transport of biotin to the liver
Báo cáo khoa học: The specific delivery of proteins to human liver cells by engineered bio-nanocapsules doc
... L(D45)-FLAG–EGFP has the potential to form a particle Topology analysis of the C-terminus of L fusion protein Consisting of 56 amino acids, the primary structure of the C-terminus of the S region is ... of fusion protein at 66.5 kDa The density of the particles obtained from both cell extracts and the conditioned media was equivalent to that of the BNC Whether from the conditioned media or the ... truncation of L protein It was necessary to truncate the C-terminus of the L protein by 45 amino acids for it to be efficiently secreted from the cells A EGFP moiety fused to the C-terminus of the L...
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Báo cáo khoa học: "Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report" pdf
... to be safe in the treatment of metastatic colorectal cancer[14] The goals of this analysis was to: 1) gain a better understanding of the value of drug eluting bead therapy when administered to ... CT scan of the liver within at least one to two months from the treatment Evaluation of the enhancement pattern of the target All subjects have been evaluated for safety Exposure to the study ... age of the 207 patients was 68.8 years (range, 39.4-83.5 years) Of these, 158 were treated for palliation, 35 to reduce symptoms, and 14 as adjuvant therapy The chemotherapy consisted of mitomycin...
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A RUSH OF BLOOD TO THE HEAD
... in the German town of Ulm used fMRIs to study the brains of consumers while showing them images of a series of automobiles, including Mini Coopers and Ferraris And what they found was that as the ... those products under the kitchen sink, to the chocolate you stash in your desk drawer, to the phone beside your bed, to the shaving cream in your bathroom, to the car sitting in the driveway Maybe ... in the second stage of the experiment This time around, Dr Montague decided to let the test subjects know whether they were sampling Pepsi or Coke before they tasted it The result: 75 percent of...
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Báo cáo khoa học: Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation ppt
... 2C) In the former preparation, the [3H]cGMP-binding activity appeared to be proportional to the level of Pab; however, the molecular ratio of [3H]cGMP to Pab in the Pabccd was < 0.01 These observations ... However, the plateau indicates the level of [3H]cGMP-bound Pabc trapped by the filter In this case, the filter trapped 16% of the Pabc existing in the mixture [3H]cGMP binding to PabcÆPc The level of ... on the conformational change of Pabc by cGMP binding (A) The time to detect the increase in the level of [3H]cGMPbound Pabc trapped by the filter The experiment was carried out as a part of the...
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PRACTICAL TAXIDERMY A MANUAL OF INSTRUCTION TO THE AMATEUR IN COLLECTING, PRESERVING, AND SETTING UP NATURAL HISTORY SPECIMENS OF ALL KINDS doc
... liberty, is used to drag the stone and to raise one end to fall on the top of B; the weight of the stone now sets the three parts in opposition to each other An animal touching the bait in the slightest ... denominated the scribe, marks upon the left side of the body, as it lies on the ground, the extent of the incision which is to be made; then another, who is called the dissector, cuts open as much of the ... overlap the other to the extent of six inches It is then turned back and pegged down in the same way as the right-hand net The next operation is to tie the forked line to each top end of the staves,...
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History Of Modern Philosophy From Nicolas of Cusa to the Present Time pot
... Aristotle to the transformed Aristotle of the Church and the distorted Aristotle of the schools Back to the sources, is the cry With the revival of the ancient languages and ancient books, the ... forms the antithesis to the supernatural, on the one hand, and to the historical, on the other This combination of the revealed and the historical will not appear strange, if we remember that the ... the understanding; and under the broad cloak of the Hegelian dialectic method, beside the reflection of the Critique of Reason and of the Science of Knowledge, the fancies of the Philosophy of...
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A Decade Of Aid To The Health Sector In Somalia 2000-2009 docx
... reduction of emergency funding following the resolution of the drought, and to lower OFDA contributions due to the USAID decision to reduce overall funding to Somalia to avoid the diversion of aid to ... ances The US$103 million is therefore a conservative estimate The total envelope of aid to the health sector is expected to be significantly higher if all other contributors to the health sector ... in the findings over the decade and in the conclusions and recommendations sections The use of the same methodology in 2007 and 2010 allows a reliable review of trends of aid to the sector The...
