transfusion therapy and the role of the medical director in blood banking
Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
... as a single-chain precursor (preproinsulin) and folded as proinsulin, in which a connecting peptide of 35 residues links the C terminus of the B chain and N terminus of the A chain After digestion ... of protein enzymes in the B-cell granule, proinsulin is converted into insulin and C-peptide of 31 amino acids [26] Previous studies completed on the unfolding process of insulin or proinsulin ... to the increased entropic penalty associated with fixing the end positions of longer linkers Considering the passive role of the linker in proteins like Rop, we may question whether the role of...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... confirming the role of endogenous FDX + FDXR in supporting the activity To further confirm the role of endogenous FDX + FDXR in supporting the catalytic activity, we transformed the FDX (Yah1)- and ... mitochondria-targeting signal in the yeast system Mitochondrial localization of intact CYP2E1 in yeast cells Because of the existing ambiguity in the literature on the nature and extent of CYP2E1 import into ... Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal hydrophobic signal sequence of the...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 ... oxygen into the benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives,...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny County West Chester University Institute for Education, Excellence, and ... Collaboration with business and government Economic Development Programs and Initiatives Business accelerators and/ or entrepreneurial initiatives Linking teaching and research to business opportunities ... stable supply of knowledge and skills in high need areas Increase the size, diversity of skills and productivity of the labor force Dimensions of Social and Economic Value Regional public institutions...
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THE ECONOMIC AND SOCIAL ROLE OF INTERNET INTERMEDIARIES pdf
... Content and Convergence in Transition 14 ECONOMIC MODELS AND ROLE OF INTERMEDIARIES IN THE VALUE CHAIN ECONOMIC MODELS AND ROLE OF INTERMEDIARIES IN THE VALUE CHAIN Role of Internet intermediaries Intermediation ... caching, storing, and “information location tools” including online directories and providing links to third party materials alleged to infringe the copyrights of others Similar principles on the ... point in time there are: i) two distinct groups of users; ii) the value obtained by one type of user increases with the number or with the ‗quality‘ of the other kind of users; and iii) an intermediary...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... Some single VH domains of anti-protein IgG, including HyHEL-10 and D1.3, were known to retain the specificity and affinity to antigen in itself [7,20] At least for these antibodies, the role of the ... in determining the interdomain interaction strength Results Construction of an FR2 combinatorial library To investigate the possible relationship between antigen-binding affinity and VH ⁄ VL interaction ... OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the type of each FR2...
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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... sources of mixed feelings Merton and Barber (1976) described the sociological ambivalence as follows: “ the ambivalence is located in the social definition of roles and statuses, not in the feeling-state ... situational conditions of gift-giving may differ according to characteristics of the gift-giving occasion, whether the presentation of the gift is public, private, or anonymous, and whether the gift is ... (p.21) These results were the same if comparing between male and female behavior is the interesting finding of Othman and Lee’s study Givers will pay different attitude to these factors when choosing...
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Báo cáo khóa học: Assembly of the silk fibroin elementary unit in endoplasmic reticulum and a role of L-chain for protection of a1,2-mannose residues in N-linked oligosaccharide chains of fibrohexamerin/P25 ppt
... FEBS 2003 Role of L-chain in the elementary unit of fibroin (Eur J Biochem 271) 361 Table Determination of molar ratios of H-chain, L-chain, and fhx/P25 in the fibroin secreted into cocoons of a normal ... the action of Golgi a1,2-mannosidases to yield only the 27-kDa molecule in the secreted fibroin In order to examine a role of L-chain in the protection of a1,2-mannose residues of fhx/P25 in the ... roles in the assembly of vesicular stomatitis viral glycoprotein [28,29], in uenza virus hemagglutinin [30,31], and IgM [32] in ER, a further role of N-linked oligosacharide chains of fhx/P25 in the...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... [11] The kinetics of the N-terminal arms swapping in the P19A-BSRNase is comparable to that of BS-RNase (Fig 5B) Interestingly, the amount of the MxM form at the plateau as evaluated by integrating ... have investigated the effects of mutation of two paradigmatic residues involved in the dislocation of BS-RNase N-terminal arms, i.e Pro19 and Leu28, located in the hinge peptide and in the intersubunit ... (D) The percentage of the MxM form as a function of the incubation time at °C (r) and 37 °C (d) is reported for each dimeric protein intrinsic flexibility of this tract of the protein Yet, in the...
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Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... (particularly the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model ... and E Hovy 2004 Determining the sentiment of opinions In Proc of COLING, pages 1367–1373 M Koppel and J Schler 2005 Using neutral examples for learning polarity In Proc of IJCAI (poster) D Lin ... relation is capturing two different situations, one in which the author himself likes the movie, and in the other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...
