tse infectivity in vivo assays as direct measurements of infectivity
Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increase in glycolytic flux exceeded the decreased gluconeogenic ... increased rate of 13C label incorporation into the C6 position of glycogen in the ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead to increased 13C labeling at the triose ... thus was assigned to reflect primarily increases in total hepatic glycogen This analysis was based on the integration of all the C2–C5 glycogen signals To determine the potential labeling of the...
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Báo cáo y học: " In vitro bioassay as a predictor of in vivo response" pdf
... analogues in their affinity for binding proteins In view of this, an important practical consequence of our simulations results are that the testing of newly designed hormones in in vivo systems ... LM, Mercado M, Baumann G: Influence of high affinity growth hormone binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH J Clin Invest 1993, 91:629-641 Baumann ... M, Franks S: Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome Clin Endocrinol (Oxf) 1995, 43:159-165 Publish...
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Characterization of Spin Coated Polymers in Nano-environments as a Function of Film Thickness pot
... morphological behavior of polymer brush films Industrial use of thin films has increased for several reasons including the development of ever-smaller electronic devices As applications of polymers become ... would dominate the behavior of the polymer Wallace used similar reasoning stating that the interactions with the surface could act as a crosslink in the polymer by restraining certain chains.11 ... material by finding the inflection point in the Tg step 3.1.3.2 Gel Permeation Chromato graphy A 3.160 mg/mL solution of PMMA in chloroform was prepared One sample of 100 µL was injected into a Waters...
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Báo cáo khoa học: "Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum" pot
... some of B Change of body weight in F9-bearing mice During administration of cytoplasmic fraction of LABs for wks, F9 was inoculated into mice at wks Though the body weight of mice before tumor inoculation ... direct intraperitoneal injection of L casei 9018 against the sarcoma-180 [19,27] For the antitumor activity of LABs in vivo, the increased specific tumor immunity in probiotic treated mice was from ... percentage of increase compared to control which was not given LABs was shown Fig Change of NK cells after administration of LABs The mice were orally administered cytoplasmic fraction of B longum...
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Báo cáo khoa học: "In vivo morphological and antigenic characteristics of Photobacterium damselae subsp. piscicida" doc
... skin was disinfected with 70% (v/v) ethanol and a cm long incision, into which the dialysis bag was inserted, taking care not to injure internal organs The incision was sutured using polyglactin ... dialysed against three changes of PBS using dialysis tubing of the same pore size as that of the implants The concentration of the ECP preparations was determined using a protein determination kit ... Comparison of bacterial growth in vivo within the dialysis bags to that of bacteria maintained in vitro revealed that scant bacterial growth occurred in dialysis tubing maintained in vitro, while...
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Báo cáo khoa học: "Variation of vessel lumen diameter in radial direction as an indication of the juvenile wood growth in oak" pptx
... dominant tree) For latewood vessels, with increasing age of growth rings, an increase in the lumen diameter and in the number of vessels per unit area was observed (table III) However, an increase ... remained more or less constant with any further increase of the cambial age of growth rings Increase in the earlywood vessel lumen diameter in the outerwood was significant compared with that in ... from each of these rings for measurements The lumen diameter of earlywood and latewood vessels was measured on samples to include all the growth rings under study Measurements were made using the...
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báo cáo khoa học: " Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes" ppsx
... assessment (HOMA)) Plasma was obtained by drawing blood samples into glass tubes containing EDTA and serum was obtained by drawing blood into glass tubes containing a clot-inducing plug The tubes ... following antagomir treatment (Figure S4C in Additional file 1), confirming the suitability of antibodies against them for in vivo profiling In contrast, analysis of CDC42 and PTBP1 proteins in ... Reitman ML, Weinstein LS: Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance Endocrinology 2004, 145:4094-4102 71 Sha H, Xu J, Tang J, Ding J,...
