phytochemicals modulation of cell cycle
MouseModels of Cell Cycle Regulators - New Paradigms
... in Mouse Models of Cell Cycle Regulators One of the hallmarks of cancer cells is misregulation of cell proliferation Cancer cells are able to evade the normal signals that stop cell division and ... only two es- Mouse Models of Cell Cycle Regulators: New Paradigms 279 sential Cdks in the regulation of the mammalian cell cycle Another surprise in the history of cell cycle research was uncovered ... functions are cell cycle phase-specific Mouse Models of Cell Cycle Regulators The advantages of mouse models over in vitro studies is that it highlights the functions of a particular cell cycle regulator...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... regulator of CDE ⁄ CHR cell cycle genes, to which promoter sites does it bind during any particular phase of the cell cycle? What is the exact mechanism of p53-dependent downregulation of CDE ⁄ ... responsible for cell cycle- dependent expression of the gene Surprisingly, deregulation of the promoter does not lead to loss of its activity but causes activation in resting cells and in G1 cells Therefore, ... identical to that of the CDE, with repression in resting cells and relief from downregulation later in the cell cycle Mutation of the CHR led to derepression of transcription in G0 cells [10] Genes...
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Báo cáo hóa học: " Research Article Computational Methods for Estimation of Cell Cycle Phase Distributions of Yeast Cells" docx
... 50 Number of cells 250 Number of cells 250 200 Number of cells 250 150 100 50 0.2 0.4 0.6 0.8 150 100 50 0.2 Cell cycle phase 0.4 0.6 0.8 0.2 Cell cycle phase (a) 0.4 0.6 0.8 Cell cycle phase ... the number of cells in each phase of the cell cycle by using a FACS histogram This is an example of an asynchronous cell population; there are 27, 27, and 26 percent of cells in cell cycle phases ... Amount of DNA 50 Number of cells ×102 80 60 Number of cells 70 50 40 30 20 1.8 1.6 1.4 1.2 10 0.2 0.4 0.6 0.8 1 1.2 Cell cycle phase 1.4 1.6 1.8 0.2 (a) 0.4 0.6 0.8 Cell cycle phase Amount of DNA...
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Báo cáo hóa học: " Research Article A Robust Structural PGN Model for Control of Cell-Cycle Progression Stabilized by Negative Feedbacks" pdf
... signals to avoid initiation of a new wave of gene expression while a first one is still going through the cell cycle A number of check-point modules, across cell cycle, regulate cell growth and genome ... (b) Simulation of the three-level PGN yeast cell- cycle model with 1% of noise (PGN with P = 99) activated by a single pulse of CS = at t = −1 After 13 time steps (period of the cycle) , the system ... cell- cycle process is an ordered sequence of events by which the cell grows and divides in two daughter cells It is organized in four phases: G1 (the cell progressively grows and by the end of...
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Báo cáo sinh học: "The nature of cell-cycle checkpoints: facts and fallacies" docx
... operation of the mitotic checkpoint The cell cycle is driven by cyclin-dependent kinases (CDKs), which are activated by binding to cyclins that are specific for the different phases of the cell cycle ... targets of the kinases Exit from each phase of the cell cycle occurs on degradation of the bound cyclin The CDK-cyclin complex that is required for entry into mitosis is CDK1-cyclin B, and cells ... and Rieder: Journal of Biology 2009, 8:88 88.5 use because fluorescence-activated cell sorting (FACS) cannot distinguish 4N G2 cells from 4N mitotic cells (or even 4N G1 cells that failed to...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
... secondary modulation of signalling pathways downstream of Fas may alter significantly the susceptibility of cells to Fas induced cell death [17] However, the expression of Fas receptor on the cell ... higher rate of spontaneous apoptosis but also were significantly more susceptible to FasL mediated cell death Of note, apoptosis of fibroblast-like cells is regulated at a number of different ... TNF-α is involved in a variety of inflammatory and tissue repair processes, the question of how it affects the apoptotic response of potential target cells is of major interest R254 In the present...
