zero plays no role in forecasting chaotic systems
Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... PDZ proteins: Mint-3, AMPA binding protein and glutamate receptor interacting protein (GRIP) It would therefore be interesting to determine whether this motif is also involved in the interaction ... phenotype of tumour cells, implicating a leading role for MT1-MMP in such processes [12,14] There is mounting evidence that the short intracellular domain (ICD) of MT1-MMP (21 amino acids) plays ... Roghi et al Role of GRASP55 in MT1-MMP activation l l l l l l l l l l l l l MINT-7897617, MINT-7897659, MINT-7897681, MINT-7897702, MINT-7897725, MINT7898032, MINT-7898011, MINT-7897907, MINT-7897884:...
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Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development docx
... is involved in regulating histone arginine methylation by converting methyl-arginine to citrulline [48] In our study, cortical granule PAD appeared to play a role in early embryogenesis since ... were incubated at room temperature in M16 culture medium containing anti-ePAD (1:100) for 45 minutes, washed in M16, and incubated 45 minutes at room temperature in M16 containing antiguinea ... Endocrinology 2005, 3:42 lectin in blots and it did not bind LCA in confocal sections of cell embryos In vitro experiments with antibodies to PAD suggest that cortical granule PAD plays a role, ...
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Tài liệu THE ROLE OF UNIVERSITIES IN REGIONAL INNOVATION SYSTEMS - A NORDIC PERSPECTIVE pdf
... future growth The role of universities in regional innovation systems I this book we will analyse the role of universities in regional innovation systems We so by studying nine Nordic regions with ... economy, is engaged in routine activities Thus, each national system of innovation is rooted in a national system of production By underlining the importance of existing economic structure innovations ... and the role of the university in relation to industry and government The knowledge base and its role in innovation are explained in terms of changing relationships between university, industry...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... 0.3% L-arabinose and is predominantly linear Potato arabinogalactan consists of 86% D-galactose and 6.6% L-arabinose, while soy arabinogalactan consists of 57% D-galactose and 38% L-arabinose Methylation ... suggesting the presence of an arabinose-releasing activity in the GALA preparation However, no a-1-,3-L-arabinofuranosidase activity could be detected using PNP-a-L-arabinofuranoside as a substrate This ... substantial amount of the L-arabinose residues (14%) in soy arabinogalactan is present as terminal residues [21], suggesting that of these arabinogalactans, soy arabinogalactan is the most highly...
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Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
... labelling intensity observed with the single-cysteine-containing isoforms Obtaining full labelling and its accurate quantitation are difficult to achieve in practice, resulting in occasional instances ... were examined by introducing cysteines at distinct positions in TM12 and assessing their accessibility to covalent modification with thiol-reactive probes In order to determine how changes in the ... prominent role in the coupling process in ABCB1 [25–28] A number of mutations in TM6 caused alterations in drug-stimulated ATP hydrolysis, irrespective of whether they contributed to drug binding...
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Báo cáo khóa học: ICAM-1 expression is highly NF-jB-dependent in A549 cells No role for ERK and p38 MAPK docx
... in pulmonary epithelial cells is currently lacking As NF-jB is considered to be a candidate for therapeutic intervention in airway in ammation, we have investigated the role of NF-jB in the induction ... continued to rise over the 18 h of the experiment To examine the role of NF-jB in the induction of ICAM-1, cells were infected with an adenoviral vector that over-expresses IjBaDN, a dominant inhibitor ... NF-jB binding site (bold text) upstream of a minimal thymidine kinase promoter driving a luciferase gene Confluent cells in 24-well plates were changed to serum-free medium and treated as indicated...
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Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... putative protein of 910 amino acids that contains a PX domain (solid underlining) and four SH3 domains (dotted underlining) (Fig 2A) Moreover, the encoded protein also contained ten polyprolines (boxed), ... domain of p47phox binds intramolecularly to the SH3 domain in the same protein, and that this intramolecular interaction suppresses the lipid-binding activity of the PX domain in the resting ... possible ligands for the SH3 domain Thus, fad49 encodes a protein containing many protein-binding domains, suggesting that this protein may be a novel scaffold protein We next tried to isolate the...
