... barking shins or scraping skin on the razor-sharp barnacles inthe process. But the pounding surf on the rocky points, the scudding clouds, and the vast cliffs that echoed back the crash-ing ... at that due to the distant happenings at sea and in the air. Is there other evidence of what happened? It turns out thatthe amount of dust reaching the deep sea confirms suspicions thatthe ... wondrous fossil treasures just for the joy of it. Discipline kicked in once again—turn around, return down into the creek, arriving in minutes once again at the striped beds. There I became busy...
... known is whether their expectations are met, howthey manage while they are in Great Britain, and whethertheir intention to return to their country of training (orelsewhere) is influenced by ... allow in- depth exploration ofsome of these issues within different groups of interna-tionally trained pharmacists. For example, whether the finding from this study that pharmacists joining via the ... August 2006 and August 2007, split by the route of entry (including GB-trained). In just one year,only a relatively small percentage (0.7%) of GB-trainedpharmacists living in Great Britain in...
... recorded in a form thatcan be evaluated, reproduced, andused by others. The uncertainties in predicting the future are vast, and makingassumptions for the most uncertain variables is often the ... down. In this instance the limiting case might have turned out to be misleading had people decided tocool their homes more than inthe past, or to build larger houses than anticipated in the business-as-usual ... tobe robust, and end-use analysis when it appears to provide more insight. Thiskind of approach is being used increasingly in both industry and government, andespecially by the utility industry...
... formation in stratified squamous epithelia. This enzyme catalyzes the cross-linking of glutamine and lysine residues in structural proteins in differentiating keratinocytes. To gain insight into the ... of the epidermis. The CE comprises severalproteins, including involucrin, loricrin, trichohyalin andsmall proline rich-proteins, that are preferred substratesfor TGases inthe skin. Of the ... cross-linking site in these proteins [32,36,37].Sequences homologous to the motif QxR ⁄ KwxxxWPare present inthe C-terminal regions of involucrin(QQKQEVQWP) and loricrin (QQKQAPTWP), whichare the...
... Fabry.(A, B) Heart – endothelial staining in Fabrymouse; (C, D) lung – epithelial cell stainingincreased in Fabry mouse; (E, F) brain micro-vascular endothelial staining in Fabry mouse.Magnification ... between the cardiac muscle fibers and appears to‘diffuse’ into the myofibrils, is also evident in the Fabry mice (Fig. 7A). The VT1 binding inthe Fabrymouse lung (Fig. 7C) was increased inthe bronchiolarepithelium. ... micemonitored by VT1 binding is shown in Fig. 6. VT1Gb3staining was not above background inthe wild-type mouse liver (Fig. 6A), but within the Fabry liverVT1 binding detected Gb3 in the stellate Kupffer...
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... tradeoff in mind, we observe that the techniques of adding additional redundancy and bet-ter exposing and monitoring for failures offer the mostsignificant “bang for the buck,” inthe sense that theyhelp ... before it wasrealized thatthe primary copy of the problem trackingdatabase had been destroyed, and thatthe re-imagingwould therefore destroy the last remaining copy.We can learn several lessons ... sys-tem’s margin of safety has been reduced. The correctoperator behavior inthe previous problem was to repli-cate the backup copy of the database before reimaging the machine holding it. But in order...
... to begin with. For example, in joke(1) the interpretation after reading the first clause,has the word miss referring to the abstract act ofmissing a dear person. After hearing the punchline, ... walked into a bar. The thirdone ducked. The humour in joke (4) results from the polyse-mous use of the word bar. The first sentence leads us to believe that bar is a place where one drinks,but the ... well, contains an obvious op-position. The first sentence invokes the sense ofsupport being that of political support. The secondsentence introduces the opposition, and the mean-ing of support...
... cell and toother susceptible individuals. Anti-bodies that bind to either the HA or the NA and block their function effec-tively prevent (or terminate) the infectious process and thus provideprotective ... example, the NS1protein produced by the influenzavirus inhibits the production of type Iinterferon, which is normally inducedby viral infection and in turn inducescellular anti-viral proteins that ... into the same virion,usually through infection of swine by both viruses, and this can result in a virus that is still adaptedto infect humans but expresses an avian hemagglutinin or neuraminidase...