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Báo cáo khoa học: "Expression of cell cycle proteins in male breast carcinoma" docx
... P21 Ki67 PCNA p16 p27 p57 Cmyc Cell Cycle Proteins Figure Percentage of Cell cycle protein expression in the tumor cells X-axis displays: the expression of the cell cycle proteins CyclinD1, p21, ... Cyc D1+ Cyc D1 - 0% Cell Cycle Proteins Figure Cell cycle protein expression and Stage of the disease X-axis displays: the expression of positive and negative tumors for cell cycle proteins CyclinD1, ... deregulation of cell cycle control is central to our understanding of the development and progression of all human malignancies [14], this was explored in our laboratory in this study protocol Cell Cycle...
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Báo cáo khoa học: "Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins" ppt
... translocations Cancer cells commonly demonstrate errors in these pathways during cell cycle proliferation Proliferative markers such as Ki67 provide an index of cells in the Go/G1 pool of cycling cells [30] ... with the progression of a normal cell to a transformed tumor cell involving many genetic events that include the checkpoints of the cell cycle machinery [44,47] Overexpression of p16 is believed ... pathways of the bcl-2 family of genes and the ICE family of proteases These components interact with other cell cycle related genes such as p53 The central role of the Bcl-2 family of genes in...
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báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt
... Effects of LA on cell cycle phase distribution and the expression of various cell cycle regulatory proteins in HL-60 cells Figure Effects of LA on cell cycle phase distribution and the expression of ... [27] Figure of Control1 cell growth and viability in HL-60 cells by LA Control of cell growth and viability in HL-60 cells by LA (A) Cells were treated with 0, 1, 2.5 and mM LA and the cell numbers ... analyses Cell cycle analysis Cell cycle phase distribution was assayed by flow cytometry Following 24 and 48 h treatment of HL-60 cells with different concentrations of LA (0, 2.5, and mM), cells...
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Báo cáo y học: " Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress" potx
... protein inhibits cellular proliferation by the induction of cell cycle arrest at S-phase through the down-regulation of cyclin A expression [7] The S-phase of the cell cycle can provide a cellular environment ... subcellular localization of CSFV NS2 protein and its effects on cell growth and cell cycle progression The swine endothelial vascular cell is one of the CSFV target cells, vascular endothelial cells ... protein induces cell cycle arrest at S-phase To determine whether the growth inhibition of CSFV NS2-expressing cells was due to the arrest of the cell cycle at a certain phase(s) of cell division,...
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Báo cáo y học: " Distinguishing between linear and exponential cell growth during the division cycle: Single-cell studies, cell-culture studies, and the object of cell-cycle research" ppsx
... pattern of biosynthesis of the cell Thus, a cell that grows adding 0.1 unit of mass at each time interval would this continuously for one cell cycle At the instant of division the two daughter cells ... the expected pattern of cell growth during the division cycle? The overwhelming majority of a cell' s mass is the cytoplasm; i.e., all that is not cell surface or cell Page of 15 (page number not ... uptake of molecules during the division cycle of bacteria [24] Figure Reanalysis of the data of Kubitschek [16] Reanalysis of the data of Kubitschek [16] At the left is the original data of Kubitschek...
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The role of adenosine, adenosine receptors and transporters in the modulation of cell death
... purines on cell growth 38 Table Strategies of the extracellular mechanism studies of AIA in BHK 184 cells Table Strategies of the extracellular mechanism studies of AIA in HeLa 185 cells xv ABBREVIATIONS ... Effect of NBTI on AIA in SKW6.4 cells 123 Fig 3.40 Effect of dipyridamole on AIA in SKW6.4 cells 125 Fig 3.41 Effect of NBTI on AIA in H9 cells 127 Fig 3.42 Effect of dipyridamole on AIA in H9 cells ... effects of adenosine on HeLa cells 66 Fig 3.4 Apoptotic effects of adenosine on SKW6.4 and H9 cells 67 Fig 3.5 Apoptotic effects of adenosine on SY5Y and MN9D cells 69 Fig 3.6 Apoptotic effects of...
