use of bcl 2 and fas to predict responses to immunotherapy
báo cáo khoa học: " Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome " pptx
... binding to Bcl- 2, which prevents Bcl- 2 from Figure The effect of oxymatrine on the mRNA expression of Bcl- 2 and IAP family The effect of oxymatrine on the mRNA expression of Bcl- 2 family and IAP ... Med Oncol 20 10 Burlacu A: Regulation of apoptosis by bcl- 2 family proteins Journal of cellular and molecular medicine 20 03, 7 :24 9 -25 7 Cory S, Adams JM: The bcl2 family: Regulators of the cellular ... competing interests 23 22 Received: February 20 11 Accepted: 29 June 20 11 Published: 29 June 20 11 24 References Hidalgo M: Pancreatic cancer The New England journal of medicine 20 10, 3 62: 1605-1617 Thompson...
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Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx
... 46.39 28 .17 Kasumi-1 Kasumi-1 Si-contril Si -Bcl- 2 Bcl- 2 GAPDH Apoptosis(%) A Page 11 of 15 C Si-control + – Si -Bcl- 2 – + Daunorubicin(0 .2 g/ml) 0.09 1.11 0.11 0.61 6.76 10.58 4. 12 22. 63 97.55 1 .25 ... 38 .27 KG1a Red 76.13 Kasumi-1 27 .68 50.05 84.76 20 .25 7 .25 0.36 15 .22 79.73 92. 74 99.63 7.08 U937 2. 58 Red/green ratio (% of control) Green Curcumin( M) Figure Curcumin decreased Bcl- 2 mRNA and ... 5C) Suppression of Bcl- 2 with siRNA induced apoptosis and increased the susceptibility of KG1a and Kasumi-1 cells to DNR-induced apoptosis To clarify if down-regulation of Bcl- 2 by curcumin plays...
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Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt
... GFP-LC3 Punctae B * 50 25 Vector Bcl- 2- wt Bcl- 2- ER Fig Bcl- 2 control of autophagic activity HL-1 cells were transfected with mCherry-LC3 and empty vector, GFP Bcl- 2- wt, or GFP– Bcl- 2- ER Experiments ... autophagy to apoptosis Nat Cell Biol 8, 1 124 –11 32 62 Duchen MR (20 00) Mitochondria and calcium: from cell signalling to cell death J Physiol 529 , 57–68 Bcl- 2 and calcium control of autophagy 63 Rizzuto ... Bcl- 2- ER versus vector (cumulative) Furthermore, in cells expressing Bcl- 2- ER, TG reduced autophagic activity to an even greater extent 40 * 30 20 10 -10 -20 Vector Bcl- 2- wt Bcl- 2- ER ** Fig Bcl- 2...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... 1075.5 522 1103.5114 1119.50 52 1131.5986 1135.5033 1136. 723 2 1137.70 82 129 9.664 1414.696 1 427 .758 1544. 822 2 1649. 827 2 1741.9448 1915.0585 1990.9105 20 06.9006 20 22. 8986 20 43.1486 22 97.06 02 2453.1048 ... and cli- FEBS Journal 27 7 (20 10) 51 12 5 123 ª 20 10 The Authors Journal compilation ª 20 10 FEBS 865.4783 1 125 .6 722 1407.646 1 427 .7954 1478.86 82 15 02. 75 92 1616.7878 18 42. 98 32 1973.9536 10 02. 54 42 ... Peptide identification in Ssa1p K245 K 521 K157 K243 or K245 K247,K248 (T1) K243 K247, K248 (T1) K504 K 322 or K 325 K157 K 420 K509 K243, K247 (T1) K384 K243, K247 (T1) K3 42, K345 (T1) Site N66GSQNNDNENNIKNTLEQHR85...
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HYGIENIC PHYSIOLOGY WITH SPECIAL REFERENCE TO THE USE OF ALCOHOLIC DRINKS AND NARCOTICS BEING A REVISED EDITION OF THE FOURTEEN WEEKS IN HUMAN PHYSIOLOGY ppt
... first bone of the thumb, standing apart from the rest, enjoys a special freedom of motion, and adds greatly to the usefulness of the hand FIG 12 [Illustration: _Bones of the Hand and the Wrist._] ... Table of 20 6 bones is exclusive of the sesamoid bones which occur in pairs at the roots of the thumb and great toe, making 21 4 as given by Leidy and Draper Gray omits the bones of the ear, and ... science of the functions of the body, has come to include Anatomy, or the science of its structure, and Hygiene, or the laws of health; the one being essential to the proper understanding of physiology,...
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Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
... Functional study of crustacean neuropeptide 19 20 21 22 23 24 25 26 27 28 hormone from the American lobster Homarus americanus Peptides 27 , 125 1– 125 8 Tiu SH, Hui JH, He JG, Tobe SS & Chan S-M (20 06) Characterization ... Journal 27 4 (20 07) 4385–4395 ª 20 07 The Authors Journal compilation ª 20 07 FEBS S H.-K Tiu and S.-M Chan 10 11 12 13 14 15 16 17 18 and biological assay of recombinant proteins FEBS Lett 4 72, 122 – 128 ... level 100 80 60 40 20 24 48 72 Time (h) after injection 30 20 10 24 48 72 Time (h) after injection Fig Expression of vitellogenin in hepatopancreas and ovary of dsRNA-injected (+) and control (–)...
