wnt beta catenin pathway in breast cancer and interactions between hif 1alpha and beta catenin in hypoxic cancer cells
EFFECTS OF INHIBITING THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) PATHWAY AND TELOMERASE IN BREAST CANCER CELLS
... FK506-binding protein 12 (FKBP12) and directly binds to and inhibits TOR proteins through an allosteric site N-terminal to its kinase domain Called the FKBP12-rapamycin binding (FRB) domain, this ... telomerase and telomeres in some cancer types, can it the same in breast cancers? In seeking to explore whether rapamycin can function as a dual inhibitor of the mTOR pathway and telomerase in breast cancer ... far highlights the relevance and importance of the mTOR pathway and telomerase in initiating, regulating and driving cancer phenotypes, including those of breast cancer It also shows that there...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... to increase We observed an increase in HIF- 1a protein, and thus were confident that the cells were being maintained in a low-oxygen environment and were responsive to low oxygen There is also increasing ... of BRCA1 in mammary epithelial cells, we subjected malignant (MDA-MB-468 and MCF-7) and nonmalignant (MCF-12A and HMEC) cells to hypoxia and examined the protein and relative nuclear and non-nuclear ... decreased in hypoxic cells to approximately 65% of the level in normoxic cells There was no change in the steady-state level of Fig Hypoxia induces nuclear accumulation of BRCA1 in breast cancer cells...
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báo cáo khoa học: " Salivary a-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells" docx
... effects in primary rat mammary epithelial cells and human breast tumor cells On the one hand the effects on healthy rat breast cells indicate that endogenous a-amylase might be involved in the ... of cells, exclusively viable, and for dead cells after and 50 U/ml for day, days, and days (n = 4-14 wells per group) For counting, cells were detached with trypsin/EDTA, and viable and dead cells ... determined amylase enzyme activity in the mammary gland tissue of F344 and Lewis rats and observed no differences in activity between both rat strains (unpublished data) These findings indicate...
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ANTI CANCER EFFECTS OF THYMOQUINONE IN BREAST CANCER CELLS INVOLVEMENT OF NON HOMOLOGOUS END JOINING AND TELOMERE TELOMERASE HOMEOSTASIS
... normal and cancer cells 1.12 Objectives To evaluate the growth inhibitory effects of TQ in breast cancer cells To investigate the DNA-damaging effects of TQ in breast cancer cells To investigate ... breast cancer cells 41 3.1.3 Changes in cell cycle protein expressions in TQ-treated breast cancer cells 44 3.2 DNA damaging effects of TQ in normal and breast cancer cells 47 3.2.1 TQ induces ... anti-proliferative effects of TQ in the breast cancer cells, followed by evaluating the effectiveness of TQ in impairing DNA damage repair as well as in inhibiting telomerase in breast cancer cells, which could...
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Investigating functions of ERp29 in mesenchymal to epithelial transition (MET) and epithelial plasticity in breast cancer cells
... domain mediates lateral cell-cell contacts by forming homotypic binding with E-cadherin of neighboring cells Its cytoplasmic domain interacts with actin cytoskeleton via α -catenin and β -catenin ... upon in vivo tumor induction by oncogene myc These cells lacked epithelial-cytokeratins and E-cadherin while expressing mesenchymal-vimentin and fibronectin Considering its involvement in cancer ... protein kinase C Adenosine triphosphate Basic helix-loop-helix Binding protein Bovine serum albumin Cyclin-dependent kinase inhibitor 2B Cytokeratin-19 Cytoplasmic lipid droplets 4’,6-diamidino-...
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Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf
... Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines Cancer Res ... be involved in apoptosis related to analogue induction of SSAT [25] In MALME-3M and SK-MEL-28 cells the increase in SSAT activity was 650- and 900-fold, respectively, 24 h after seeding [14] In ... and Phase II clinical evaluations in the US In L56Br-C1 cells, DENSPM treatment induced an increase in SSAT activity, which resulted in a decrease in the polyamine pools The spermine analogue thus...
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Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors potx
... in an incubator at 37°C with 5% CO2 and maintained at a cell concentration of between × 105 and × 10 viable cells/ mL MDA-MB-231 cells were cultured in an incubator at 37°C with no CO2 and maintained ... added in order to label actin filaments After washing in PBS, cells were incubated in 4’,6-diamidino-2-phenylindole (DAPI) or Topro-3 (Invitrogen Corporation) to counterstain nuclei and were inverted ... cells (2.75 × 106), MCF7 breast cancer cells (0.18 × 106), and MDA-MB-231 breast cancer cells (0.11 × 106) The Chinese hamster ovary (non -breast) cell line has a very low number of Her2-binding...
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Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot
... breast cancer cell lines, there was a correlation between GPR30 upregulation and progestin-induced growth inhibition The ligand of GPR30 and its role in growth regulation are not known In amino ... during progestin-induced growth inhibition To study genes associated with progestin-induced growth inhibition, a comparison was made of the gene expression patterns in MCF-7 breast cancer cells ... number of proteins; the highest identity is with angiotensin II type 1, interleukin and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties...
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Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
... transmembrane domain, and an intracellular domain that contains a catalytic tyrosine kinase domain and a carboxyl terminal tail Numerous sites of tyrosine phosphorylation within the tyrosine kinase and carboxyl ... frequent cancers affecting Singapore women, 2003-2007 Breast cancer is the top cancer type affecting the women in Singapore Data extracted from Singapore Cancer Registry, Interim Report: Trends in Cancer ... Chapter Introduction CHAPTER INTRODUCTION 1.1 Breast cancer 1.1.1 Incidence of breast cancer Breast cancer is the second leading cause of cancer deaths in women today after lung cancer and is...