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Báo cáo khoa học: Peroxisome proliferator-activated receptor a plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors docx
... levels of 17b-HSD11 in the liver during this period A low level expression of the enzyme in the intestine was also observed in the intestine of the knockout mice (Fig 2C), indicating that expression ... antibody C: Induction of 17b-HSD11 in the intestine of PPARa knockout mouse by sesame The levels of induction of 17b-HSD11 in the intestine were compared between the mice fed with a diet containing Wy-14 ... xenobiotic nuclear receptors In this study, we showed that PPARa is a xenobiotic receptor, in addition to PXR, CAR and Ah, playing an essential, direct and indirect role in inducing various xenobiotic...
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Báo cáo khoa học: NtKTI1, a Kunitz trypsin inhibitor with antifungal activity from Nicotiana tabacum, plays an important role in tobacco’s defense response pot
... were initially classified into nonspecific and class-specific superfamilies, and the latter was subcategorized into several families, including serine, cysteine, aspartic and metalloproteinase inhibitors ... degrading the Kunitz trypsin inhibitor and glycinin in germinating soybeans (Glycine max) Plant Physiol 88, 355–360 ´ 45 Jimenez T, Martı´ n I, Labrador E & Dopico B (2007) A chickpea Kunitz trypsin ... arrow in the right lane (B) In vitro bovine trypsin inhibition by the recombinant NtKTI1 protein (open circles) Soybean trypsin inhibitor (triangles) was assayed in parallel as a positive control...
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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx
... the a1-containing insensitive and a2 /a3-containing sensitive Na+/K+-ATPase in rat cardiac tissue is not well known as only the latter can be determined in [3H]ouabain binding studies In a membrane ... concentrations of ouabain Plasma concentrations of putative endogenous ouabain In another recent minireview in Eur J Biochem [20] endogenous ouabain was claimed to be a novel steroid hormone and ... the hypothesis The main objections to a normal signaltransducing function of ouabain interaction with Na+/K+ATPase, however, are the following To place this phenomenon into a normal physiological...
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Báo cáo khoa học: "The role of positive feedback in Intelligent Tutoring Systems" ppt
... Bing Liu 2006 Web Data Mining Springer, Berlin Xin Lu 2007 Expert Tutoring and Natural Language Feedback in Intelligent Tutoring Systems Ph.D thesis, University of Illinois at Chicago Antonija ... improves learning: Experiments in natural language generation for intelligent tutoring systems In ACL05, 36 Proceedings of the 42nd Meeting of the Association for Computational Linguistics, Ann ... and integrated into iList The model will encode knowledge extracted with machine learning approaches, and such knowledge will inform a discourse planner, responsible of organizing and generating...
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Báo cáo khoa học: Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide ppt
... suggesting a role for LPCAT in the LPS-induced signaling pathways in monocytes In addition, LPCAT was found to be crucial for IL-6 production in a similar manner, indicating that it may generally in uence ... did not affect the LPCAT activity (data not shown) The stimulation of LPCAT by IFN-c could be inhibited by the tyrosine kinase inhibitor tyrphostin (2.5 lM) but not by the protein kinase C inhibitor ... bisindolylmalamide (1 lM) (data not shown) This suggests that the signaling pathway from the IFN-c receptor to the acyltransferase involves tyrosine kinases but not protein kinase C Such a finding...
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Báo cáo Y học: The a1b1 contact of human hemoglobin plays a key role in stabilizing the bound dioxygen Further evidence from the iron valency hybrids potx
... DISCUSSION In hemoglobin research, the central problem is understanding the cooperative binding of molecular oxygen to the a2b2 tetramer For human HbA, the a and b chains contain 141 and 146 amino-acid ... observed in the autoxidation of myoglobins lacking the usual distal histidine residue, no matter what the protein is, the naturally occurring or the distal His mutant as well [30] The other role is in ... the a1b2 interface have altered oxygen af®nity, but bulk of evidence suggests that the a1b1 interface is much more important in maintaining normal hemoglobin stability than is the a1b2 interface...