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Báo cáo y học: "Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells" pdf
... http://respiratory-research.com/content/6/1/10 Figure increases the expression of TNFRI, TNFα and caspase in vivo Hyperoxia Hyperoxia increases the expression of TNFRI, TNFα and caspase in vivo Lung sections of normoxic (control) ... shown in Table 3, in TIIcells the activity of caspase and increased in response to hyperoxia, whereas the activity of caspase did not change Pre-incubation with granzyme activated pro-caspases ... and caspases increased (Table 6) The increment of caspase-8 mRNA was not significant, but even a ∆∆ct of -1.15 indicates a 2.2-fold increase of mRNA content Hyperoxia of rats does not induce apoptosis...
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IN VIVO MECHANICAL AND PHYSIOLOGICAL CHARACTERISATION OF LOWER LIMB SOFT TISSUE BY a LOCAL INDENTATION TECHNIQUE
... composition of sweat [133] It was found that there was a significant increase in sweat lactate during loading and a decrease in sweat volume during ischemia 2.4.9 Skin Abrasion The human skin is subjected ... for measuring the Poisson’s ratio of soft tissues in vivo are lacking and require further investigation 2.4.5 Viscoelasticity Viscoelasticity of soft tissues can be observed in load-indentation ... is not of obtaining the mechanical properties of prosthetic components or bone, but the in vivo mechanical properties of the soft tissues Soft tissues are non-homogeneous, comprising of skin, fat,...
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Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... stability of PANs was studied in the aqueous medium, and the acute toxicity of PANs was evaluated in mice Morever, EPI was loaded into PANs and its pharmacokinetics was also assessed in rats to ... of 200 mg/kg In vivo pharmacokinetics The plasma levels of EPI were determined following a single i.v injection of EPI or PA/EPI (10 mg/kg EPI equiv.) in female Wistar rats The plasma levels over ... University of Technology Sydney on 03/01/11 For personal use only In vivo toxicity To evaluate whether i.v administration (at dose of 200 mg/kg) of PANs was associated with any toxicity in vivo, animals...
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báo cáo hóa học: " CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity" potx
... within the manually defined regions of interest (ROIs) of VLWM (Figure 2B) Axon and myelin injury in VLWM, most severe in the control groups, was apparent in EAE mice as evidenced by the intensity ... relevance of CXCR7 as a disease modifying molecule not only during the effector phase of EAE, by preventing intraparenchymal leukocyte migration, but also during the recovery phase, by preserving axonal ... were maintained in pathogen free conditions (Department of Comparative Medicine, Washington University, St Louis, MO) and studies were performed in compliance with the guidelines of the Washington...
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Screening of Bacillus strains as potential probiotics and subsequent confirmation of the in vivo effectiveness of Bacillus subtilis MA139 in pigs doc
... type of exogenous spore-forming bacteria, are not normally found in the gastrointestinal tract but have also been shown to be effective in keeping a favorable balance of microflora in the gastrointestinal ... antimicrobial activity screening assay was repeated in triplicate for these six strains 141 at 37°C Simulated small intestinal fluid without inoculation was used as a control Determination of total spore counts ... count of the washed bacterial spore suspension was determined prior to the gastrointestinal tract tolerance test Simulated gastric fluid tolerance test A pH of was selected as the critical point...
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Báo cáo y học: "Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity" docx
... rating of "minimal," scores of to receive a vaginal irritation rating of "mild," scores of to 11 receive a vaginal irritation rating of "borderline," and scores of 12 to 16, receive a vaginal ... particles in vitro [25], caused lesions in the vaginal epithelium in vivo and increased the probability of being infected with HIV-1 [26] To assess whether biological activity of C14 causes inflammation ... lyophilization of the resulting product to obtain the pure final derivative in the form of a powder soluble in water Synthesis of zinc tetra-ascorbocamphorate derivative is around 10 cents of euro per...