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The Weapons Mix Problem - A Math Model to Quantify the Effects of Internetting of Fires to the Future Force pptx
... B.1 The IOF Allocator as Part of a Suite of Analytical Tools xii Internetting of Fires Is the Dynamic Pooling of Resources Enabled by C4ISR The IOF Allocator as Part of the WMT Suite of ... back into the situation map The process iterates until the allocation of fires provides the decisionmaker with the desired level of attrition to the targets The IOF Allocator works above the tactical ... make changes to the scenario quickly and easily, at the cost of having to run the preprocessor again to create the input to the math solver The ability to make quick changes to the scenario also...
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BOHN''''S SCIENTIFIC LIBRARY. HUMBOLDT''''S PERSONAL NARRATIVE VOLUME 3. PERSONAL NARRATIVE OF TRAVELS TO THE EQUINOCTIAL REGIONS OF AMERICA DURING THE YEARS 1799-1804 pot
... Ignorant of the idiom of the natives, they seemed to see everywhere, at the foot of the Cordilleras, the reflexion of the greatness of the temples of Iraca (Sogamozo), which was then the centre of the ... to solve The Orinoco and the Nile, contrary to the direction of the Ganges, the Indus, the Rio de la Plata, and the Euphrates, flow alike from the south toward the north; but the sources of the ... south-west of the Rio Negro; that is, to Parima (or the isthmus between the Carony, the Essequibo, and the Rio Branco), and to the ancient abode of the Manaos, the inhabitants of the banks of the Yurubesh...
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Báo cáo khoa học: Irreversible cross-linking of heme to the distal tryptophan of stromal ascorbate peroxidase in response to rapid inactivation by H2O2 ppt
... spectrum Of these three residues, Trp35 is the only reactive residue and therefore the most likely to crosslink to the heme The 1892.8 m ⁄ z value obtained was 15.7 higher than the sum of the calculated ... part of the heme molecule is cross-linked to the distal tryptophan in the cytosolic APX isoform when it reacts with excess H2O2 in the absence of ascorbate They proposed that a vinyl group of heme ... in the reaction to exclude the possible effect of contaminating apoprotein (data not shown) These results strongly support the idea that the formation of the cross-link is at least part of the...
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Báo cáo khoa học: Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase pdf
... redistributions at the cofactor sites, reflecting the reorganization of the hemes, of the polypeptide backbone and of the amino acid side chains upon electron transfer to ⁄ from the redox active centers ... contributions of the m(C¼O) vibrational mode of glutamines can be expected at 1668 to 1687 cm)1 and of the d(NH2) at 1585 to 1611 cm)1 407 Proton access to Paracoccus cytochrome c oxidase [32] The increase ... groups and the modes at 1556 and 1402 cm)1 from the m(COO–)s ⁄ as vibrational modes of the corresponding deprotonated form The relation of the extinction coefficients of these modes are close to model...
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Báo cáo Y học: Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli pptx
... in the polarity of the active site In this hypothesis, the environment of the cofactor is more hydrated in the lowpH conformation Thus, the increased polarity favors the 420 nm-ketoenamine tautomer ... positioning the Ca-COO– bond orthogonal to the plane of the delocalized cofactor imine system Moreover, the release of cofactor as PLP when the enzyme was treated with NaOH after completion of this ... enolimine tautomer of the wild-type cofactor and the 388 nm-absorbing unhydrated aldehyde of PLP in the mutant enzymes (Fig 6) Fig Chemical structures of the chromophore proposed to be present at the...
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The Education Of The Negro Prior To 1861 - A History of the Education of the Colored People of the United States from the Beginning of Slavery to the Civil War pdf
... information to the minds of their Negroes The necessity of choosing either of these alternatives was obviated by the enactment of provincial statutes and formal declarations by the Bishop of London to the ... given to the instruction of the slaves to prevent the Church from falling into discredit, and to obviate the causes for blasphemy on the part of the enemies of the Church who would not fail to point ... are men To strengthen their position these defendants of the education of the blacks cited the customs of the Greeks and Romans, who enslaved not the minds and wills, but only the bodies of men...
