... this could have introduced the potential for bias inthe results andis a limitation of the study Medical errors are among the leading causes of death inthe United States In its highly publicised ... change in vital signs There were four errors, however, that caused either patient harm or increased monitoring and 34 intercepted errors that could have potentially caused harm had they been administered ... concern with this CPOE system This is not an isolated finding [13] and should be noted by clinical directors as they review the need for CPOE on their units As clinicians embrace CPOE, they should...
... analysis of ARF intheICU One possible explanation for this is that a relatively low creatinine threshold was usedinthe definition of ARF; in comparison with studies using a creatinine of ... conditions (Table 2) Reason for intensivecareunit admission The reasons for ICU admission were similar inthe three groups, with postoperative patients and those with infection dominating, ... mortality rates in patients with ischaemic and mixed ARF to be three times the rate in patients with nephrotoxic ARF Itis conceivable that ischaemia is a determining factor in mortality rates in...
... it was less than the initial creatinine on entry to theICUand not obviously AKI (n = 45) If a preadmission creatinine was not available, then the lowest value of either the initial creatinine ... of the time course and reliability role of uCysC inthe critically ill Key Messages • Inthe ICU, urinary cystatin C is diagnostic of acute kidney injury • Inthe ICU, urinary cystatin C is independently ... years, and creatinine was stable (within 15% of the lowest ICU creatinine) (n = 7); (c) pre -ICU value >365 days, if it was less than initial creatinine on entry to ICU (n = 58); and (iv) pre-ICU...
... pathophysiological and therapeutic targets in critical disease At present, itis unclear whether serum suPAR is truly causatively involved in mechanisms of critical disease resulting in high mortality or whether ... with SIRS and suspicion of having communityacquired infections in a non -intensive care setting suPAR was found to have a low accuracy in diagnosing bacterial infection in SIRS patients [17] The ... the first week after ICU admission We next investigated whether suPAR levels changed in individual patients during the first week of ICU treatment Within the first week, the following surviving...
... wasting of vitamin D and its metabolites, providing another mechanism to explain why vitamin D insufficiency is common in patients with sepsis The classic function of vitamin D is to maintain ... subjects with Plasma criticallyD binding protein insepsis andillhealthy subPlasma vitamin D binding protein in critically ill subjects with sepsis, critically ill subjects without sepsis and healthy ... decreased in critically ill subjects with sepsis which further exacerbates vitamin D insufficiency Whether this effect is due to decreased vitamin D binding protein synthesis, increased clearance and/ or...
... Principle and Practice of IntensiveCare Monitoring Edited by Tobin MJ New York: McGraw-Hill, Inc; 1998:33–44 Lawless ST: Crying wolf: false alarms in a pediatric intensivecareunit Crit Care Med ... prognosis for existing monitors intheintensivecareunit Crit Care Med 1997, 25:614–619 Chambrin MC, Ravaux P, Calvelo D, Jaborska A, Chopin C, Boniface B: Multicentric study of monitoring alarms ... description of the signal composition is given in terms of its characteristics in time and frequency according to the level of priority, resulting in a sequence of notes in a distinctive rhythm...
... wide as with succinylcholine [18] Many studies have shown that rocuronium is a highly acceptable replacement for succinylcholine inthe ICU; therefore, in my opinion, succinylcholine is obsolete ... with sepsis, malignancy, burn trauma and liver disease [12] In such patients there is a wide variability inthe neuromuscular blocking effect, onset and duration of paralysis caused by succinylcholine ... Finally, the histamine-releasing properties of muscle relaxants are well known, and succinylcholine has the strongest histaminereleasing effect of all such agents Candidates to replace succinylcholine...
... learned, to discuss the dilemmas we continue to face and to discover together how to resolve them Inthe upcoming Critical Care theme issue on research ethics, we shall examine some of the common ... arise inthe publication stage How journals increase their readership impact score? What obligations they have to the broader ICU community to ensure the quality of research or the quality of the ... some of the common challenging ethical and legal issues that plague us within theICU community, provide guidance in avoiding common pitfalls, and discuss an approach to think through as yet unresolved...
... of such devices and their ability to optimize life-saving intensive insulin therapy intheICU Until this becomes a reality, insulin titration algorithms should include frequent measurement of ... morbidity as well as mortality [8] 152 In order to achieve normoglycaemia during intensive care, most ICUs require a titration algorithm, particularly during the start-up phase when itis introduced ... adipose tissue still require validation intheICU setting Availability and validation of such devices will render intensive insulin therapy easier and safer Closed loop systems, with computer-assisted...