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Explaining Bank Failures in the United States: The Role of Self-Fulfilling Prophecies, Systemic Risk, Banking Regulation, and Contagion pdf
... Another strand of literature investigates the impact of the industry structure and sector specific regulation in banking upon incidents of banking crises, as defined by events where the banking system ... underscoring the importance of introducing fixed effects into the present count regressions Then again, in the case that determinants interrelate with the number of bank failures—meaning that the strict ... dramatically aggravating degree of fragility in the banking industry culminating in the savings and loans (S&L) crisis After dropping the 1982 to 1992 period, with in excess of 100 bankruptcies...
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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... bridging the A’ and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... measure the elongation of b-strands A’ and G for unfolding the I27 protein in D2O The pulling coordinate for the separating b-strands is defined as the distance between the first amino acid of strand ... unfolding of one of the I27 modules in the chain Unfolding then extends the overall length of the protein, relaxing the pulling force to a low value As the slack in the length is removed by further...
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Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot
... regions within the bulk of fluid membrane and which are enriched in cholesterol and (glycero-)sphingolipids In addition the fatty acid chains of the phospholipids composing these rigid domains are ... than those in the lipids of the surrounding membrane In fact, this fatty acid composition favors a tighter packing of phospholipids and cholesterol, increasing the rigidity of these domains [32–35] ... implications of this subfamily of receptors in cellular signalling make them attractive therapeutic targets The coupling between stimulation of the P2X receptor and the generation of intracellular...
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Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf
... site of the N-terminal lobe of human and bovine lactotransferrins Importance of the glycan moiety and of the non–covalent interactions between the N- and C-terminal lobes in the stability of the ... trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum Unusual resistance of human apolactoferrin to proteolytic digestion ... lactoferrin where the protein has to survive the harsh environment of the gastrointestinal tract Thus, on the basis of this study, rhLF may be preferred over bLF in oral applications of lactoferrins in...
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Báo cáo hóa học: " The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C" ppt
... for correct folding and intracellular transport of viral glyco- proteins, as shown for instances for influenza hemagglutinin [19] In order to investigate the importance of the individual N-glycosylation ... analysing the role of glycosylation of GP in the correct viral context Conclusion Taken together, our study suggest that individual N-linked oligosaccharides of the Lassa virus glycoprotein differ ... GP-C indicating that each N-glycosylation site is used for N-glycan attachment Next we determined the effect of the individual N-glycans on the maturation cleavage by analysing the presence of the...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... I and II and proteoglycans are involved in rendering the disease chronic [16,17] Beyond the 100% incidence of arthritis, another major advantage of the AIA model is that the time point of induction ... rest of the body was determined using a γ-counter Thereafter, the total radioactivity recovered per animal was calculated by adding the counts of the organs and the rest of the body (a) The proportion ... chronically inflamed skin in a Leishmania infection model [30], and in the mucosa and mesenteric lymph nodes in inflammatory colitis in severe combined immunodeficient (SCID) mice [31] Interestingly,...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... of lung interstitial and intra-alveolar fibrosis and ALI [93] The role of TLRs has been intensively studied in influenza infection TLR7 expression on pDCs plays a cell-specific role against influenza ... distinct role in the adaptive immune response to influenza through regulation of B-cell isotype switching [95,96] The role of TLR3 in the immune response to influenza has been debated in the ... variety of other PRRs including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation For example, the cytoplasmic NALP3 protein, a member of the NLR family that...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot
... polymorphisms in MRL-lpr lupus mice and that enhanced expression of α-actinin may determine the extent of antibody deposition [10] These observations, together with the demonstration that α-actinin immunization ... anti-α-actinin antibodies in lupus patients was associated with a 2.5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin antibodies correlated with those of anti-DNA ... anti-α-actinin antibodies How can the discrepancies between these disappointing results and the previous studies be explained? No doubt, a longitudinal design is important, although the number of patients...
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Báo cáo y học: "The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and metaanalyses" pptx
... explicit in describing the methods by which they captured infection, nonreporting of infection within the results was assumed to represent no infections in either group Absent reporting of infection ... is important for GC therapy in RA because of its intermittent pattern of use and multiple routes of administration GC therapy was rarely the primary exposure of interest in these observational ... to examine the influence of study design, definition of GC exposure, and type of infection Materials and methods Search strategy A search was conducted in MEDLINE, EMBASE, CINAHL, and the Cochrane...
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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc
... pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence of calcium and is thought to enhance mucociliary and phagocytic ... pneumococci in the blood of both strains of mice reflected their levels in the lung These results strongly suggest that lung surfactant protein D plays an important role in delaying the appearance of ... required to further elucidate the role of SP-D in regulating adaptive immune responses in vivo The potential of truncated recombinant forms of SP-D as a new therapy for infectious and inflammatory...
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