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Báo cáo khoa học: " Effects of osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells" doc
... OPN treatment and an association of uPA expression with OPN-induced invasion and migration in human breast cancer cells These findings are consistent with our data analyzing the protein expression ... inhibition are in agreement with previous findings that the knockdown of OPN reduces the clonogenic survival, migration and invasion rate, and proliferation in different breast cancer cell lines ... outside -in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells Cancer Res 2007, 67:2089-2097 42 Abend M, Kehe K, Kehe K, Riedel M, Van Beuningen...
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Understanding structure mechanical property relationship of breast cancer cells
... cancer cells can undergo including being adherent and in suspension, we studied cancer cells in these two conditions Firstly, A microfluidic device was designed to mimic cancer cells traversing ... widely used in studies involving cell mechanics, like imaging and indentation and novel force measurement in molecular interaction 2.1.2.1 AFM imaging of cells The morphology of live cells (Henderson ... Microfluidics study of breast cancer cells in suspension Chapter Microfluidics Study of Breast Cancer Cells in Suspension 3.1 Introduction Metastasis is the predominant cause of death in cancer To effectively...
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Atomic force microscopy study of emodin treated MCF 7 human breast cancer cells
... curve and Z sensor signal collected in AFM indentation on living MCF-7 cells The black line represents the approaching curve, and the gray line is the retracting curve The approaching curve includes ... Correlated AFM and CFM of cells double stained for actin and vimentin (Pesen and Hoh 2005) AFM images on living BPAECs were collected and the cells were immediately fixed and processed for ... overall cell shape Confocal planes of cells stained for actin using Alexa-phalloidin (C, E, and G) and vimentin using Cy3-anti-vimentin antibody (D, F, and H) Correlated features are marked with...
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Báo cáo khoa học: "Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome" pps
... relationship of E-cadherin, α -catenin, β -catenin and γ -catenin in breast tumours to Nottingham Prognostic Index (NPI) (E-cadherin p = 0.094, catenin p = 0.144, β -catenin p = 0.378, γ -catenin p = 0.131) ... The main structure of E-cadherin catenin complex consists of transmembrane E-cadherin, cytoplasmic proteins, called catenins (α-, β- and γ -catenin) , and actin cytoskeleton filament β -catenin and ... disease and/ or local recurrence and/ or death from breast cancer) p = 0.012) There was no difference in α -catenin and γ -catenin expression between the groups β -catenin expression was increased in patients...
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báo cáo khoa học: "Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/b-catenin pathway" potx
... role in the maintenance of CSCs [24-27] In addition, Wnt signaling pathway is also activated in SP breast cancer cells in vitro [14,27] Accordingly, in order to know the importance of Wnt signaling ... H: Linking colorectal cancer to Wnt signaling Cell 2000, 103:311-320 Polakis P: Wnt signaling and cancer Genes Dev 2000, 14:1837-1851 Nelson WJ, Nusse R: Convergence of Wnt, beta- catenin, and ... in tumors of CKI group than those of control group as well as the key proteins including wnt1 , CyclinD1, c-Myc (Figure 7), which indicated that canonical Wnt/ b -catenin signaling pathway was inactive...
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Regulation of WNT beta catenin pathway in the disease progression of osteosarcoma
... least six of the 19 Wnt ligands, including Wnt 1, Wnt 2, Wnt 3, Wnt 3a, Wnt and Wnt 8b, have been reported to activate the canonical Wnt/ β -catenin pathway while Wnt 4, Wnt 5a and Wnt 11 can activate ... directly squelching Wnt ligands, thus preventing FZD -Wnt binding, while the Dickkopf (DKK) family inhibits Wnt signaling by binding to LRP and Kremen receptors, and sterically hindering Wnt interaction ... Overview of Wnt/ β -catenin signaling pathway and its implication in oncology…….5 1.4 Strategies in inhibiting the Wnt/ β -catenin signaling pathway ……………………16 1.4.1 Existing drugs as Wnt therapeutics……………………………………………17...
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Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study pptx
... Factors in Breast Cancer: Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and ... Labourers in Processing, Manufacturing and Utilities 332813 9422 Plating, Polishing, Anodizing, and Coloring Plastics Processing Machine Operators 336320 9422 Motor Vehicle Electrical and Electronic ... Food canning Food canning industry exposures could include pesticide residues and exposures specific to canning processes involving lead (historically) and coating emissions Canning processing has...
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Familial breast cancer - The classification and care of women at risk of familial breast cancer in primary, secondary and tertiary care potx
... service, including counselling and genetic testing For women being cared for in tertiary care • Standard written information (as above) • Information about hereditary breast cancer • Information ... screening and proportion of interval cancers Nil Nil NICE clinical guideline 41 – Familial breast cancer Information includes written information and discussion on: • reduced sensitivity in younger ... testing, both predictive testing and mutation finding, including details of what the tests mean and how informative they are likely to be, and the likely timescale of being given the results • Information...
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European guidelines for quality assurance in breast cancer screening and diagnosis pot
... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring and ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual...
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Factors infl uencing the risk of breast cancer – established and emerging ppt
... briefing will outline: The established risk factors for breast cancer, and The current thinking regarding the involvement of certain chemical exposures in breast cancer, and in particular, the ... pregnancy in breast cancer Breast Cancer Res., 7(3), pp131-42 20 Collaborative Group on Hormonal Factors in Breast Cancer (2002b) Breast cancer and breastfeeding: collaborative reanalysis of individual ... oestrogenmimicking chemicals and their involvement in breast cancer increasingly plausible Studies have been published which investigate the timing and nature of exposure to oestrogen-mimicking chemicals and...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose