... Landis did much to translate his office’s potential into precedents But also like Jackson, his rise to power owed A N E W E R A as much to powerful patrons as to his own struggles, and his concern ... MUCHMORETHAN A GAME MUCH MORETHAN A GAME & PLAYERS, OWNERS, AMERICAN BASEBALL SINCE 1921 ROBERT F BURK The University ... of his anticorruption campaign, another pattern quickly emerged in Landis’s handling of such issues After the initial flurry of action on scandals predating his commissionership, he showed a disturbing...
... cycle This pathway is called the primary processing path way [5,6] The mechanism of their production, however, has been largely unclear During spermatogenesis in Drosophila males, antisense piRNAs ... Hannon GJ: Argonaute2 is the catalytic engine of mammalian RNAi Science 2004, 305:1437-1441 doi:10.1186/gb-2010-11-3-109 Cite this article as: Sato K, Siomi H: Is canalization morethan just a beautiful ... there is a loss of bristles from the head and thorax of the adult), which is caused by a mutation in the noc gene The authors demonstrated that the coding sequence of the noc gene in this fly...
... determine More importantly, the pathophysiology of tissue injury in the critically ill can be quite complex, involving many interacting factors [10,11] The history of clinical trials in sepsis should ... 2002, 288:2827-2835 10 Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis N Engl J Med 2003, 348:138-150 11 Cohen J: The immunopathogenesis of sepsis Nature 2002, 420:885-891 12 ... critically ill, the potential for EPO to be of benefit in the critically ill is an important issue At a minimum, EPO is clearly effective in reducing the number of RBC units transfused in patients with...
... marketing strategies, and realistic goals and objectives that have to be: Specific, Measurable, Realistic Attainable, Time- based Sales prioritisation Help Sales prioritise its pipeline through segmentation ... say for example into key accounts (highest value customers) – and by making customer trends more visible This can enable salespeople to target customers more effectively Closed-loop reporting Closed-loop ... customers’ transactional histories Sales and Marketing alignment Better sales and marketing alignment by applying and sharing metrics to show how each function is performing This information can be...
... hypothesis, because aging in this model is not accompanied by increased ROS production, even though mitochondrial function is severely impaired and the mutational burden is at least 10 times higher than ... mutant mtDNA, below which no diseased phenotype is observed [137] This threshold is variable, but is usually quite high, around 70–90% [138] In practical terms, this means that a substantial fraction ... defenses of antioxidants and mtDNA repair, is required to sustain this rate A second, equally important, question is whether this level of ROS imbalance is physiologically attainable To our knowledge,...
... this presentation? What differential diagnosis should be considered for this patient? Based on this presentation, what diagnostic tests should be considered? Is anything missing from the history ... craniotomy with excision of the brain abscess He was started on antibiotic therapy and was discharged in good condition days after admission Discussion Brain abscess is a rare diagnosis; there are ... anaerobic microorganisms, and should be later tailored to the specific organism that is identified [2,3] The duration of therapy is dependent upon the organism identified; longer therapy is indicated...
... vitro data Much of this is likely to be a consequence of the fact that many of the other 13 parameters are correlated with %GC - AAAA is obviously unlikely in high-GC sequences Furthermore, many ... yeast promoters is visible as a prominent valley in both datasets, whereas the stereotyped positioning of the +1 nucleosome relative to the transcription start site is clearly visible as a prominent ... the dyad axis, the frequency of each dinucleotide was calculated from reconstitution data, and then 147-bp sequences were scored for their match to this distribution Predictions of this model correlated...
... new Let us now point out why this recurrence is so special! First of all, notice that all terms in (8) involve only successive generating functions It is precisely this property that leads to a ... later occured to us that this is the number of basketball games (post-1896 and pre-1961, when the three-pointer did not exist) in which the home team always leads the visitor by at most w points ... walk [WSCM, MTW] Since this is a tough nut to crack, one simplifying approach is to treat the polymer as a directed walk Studies of this kind have been done in the literature...
... competing risks [7] However, cumulative incidence of mortality can be adjusted for competing risks [7] Our finding that the cumulative mortality risk is lowered after adjustment for competing risks is ... Canada Discussion We have shown that the median survival from non-prostate-cancer deaths for men who are treated with radiation for prostate cancer ismorethan ten years, up to age 80 at the time ... oncologists are successful in selecting for curative treatment men whose life expectancy is greater than would be estimated from their age alone An important limitation of our analysis is that...
... neoepitope-specific ELISA is clearly a more powerful tool to distinguish diseased and injured joints from healthy than quantification of aggrecan fragments either by 1-F21 ELISA or by measuring ... of ARGS ismore sensitive in distinguishing diseased and injured joints from healthy ones than methods that not rely on the specific detection of this aggrecan neoepitope The ARGS ELISA could ... lower limit of linearity of the ARGS ELISA in SF was pmol/ml SF, and samples below this level were assigned half that value to allow statistical analysis All study groups had significantly lower...
