utilization of maldi tof to determine chemical protein adduct formation in vitro
Tài liệu Báo cáo Y học: Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor pot
... CNTF-R In contrast to the existing cytokine–cytokine receptor fusion proteins, Hyper-IL-6 and Hyper-IL-11, which directly activate the ubiquitously expressed gp130 protein, such a protein allows ... immunoglobulin-like domain, D2 and D3 the two cytokine-binding receptor domains RESULTS Construction of CNTF/sCNTF-R fusion protein We engineered an expression vector encoding a CNTF/ sCNTF-R fusion protein ... polypeptide linker in order to minimize immunogenicity Instead, the 16 C-terminal amino acids of CNTF-R (amino acids 331–346) that are not part of the membrane-proximal cytokine binding domain [33]...
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Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc
... equation was integrated in the model [27] to estimate the amount of drug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, ... quantified by using LC/MS/MS Briefly, an internal standard (in- house compound) was added to samples followed by protein precipitation involving the addition of acetonitrile Chromatography of DCU was ... delivery of low solubility compounds in the preclinical setting Based upon the positive results of our investigation, the continued use of nanosuspension to deliver low solubility compounds in preclinical...
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Báo cáo lâm nghiệp: " Comparison of three methods to determine optimal road spacing for forwarder-type logging operations" pdf
... terrain Sundberg provides several explicit factors of adjusting for the terrain The method of total cost minimization to study ORS allows engineers to see the sensitivity of roading, forwarding ... similar terrain and forest removals CONCLUSIONS Optimal road spacing is an important factor in logging planning to help minimizing the total cost of harvesting and roading The comparisons of different ... optimum road spacing varies if forwarding cost (including travelling, loading and unloading cost) or travelling costs (without loading and unloading cost) are used in the calculation using observations...
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Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt
... direct interaction between the two proteins has been not been demonstrated [5,6,17] Data are emerging that point to perilipin as a key player in directing proteins involved in lipolysis to a subset ... the identity of the purified protein as HSL (data not shown) The yield of pure protein was mg per litre of insect cell culture The specific activities of the purified protein against TO, 1-mono-oleoyl-2-O-mono-oleylglycerol ... phosphorylation-induced gain in hydrophobic surface area described here affects other properties of HSL than binding to lipids, e.g binding to lipid droplet-associated proteins In conclusion,...
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Strengthening country office capacity to support Sexual and reproductive health in the new aid environment docx
... need to be able to offer SRH strategies and ensure that SRH indicators are integrated into information systems for sector-wide evaluations, performance-based financing mechanisms and routine programme ... country office capacity to expand into new areas, and to gain new skills in working with the UN OneHealth costing tool (12), abbreviated expenditure tracking methodologies, and monitoring and ... historical distortions within SRH, marginalizing attention to family planning, and often neglecting the rights agenda and prevention of unsafe abortion In terms of maintenance of a dedicated...
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Footprints of genetic susceptibility to pulmonary tuberculosis: Cytokine gene variants in north Indians pdf
... cells is the principal Th1 response inducing cytokine11 This cytokine is important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to intracellular ... population, indicating that overproduction of IL-12 by these individuals might be interfering with the cytokine homeostasis and thus affecting the immune function of the cytokine in these individuals ... risk of association for PTB in north Indians Interestingly rs1041981 contributed to a haplotype block with rs2229094 confirming the importance of this locus in risk of developing PTB in north Indians...
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báo cáo hóa học:" Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients" doc
... and the use of 10 μL was found to be optimal Long term performance of the tetramer was monitored to achieve optimal binding and to assure longitudinal assay performance Tetramer binding temperature ... our clinical testing regimen; all longitudinal frozen PBMC samples from each patient were tested in a single assay by a single operator, allowing assessment of vaccine potency compared to pre-treatment ... recovery of an analyte in biological matrix (matrix effect) is defined as the direct or indirect alteration or interference in response due to the presence of unintended analytes or other interfering...
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Báo cáo hóa học: " Research Article Bandwidth Impacts of Localizing Peer-to-Peer IP Video Traffic in Access and Aggregation Networks" ppt
... (12) Here, the gamma model determines serving area radii according to the averages in Table Given the radius, r, of the serving area, the number of subscribers in the serving area is simply the average ... according to the model of Section A title is assigned to each demanded video stream using the model of Section Each subscriber is assumed to store some number of P2P titles The identity of these stored ... the number of subscribers in each individual VSO serving area is generated, until the sum number of subscribers in all VSOs in this VHO equals or exceeds the total number of subscribers in the VHO,...
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Báo cáo khoa học: "The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer" doc
... modality into clinical practice [5] After our preliminary experience with this technique dealing with staging of colorectal cancer [6], in the current prospective study we aim to specifically determine ... head to avoid beam hardening artefacts as well as errors caused by truncation of the field of view A PET-CT scan of the whole body was performed using an acquisition time of to (depending of the ... classified as TRG1 in 11 cases (22%), TRG2 in (18%), TRG3 in 10 (20%), TRG4 in 12 (24%), and TRG5 in (16%) (Table 1) According to the prognostic value of TRG score, they were classified into two groups:...
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Báo cáo nghiên cứu khoa học " Development of Modeling System to Simulate Hydrodynamic and Environmental Quantities in the Hai Phong Estuary, Vietnam " pot
... vulnerability of sea front to flooding is intensified This study investigates a hindcasting of water level during a storm surge in the Gulf of Tonkin The Do Son beach area is of special interest because ... HUS-VNU modeling system has been used to simulate offshore water circulations in the South China Sea and the Gulf of Tonkin In this study, we applied the system to the near-shore flow in the Hai ... variations at W (indicated in figure 1) due to some wind conditions: tide alone (op), SE wind speed of m/s, SE wind speed of 15 m/s The current velocity of the tide causes the onshore–offshore sediment...