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Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
... Rat Mouse Human 2. 8 (2. 6–3.0) 45.9 (37.8– 52. 9) 0.06 19.1 (17.9 20 .0) 49.5 (43.1–53.3) 0.39 0.45 24 .7 (22 .5 26 .3) 46.9 (38.4– 52. 5) 0.53 13.8 ( 12. 8–15 .2) 26 .1 (19.9–33.6) 0.53 ND ND ND – 14 .2 (13.6–15.8) ... (13.6–15.8) 24 .6 (17.9–30.8) 0.57 14.0 ( 12. 9–14.8) 35.7 (26 .4–40.8) 0.39 4 .2 (37.–4.7) 64.6 ( 52. 4–77.1) 0.06 0.45 16.5 (15.1–17.7) 34.8 (27 .2 40.9) 0.47 FEBS Journal 27 3 (20 06) 17 72 1781 ª 20 06 The ... 12. 1 (8.5–14 .2) 0.34 0.64 12. 4 (11.3–14.3) 21 .0 (13.1 24 .2) 0.59 17.8 (16.6 20 .3) 26 .1 (18.9–31.3) 0.68 15.7 (15.1–16.0) 9 .2 (8.3–10.3) 1.71 2. 39 38.8 (37.3–40.0) 13.9 ( 12. 5–14.9) 2. 79 selectivity...
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Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
... regulator of apoptosis is the Bcl- 2 family of proteins, which consists of proapoptotic and antiapoptotic proteins Bim, one of the proapoptotic members, is transcriptionally regulated by Foxo3a ,27 and ... and 2. 4G2 rat Ab Since aggregation using 2. 4G2 rat Ab together with TNP7-MAR F(ab´ )2 does not cause degranulation, this indicates that expression of Fc␥RIII (an activating low-affinity receptor ... expression .22 Antibodies and Reagents AffiniPure rabbit anti-mouse IgG (RAM IgG), AffiniPure RAM IgG F(ab´ )2 fragment (RAM F(ab´ )2) , and AffiniPure mouse anti-rat IgG (H+L) F(ab´ )2 fragment (MAR F(ab´ )2) ...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
... μmol/L, 20 μmol/L, 25 μmol/L and 30 μmol/L) for 24 hours The early and late apoptosis/necrosis rates were 11.49 ± 0.63%, 2. 28 ± 1.46%, 3.97 ± 1 .28 %, 16.94 ± 3. 42% , 21 .50 ± 4.51%, 19.16 ± 4 .21 %, 21 .53 ... as pro- and anti-apoptotic proteins [14-17] Downregulation of Bcl- 2, an "anti-apoptotic" protein, has also been considered as one of its significant mechanism of action [ 12, 18 -20 ] Bcl- 2 is considered ... NF-κB activities [14-17 ,28 ] Interestingly, the apoptotic effect of arsenic trioxide largely depends on a Bcl- 2- controlled pathway [ 12, 18 -20 ] Bcl- 2, an anti-apoptotic Bcl- 2 family member, for which...
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báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx
... Stefano F, Anderson L, Vaughan GH, Mason D, Selby P, Linch DC: Prognostic significance of BCL- 2 expression and http://www.jhoonline.org/content /2/ 1/8 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 ... Oncology 20 09, 2: 8 A) Con.(nM) 24 hr 25 0 500 750 http://www.jhoonline.org/content /2/ 1/8 48 hr 25 0 500 B) 24 hr Con.(nM) 25 0 500 750 48 hr 72 hr 25 0 500 750 25 0 500 750 Bcl- 2 Bcl- 2 Bcl- XL Bcl- XL ... C) Con.(nM) 0 750 β -actin 25 0 24 hr 500 750 25 0 48 hr 500 750 25 0 72 hr 500 D) 750 24 hr Con.(nM) 25 0 500 750 Bcl- 2 72 hr 25 0 500 750 25 0 500 750 Bcl- 2 Bcl- XL 48 hr Bcl- XL Mcl-1 Bax Bim β -actin...
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Báo cáo y học: "Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report" ppt
... dermatosis of the hands: presentation of eight cases and review of the literature J Dermatol 20 07, 34 :24 3 -24 7 Edlich RF, Cross CL, Dahlstrom JJ, Long WB: Modern concepts of the diagnosis and treatment ... Dermatol 1998, 27 (5) :29 1 -29 6 Ekenstam EA, Callen JP: Cutaneous leukocytoclastic vasculitis: clinical and laboratory features of 82 patients seen in private practice Arch Dermatol 1984, 120 :484-489 ... life-threatening septicemia and worsening rhabdomyolysis with peak myoglobin 22 94 ng/mL (normal: 25 to 58 ng/mL), CPK 9975 U/L (normal: 26 to1 92 U/L), BUN 16 mg/mL (normal: to 20 mg/mL), creatinine...