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Báo cáo y học: "Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis" potx
... inflammation during an acute response that may offer insight into early proinflammatory cytokine release in the initial phases of the inflammatory response This is often lost by using models such as CIA ... critical in acute inflammation of murine joints in as early as 24 hours after zymosan injection (n = number of joints analyzed) in EL4/6.1 thymoma cells [31,64] From our previous findings, we ... Murine LN showing recruited cells (red fluorescent staining, see arrow) (g) Merger of (e) and (f ) showing a lack of nonspecific cellular staining (h) DAPI staining showing cell nuclei (original...
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Báo cáo y học: "Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo" ppt
... viral infectivity of rabbits at 1–2 days post inoculation will be required to definitively rule out an early block in infection in vivo Interestingly, the gross phenotype of HTLV-2Δp28 in vivo ... function of p28 Such studies will entail identifying the functional domains of the protein involved in localization, protein interactions, and RNA binding as well as precisely identifying the ... Figure Assessment of HTLV-2 infection in rabbits Assessment of HTLV-2 infection in rabbits Antibody response against HTLV-2 from each rabbit was measured by antiHTLV commercial ELISA assay, using...
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Báo cáo sinh học: "Selection on testis size as an indicator of maturity in growing animals. I Direct and correlated responses in growth" pdf
... within the gth type of selection; Lg (i i 1, , 5) is the effect of the line nested within type of selection; RL is the replicate x line within type interaction, 9hi which was interpreted as the ... of the order of sd of increasing body weight and decreasing testis weight Estimates of realized heritability from within family selection (h!) obtained from regression of divergence of response ... more direct method of selecting directly on weight at different ages which has been applied with varying success in different species Substantial bending of the growth curve has been achieved in...
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Linear and branched chitosan oligomers as delivery systems for pDNA and siRNA in vitro and in vivo
... efficiency in the selected cell lines was mediated by targeting cell-surface lectins with the A-A-M branch, the transfection of various cell lines was repeated in the presence of increasing amounts of ... polyplexes in vivo The ease of dissociation in the presence of heparin suggested that the polyplexes can mediate an early onset of gene expression in vivo Indeed, luciferase gene expression of DPn18 ... toxicity and upregulation of genes involved in inflammatory processes following in vivo lung administration [134,135] The unfavourable in vitro /in vivo safety profile of most available non-viral...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... nucleotide including 45 bases was used to connect the 3’ terminus of GLP-1-A gene and 5’ terminus of gAd gene The product of this nucleotide sequence was a glycine-rich short peptide including 15 amino ... [N-(Serine-glycine)7 - Serine-C], which was used as a linker to connect the N-terminus of gAd and the C-terminus of GLP-1-A Because the protein produced from plasmid vector PET28a was an N-terminal ... measured by BCA Protein Assay Kit PEG20000 was used to concentrate the refolded protein Removal of N-terminal His-tag The refolded protein was incubated with enter- 205 okinase (1U enterokinase...
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Tác dụng kháng viêm in vivo của dẫn chất polyoxychalcon
... synthesis of heterocyclic chalcone, and their anti-inflammatory activity is measured by the model of carrageenin-induced edema in hind paw of the rat Results: 10 Polyoxychalcones were obtained with ... the in vivo anti-inflammatory activity of tested chalcones The polyoxychalcone which possessing a hydroxy group at position C2 of A ring and at least one group methoxy in B may be consider as ... results of in vivo anti-inflammatory activity showed that chalcones with hydroxyl group at position of A ring are stronger than that of mother chalcone Conclusions: The methoxy groups on B ring may...
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USING BRAND AS AN EFFECTIVE WEAPON TO COMPETE IN THE MARKET: A CASE STUDY OF NHAT LINH COMPANY
... in existing in existing Product Class Product Class Stretching Stretching Down Down Brand Brand Extensions Extensions in in different Product different Product Class Class Stretching Stretching ... and stronger business entities LEVERAGING LEVERAGING THE BRAND THE BRAND Line Extensions Line Extensions in existing in existing Product Class Product Class Stretching the Stretching the Brand ... meeting the increasing demands of electric industry and the development of national power infrastructure The Company considers this product as one of its core products in the future, because of...
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