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An immunohistochemical study of cell cycle regulator proteins in epithelial proliferation
... ANNETTE 1.4 1.5 Control of the mammalian cell cycle 1.4.1 The mammalian cell cycle 42 1.4.2 Cell Cycle regulator proteins 1.4.2.1 p21 cell cycle regulator protein 1.4.2.2 p27 cell cycle regulator protein ... Comparison of expression of cell cycle markers 3.3.1 Differential expression of p21 cell cycle protein in epithelium of polypoidal and non-polypoidal mucosa 91 3.3.2 Differential expression of p27 cell ... quest of practising physicians and researchers 1.4 Control of the mammalian cell cycle 1.4.1 The mammalian cell cycle Dividing normal cells execute an ordered set of steps called the cell cycle...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... critical regulator of most cell cycle responses While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest upon growth ... in cell cycle exit/arrest and cell cycle entry/progression, respectively Inactivation of this proliferation controlling pathway seems to be an essential step in the transition of a normal cell ... with E2F in the S-phase of the cell cycle (Dyson 1998) This might reflect the not yet fully understood specific functions of these proteins at these specific stages of the cell cycle 4.4 pRb Family...
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Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc
... understanding of systemic properties (such as the emergent RP in the mammalian cell cycle) in terms of the multitude of reaction steps and interactions between the cell s molecular parts (e.g cell cycle ... basis of our definition of RP as a fraction of the cell division cycle The control coefficient of reaction step x on RP is the percentage change in the fraction of the cell cycle length at which ... of occurrence of RP (as a fraction of total cell cycle time) upon a 1% change in activity of a reaction step A positive control of a reaction step indicates that an increase in the activity of...
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Báo cáo khoa học: Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells pot
... transitions in the cell cycle are also required to prevent re-replication of DNA in a single cell cycle Inactivation of CDK1 leads to re-replication of DNA in eukaryotic cells including human cells [7] ... Linearity of DAPI-stained DNA content of a nucleus was preserved throughout such treatments; i.e the DNA content of G2, M cells are almost double that of G1 cells and the DNA content of S cells ranges ... in Fig In addition, the cell- cycle phases of individual cells were identified based on the dual parameters of DNA content and BrdU incorporation Images of triple-stained cells on a slide were successively...
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Báo cáo khoa học: Injection of poly(b-L-malate) into the plasmodium of Physarum polycephalum shortens the cell cycle and increases the growth rate pot
... S-phase and G2-phase of the cell cycle but not in G1-phase have been reported for HeLa cells [26] In some other mammalian cells, examples of cytoplasmic accumulation of H1, but not of core histones ... 2004 Polymalate effects growth and cell cycle (Eur J Biochem 271) 3809 Fig Effects of polymalate injection on growth and duration of the cell cycle Variable amounts of PMLA (A–D) or poly(L-glutamate) ... contents of nuclear extracts from yellow and white plasmodia are similar (Table 1), and this correlates with the almost equal degree of shortening of the cell cycle (Fig 2B,D) The kinetics of PMLA...
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Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx
... stages of the HeLa cell cycle This information adds to the growing knowledge of hCdc6p expression in mammalian cells The expression of hCdc6p in mammalian cells is strictly associated with cell ... abundance at the onset of S phase [25,28] Consistent with the continuous presence of mRNA, levels of Cdc6p remain high in poliferating human cells at most stages of the cell cycle [24,25,27,35,37] ... during the 2-h label period Rates of hCdc6p synthesis To investigate whether the synthesis of hCdc6p was restricted to specific phases of the cell cycle, HeLa cells were arrested by a double-thymidine...
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Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt
... Knockdown of HCF1 results in cell cycle arrest at G1 Therefore, both physical and functional interactions of MLLs with cell cycle regulatory proteins indicate potential roles of MLLs in cell cycle ... Dynamics of MLL1 and its interacting proteins during the cell cycle Prior to the analysis of the dynamics of MLL and histone methylation, we synchronized HeLa cells at different phases of the cell cycle ... with chromatin during the cell cycle, we performed immunofluorescence staining of HeLa cells with anti-H3K4 trimethyl serum at different stages of the cell cycle The cell nucleus was counterstained...
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Báo cáo khoa học: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors pdf
... After days of incubation, a cell viability test was performed using the MTT assay to estimate quantitatively the number of cells For cell- cycle analysis, the cells were harvested after days of lipid ... transcription of p21, a cdk Table Cell- cycle profile of CHO-BP1a and CHO-BP2 cells inducibly expressing nuclear SREBP-1a and SREBP-2, respectively, with CHO-Lac cells as control The three types of CHO ... inhibition of cell growth Effects of endogenous SREBP-1 on cell growth To determine the physiological relevance of the growth-inhibitory action of SREBP-1a, the role of endogenous SREBP-1a in cell proliferation...
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