... encephalomyelitis (EAE), colitis and type diabetes [15-17] Early thymectomised mice display impaired nTreg development but normal Foxp3+ iTreg numbers, and these mice develop a less severe disease than ... CD4+CD25high and isolated from peripheral blood, other studies have shown that CD4+CD25+ Tregs isolated from joints of patients with active arthritis had a more powerful suppressor activity than peripheral ... recapitulated by administration of agonistic anti-CD40 [61] Although the therapeutic use of agonistic anti-CD40 monoclonal antibodies is not a viable therapy for autoimmune diseases, enrichment...
... impact of these two mechanisms on T cell-mediated containment of virus replication at this time Sequence variation and escape were found to occur muchmore frequently than reduction in T cell ... (Gp160 MM56 584-592) ERYLKDQQL ERYLKDQQL ERYLKDQQL ERYLKDQQL Unknown RDISGWILSTY (Rev 53-63) RDISGWILSTY RDISGWILSTY RDISGWILSTY RDISGWILST/AY d14 TSTLQEQIGW d75 TSTLQEQIGW d186 TSNLQEQIGW d375 TSNLQEQIGW ... available time- point and those which persisted at frequencies high enough for analysis over the first year of infection were selected for study It is thus conceivable that our mapping may have missed...
... reporting percentage time in bands on a per patient basis as well as indicating the variability across the cohort via the box and whiskers plot of Figure From this data and Table it is possible to ... patient basis – the same basis on which tight control has a clinical impact It is also something not reported in most similar studies, making this study unique for its transparency Variability is particularly ... stay” However, their results are similar in average value and tighter in distribution than the very successful results of Krinsley [4], based on values estimated from Figure and Table in Krinsley's...
... biology of Bacillus could allow this regulatory mechanism to be elucidated depolarization, releasing the lysozyme from the lipid bilayer After release, disulfide-bond isomerization occurs, utilizing ... segments This study shows once again that bacterial cells can respond to external conditions and adapt by means other than point mutation or horizontal gene transfer As a whole, the morethan 100 ... Richard Gourse (University of Wisconsin, Madison, USA) independently reported structural biology studies, and in vitro and in vivo assays, suggesting that ppGpp is stabilized in its binding to...
... by the lemma is tight We now prove the main result aimed by this paper: linearity is a strictly more powerful encoding than contiguity, which means, more formally, that there exists some graph ... (σj )1≤j≤2k It is enough for j , since they admit a 2k − 1-line-model by recursion hypothesis, w ∈ U≤k−1 but one order is missing for uj which is minimally of linearity k and is then only guaranteed ... a graph is always less or equal to its contiguity Then the question naturally arises to know if there are some graphs for which the linearity is significantly less than the contiguity More formally,...
... S, F, hay đứng trước âm L Ví dụ: • castle ['kɑ:sl] • Christmas ['krisməs] • fasten ['fɑ:sn] • listen ['lisn] • often ['ɔfn] • whistle ['wisl] Âm U câm: Âm U âm câm đứng sau âm G đứng trước nguyên ... dụ: • psychiatrist [sai'kaiətrist] • pneumonia [nju:'mouniə] • psychotherapy ['saikou'θerəpi] • pneuma ['nju:mə] Âm S câm: Âm S âm câm đứng trước âm L từ sau: • island ['ailənd] • isle [ail] Âm ... mạo từ “an” Ví dụ: • hour ['auə] • honest ['ɔnist] • honor ['ɔnə] • heir [eə] Những từ lại dùng với mạo từ “a” Ví dụ: • hill [hil] • history ['histri] • height [hait] • happy ['hæpi] Âm K câm:...
... ethical issues The expectations of the graduates are also changing More and more graduates are beginning to realize that there is no job for life in our modern world Their main focus is to maintain ... this is only anecdotal evidence However, it is rare to find graduates who are able to point to specific elements in their course and relate them to their jobs This makes the above comments more ... jobs when they graduate? The big issue we have with recruitment is how to determine if a candidate is able to design and problemsolve logically and methodically This is particularly pertinent with...
... year for the rest of the time you are living in this house As long as I'm still in business, I'll clean your ducts again for free." Jeff's offer was generous and morethan we would have asked ... this customer satisfied? They won't be a repeat customer anyway for years, if ever." But Jeff understands the power of both positive, and negative word of mouth He understands that as a dissatisfied ... of advertising The original mistake is largely forgotten and entirely forgiven, replaced by admiration for their approach to remedying the problem When you are servicing customers, mistakes will...
... it? - It is - What timeis it? - It is - What timeis it? - It is - What timeis it? - It is - What timeis it? - It is - What colour is it? - It is - What colour ... What is their job? - They are teachers What timeis it? - It is three o'clock What timeis it? - It is a quarter to seven What timeis it? - It is half past twelve What colour is it? - It is brown ... - What is it? - It is a - What are they? - They are - What is your job? - I am a - What is her job? - She is a - What is his job? - He is a - What timeis it? - It is ...