Expression and function of glial cell line derived neurotrophic factor family receptor alpha 1 alternatively spliced isoforms

... effects of GDNF 1. 5 GFR 1 9 10 11 1. 5 .1 GFR 1 and its spliced isoforms 11 1. 5.2 Expression and functional role of GFRα1a 12 ii 1. 6 Alternatively spliced isoforms 13 1. 7 Quantification of gene expression ... of The Two GFR 1 Spliced Receptor Isoforms 54 4 .1 Introduction 55 4.2 Materials and Methods 56 4.2 .1 Stably transfected cell lin...

Ngày tải lên: 05/10/2015, 22:31

... and Akt in both LN-229 and A1 72 human glioblastoma cell lines GDNF was however found to reduce the background activation of JNK and the A1 72 human glioblastoma cell line in a timedependent fashion ... potentiate adjuvant therapy It is likely that the chemoresistance properties are potentiated by autocrine and paracrine pathways and facilitated by mit...

Ngày tải lên: 14/09/2015, 12:13

... investigate the physiological relevance of Noxo1c expression in the testis, we examined expression of Nox1 and Noxa1 by PCR analysis and found a small but significant amount of the Nox1 and Noxa1 mRNAs ... al Expression and function of Noxo1c A B C Fig Alternative splice forms of human Noxo1 (A) The genomic organization of human NOXO1 gene Translated seque...

Ngày tải lên: 19/02/2014, 06:20

... role in innate and acquired immune response Elucidating the mechanisms by which miR-155 expression is controlled and finding its targets will bring more understanding of the mechanisms of tumor induction ... promising techniques for modulating miRNA action The same stands for the use of mimic miRNAs in order to reconstitute the expression of lost miRNAs in tumors The devel...

Ngày tải lên: 08/08/2014, 17:20

... biotinylated using FluoReporter® Mini-biotin-XX Protein Labeling Kit (Invitrogen Japan K.K., Tokyo, Japan), in accordance with the manufacturer's instructions Biotinylation was confirmed by coating ... biotinylated JMAb23 (human IgG2; thin line) and streptavidin-FITC, and then analyzed using flow cytometry (e) Human ICOS expressing CHO-K1 cells were stained biotinylated SA12 (6.25 µg/...

Ngày tải lên: 09/08/2014, 07:20

... against human JAM-C Interestingly, expression of JAM-C was mainly found in the lining layer and was associated with vessels in the sublining layer (Figure 1a,b) in OA and in RA synovial biopsies ... Expression of junctional adhesion molecule-C in human and mouse synovial tissues We investigated JAM-C expression in human OA and RA synovial samples by IHC usi...

Ngày tải lên: 09/08/2014, 10:20

... Characterization of hHK-1- and endokinins-induced responses in guinea pig airways Contractile effects of hHK-1 and endokinins in isolated guinea pig airways Human hemokinin-1 induced concentration-dependent ... TAC4 and hHK-1 in human bronchi, together with a role of hHK-1 and endokinins in the contraction of human and guinea pig airways Methods...

Ngày tải lên: 12/08/2014, 11:22

... doi:10.1186/1465-9921-12 -39 Cite this article as: Nikota et al.: Differential expression and function of breast regression protein 39 (BRP -39) in murine models of subacute cigarette smoke exposure and allergic airway ... the induction of BRP39 In contrast, BRP -39 was required for the expression of allergic airway inflammation Our study...

Ngày tải lên: 12/08/2014, 13:22

... transcription factor function The combined results of these studies have expanded our current understanding of the expression and function of the PRL family of enzymes as well as of the role these important ... Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Expression and Function of the PRL Family of Protein Tyro...

Ngày tải lên: 24/08/2014, 11:44

... microcapsule transplantation …… 11 1 4 .1. 3.4 Behaviors of microencapsulated MEPI -1 cells. …………….… 11 2 4 .1. 4 Immaturity of encapsulated MEPI -1 cells ….………………… 11 3 4 .1. 5 Summary of transplantation of microencapsulated ... diabetes ………………….……………9 1. 2 .1 Human islet transplantation for type diabetes mellitus…………… …9 1. 2.2 Substitute -cell therapy for t...

Ngày tải lên: 11/09/2015, 09:58

... aspartate, arginine, asparagine, tyrosine and valine were also demonstrated to be elevated in the CSF of chronic pain patients as compared to that of acute pain patients On the other hand, GABA ... microglia are involved in the early development of chronic pain, while astrocytes function in sustaining the pain (Vallejo et al., 2010) An interesting findin...

Ngày tải lên: 02/10/2015, 17:15

... GFRa1 Dr GFRa1a Dr GFRa1b Rn GFRa1 Hs GFRa1 Mm GFRa1 (1) (1) (1) (1) (1) (1) Ol GFRa1 Dr GFRa1a Dr GFRa1b Rn GFRa1 Hs GFRa1 Mm GFRa1 (69) (72) ( 81) (69) (69) (69) Ol GFRa1 Dr GFRa1a Dr GFRa1b ... Rn GFRa1 Hs GFRa1 Mm GFRa1 (14 5) (14 8) (15 7) (14 9) (14 9) (14 9) Ol GFRa1 Dr GFRa1a Dr GFRa1b Rn GFRa1 Hs GFRa1 Mm GFRa1 (225) (228) (237) (225) (225) (225) Ol GFRa1 Dr GFRa1a Dr GFRa1b Rn GFRa1...

Ngày tải lên: 03/10/2015, 20:57

... the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this siRNA 72 hours after the transfection, the cells ... that it was a candidate tumor suppressor gene The over-expression of DLEC1 in hepatocellular carcinoma (HCC) cell lines such as HepG2 and SK-Hep-...

Ngày tải lên: 16/10/2015, 15:37

... Consequently, the molecular studies of the interaction of SAgs with their specifics ligands will not only advance understanding of the physiological mechanisms of these molecules, but may lead to the development ... Fig 1B–D, expression of the mutant yields only monomeric SSA, free of dimer T-cell proliferation assay We next analyzed the ability of recombinan...

Ngày tải lên: 07/03/2014, 16:20