... Surgeons, intensivists andthe covenant of care — administrative models and values affecting care at the end of life — updated Crit Care Med 2003, 31:1551-1559 66 Levy MM End-of-life careintheintensive ... responsibility for it, studying itand writing about it, and being accountable for all aspects of the process — including the determination of brain death, identification of the possibility of organ ... legitimacy of the family decision The discussion might therefore begin (after evident understanding of the fact and meaning of brain death from the family) with a statement such as “There is one other...
... other diagnostic tests, the use of intermittent 12-lead ECG in combination with monitoring troponin levels isthe practical approach that most physicians use to diagnose MI intheICUInthe ICU, ... obtained at the direction of theICU team as clinically indicated ECGs were performed by a technologist during the day, and by theICU bedside nurse in emergencies and during the evenings and ... MI and both ICUand hospital mortality Because troponin is a key component of the diagnosis of MI but may be increased in conditions other than MI, we examined the independent additional risk...
... RC, Cerra F, Kaye W: Descriptive analysis of critical care units inthe United States: patient characteristics andintensivecareunit utilization Crit Care Med 1993, 21:279-291 26 Hebert PC, ... incubation for exactly minutes at ambient room temperature Tests were recorded as positive if there was a blue line inthe control window and a pink line inthe test window, and negative if there ... unexplained decline inthe hemoglobin level, showing gastric or duodenal ulcer in 45%, oesophageal ulcer in 24% and diffuse gastritis in 12% of the cases H pylori antigen was positive in 2.5% of the patients...
... definitions for AKI exist and are being increasingly usedinthe literature [7,8] The advent of RIFLE (Risk-InjuryFailure-Loss of renal function-Endstage renal disease) and AKIN (Acute Kidney Injury ... is crucial Aside from how to intervene, the other important question is when to intervene Over the time course of AKI, just like with sepsis, we can distinguish between a biological and a clinical ... criteria provides us a framework for identifying and staging AKI This will not only aid us in recruiting patients, but also serve as clinical endpoints for evaluating interventions in AKI In the...
... crisis but should be part of an ongoing discussion intrinsic to the doctor–patient relationship Establishing why rather than whether the patient accepts or rejects treatments gives insight into ... hospitalized patients: effectiveness with the patient self-determination act andthe SUPPORT intervention SUPPORT Investigators Study to Understand Prognoses and Preferences for Outcomes and Risks ... Critical Care Ethics: Treatment Decisions in American Hospitals Kansas City: Sheed & Ward 1991 Bishop M: Quality of life and psychosocial adaptation to chronic illness and acquired disability:...
... potential, to accept the individual diversity of their coworkers and try to utilise it positively in relation to the team, in disputes and discussions, in planning and organisation, in performance ... for the existence of the unit, a compromise is impossible: itis either one or the other The danger here is that someone ‘loses’ if an opposite direction is chosen If this happens, there is a good ... stopping treatment or continuation of treatment does not allow a compromise: itis either one or the other Also here, listening isthe key to finding a solution Taking time to understand the position...
... of lung injury Frequency histograms are shown for the timing of intensivecareunit (ICU) admission relative to development of clinical risk condition (a), and diagnosis of acute lung injury (ALI)/acute ... ways First, our finding that most patients entering theICU so on the day of developing their clinical insult is new, andit underscores the potential need for rapid intervention in these patients ... data, including hospital mortality and length of hospital stay, and if applicable, mortality in ICU, the length of stay inthe ICU, andthe duration of mechanical ventilation Available online...
... individuals and usually is associated with conjunctivitis and other extrapulmonary manifestations, such as gastrointestinal disease, hepatitis, meningitis, and hemorrhagic cystitis [68] The extrapulmonary ... between them The initial incubation period after exposure to the virus is to days, with clinical disease beginning with the onset of fever, chills, malaise, severe headache, nausea, vomiting, diarrhea, ... diarrhea, and abdominal pain [92-94,96] With this initial infection, macrophages and dendritic cells initially are the site of viral replication, followed by spread to the reticuloendothelial system...
... Commensal organisms additionally interact with TLR-9, thereby producing an anti-inflammatory cytokine milieu rich in interleukin-10 [14] In aggregate, these cellular mechanisms provide intestinal host ... Pseudomonas aeruginosa infections: a randomized, double-blind, placebo-controlled pilot study inintensivecareunit patients Crit Care 2008, 12: R69 Joint FAO/WHO Working Group: Guidelines for the evaluation ... unknown whether there are optimal probiotic species, doses, and/ or formulations Another area of particular clinical interest is whether combination therapy is superior to single-agent therapy The recent...