transforming growth factor b and cns scarring
Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... 753–791 Sporn MB & Roberts AB (1992) Transforming < /b> growth < /b> factor-< /b> beta: recent progress and new challenges J Cell Biol 119, 1017–1021 Roberts AB (1998) Molecular and cell biology of TGFbeta Miner Electrolyte ... Short-term and sustained actin cytoskeleton remodeling has been investigated thoroughly in fibroblasts such as H-ras transformed NIH3T3 fibroblasts, mouse embryo fibroblasts and Swiss3T3 fibroblasts ... of Rab5 and Rab11 in TGFb receptor endocytosis and recycling The cycling of Rab5 between the GTP and GDP forms may influence the length and intensity of TGFb ⁄ activin signaling cascades by regulating...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... & Sporn, M .B (1990) The transforming < /b> growth < /b> factor-< /b> bs In Peptide Growth < /b> Factors and Their Receptors I (Sporn, M .B & Roberts, A .B. , eds), pp 419–472 Springer-Verlag, Berlin, Heidelberg, New York ... McDonald, J.A (1988) Transforming < /b> growth < /b> factor-< /b> b stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human fibroblasts J Biol Chem 263, 4586– 4592 ... Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming < /b> growth < /b> factor-< /b> beta, activin, and bone morphogenetic proteininducible enhancer...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... JJ, Roberts AB: Regulation of immune responses by TGF-beta Annu Rev Immunol 1998, 16:137-161 Geiser AG, Letterio JJ, Kulkarni AB, Karlsson S, Roberts AB, Sporn MB: Transforming < /b> growth < /b> factor-< /b> beta1 ... washed in PBS and resuspended in ml staining buffer (50 µg/ml PI, 0.5 µg/ml RNase A, PBS) Samples were incubated at 4°C for hours, washed once in PBS, resuspended in PBS and ana- lyzed by flow cytometry ... antibodies (ANAs), antibodies to double stranded (ds)DNA and anticardiolipin (ACL) were measured ANAs were measured by indirect immunofluorescence on Hep2 cells Antibodies to dsDNA (IgG) and...
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Báo cáo y học: "Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix" ppsx
... as the TGFβ isoforms and the BMPs [15] Also important are the fibroblast growth < /b> factor < /b> isoforms and insulinlike growth < /b> factor < /b> (IGF-1) TGFβ super family cytokines act through binding to cell-surface ... available adult stem cell because of the ease of harvest and their abundance [11,12] AD-MSC are capable of differentiating into adipocytes, chondrocytes and osteoblasts, and, more recently, have been ... interactions between neighbouring cells, perhaps through contact or growth < /b> factor < /b> upregulation leading to increased matrix production TGFβ, IGF-1, epidermal growth < /b> factor < /b> and platelet-derived growth < /b> factor...
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Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx
... Casslen B, Sandberg T, Gustavsson B, Willen R, Nilbert M: Transforming < /b> growth < /b> factor < /b> beta1 in the human endometrium Cyclic variation, increased expression by estradiol and progesterone, and regulation ... of COX-2 Expression by Bombesin and Transforming < /b> Growth < /b> Factor-< /b> beta Dig Dis Sci 2008, 53(8):2045-2052 Macedo FY, Baltazar F, Mourao LC, Almeida PR, Mota JM, Schmitt FC, Ribeiro RA: Induction ... 83:140-147 Smith EL, Batuman OA, Trost RC, Coplan JD, Rosenblum LA: Transforming < /b> growth < /b> factor-< /b> beta and cortisol in differentially reared primates Brain Behav Immun 2002, 16:140-149 Ewan KB, Shyamala...
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Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot
... RBBP4: retinoblastoma-binding protein 4; RUVBL1: RuvB-like 1; SOD2: superoxide dismutase 2, mitochondrial; SSc: systemic sclerosis; STMN1: stathmin 1; TBP: TATA box-binding protein; TGFB1: transforming < /b> ... upstream element-binding protein 2); LMNA: lamin A/C; PCBP2: poly(rC)-binding protein 2; PRDX2: peroxiredoxin 2; RB1: retinoblastoma-associated protein; RBBP4: retinoblastomabinding protein 4; ... Terrier B, Tamby MC, Camoin L, Guilpain P, Berezne A, Tamas N, Broussard C, Hotellier F, Humbert M, Simonneau G, Guillevin L, Mouthon L: Antifibroblast antibodies from systemic sclerosis patients bind...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... be additional factors and/ or cofactors that secondarily contribute to their function and that may become prevalent in the absence of TGF-β and/ or if TGF-β is dysregulated The identification and ... possess antinuclear antibodies and 50 to 80% of these have antidouble-stranded DNA antibodies, the result of unchecked B lymphocyte activation and antibody production, probably due to uncontrolled ... Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S: Transforming < /b> growth < /b> factor < /b> β1 null mutation in mice causes excessive inflammatory response and early...
