Modulation of dorsal hippocampus field CA1 pyramidal cell excitability by an ascending relay from hypothalamic supramammillary nucleus
Modulation of dorsal hippocampus field CA1 pyramidal cell excitability by an ascending relay from hypothalamic supramammillary nucleus
... Effects of carbachol microinjection on CA1 pyramidal cell excitability 86 3.2.2 Spatial analysis of the effect of carbachol microinjection on CA1 pyramidal cell excitability 3.2.3 98 Relationship of ... field CA1 of the rat Brain Res 1004(1-2): 167-176 Jiang, F and Khanna, S (in preparation) Cholinergic mechanisms in supramammillary region mediate suppression of CA1 pyramidal cell synaptic excitability ... stratum pyramidale has 3-4 rows of the principal (pyramidal) cells The pyramidal cells of hippocampus along with the principal (granule) cells of the dentate gyrus make up the bulk (~90%) of the cell...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... shown) Inhibition of pneumococcal murein hydrolases by bicyclic amines As shown above, tropic esters of bicyclic amines were selected and characterized by biophysical methods as strong ligands ... that the bicyclic amines are also able to bind to the active site of Pce Effect of choline analogs on cell growth and viability Fig Effect of choline and analogs on the activity of cell wall ... by CD Fig Spectroscopic analysis of ligand binding to C-LytA (A) Conformational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligands:...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
... This report outlines the design of novel DNAzymes that target uPAR mRNA as a method of inhibiting its expression and thereby decreasing the invasive potential of tumor cells Results In vitro cleavage ... Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells ... be interesting to perform further studies in other cancer cell lines and in an animal model to show the efficacy of anti-uPAR DNAzymes in preventing cancer cell growth and metastasis A number of...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... activity of HL-60 Cells Utilizing the induced differentiation of HL-60 promyelocytic leukemia cells as a model of myeloid maturation, we examined the expression and location of Rac and PAK The interaction ... cells induced with ATRA Induction of Rac and PAK HL-60 cells were treated with lM ATRA for a week, and Rac and PAK were assayed in both cytosol and membrane fractions Rac occurs as two isoforms (Rac1 ... Immunoblot analysis of Rac in the cytosolic and membrane fractions of HL-60 cells The differentiation of the cells were induced with lM ATRA for 0, 1, 3, and days (lane 0–7) and lane N indicates human...
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Báo cáo sinh học: " Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274" pdf
... independently analyzed by two investigators The staining score was calculated from the staining intensity and percentage of positive staining cells The staining intensity was scored as (very weak), (weak), ... http://www.translational-medicine.com/content/9/1/64 Page of 10 Figure Analysis of the expression and localization of phosphorylated c-MET in RMS tissue samples Represent images of HE staining and IHC staining of myogenin and phospho -c-Met ... sustain tumor survival (EGFRmut in non -small cell lung carcinoma [11,12] and c-Kit in gastrointestinal stromal tumors [13]) Inhibiton of RTKs by small, targeted molecules has exhibited significant...
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báo cáo hóa học:" Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274" pdf
... independently analyzed by two investigators The staining score was calculated from the staining intensity and percentage of positive staining cells The staining intensity was scored as (very weak), (weak), ... http://www.translational-medicine.com/content/9/1/64 Page of 10 Figure Analysis of the expression and localization of phosphorylated c-MET in RMS tissue samples Represent images of HE staining and IHC staining of myogenin and phospho -c-Met ... sustain tumor survival (EGFRmut in non -small cell lung carcinoma [11,12] and c-Kit in gastrointestinal stromal tumors [13]) Inhibiton of RTKs by small, targeted molecules has exhibited significant...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx
... volunteers in Rio de Janeiro (Brazil) after oral vaccination with M bovis BCG Moreau RDJ Methods Volunteers and skin testing Healthy subjects aged 18–50 years were recruited who gave no history of pulmonary ... dose of oral vaccine and had been immunised in infancy via the oral and intradermal routes respectively, displayed an altered humoral immune response with antibodies of isotype IgA Arrows indicate ... explain the paucity or lack of DTH response in orally immunised individuals is that different populations of T cells are activated by BCG vaccination via the oral and intradermal routes [20] strains,...
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Báo cáo khoa học: Characterization of the tRNA and ribosome-dependent pppGpp-synthesis by recombinant stringent factor from Escherichia coli pot
... 6E) From these results it can be concluded that tRNAs were bound in classical states with the tRNAMet bound f in the P-sites of the 30S and 50S subunits and the tRNAPhe bound in the A-site of the ... SF and tRNA were added simultaneously to the reaction mixtures, in agreement with the results presented by Wendrich et al [7] tRNA and ribosome-dependent synthesis by stringent factor the tRNA ... and purified SF from E coli and examined the ribosome, template and tRNA- dependence of the pppGpp synthesis reaction Purification of recombinant SF We started out by purifying SF by affinity-chromatography...
