận tác dụng thành phần khác vị thuốc có cơng nhiệt giải độc 150 Tác dụng sinh học vị thuốc có cơng nhiệt giải độc 147 Đặc điểm chung vị thuốc có cơng nhiệt giải độc 147 2 Bàn luận tương đồng quan điểm đông y với kết nghiên cứu khoa học đại 150 3 Tác dụng bất lợi 154 KẾT LUẬN VÀ ĐỀ XUẤT 157 TÀI LIỆU THAM KHẢO 158 DANH MỤC CÁC CHỮ VIẾT TẮT 3CLpro Protease virus SAR-CoV-2 ABTS 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) AChE Acetylcholinesterase AD Alzheimer ALT, AST, GPT Men gan Apoptosis Sự chết tế bào theo chương trình Autophagy Quá trình suy thối tự nhiên BCA Bồ cơng anh BchE Butyrylcholinesterase BCL Bán chi liên BĐN Bạch đồng nữ BHXTT Bạch hoa xà thiệt thảo BLMH Bảy một hoa BTT Bạch tiễn bì CAT Catalase COX Cyclooxygenase DC Diếp cá DHC Diệp hạ châu DHCĐ Diệp hạ châu đắng ĐK Đơn kim ĐLĐ Đơn đỏ DPPH 2,2-diphenyl-1-picrylhydrazyl EC50 Nồng độ hiệu tối đa một nửa FBG Đường huyết lúc đói GCL Giảo cổ lam GPx Glutathione peroxidase GR Glutahthione reductase GSH Glutahthione GSTs Glutathione S-transferase HbsAg, HbeAg Kháng nguyên virus viêm gan B HBV, HCV Virus viêm gan virus B, C HDL-C, LDL-C Lipoprotein cholesterol tỷ trọng cao thấp HIV Virus gây suy giảm miễn dịch người HKT Hạ khô thảo HMC-1 Tế bào mast người HSV Herpes Simplex virus IBV Virus gây bệnh viêm phế quản truyền nhiễm gà IC50 Nồng độ ức chế tối đa một nửa IgE Globulin miễn dịch E IL Interleukin KNH Kim ngân hoa LD50 Nồng độ gây chết LK Liên kiều LPS Lipopolysaccharid MAPK Mitogen activated protein kinase MDA Malondialdehyde MIC Nồng độ ức chế tối thiểu MRSA Tụ cầu vàng kháng Methicilin MT Mần tưới MTT Mã tiên thảo NF-кB Nuclear factor kappa B NO, iNOS Nitric oxid, tổng hợp nitric oxid -OH Gốc Hydroxyl PGE2 Prostaglandin E2 PLpro Proteinase giống papain RdRp Enzym RNA polymerase phụ tḥc RNA mã hóa SARSCoV-2 RG Ráy gai ROS Reactive oxygen species RS Rau sam RSV Virus hợp bào hô hấp SĐ Sài đất SOD 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(kaempferol-3-O-[2-O-(6-O-E-feruloyl )-? ?-d- glucopyranosyl ]-? ?-d-galactopyranosid, quercetin-3-O-[2-O-(6-O-E-feruloyl )-? ?-d glucopyranosyl ]-? ?-d-galactopyranosid, quercetin-3-O-[2-O-(6-O-E-feruloyl )-? ?-dglucopyranosyl ]-? ?-d-glucopyranosid,... ĐẠI HỌC DƯỢC HÀ NỘI LÊ NGỌC THÙY LINH Mã sinh viên: 1701311 TỔNG QUAN VỀ THÀNH PHẦN HÓA HỌC VÀ TÁC DỤNG SINH HỌC CỦA THUỐC CỔ TRUYỀN CĨ CƠNG NĂNG THANH NHIỆT GIẢI ĐỢC KHÓA LUẬN TỐT NGHIỆP