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Báo cáo y học: " Aging, osteoarthritis and transforming growth factor-β signaling in cartilage" pps
... focus on members of the BMP family such as BMP-2, BMP-7, and growth < /b> differentiation factor < /b> (GDF-5) GDF-5 is also known as cartilage-derived morphogenetic protein (CDMP 1) and has been implicated ... proteins to body morphogenetic proteins Cytokine Growth < /b> Factor < /b> Rev 2005, 16: 249-250 Lories RJU, Luyten FP: Bone morphogenetic protein signaling in joint homeostasis and disease Cytokine Growth < /b> Factor < /b> ... 2:ii73-ii88 Davidson ENB, Schartstuhl A, Vitters EL, van der Kraan PM, van der Berg WB: Reduced transforming < /b> growth < /b> factor-< /b> beta signaling in cartilage of old mice: role in impaired repair capacity...
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Báo cáo y học: "Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling" pot
... NM_002450 B OB NM_016109 A NM_015675 B NM_000358 A, B NM_017817 Symbol Name NM_004967 B, C OB, CB AB014526 B NM_004142 A, B, C OB, OC, CB 15 NM_002025 B 18 NM_005953 B 20 NM_013258 A, B 21 NM_003155 ... factor,< /b> beta 2.739 3.054 TGF-β/BMP pathway components and modulators M38449 AK021486 A, B, C OB, OC, CB B, C OB, CB BMP5 Bone morphogenetic protein -10.314 -2.263 NM_002192 A, B, C OB, OC, CB INHBA ... B, C OB, OC, CB IL6 Interleukin 2.589 -3.612 B, C OB, CB FST Follistatin -2.137 -7.912 FST 0.38 B OB RUNX2 Runt-related transcription factor < /b> 1.611 1.050 RUNX2 2.07 TGFB1 Transforming < /b> growth < /b> factor,< /b> ...
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Association between transforming growth factor b1 polymorphisms and atrial fibrillation in essential hypertensive subjects pptx
... Genotypic variation in the transforming < /b> growth < /b> factor-< /b> beta1 gene: association with transforming < /b> growth < /b> factor-< /b> beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation ... Association between transforming < /b> growth < /b> factor < /b> b1 polymorphisms and atrial fibrillation in essential hypertensive subjects Journal of Biomedical Science 2010 17:23 Submit your next manuscript to BioMed ... clinical and biochemical data of all subjects were listed in Table There were no significant differences in age, sex, height, weight, BMI, SBP, DBP, serum TG, TC, HDL-C, and LDL-C between EH+AF- and...
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báo cáo khoa học: " Effects of enamel matrix derivative and transforming growth factor-b1 on human osteoblastic cells" pot
... blue-stained cells Bromodeoxyuridine-labeling (BrdU) index Effect of EMD, TGF -b1 and the combination of both on osteoblastic cells proliferation was assessed by direct counting of cell number and BrdU incorporation ... 14040-904 Ribeirão Preto, SP, Brazil Authors’ contributions DBP designed the research MMB and ALR established the cell culture protocol TLSR, JTM and MMB performed the research DBP and PTO analysed ... probes Briefly, cells were permeabilized with 0.5% Triton X-100 in PB for 10 followed by blocking with 5% skimmed milk in PB for 30 Primary monoclonal antibodies to bone sialoprotein (anti-BSP,...
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Báo cáo y học: "Bone Morphogenetic Protein (BMP)-4 and BMP-7 regulate differentially Transforming Growth Factor (TGF)-β1 in normal human lung fibroblasts (NHLF)" pdf
... cells Both BMP-4 and BMP-7 inhibited the differentiation of fibroblasts into myofibroblasts and blocked the release of matrix metalloproteinase (MMP)-13, whereas only BMP-7 was able to inhibit ... pulmonary interstitial fibroblasts is mediated by transforming < /b> growth < /b> factorbeta1-induced release of extracellular fibroblast growth < /b> factor-< /b> 2 and phosphorylation of p38 MAPK and JNK J Biol Chem 2005, ... and specific bioassay for measuring bioactive TGF-beta BMC Cell Biol 2006, 7:15 35 Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G: Transforming < /b> growth < /b> factor-< /b> beta induces alpha-smooth muscle actin...
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Báo cáo y học: "Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes" potx
... platelet derived growth < /b> factor < /b> B chain (PDGFB/c-sis) mrna and immunoreactive PDGF B- like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth < /b> factor-< /b> 1 J Rheumatol ... Buchdunger E, Zimmermann J, Lydon NB, Gilliland DG, Druker BJ: CGP 57148, a tyrosine kinase inhibitor, inhibits the growth < /b> of cells expressing BCR-ABL, TEL-ABL, and TELPDGFR fusion proteins Blood ... Platelet-derived growth < /b> factors and heparin-binding (fibroblast) growth < /b> factors in the synovial tissue pathology of rheumatoid arthritis Semin Arthritis Rheum 1991, 21:191-199 Li MO, Wan YY, Sanjabi S, Robertson...
