... participated in designing the study and in collecting and entering data OvR and BL participated in designing the study RW participated in collecting and entering data JR participated in advising on ... antimycotic therapy with any antifungal agent Prophylaxisin this review is defined as antifungal therapy without a proven fungal infection Preemptive therapy is defined as antifungal therapy given ... examining the effects of antifungalprophylaxis without measuring or reporting the incidence of Candida or yeast infection or colonisation were also excluded We aimed to retrieve the following...
... prognostic indicator in fulminant hepatitis in patients without encephalopathy upon admission [10,11] Inthe present study, we examined 11 proinflammatory genes in patients receiving therapy intheICU ... levels (a) Change in circulating CRP mRNA expression during the clinical course inICU Upregulation of CRP mRNA was induced at POD by the surgical intervention The longitudinal axis is relative ... GPIb-IX-V Therefore, upregulated VWF may represent unstable hemostasis and reflect damage to endothelial megakaryocytes expressing VWF Inthe signaling pathway, VWF interacts with integrins in the...
... [22]; 35.2% at 12 weeks inthe PATH study [12]; 37.9% inthe ECMM study [8]; and 53.4% in non -ICU vs 85.9% inICU patients inthe Brazilian SCOPE study [11] Inthe PATH study, the highest mortality ... [57] The index increased significantly by 0.1 during theICU stay (p = 0.016) and the threshold of 0.5 was reached in 36 (39.1%) of 92 nonsurgical ICU patients staying > days; of them developed invasive ... non-albicans Candida species, in particular C glabrata, are emerging In addition to differences inthe fungal ecology of the different continents, the large use of azoles antifungal agents may have...
... was no increase inthe number of unscheduled CXRs performed inthe afternoon or inthe night inthe on-demand strategy, and therefore no disruption inthe organisation of the medical imaging department ... design and inthe redaction of the first draft of the article, corrected and approved the final version Competing interests The authors declare that they have no competing interests Received: ... from the nostril and should not get coiled inthe pharynx When the EFT is accidentally inserted into the respiratory tract, the capnograph displays a normal capnogram, whereas when the EFT is inserted...
... hypothalamus to the reticular activating system via the reticular formation, beginning inthe medulla and extending to the midbrain This pathway links the brain with perception of external events Pain is ... epinephrine and norepinephrine are released into the blood stream from the adrenal medulla The more intense the stimuli, the more pronounced the response The levels of norepinephrine generally increase ... complexes inthe brain, enhancing chloride conduction resulting inthe release of GABA This opens a chloride channel leading to inhibition of neuronal excitation inthe limbic system, resulting in anxiolysis,...
... of ICUs with a full-time doctor, while The Netherlands and Finland had the lowest number In 67% of the ICUs surveyed there was an ICU director In a recent survey from the German Interdisciplinary ... defined the requirements for certification of an ICU for training in ICM [9] Under the prerequisites of a training institution providing optimal specialist training in base specialty-related intensive ... dedicated ICU team: Experience in inserting, controlling, and maintaining invasive catheters is built up Insertion techniques (e.g for pulmonary artery catheters) can be standardised Experience is gained...
... of the drugs used intheICU and those used in HIV therapy The protease inhibitors and the non-nucleosides can act as cytochrome P450 3A4 inhibitors, and affect the metabolism of many of the ... needed on drug absorption and stopping-and-starting therapy inthe ICU, as well as drug interactions The effect of HAART on ICU outcomes, either directly or indirectly through its effect on viral ... with HAART, in its own right and in combination with certain other agents used in ICU, especially in patients with chronic viral hepatitis Resistance, absorption, and interactions The critically...
... (FFP) is available in limited amounts • If done continuously, after a while one is removing the FFP given • FFP contains many of the proteins we want to remove Intermittent therapy is unlikely ... “toxemia” • “Toxemia” induces widespread injury • The mediators of “toxemia” are ill-defined • Continuous removal beneficial ? • Use Hemofiltration? The Mediators of Sepsis (the Humoral Theory of Sepsis) ... 1998; 13: 1458-64 CPFA in animal models • Test whether biochemical findings translate into clinical effects • • • • Assess magnitude of clinical effects Assess nature of clinical effects Exclude...
... study include the use of standard definitions for septic shock and infection as well as invasive monitoring with goal directed therapy Patients were excluded if they received steroids inthe month ... especially during the first 24 hours after administration [4], though the duration of adrenal suppression induced by etomidate is controversial [5] Exclusion of these patients may explain the lower ... septic shock who can benefit from steroid replacement; on the other hand, steroids can cause important side effects, such as increased risk of infection or impair wound healing Furthermore, there is...