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Báo cáo y học: "The use of a blood conservation device to reduce red blood cell transfusion requirements: a before and after study" doc
... 0. 02* Hb on admission (g/dL) 12. 4 ± 2. 5 11.58 ± 2. 8 0. 02 Hb on discharge (g/dL) 10 .2 ± 1.8 10.1 ± 0.6 Loss of Hb (g/dL) 2. 13 ± 2. 32 1.44 ± 2. 08 0. 02 Patients with transfusion, n (%) 17 (21 .3) 52 ... 1Department Received: 28 September 20 09 Revisions Requested: November 20 09 Revised: 18 November 20 09 Accepted: 27 January 20 10 Published: 27 January 20 10 12 13 14 15 16 17 18 19 20 21 22 Tinmouth AT, ... 2. 13 g/dL, P = 0. 02, Table 2) Seventeen (21 .3%) patients in the control group received 62 units of PRBC over 42 episodes of transfusion and 52 (30.6%) patients in the active group received 129 ...
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AN INVESTIGATION INTO THE USE OF PAIR WORK AND GROUP WORK ACTIVITIES TO DEVELOP SPEAKING SKILLS OF THE FIRST YEAR ENGLISH MAJOR STUDENTS AT THE FACULTY OF FOREIGN LANGUAGES, THAI NGUYEN UNIVERSITY = Nghiên cứu thực trạng sử dụng các hoạt động theo cặp và
... pairs/ groups 24 2. 2.1.4 Students’ desires to learn English speaking skills 25 2. 2 .2. Teachers’ survey 27 2. 2 .2. 1 Teachers’ opinions on teaching English speaking skills 27 2. 2 .2. 2 Teachers’ opinions ... setting of the study 17 2. 1 .2 Data collection instrument 18 2. 1.3 The Participants 19 v 2. 1.3.1 The students 19 2. 1.3 .2 The teachers 19 2. 2 Presentation and discussion of the results 19 2. 2.1 Students’ ... work (Question 12, 13, 14) (by percentage) A Options Questions s 12 A Students of the same age B C D E F G H 34 28 32 27 20 32 69 10 21 24 0 B Students of the same sex C Students of different sexes...
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Developing critical capacities for the efficient use of public investments in infrastructure to support trade and economic development in vietnam
... DEVELOPMENT 11 2. 1 Introduction 11 2. 2 Goals of economic development 11 2. 2.1 Growth of gross national product 11 2. 2 .2 Quality of life 12 2. 2.3 Sustainable ... 21 2. 3 .2. 4 Neoclassical counter-revolution models 23 2. 3.3 Contemporary theories of economic development 24 2. 3.3.1 New growth theory 24 2. 3.3 .2 Theory of coordination ... analysis of problems’ occurrence 20 3 8.3.3.1 Assumptions in factor analysis 20 3 8.3.3 .2 Choosing factor models and number of factors 20 8 8.3.3.3 Factor interpretation 21 5 ...
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Role of bcl 2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells
... and death homeostasis is the key to the onset and maintenance of the transformed phenotype 1 .2 Bcl- 2 and Bcl- 2 family proteins: Since the discovery of Bcl- 2, many other Bcl- 2- like proteins ... intracellular production of H2O2, leading to MOMP and release of apoptogenic factors such as cytochrome c and AIF (Reed and Kroemer 20 00) Nonetheless, of interest to this thesis is to pinpoint the mechanisms ... activity of mitochondrial Ras (Downward 1998; Denis, Yu et al 20 03) With regard to Bcl- 2 interaction with Nur77, a highly novel function of Bcl- 2 was reported Interaction of Bcl- 2 with Nur77 led to...
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Managing projects in organizations how to make the best use of time techniques and people
... topic in the late 1990s and continues to be important today: how to establish and maintain a project of ce Chapter Eight then brings together the different pieces into a cohesive whole Good tools ... management of projects, poor planning and control, and then ties together the many components of project management Chapter Six describes the standard tools used for enhancing planning and control—for ... and control; on the other hand, the project may fail owing to a lack of plans and tracking mechanisms Chapters Six and Seven address frequently encountered planning and control problems and offer...
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Overview of the PSTN and Comparisons to voice over IP
... based on H. 323 v1 H. 323 v2, however, enables H .24 5 negotiation to be tunneled in the H .22 5 setup message This is known as fast-start , and it cuts down on the number of roundtrips required to set ... flow of the call: I pick up the phone and send an off-hook indication to the end office switch The switch sends back a dial tone I dial the digits to call Grandma's house (they are sent in-band ... OC- 12, and OC-48 rates, which are 155. 52 Mbps, 622 .08 Mbps, and 2. 488 Gbps, respectively Network -to- network signaling types include in-band signaling methods such as Multi-Frequency (MF) and...
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