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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
... with an intra-peritoneal injection of 400 mg/kg chloral hydrate (Pharmaceutical Plant of Tiantan Hospital, Beijing, China) The rectal temperature was monitored and maintained at 37.5°C A scalp incision ... infarcted brain parenchyma of transplanted rats (A- iii and A- iv) A comparable extent of class II MHC was noted in ischemic rats irrespective of any therapy but unremarkable in normal rat (panel B, ... staining of Class II MHC was evident in the infarcted brain parenchyma (B-i), along the meninge (B-ii), areas near the ventricular lining and vascular wall near the hippocampus (B-iv) of transplanted...
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Báo cáo sinh học: " Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line" docx
... that anti-RSV IgG incubation induced the removal and re-appearance of intracellular viral pro- Figure Confocal laser scanning image of intracellular RSV proteins Confocal laser scanning image of ... HEp-2 cells, anti-RSV IgG was added, and cell viability was determined at 2, 24, 48, and 72 h of incubation Sterile 0.2% ethylenediamine tetra acetate (EDTA) in 0.9% saline was added to each cell ... times in sucrose medium permeabilized and fixed, in acetone and methanol Confocal laser scanning was used to obtain images of intracellular viral proteins visualized as described in Figure Page of...
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Báo cáo hóa học: " Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line" pot
... that anti-RSV IgG incubation induced the removal and re-appearance of intracellular viral pro- Figure Confocal laser scanning image of intracellular RSV proteins Confocal laser scanning image of ... HEp-2 cells, anti-RSV IgG was added, and cell viability was determined at 2, 24, 48, and 72 h of incubation Sterile 0.2% ethylenediamine tetra acetate (EDTA) in 0.9% saline was added to each cell ... times in sucrose medium permeabilized and fixed, in acetone and methanol Confocal laser scanning was used to obtain images of intracellular viral proteins visualized as described in Figure Page of...
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Báo cáo y học: " Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses" pps
... altering cytokine production of a CD8+ T -cell subpopulation and by decreasing the antigenpresenting activity of dendritic cells Figure Effect of chitosan interferonc nanogene (CIN) therapy on the dendritic ... identified by intracellular cytokine staining and counted by flow cytometry after gating for tetramer-labelled cells C, Apoptosis of OVA-specific CD8+ T cells from lungs determined by TUNEL assay and ... cells that are also CD11b+ The data are based on cytometry of a minimum of 15,000 cells and were substantiated by a repeat experiment Kong et al, Chitosan Interferon-c Nanogene Therapy for Lung...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
... Takeno M, Saito N, Yokoe T, Kaneko A, Asai T, Sakane T: Modulation by proinflammatory cytokines of Fas/ Fas ligand- mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis ... to FasL -induced cell death, and TNF -α prevented these cells from undergoing FasL -induced cell death in a dose-dependent manner No such inhibitory effects of TNF -α on FasL -induced apoptosis were ... the proinflammatory cytokine TNF -α has strong apoptosis inhibiting effects in periarticular tenocytes from OA patients but does not affect apoptosis significantly in normal tenocytes In our experiments,...
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Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx
... against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice Genetic Vaccines and Therapy 2010, 8:2 Page of ... and mature DCs, resulting in tolerogenic interaction with T cells in SIT We found that the combination of DNA vaccination with Fc and OVA had better effects onOVAinduced alterations in the spleen ... pathway of regulation of type immunity in asthma Competing interests The authors declare that they have no competing interests Authors' contributions YL performed all analyses and wrote the initial...
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The role of adenosine, adenosine receptors and transporters in the modulation of cell death
... The number of amino acids comprising the extra- and intracellular loops and the extracellular N-terminal and intracellular C-terminal regions of the bovine A1 receptor are indicated in parentheses ... during the adenosine- induced apoptosis in 163 BHK cells Fig 3.70 Activation of caspase during the adenosine- induced apoptosis 165 in BHK cells Fig 3.71 Caspase-3 activity during the adenosine- induced ... ADP, AMP and adenosine, selective antagonism of the effects of adenosine by methylxanthines, activation of adenylate cyclase by adenosine and stimulation of prostaglandin synthesis by ATP and ADP...
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Từ khóa: modulation of t cell mediated immunity by cytomegalovirusphytochemicals modulation of cell cyclemodulation of regulatory t cell proliferation conversionlipid modulation of cell functionslipids and the modulation of cell functionmodulation of cell signalingmodulation of cell fate using nuclear and cytoplasmic extracts pdfacids mitochondrial function and the modulation of butyrate induction of cell maturation1 modulation of cell signallingneuroendocrine modulation of cell mediated immunity and cancer development in the perioperative perioddocosahexaenoic acid signalolipidomics in the homeostatic modulation of photoreceptor retinal pigment epithelial cell integrity during oxidative stressstructural and functional modulation of ion channels by specific lipids from model systems to cell membranesthe modulation of cooperationtrace of a tensor fieldfactors affecting the production of vegetable and field cropsBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