... No Gladman and Lapinsky Regardless of the potential risks, wireless technology is becoming increasingly prevalent inthe critical care environment Hospitals are routinely using wireless solutions ... medical engineers must determine the impact on existing hospital network infrastructure and medical devices There are those that argue that the intangible benefits of improved communication using wireless ... equipment Competing interests The author(s) declare that they have no competing interests References van Lieshout, JE, van der Veer SN, Hensbroek R, Korevaar JC, Vroom MB, Schultz MJ: Interference...
... retain their clinical and even prognostic value and therefore should not be forgotten whenever performing an echocardiographic investigation Competing interests The authors have no competing interests ... Roosens Finally, there is the discussion on load dependency of E’ This issue remains controversial and not at all completely clarified, as outlined in a recent commentary [12] In particular, the disparity ... the disparity of the mitral annular motion as described recently [13,14], should be evaluated more closely, but indeed could be of certain help in understanding differences in diastolic mitral...
... 45% and ICU mortality from 6.3% to 37% Studies were heterogeneous inthe way they used SOFA The major themes identified inthe evaluation studies were investigating the performance of: single SOFA ... regression); and whether the model was validated on the developmental or independent validation set Emailing the authors confirmed the type of ICU outcome (hospital or ICU mortality) used in one study ... prespecified time interval, and mean SOFA was always calculated by taking the average of all total SOFA scores inthe prespecified time interval These intervals varied in length, but generally they were...
... and the baseline infection rates were low BSI at baseline, costs of treating the infection, the proportion of patients requiring central venous catheters, the duration of catheterization and the ... dressings [16] Competing interests The author declares that they have no competing interests References 10 11 12 The findings of Halton and colleagues’ study should be interpreted inthe context of ... No Safdar institution based on benchmark rates and local factors The comprehensive strategy should include the following three components: educating persons who insert and maintain catheters,...
... area under the curve; CABG, coronary artery bypass grafting; GLP-1, glucagon-like peptide-1; ICU, intensive care unit insulin secretion in euglycemic ranges, thus potentially eliminating the risk ... nondiabetic patients may be alleviated with use of GLP-1 infusion, resulting in either no or reduced insulin requirements, which in turn should reduce the incidence of hypoglycemia and avoid adverse outcomes ... feeding No parenteral feeding Allowed to eat Fasting Intervention GLP-1 at 1.2 pmol/kg/minute GLP-1 at 3.6 pmol/kg/minute GLP-1 at 1.5 pmol/kg/minute GLP-1 at 1.2 pmol/kg/minute Duration of intervention...
... of the general population [12,13] These overestimations exaggerate the affordability of empiric micafungin Nevertheless, the main finding of this study by Zilberberg and colleagues is encouraging ... revisited Clin Infect Dis 2003, 37: 1172-1177 Kumar A; CATSS Study Group: The high mortality of Candida septic shock is explained by excessive delays in initiation of antifungal therapy In Proceedings ... by Zilberberg and colleagues is encouraging The reduction inthe acquisition cost of micafungin, as well as that of other echinocandins, has made these effective anti-Candida agents more affordable...
... disturbances and the fluctuating nature of consciousness were the most difficult points for theICU nurses Individual problems with the assessment were addressed by focusing the training on the difficulties ... from the delirium website [22] such as the training video and the Harvard CAMICU flow sheet We appointed 'delirium key-nurses', who received supplementary training, for further instruction and introduction ... All ICU nurses were trained inthe use of the CAM -ICU and performed a knowledge test prior to the training The education consisted of a one-hour group training prior to the implementation of the...
... results are sufficiently interesting to warrant more clinical trials evaluating the effects of EMS inICU patients, particularly in those who are unable to participate in early mobilization because ... complement to current strategies for early physical therapy and mobilization intheICU Competing interests The authors declare that they have no competing interests Page of (page number not for citation ... duration of EMS therapy? What should be the magnitude of stimulation (in previous studies of EMS, treatment effects did not correlate closely with the intensity of stimulation)? In summary, there is...
... categories The majority of studies (20) were published after 2002, indicating the increasing interest inthe practice of sedation quality in recent years, in particular following the publication ... further study [2] that looked at the introduction of a sedation guideline did not record the incidence of sub-optimal sedation but recorded the median Ramsay scale values These were during the ... high incidence of deep sedation This finding illustrates the importance of the perception of the health care worker or assessor or both in describing the prevalence of sub-optimal sedation The...