vegf expression and inhibits vegf and its receptor binding in vitro
Báo cáo y học: "Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA" pdf
... as a continuous sinusoidal staining and in the stroma of portal tracts (Fig 7A) In the cirrhotic liver, the sinusoidal staining was enhanced, whereas a very faint staining was observed in fibrous ... LIF-M expression in various cell lines and in human liver RT-PCR analysis of LIF-M expression in various cell lines and in human liver (A): LIF-M expression was analyzed with the hLIF-M2 and hLIF-3N ... questioned in humans [2] LIF exerts its biological activities through its binding to a hetero-oligomeric receptor complex between the low-affinity LIF receptor subunit gp190 and the signal-transducing...
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Báo cáo y học: "Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis" pps
... proliferating FLSs produce proteinases that degrade cartilage and underlying cortical bone [4] We noticed that proinflammatory cytokines upregulate NGF/TrkA in FLSs, NGF/TrkA is upregulated in FLSs of in ammatory ... stimulated cells were cultured in DMEM with cytokines tumor necrosis factor-alpha (TNF-α) (1 ng/mL) and interleukin-1-beta (IL-1β) (1 ng/mL) Data are expressed as mean ± standard deviation Nerve growth ... competing interests Published: 28 June 2010 References Barthel C, Yeremenko N, Jacobs R, Schmidt RE, Bernateck M, Zeidler H, Tak PP, Baeten D, Rihl M: Nerve growth factor and receptor expression in...
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Báo cáo y học: "Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo" ppt
... chondrosarcoma (G), and mesenchymal chondrosarcoma (H), and aromatase and ESR1 protein expression in conventional chondrosarcoma (I and J, respectively) ESR1 protein expression in the JJ012 and CH2879 ... al.: Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo Clinical Sarcoma Research 2011 ... chondrosarcoma cells in vitro by measuring the effect of steroids and clinical drugs inhibiting estrogen-signaling We evaluated responsiveness of central chondrosarcoma cell lines and primary cultures...
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Functional characterization of HGF and its receptor c met in zebrafish development
... β1-integrin and erbB2 p125FAK (focal adhesion kinase) is a 125 kDa protein, consisting of a N-terminus integrin -binding site, a central kinase domain, and a C-terminus focal adhesion targeting and ... paxillinbinding domains (Schaller and Sasaki, 1997) p125FAK family members include proteins such as PYK2 and FAK-B p125FAK can interact with integrins, paxillin, PI3-K, SH3 domain-containing adapter ... docking site (Y1349VHVX3Y1356VNV) that can bind Src homology-2 (SH2) domains, phosphotyrosine binding (PTB) domains, and Met binding domains (MBD) of signal transducers and adapter proteins Chimeric...
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Cloning of medaka glial cell derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
... its alleged receptor in the brain This suggests the presence of another binding ligand to Gfrα1 in the medaka brain and also probably, a different role for Gdnf in the medaka fish (Clermont and ... brain, ligand expression coincides with that of the receptor in all of the tissues investigated b) Faint Gdnf expression was detected in the brain only after the number of PCR cycles was increased ... multiplication and stem cell renewal Fig GDNF-family ligand interaction with their receptors Fig Schematic illustration of initial signaling events mediated by the binding of GDNF to RET receptor complex in...
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Tài liệu Economic Reforms, Foreign Direct Investment and its Economic Effects in India pdf
... support India’s industrial upgrading In 199091, such transfers were largely confined to FDI in engineering They still figure most prominently in this area, with transport equipment standing out ... our findings on manufacturing are in line with the cross-country findings on FDI and trade reported in Aizenman and Noy (2005) Using Granger causality tests on disaggregated measures of financial ... sectors, including mining, financial services and telecommunication (though still subject to limits of foreign ownership); lifting foreign ownership restrictions in most manufacturing industries;...
