... Springer-Verlag Berlin Heidelberg 2005II.3.1 Phenothiazines by Akira Ishii and Yoshinao KatsumataIntroductionPhenothiazine drugs, including chlorpromazine and levomepromazine, have been being ... Poisoning due to psychotropic agents. Adverse Drug React Acute Poisoning Rev 4:83–126 3) Geraut A, Kintz P, Traqui A et al. (1994) Toxicological findings in a fatality involving chlorpromazine. ... (1 min) →15 °C/mine →290 °C (10 min); injection temperature: 270 °C; interface temperature; 270 °C; carrier gas: He; its ow rate: about 1.5 mL/min; injection: splitless mode for 1 min followed...
... IgarashiIntroductionButyrophenone drugs including haloperidol are being widely used in the eld of psychiatry. e acute butyrophenone poisoning incidents sometimes take place; in such cases, ... solution, because it increases extraction e ciency due to its salting-out e ect.c) ere is a report using a haloperidol analog as IS, in which chlorine is substituted for the uorine; but this ... temperature: 100 °C (1 min) → 30 °C/min →270 °C (30 s) → 5 °C/min → 290 °C (5 min); injection temperature: 260 °C; separator tempera-ture: 280 °C; carrier gas: He; its ow rate: 1.5 mL/min; MS ionization...
... carbamazepine obtained by GC/MS. A: amitriptyline, B: mianserin, C: nortriptyline, D: imipramine, E: desipramine, F: promethazine (IS), G: setiptiline, H: carbamazepine, I: maprotiline, J: clomipramine, ... also in- cluded in this chapter. GC/MS analysisReagents and their preparation • Amitriptyline, carbamazepine, clomipramine, desipramine, imipramine, maprotiline, mi-anserin, nortriptyline ... solvent can be chosen according to the kind of a target drug.e) Imipramine and amitriptyline are metabolized into desipramine and nortriptyline, respec-tively, in a human body. Both metabolites...
... relaxants in urine, serum and tissue homogenate can be extracted, but especially suxamethonium (succinylcholine) is rapidly hydrolyzed in blood by the action of cholinesterase; since it is ... dissolved in methanol just before use a.• Synthesis of succinylmonocholine iodide [2]: 2.3 g choline iodide and 5 g succinic anhy-dride are mixed and fused for reaction by heating the mixture ... for 1–2 h in an oil bath. A er cooling to room temperature, the excessive (not reacted) succinic anhydride is washed with 100 mL acetone, succinyl monocholine iodide is crystallized in the mixture...
... vessels; in the eye, they decrease intraocular pressure by suppressing the production of aqueous humor. Since the drugs are also e ective in suppressing muscle quivering and in suppressing overreaction ... with intravenous ad-ministration of the same drugs to rats, depending on each drug.Although in Japan reports on β-blocker poisoning are not many, Kiyota et al. [5] reported a fatal poisoning ... chromatograms for β-blockers extracted from urine of subjects, who had ingested each of them. The results were obtained after single oral intake of each drug. In the analysis of atenolol, double peaks...
... report describing the di culty for detecting hypochlorite from blood of a victim, who committed suicide by ingest-ing a bleaching agent [3].Notesa) Hypochlorite is very unstable in acidic aqueous ... alkaline or weakly acidic conditions to produce chloride ion together with oxygen in the activated state, resulting in its bleaching action.References 1) Yokogawa Analytical Systems (1999) Instruction ... chlorate ions are contained. During preparation of the solutions and also during analysis, there is a possibility of decomposition of the hypochlorite ion. As shown in > Figure 1.1, the...
... Springer-Verlag Berlin Heidelberg 2005II.5.4 Permethrin by Naoto MatsumotoIntroduction Pyrethroids are the general term for insecticide pyrethrins and their analogs ( cinerins and jasmolins) ... present time.Products containing pyrethroid insecticides are numerous; their toxicities for humans are generally low. However, since phenotrin, permethrin and empenthrin are ubiquitous as powders, ... ey are not only being used for household insecti-cides, but also being used in agriculture worldwide. ey count about 1/3 of the total insecti-cides, and are even increasing at the present...
... (in Japanese) 2) Fukui S (1983) A method for determination of boric acid in foods using chelating extraction with 2-ethyl-1,3-hexanediol and protonated curcumin. Eisei Kagaku 29:323–328 (in ... acid poisoning symptoms, nausea, vomiting, diarrhea and abdominal pain is most common as observed in the above case; headache, scarlet fever-like exanthemas and desquamation of the skin are sometimes ... spectrophotometric analysis of boric acid in a urine specimen, the value obtained may be slightly greater than the true value. is is probably due to interference by a certain urinary element, which also...
... are being extended to ultra-sensitive analysis of toxins in hair, nails, saliva and sweat; these specimens are proving to be useful for toxin analysis, because many toxins are excreted into ... hair cells. e cells are keratinized during their growth. rough this procedure, drugs and poisons are incorporated into hair, resulting in their stable storage in it. e growth rate of hair ... secretion. However, it should be kept in mind that during the change in the secretion rate, the amount of a drug excreted into saliva may change according to changes in its pH [17].A close relationship...
... matrices in which poisons were mixed, viz, drink in a glass bottle, drink in a can, drink in a paper package, drink in a plastic bottle, drink in an un-known container, tea in a pot, tea in a water ... YoshiokaIntroduction In addition to the well known Tokyo Sarin Incident in 1995, the arsenic-adulteration incident in Wakayama and the cyanide-adulteration incident in Nagano both in 1998 seem to ... and melting point, are used as keywords for narrowing down toxins.Database according to poisoning symptoms( assisting system for diagnosis of a causative toxin)of subjects of studies being conducted...
... communication quality is being maintained to be able to cope with the sudden outburst of a poisoning incident or accident; the complementary talks are being refrained as possible. e mailing list is convenient ... point of August, 2001. A password is given to each registrant to enable looking into the poisoning information part of HP of the poison-net. Analysis mailing list ( ml-anal) In 1998, the Ministry ... made in the mailing lists (ml-poison plus ml-anal) e contents of talks made in both ml-poison and ml-anal were rearranged according to causa-tive toxins, and shown in the “poisoning-talking...