... biopsy based on careful exclusion of other diseases When cerebral angiography shows stenosis or occlusion ofthe cerebral Page of vessels, brain biopsy should be performed [15] However, the classic ... angiitis ofthecentralnervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis ofthecentralnervoussystem ... mimicking primary angiitis ofthecentralnervoussystem Arch Neurol 2002, 59:1480-1483 21 Dawson TM, Starkebaum G: Isolated centralnervoussystem vasculitis associated with hepatitis C infection J Rheumatol...
... Symptoms are graded as mild, moderate and severe, and are assessed clinically using scales The scales are used to assess and monitor symptoms and measure a patient s response to medication PRE-ASSESSMENT ... concentration of adenosine is firmly kept under check by various enzymes such as adenosine kinase (Boison, 2006) in physiological conditions As discussed earlier in this thesis, oxidative stress is considered ... and agnosia after several years (APA) The ICD-10, classifies Alzheimer sdisease as early and late onset There is also as a classification for mixed type, this is where Alzheimer sdisease may...
... experiments are designed to study the induction phase of disease, whereas MS is studied after disease induction, as its cause is unknown [52], and most MS patients not develop symptoms until inflammation ... Qin S, Rottman J, Sellebjerg F, Strieter RM, Frederiksen JL, Ransohoff RM: Expression of specific chemokines and chemokine receptors in thecentralnervoussystemof multiple sclerosis patients ... cells in MS and could be used as a tool for monitoring disease activity [78], and response to treatment [79] The process of inflammation in EAE is limited at the remission stage ofthe disease, ...
... techniques of internal fixation This unusual case of delayed union ofthe femur fracture associated with Paget 'sdiseaseofthe bone for which functional bracing was ultimately successful illustrates ... biological osteosynthesis has gained a reputation in fracture treatment Minimally invasive plate osteosynthesis (MIPO) techniques minimize the extent of soft tissue trauma to the injury zone, theoretically ... involving the entire femur ofthe fracture (Figure 5), the patient is able to walk unaided with a single T-cane Discussion Although Paget 'sdiseaseofthe bone is a relatively common disease in Australia,...
... doses of chemotherapy is clearly demonstrated by Noble and colleagues [1], yet these proposed studies not take into consideration the possible effects of high-dose chemotherapy on either CNS ... dose and large volume radiation (craniospinal versus whole brain versus local) radiation The response of investigators has been to reduce the dose and/or volume of radiation and, in some cases, ... transplantation or peripheral stem cell support to boost the immune system, and either no craniospinal radiation or focused radiation to the tumor bed The increased risk of neurotoxicity associated...
... loss in the pathology of MS: consequences for understanding the progressive phase ofthedisease J Neurol Sci 2003, 206:165-171 158 Bruck W: The pathology of multiple sclerosis is the result of ... effects in multiple organ systems In the hematopoietic system, the tissue in which such adverse effects have been most extensively studied, their detailed analysis has led to the discoveries that ... latencies in either the control or the treated groups 5-FU treatment causes delayed changes in expression of Olig2 and loss of myelin integrity The results of our ABR analysis raised the possibility...
... is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression of ... Immunohistochmical study of nitric oxide synthase in thecentralnervoussystemof goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected brain At necropsy, case (6 months old) showed ... Shin et al immunoreactivity of both iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years old) (Cases...
... nuclei [1,2] The pathogenesis of Paget sdisease is still a subject of debate with two main hypotheses The epidermotropic hypothesis proposes that Paget s cells originate from ductal epithelium, ... where they migrate towards the epidermis This hypothesis is supported by the association between Paget s and an underlying breast carcinoma in the majority of patients The second hypothesis, the ... Paget sdiseaseofthe right nipple with no evidence of underlying invasive ductal carcinoma, ductal carcinoma in situ ofthe breast tissue or lymph node invasion Discussion Paget sdisease is an...
... with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in thenervoussystemofthe cockroach Discussion The results of characterization ... nervoussystem (NS) of Blaberus discoidalis roaches was used This method allowed us to study effects of nanoparticles on the roach s CNS in vivo Two groups of roaches were selected for this study ... energy for gold is at 85 eV The high signal-to-noise ratio ofthe XPS scans was caused by too few particles on the scanned surface The samples used for these scans were 12 μm thick slices that were...
... alendronate seemed to be more suitable for the treatment of Japanese patients since the dose of alendronate used for the treatment of osteoporosis in Japanese patients (5 mg per day) was half of that used ... other sclerosing bone dysplasia [2,3] To monitor disease activity and the effects of treatment, we measured T-ALP and uNTX levels of our patients every three to six months and assessed their ... vs etidronate for the treatment of Paget 'sdiseaseof bone J Clin Endocrinal Metab 1996, 81:961-967 12 Woo S- B, Hellstein JW, Kalmar JR: Systematic review: bisphosphonates and osteonecrosis of...