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Báo cáo y học: " Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung" docx
... Assay ID Vascular endothelial growth < /b> factor < /b> A Vascular endothelial growth < /b> factor < /b> B Vegfa Vegfb Placenta growth < /b> factor < /b> Pgf Rn00585926_m1 Vascular endothelial growth < /b> factor < /b> receptor Vegfr1 Rn00570815_m1 ... tissue VEGFB protein was expressed within alveolar wall and type II pneumocytes (black arrows, B and F) and the wall of intra-acinar blood vessels (C and G) Panels (I) and (J) show stained and unstained ... et al: Placenta growth < /b> factor < /b> Potentiation of vascular endothelial growth < /b> factor < /b> bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR J Biol Chem 1994, 269(41):25646-54...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... Inhibition of Mycobacterium bovis BCG-induced tumor necrosis factor < /b> alpha secretion in human cells by transforming < /b> growth < /b> factor < /b> beta Clin Diagn Lab Immunol 5, 588–591 30 Dlugovitzky D, Bay ML, ... known to modulate TNF-a, is induced by TGF -b1 but not by LPS The specific role of FXR1 in this process was shown by inhibition by siRNA on the one hand, and stable overexpression of FXR1 on the ... Molteni O & Bottaso OA (1999) In vitro synthesis of interferon-gamma, interleukin-4, transforming < /b> growth < /b> factor-< /b> beta and interleukin-1 beta by peripheral blood mononuclear cells from tuberculosis...
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transforming growth factor-beta protocols
... M B and Roberts, A B (1988) Peptide growth < /b> factors are multifunctional Nature 332, 217–219 Roberts, A B and Sporn, M .B (1990) The transforming < /b> growth < /b> factor < /b> betas, in Peptide Growth < /b> Factors and ... role of growth < /b> factors in peritoneal healing: transforming < /b> growth < /b> factor < /b> beta (TGF-beta) Eur J Surg.–Suppl 577, 17–23 16 O’Kane, S and Ferguson, M W (1997) Transforming < /b> growth < /b> factor < /b> betas and wound ... Danielpour, D., Ebbs, S R., Sporn, M B. , and Baum, M (1990) Anti-oestrogens induce the secretion of active transforming < /b> growth < /b> factor < /b> beta from human fetal fibroblasts Br J Cancer 62, 405–409 29 Boulanger,...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
... inflammatory cell injury and fibrogenesis, mediated by hepatic stellate cells (HSCs) via up-regulation of transforming < /b> growth < /b> factor-< /b> beta1 (TGF-β1) [3] An alternative pattern is followed by leptin that ... parameters was done before the histological classification, whereas serum ferritin and growth < /b> factor < /b> concentrations were obtained on stored samples The liver biopsy, blood samples and US parameters ... TGF-β1, transforming < /b> growth < /b> factor-< /b> beta1 To let us get down to the grassroots of the FL benignity from the beginning we should relay on longitudinal observations lasting several years, but this...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... activity The sections were blocked with 0.5% bovine serum albumin (BSA) in PBS, and incubated with primary antibodies in PBS containing 0.2% Triton X-100 and 0.1% BSA The incubations were performed ... alteration of cerebrospinal fluid (CSF) dynamics – probably due to clearance obstruction – and present, at one year of age, a reduction in brain blood flow and metabolism, signs of vascular and neuronal ... to PVDF membranes (BioRad) by semi-dry electrophoresis The membranes were blocked in 10% milk in 10 mM Tris/150 mM NaCl containing 0.1% Tween-20 (TBS) and incubated overnight in TBS containing...
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báo cáo hóa học: " Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients" pot
... expression of VEGF-A (A) and CCL2 (B) in PBMCs of definite, probable and possible ALS patients Values are plotted as mean ± SE (Standard error) in the bar diagram Data was analyzed by one-way analysis ... peripheral blood mononuclear cells levels did not vary between definite, probable and possible ALS cases (Figure 2B; p > 0.05) To find association of respiratory dysfunction, VEGFA and CCL mRNA ... Further, both probable and possible ALS patients were shown to have higher VEGF-A than controls (Figure 2A; p = 0.0001 and p = 0.0001 respectively) However, CCL2 Table Characteristics of the subjects...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... Sporn MB, Roberts AB: TGF-beta: problems and prospects Cell Regulat 1990, 1:875-882 Roberts AB, Sporn MB: Physiological actions and clinical applications of transforming < /b> growth < /b> factor-< /b> beta (TGF-beta) ... Moses HL: Transforming < /b> growth < /b> factor-< /b> beta A family of growth < /b> regulatory peptides Ann NY Acad Sci 1990, 593:208-217 Sporn MB, Roberts AB: Transforming < /b> growth < /b> factor-< /b> beta Multiple actions and potential ... human transforming < /b> growth < /b> factor < /b> beta (Ad.TGF-β1) (Exp.) or the control adenoviruses (Con.) (A, D) Short-term naïve rabbits (B, E) Long-term naïve rabbits (C, F) Antigen-induced arthritis rabbits...
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