... be interpreted bythis hypothesis. The hypothesis will also be extendedto the analysis ofthe possible roleof C-terminalmulti-helix domain in this process.Investigation of bacterial PAL structuresAs ... of Tyr110 more than 17 A˚apart from the exocyclicmethylene C-atom ofthe MIO prosthetic group.On the basis ofthe experimental structures, hypothe-ses on theroleofthe Tyr110-loop have been put ... study the behavior ofthe Tyr110-loop in PAL in moredetail.Results and discussionModeling the active conformation of the essential Tyr110-loop of parsley PALBecause ofthe uncertainty of the...
... causes the distortion and twist-ing ofthe substrate, so that the glycosidic oxygen facestowards the bottom ofthe deep cleft.Enzyme–substrate interactions The crystal structures ofthe AD2 ... of SmChiB, catalysis in family 18 chitinases involves the N-acetyl group ofthe sugar bound at the –1 subsite of the enzyme (substrate-assisted catalysis) [24,40–42].Protonation ofthe glycosidic ... these residues stabilize the distortion ofthe NAG3 residue. In these interac-tions, we particularly focused on the Trp664 residue,which is located at the bottom ofthe active site cleft.The...
... (generalist)management companies offer SRI funds and have more (less) than 50% of their assets in this type of funds. A positive sign indicates that the value ofthe outcome variable is higher ... funds in the period 1994-2003 using the same measure of performance.Neither of these studies documents statistically significant differences in performance. Both the approach and the results of our ... (2007), they are set taking into account the performancesensitivity of funds’ clienteles. This is especially relevant in the context ofthe recent debatein the literature regarding the sensitivity...
... the behaviour of short cracks themselves; this has been the subject of intensive research over the past 20 years [13-18]. A form of notch which has received relatively little attention isthe ... Where ȡ isthe notch root radius. These differ in the square root term. However Taylor [4] has demonstrated that the two expressions are two different aspects ofthe same critical distances theory ... ahead ofthe notch root (Peterson) was equal to the fatigue limit of pristine sample. The distance was considered a material characteristic and put in relation with material strength [3]. The...
... than those of any general, statesman, or poet whoever adorned the pages of English history.Whatever may be thought of this spread of athle-ticism, and worship of muscle, one thing is certain, ... he displayed any want of courageor failed to exert himself for the time to the utmost of his strength.But what are the after effects of all this violentexercise? This is a subject on which ... exact.They would fain learn the names ofthe crew who somiserably perished, the particular circumstances underwhich the feat was accomplished, and the year in whichit took place. In the case of...
... activity. The crystal structures show thatthis residue is important for positioning the N-acetyl group of the )1 sugar residue close to the sugar’s C1 atom. In thisway, the sugar is able to ... catalytic roleof Asp125 has also beendeduced from crystal structures. The side chain O1 atom of Asp125 is at hydrogen bonding distance from the amidenitrogen ofthe N-acetyl group ofthe )1 sugar ... with the Asp125 side chain,which, in turn, is hydrogen bonded to the nitrogen atom of the N-acetyl group ofthe )1 sugar residue, o rienting the carbonyl oxygen towards the C1 atom. Tyr183 is believed...
... places, but declares at the bottom of page 135, " ;The reign of Akbar is one ofthe most important in the history of India; it is one ofthe most important in the history ofthe world"); Mountstuart ... is sufficient to brand Islam and its supreme contempt for followers of other faiths, with one ofthe greatest stains in the history of humanity. When a tax-collector gathered the taxes ofthe ... learned ofthe horrors ofthe Inquisition at Goa. Moreover, the clearness of Akbar's vision for the realities of national life had too often put him More worthy of admiration than the subjugation...
... cholesterol is removed from peripheral tissues, and is transported byHDL to the liver for excretion in the bile. Therefore,RCT isthe major mechanism by which HDL protectsagainst atherosclerosis and ... other cardiovascular dis-eases. Stimulation of RCT is a primary target for the development of drugs enhancing the level or reducing the catabolism of HDL [4,5]. Apolipoprotein A-I(ApoA-I), the ... alone in the culture mediumdid not affect their cholesterol delivery to the cells.Discussion The capacity of HDL to protect against atherosclerosishas already been reported [4]. However, the protectiveeffect...
... aspects. The Ministry of Youth (MOY), Ministry of Education (MOE) and Ministry of Social Affairs (MOSA) will be the key players. Although health is mentioned in this strategy, there is no explicit ... attention to the SRH of these age groups and no cross-references to other strategies. Theroleofthe MOHP in implementation of this strategy is not explicitly stated, as RH service delivery is included ... ofthe project among the authorities. A further problem in Egypt is that although the RH rights of a couple may be acceptable, there is a reluctance to accept the concept ofthe RH rights of...
... system, it is also the function ofthe judges, and hence it involves the justice system. Enforcing the law isthe function ofthe police, the prison and probation services, and, of course, the courts, ... Sir Anthony May, the recently retired President ofthe Queen’s Bench Division put it recently, the fabric of justice . . . is part ofthe fabric of society.7’ The fabric of justice demands ... by the judge, the lawyers, and any witnesses in their respective offices, the only way will be if there is electronic recording and electronic transmitting ofthe proceedings. 34. But there is...
... affirm the findings of other historians that in the decade of the 1920s the United States did not pursue an isolationist policy. Even 28 Negotiating for the PastSometimesthe Germanspursued their ... iteverydayofHislifethere.WeshallneverknowhowoftenHisownvisions of future peace and brotherhood may have been clouded by the contemplation of that great battlefield where the fate ofthe world ... ORDERWith the end of World War I and soon thereafter the demise ofthe Otto-man Empire, a spirit of nationalism slowly spread throughout the Turkishpopulation of Anatolia and Thrace. The courageous...