... Photograph ofthe penile lesion Photograph ofthe penile lesion Figure H&E stain ofthe resected specimen showing a clear margin H&E stain ofthe resected specimen showing a clear margin Discussion ... planus, psoriasis and seborrheic dermatitis This can result in delayed presentation as was the case with our patient In order to make the correct diagnosis, a high index of suspicion is required The ... CKs, have consistently been proven to be the most useful diagnostic markers [2] This observation was confirmed in our case A recent classification based on the origin ofthe Paget 's cells has...
... Paget 'sdisease is to control disease activity with bisphosphonates This is the first reported case of Paget 'sdisease affecting pituitary gland function by involvement ofthe sphenoid bone In this ... function Discussion Erectile dysfunction is a common disorder and is an important health-care issue as it acts as a surrogate marker of other diseases of more concern, such as diabetes mellitus and ... fossa The hypothesis was that the hyperprolactinaemia may have been consequent upon the increased vascularity and blood flow through the sphenoid secondary to the activity ofthe Paget 's disease...
... spite of rapid advancement of biomedical science and technology, a number of complicated diseases still remain incurable Many of these unconquered diseases such as CentralNervousSystem (CNS) ... methods, should contribute to the development ofCentralNervousSystem gene therapies as well as to the progression of various virus- and gene delivery-related studies VII LIST OF PUBLICATIONS Publications: ... to my co-supervisors, Dr Feng Si-shen, Associate Professor, Division of Bioengineering, National University of Singapore, for the in-depth discussions and useful suggestions I would also like...
... brains injected with recombinant baculoviruses Fig 3.1 Schematics ofthe expression cassettes ofthe recombinant pGL3 plasmids used in this study Fig 3.2 Schematics ofthe expression cassettes of ... neurodegenerative diseases and possibly for malignant glioma tumors in the CNS X LIST OF FIGURES Fig 2.1 Schematics ofthe expression cassettes ofthe recombinant AAV vectors used in this study Fig 2.2 Schematics ... almost impossible to create an universal gene delivery system for the treatment of all diseases, or even for several similar diseases, since each disease has its specific requirements for the...
... theory of FCS as well as the experimental setup of this instrument The calibration ofthe FCS system is also discussed The last part of this chapter presents necessary and critical steps in applying ... the results and discussion of FCS measurements in both the fruit fly embryos and in larval primary cultures The statistical analysis employed was discussed The purpose of these experiments was to ... embryos ofthe crosses were dissected for FCS measurements By using a single copy of driver and reporter, the expressions of fluorescent probes were kept low enough for the success of FCS measurements...
... four groups, which consists of sea snakes, sea kraits and land cobras (groups 1–4) The observation that sea snakes and sea kraits diverging into separate groups correlates with the results obtained ... rodents, reptiles and fishes The hydrophiids are mostly found in Southeast Asian and Australian coastal waters and they prey on fishes, eels and marine invertebrates The clinical manifestations of ... has made it uncommon to find fossilized remains ofthe Serpentes suborder This made the understanding ofthe phylogeny of snakes difficult (Evans, 2003) Molecular phylogenetics is the study of...
... Asada et al (coral, jellyfish, sea anemones), which possess the most primitive form ofnervous system, suggesting that the archetype nervous systems may have relied on amidated peptides [5] The ... Carstensen K (1996) Peptides in thenervous systems of cnidarians: structure, function, and biosynthesis Int Rev Cytol 167, 37–89 Eipper BA, Stoffers DA & Mains RE (1992) The biosynthesis of neuropeptides: ... vesicles equivalent to those seen in the present-day neurons of higher animals by the time ofthe emergence ofthe Plathelminthes in the evolutionary history The eye ofthe planarian is one of the...
... require the same data used to establish the transmitters ofthe autonomic nervoussystem (seeChapter 6: Neurotransmission: The Autonomic and Somatic Motor Nervous Systems) The transmitter must be shown ... components ofthe surgical stress response, which would otherwise lead to short- or long-term sequalae The Surgical Stress Response The stress of surgery includes (presumably) adaptive responses involving ... the case Assessing the patient 's level of consciousness, assuring adequate depth of anesthesia, and minimizing recall obviously are central to the goals of general anesthesia Signs and Stages...
... mechanistic basis for the results of studies in cancer patients A recent study of breast cancer survivors 3-6 years after chemotherapy was completed found that patients had abnormalities in the ... brainstem response in the mice at various times following treatment Loss of myelin is known to increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of ... also found that the agents caused increased cell death and decreased cell division in the subventricular zone, the dentate gyrus ofthe hippocampus and the corpus callosum in mice These effects...