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Báo cáo hóa học: "Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque" ppt
... regulating secretion in thrombin-stimulated human platelets linking Rac1 activation to actin dynamics: Calcineurin®Rac1 ®class-II PAKs activation®cofilin dephosphorylation and activation [13] In ... and 26%, respectively, indicating that integrin aIIbb3 signaling stimulated by platelet-to-platelet contact plays a role that is more important in collagen- than in TRAP-induced dense granule ... PBS (containing 0.3% albumin) for 10 at a wall shear rate of 500s-1 Then hirudin-anticoagulated blood containing mepacrine (10 μM) in order to visualize platelets was added to the inlet well,...
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báo cáo hóa học: " LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury" doc
... dominant role early in the response to ischemia because infiltrating leukocytes not appear in substantial numbers in the brain until 24 hr following injury [4] Stroke also induces an acute inflammatory ... without influencing pro-inflammatory cytokine production [3,31] In particular, administration of the NFB inhibitor Tat-NEMO Binding Domain provided protection against hypoxia-ischemia in neonatal ... the cytokine and chemokine response in the blood paralleled the pattern of gene expression in the brain Overall, inflammatory cytokine protein levels were similarly induced in LPS and saline preconditioned...
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báo cáo hóa học: " Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway" doc
... IRF3 influences other signaling pathways In addition, we have obtained novel findings that indicate that the PI3K pathway plays a predominantly anti-inflammatory role in microglial activation It ... signaling [36] The antiinflammatory role of Akt in mouse macrophages has been most convincingly demonstrated in a study in which Akt1-deficient mice injected with LPS showed increases in proinflammatory ... including IFNα Studies in vitro show that IRF3 plays an indispensible role in innate antiviral immunity including in microglia and astrocytes [14,20,21] In addition, IRF3 is critical in neuroprotection...
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the role of human resource systems in job
... developed and tested by Ravlin and Meglino (1987), Meglino et al (1989), and Ravlin and Meglino (1989) The values represented in the CBS were chosen Human Resource Systems 21 from a set of many ... determine which values are predominant in individuals (Ravlin & Meglino, 1987, 1989; Rokeach, 1973) However, the intensity dimension also makes it clear that in regard to values, more is not necessarily ... human resource systems included in this study exhibited significant main effects on job choices Main effects were noted for individual reward distribution systems, contest mobility systems, and...
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Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla pps
... MEK/ ERK/MNK cascade in RVLM plays a pro-life role during experimental brain stem death by sustaining the central cardiovascular regulatory machinery via NOS I/PKG signaling Acknowledgements Supported ... vehicle controls, exerted no influence against the increase of NOS II and nitrotyrosine protein expression in ventrolateral medulla during both phases of experimental brain stem death (fig 4) Activation ... did not affect NOS II/peroxynitrite signaling in RVLM during experimental brain stem death Illustrative gels or summary of fold changes against aCSF controls in ratio of NOS II or nitrotyrosine...
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Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla pps
... selectively the Mev-induced Phase I increase in NOS I or PKG protein expression in ventrolateral medulla None of these pretreatments affected the progressive increase in NOS II or nitrotyrosine (marker ... against the phasic Mev-induced NOS I, PKG, NOS II or nitrotyrosine protein expression in ventrolateral medulla Effectiveness of gene knockdown We also ascertained that our results from gene knockdown ... of NOS I/PKG signaling in RVLM Illustrative gels or summary of fold changes against aCSF controls in ratio of nitric oxide synthase I (NOS I), protein kinase G (PKG), NOS II or nitrotyrosine...
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báo cáo khoa học: " Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses" ppt
... up-regulated in signal transduction and ligand-receptor interaction pathways Probe sets involved in protein folding, sorting, and degradation include heat shock proteins It is worth noting that the ... underlined) An NcoI-SpeI fragment containing MtCBF4 cDNA was inserted into pCAMBIA1302 containing the 35S CaMV promoter and a hygromycin (kanamycin) resistance marker The plasmid was introduced into ... Dubouzet JG, Abe H, Shinozaki K, Yamaguchi-Shinozaki K: DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression...
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