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
... for the majority of cells to contain sub2N DNA Furthermore, the Ymin (minimum response of the dose response curve) and the T = values (the number of cells at Time zero) were determined from the ... GSK1070916 Ymin values represent the bottom of the response curve and define the largest effect of the compound These Ymin values are evaluated relative to the number of cells at time zero using a ... identification of predictive biomarkers can accelerate the clinical development of therapies for hematological malignancies through the identification of the tumors most likely to respond One successful story...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part1 docx
... www.adultpdf.com BOARD OFFICIALS ILLINOIS BOARD OF ADMISSIONS TO THE BAR Director of Administration Ms Jan Hefti Deputy Director of Administration Ms Lillian Walton Members of the Board President ... H Funk Member of the Board Mr Neil K Quinn Member of the Board Mr Richard J Prendergast Member of the Board Mr Theodore L Kuzniar Member of the Board Mr John J Rekowski Member of the Board Mr ... criteria established by the Audit Guide, issued by the Illinois Office of the Auditor General As required by the Audit Guide, immaterial findings relating to instances of noncompliance excluded...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part2 potx
... BOARD OF ADMISSIONS TO THE BAR SCHEDULE OF FINDINGS For the Two Years Ended September 30, 2005 Prior Audit Findings Not Repeated There were no findings noted during the compliance testing for the ... version www.adultpdf.com The accompanying notes are an integral part of this financial statement 14 Illinois Board of Admissions to the Bar Statement of Activities For the Years Ended September ... BOARD OF ADMISSIONS TO THE BAR FINDINGS AND RECOMMENDATIONS For the Two Years Ended September 30, 2005 Current Findings There were no current findings noted during our compliance testing for the...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part3 docx
... Illinois Board of Admissions to the Bar Notes to Financial Statements Note A Summary of Significant Accounting Policies Nature of Activities The Illinois Board of Admissions to the Bar (the Board) ... (the Committee) The Committee has the responsibility of determining whether applicants for admission to the bar are of good moral character and general fitness to practice law in the State of ... capital leases are amortized over the shorter of their useful lives or the term of the related leases by use of the straight line method The estimated useful lives of property and equipment are as...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part4 pot
... PROGRAM The Illinois Board of Admissions to the Bar (the Board) was established by the Illinois Supreme Court primarily to monitor the Illinois Bar Exam This includes the processing of exam applications, ... of exam applications, the collection of exam fees, the administration of the examination and the supervision of exam grading Additionally, the Board has the responsibility of processing applications ... collecting the related license fees The Illinois Supreme Court also established the Committee on Character and Fitness (the Committee), the expenses of which are paid from receipts of the Board of Admissions...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt
... for the majority of cells to contain sub2N DNA Furthermore, the Ymin (minimum response of the dose response curve) and the T = values (the number of cells at Time zero) were determined from the ... GSK1070916 Ymin values represent the bottom of the response curve and define the largest effect of the compound These Ymin values are evaluated relative to the number of cells at time zero using a ... identification of predictive biomarkers can accelerate the clinical development of therapies for hematological malignancies through the identification of the tumors most likely to respond One successful story...
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Báo cáo hóa học: " The existence of solutions to the nonhomogeneous A-harmonic equation" docx
... ( ), then v ≥ u a.e in Ω The proof is similar to Lemma 2.2 The existence of solutions In this section, we introduce the main work of this paper, to prove the existence and the uniqueness of solutions ... sequence of X For any subsequence xij of xi, there is a subsequence xijk of, xijsuch that xijkconverges to x0 weakly in X and the weak limit x0 is independent of the choice of the subsequence of xi Then ... ▽ = (∂1 , , ∂n ) is the gradient of The Sobolev space H1,p(Ω) is defined to be the completion of the set { Î C∞(Ω): || ||1,p
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