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Báo cáo khoa học: Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus – the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress pot
... that in the Bay, low temperatures during winter and anoxia during summer, in combination with the changes in salinity, are associated with high mortality in this species [25–27] In view of CHH involvement ... Expression and release of CHH in the blue crab J S Chung and N Zmora 694 Results Identification and bioactivity of CHHs from ES sinus glands and PO Two RP-HPLC peaks (1 and 2) as presented in ... experiences migration and seasonal changes in environmental conditions, including temperature, salinity and dissolved oxygen (http://www.dnr.state.md.us/bay/ monitoring/water/index.html) In particular,...
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Báo cáo khoa học: Oxygen binding and its allosteric control in hemoglobin of the primitive branchiopod crustacean Triops cancriformis pdf
... effectorbinding functions This approach successfully describes proton binding [59] and urate binding [63] in hemocyanins Here, we assume the simplest effector -binding model with h identical proton -binding ... saturations of the ith point, and k is the number of data points Adair equation To determine the minimum number of interacting binding sites necessary to describe the data, the binding curves were analyzed ... purified Hb in Hepes buffer (Fig 4B,D) Error contour maps were calculated for nine different combinations of the number of proton -binding sites (h) and magnesium -binding sites (m) per oxygenbinding site...
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phase explosion and its time lag in nanosecond laser ablation
... superheated, i.e., its temperature is higher than the vaporization temperature corresponding to its surface pressure In this case, the heating process follows a superheating line shown in Fig 1, and the ... the critical point temperature diagram shown in Fig The ‘normal heating’ indicates heating of a liquid metal when the temperature is below the boiling temperature The binode line represents equilibrium ... measured using the optical deflection technique [3] and is used to obtain the velocity of the vapor front) shown in Fig The onset of ablation obtained using these two methods is shown in Fig 6a and b...
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báo cáo hóa học: " Assessment of psychosocial functioning and its risk factors in children with pectus excavatum" ppt
... patients and parents gave the same answer, at least that information could be included All of the interviews were conducted by authors They had been trained in interviewing and administering questionnaires ... problems, delinquent behavior, and aggressive behavior A Chinese Mandarin version of the 1991 CBCL/4-18 was used in this study Previous studies confirmed its acceptable reliability and discriminant ... is a fascinating finding, providing very strong support for the inclusion of objective measures of appearance in studies exploring the psychosocial impact of PE, particularly where this includes...
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Báo cáo hóa học: " Facile preparation of highly-dispersed cobaltsilicon mixed oxide nanosphere and its catalytic application in cyclohexane selective oxidation" ppt
... Dalian, China Cobalt oxide [Co3O4] (98%) denoted as C-Co O was purchased from Tianjin Institute of Jinke Fine Chemical, Tianjin, China Firstly, two kinds of solution (solutions A and B) were obtained, ... were determined by the internal standard method using methylbenzene as an internal standard The concentration of CHHP was determined by iodometric titration, and the by-products acid and ester, ... Microemulsion was obtained with the blending of solutions A and B After stirring for 15 min, to this microemulsion, 5.2 g of TEOS was added slowly under stirring After stirring was continued for 12 h,...
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Báo cáo y học: "Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice." ppt
... M, Sorsa T, Konttinen YT: Distribution of vasoactive intestinal peptide (VIP) and its binding sites in labial salivary glands in Sjogren's syndrome and in normal controls Clin Exp Rheumatol 1994, ... in submandibular glands Double labelling of CD31 and M3R revealed M3R in the wall of blood vessels in submandibular glands of both NOD mice and BALB/c mice (Figure 5a,b) In addition, M3R staining ... toxylin and eosin staining was performed, and evaluation was performed in a representative section from each gland Salivary gland sections were evaluated and morphometrically analysed using a...
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Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx
... Kresse H: Decorin-type I collagen interaction Presence of separate core protein -binding domains J Biol Chem 1995, 270:8877-8883 Hedbom E, Heinegard D: Binding of fibromodulin and decorin to separate ... adhesion and responses to growth factors and cytokines [2,3] The SLRPs all bind to fibrillar type I and/ or II collagens [4-6] and, in the case of decorin, to fibromodulin and lumican; these interactions ... cartilage in both MTP and LTP, and there was a generalized decrease in staining following meniscectomy (Fig 2e–h) As expected [31,32], types I and III collagens were also prominently immunolocalized in...