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Báo cáo y học: "An ethnobotanical survey of plants used to manage HIV/AIDS opportunistic infections in Katima Mulilo, Caprivi region, Namibia" ppt
... C tomentosa Drinking, Steaming Drinking Drinking Swollen pancreas Drinking Ntulwantulwa Roots - Skin rashes, Tuberculosis, Rubbing Drinking Roots Cryptococcal meningitis, Oral candidiasis, Drinking ... Rubbing Cryptococcal meningitis, Herpes zoster, Herpes simplex, Skin rashes Tuberculosis Chronic diarrhoea, Drinking Malaria, diarrhoea Steaming, Drinking Drinking Drinking Rubbing Rubbing Drinking ... Stomachache, Malaria Drinking Drinking Dwarf custard apple Malolo Root Herpes zoster, Cryptococcal meningitis, Rubbing Drinking Skin infections Rubbing Herpes simplex, diarrhoea Rubbing Drinking CM65 Annona...
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báo cáo khoa học: " The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis" potx
... regulator of SULTR1;3 It is interesting to note that while SQD1 and SQD2, two genes involved in the replacement of phospholipids by sulfolipids, have been identified as containing a PHR1binding ... regulator of Pi starvation responses and is involved in the up-regulation of the IPS1 gene in Pi-deficient plants [25] In the promoter of IPS1, PHR1 binds the P1BS cis-acting element, defined ... Sugimoto K, Sato N, Tsuzuki M: Utilization of a chloroplast membrane sulfolipid as a major internal sulfur source for protein synthesis in the early phase of sulfur starvation in Chlamydomonas reinhardtii...
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báo cáo khoa học: " Years of life lost to prison: racial and gender gradients in the United States of America" pps
... time spent in prison becomes a matter of public health importance The goal of the present study was to determine the differences in the number of years of life lost to imprisonment in the United ... high rate of imprisonment in the United States may translate to a significant proportion of time being spent in prison, especially for certain sub-groups of the population If imprisonment influences ... coordinating services as inmates move back into the community [12] The most direct way to reduce these consequences would be to reduce the number of people who go to prison One way to accomplish...
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Báo cáo y học: " Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study" pdf
... each of total cholesterol (TC), systolic (SBP) and diastolic (DBP) blood pressure in terms of ability to quantify risk of atherosclerotic CAD in patients with SLE Methods: Patients in the Toronto ... sixmonthly intervals wherein clinical and laboratory data, including TC, systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels are obtained and recorded according to a set protocol ... Erythematosus International Collaborating Clinics / American College of Rheumatology Damage Index; TC: total cholesterol Competing interests The authors declare that they have no competing interests...
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Báo cáo khoa học: " Randomized controlled trials are needed to determine appropriate blood transfusion strategies in patients with acute coronary syndromes" pdf
... Trial Investigators Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy N Engl J Med 1998, 339:436-443 Global Organization Network (PARAGON)-B Investigators: ... applied to a general population of ICU patients [2] The restrictive strategy sought to maintain circulating hemoglobin concentrations ≥7.0 g/dL whereas the liberal strategy sought to maintain hemoglobin ... Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb investigators N Engl J Med 1996, 335:775-782 Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients...
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Báo cáo y học: "Comparison of cooling methods to induce and maintain normoand hypothermia in intensive care unit patients: a prospective intervention study" ppsx
... first study comparing the efficiency and safety of five different cooling methods in inducing and maintaining hypo- and normothermia in ICU patients Cooling using watercirculating blankets, gel-coated ... water circulating pads and intravascular cooling was equally efficient in inducing hypoand normothermia Intravascular cooling was superior to all other cooling methods for maintaining a stable ... Hoedemaekers et al this study is to compare five different cooling techniques during induction and maintaining of mild hypo- and normothermia in terms of efficiency and cooling performance Materials...
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Báo cáo y học: "A novel combination of Chinese medicines to treat advanced cancers and lymphomas in rats" ppt
... depletion of GSH enhances utilization of protein thereby increasing the urea level that is accompanied by an increased creatinine level suggested by Mostafa [33] Table 1: Effects of KT and TCE administration ... were inserted into the EPR of quartz tubes and measured at suitable instrument parameters The peak height of the radiation-induced EPR signals was determined for each sample The reading intensities ... UDP-glucuronic acid is formed in the liver of all animals and conjugates toxins for subsequent elimination [3] Andlaur et al reported that potential phytochemical toxins were detoxified in mammalian tissue...
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Báo cáo y học: " Mathematical model of blunt injury to the vascular wall via formation of rouleaux and changes in local hemodynamic and rheological factors. Implications for the mechanism of traumatic myocardial infarction" pot
... that an increase in shear stress results in a decrease of the number of rouleaux I can now determine the concentration of rouleaux, assuming that viscosity is determined by the numbers of erythrocytes ... increase of shear stress causes a decrease of viscosity Thus, an increase in the concentration of erythrocytes will result in an increase of viscosity and a decrease in shear stress It Page of ... shade" of the original attached rouleaux The escalating formation of rouleaux continues within the entire "hemodymanic shade" zone The model of traumatic damage to the vessel that takes into account...
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Báo cáo sinh học: "Effects of data structure on the estimation of covariance functions to describe genotype by environment interactions in a reaction norm model" potx
... exists in both within country and international breeding value estimation The objective of this paper was to investigate the in uence of definition of EP and levels of preferential sire use in herds ... appear in the estimation of variance components for such multi trait models Therefore, the application of CF is of interest to take G × E into account for example in international breeding value ... average of the analysed trait showed that genetic variances increase with increasing herd level of the trait [1, 8] In order to simulate mainly increasing genetic variance across environments, 99% of...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25