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Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis pdf
... 2005:870-874 36 Etrych T, Jelinkova M, Rihova B, Ulbrich K: New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties ... citation purposes) retention, and release of drugs in the treatment of RA and related forms of inflammatory arthritis Competing interests DW and SCM are inventors named in a patent application partially ... manuscript X-ML participated in the synthesis, characterization, and in vitro evaluation of P-Dex BA participated in the histology study SXW participated in the synthesis and in vitro evaluation of P-Dex...
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Báo cáo y học: "Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis" potx
... types through binding to G-protein-coupled cell surface receptors with seven transmembrane domains [14] Chemokine receptors may be specific for one ligand or they may bind several chemokines [15], ... prevent nonspecific binding, × 105 cells were preincubated for 10 minutes with heat-inactivated (20 minutes, 56°C) human serum and were then incubated with a combination of fluorescein isothiocyanate-conjugated ... be increased by additional stimulation with cytokines such as IL-10 and IL-4 as well as vitamin D3 [18,19] In RA, expression of mRNA encoding CCL18 was observed in synovial tissue and it coincided...
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Báo cáo y học: "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc" pdf
... processes within the degenerate IVD since expression of the pain-related neuropeptide and its receptor have been identified in both disc cells and nerves growing into the diseased IVD [5,37-39] In the ... also increases with the severity of degeneration Using immunohistochemistry we have therefore investigated NGF and BDNF expression, including expression of the receptors Trk-A and Trk-B, in nondegenerate, ... BDNF protein expression in the nondegenerate and degenerate human IVD Immunopositive staining was observed for both neurotrophins Cellular staining for NGF and BDNF was identified in the native...
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Báo cáo y học: "Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway" pps
... enzyme involved in joint inflammation through production of prostaglandins COX-2 is induced in human joint tissues, including chondrocytes and synoviocytes, by inflammatory stimuli such as interleukin ... be involved in the induction of COX-2 and PGE2 production in the current study Toll-like receptors have been shown to be involved in synovial inflammation in a wide range of inflammatory joint ... using an EMSA kit according to the manufacturer's instructions (Panomics, Redwood City, CA, USA) Nuclear protein (8 μg) was used to bind biotinylated oligonucleotides containing the NFκB binding...
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Báo cáo y học: "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice" ppt
... suppresses cytokine-stimulated expression of sPLA2 and MMP genes and secreted proteins is depicted in Figure In this proposed model, PIP-18 binds sPLA2 and inhibits its enzymatic activity, leading to ... protein kinase (MAPK) proteins was examined using SuperArray CASE™ cell-based ELISA kit [18], and specific MAPK inhibitors (p38 inhibitor SB202190, Erk inhibitor PD98059, and Jun N-terminal Kinase ... protein kinase B and cAMP-response-element -binding protein Biochem J 2000, 350:717-722 19 Pachiappan A, Thwin MM, Manikandan J, Gopalakrishnakone P: Glial inflammation and neurodegeneration induced...
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Báo cáo khoa hoc:" Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study" ppt
... of tandem repeats (VNTR) within the promoter region of the gene The ESR1 is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and ... supervised BK and CD, was instrumental in drafting and revising the manuscript, and give final approval for the publishing of this document All the authors have read and approved the final manuscript ... C, Crutchfield M, D'Agostino D, Jannausch M: Bone mineral density and its change in white women: estrogen and vitamin D receptor genes and their interaction J Bone Miner Res 1998, 13:695-705...
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báo cáo khoa học: " Plant origin and ploidy influence gene expression and life cycle characteristics in an invasive weed" ppsx
... of interest and normalized using the geometric mean of the standards actin, cytochrome c oxidase, and ubiquitin as suggested in Vandersompele et al 2002 [61] Significant differences in gene expression ... gene expression remain unclear, and further work is needed in this area A better understanding of the genetic and molecular basis of invasiveness in exotic plants is not only an interesting case ... determining plant ploidy in ecological and genomics investigations, and suggests that C stoebe invasion can be influenced by both plant ploidy and altered gene expression in the introduced range We...
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