the use of primary circulating prostate cells to select patients for prostate biopsy evidence utility and cost benefit
PULMONARY HYPERTENSION – FROM BENCH RESEARCH TO CLINICAL CHALLENGES pot
... to promote the adhesion and the eventual organization of explanted embryonic endothelial cells into monolayers forming AJs, whereas the addition of EGF or TGF-α and ChS may lead to the loss of ... PY) of signal transducer and the activator of transcription (STAT) have been shown to occur before the onset of PH; and the rescue of endothelial caveolin-1 inhibits PY-STAT3 activation and attenuates ... Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher No responsibility is accepted for the accuracy of information...
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Báo cáo y học: " Involvement of mast cells in monocrotalineinduced pulmonary hypertension in rats" pot
... may be attributable to the inhibition of c-kit and to an interference of the interaction of MCs with other factors [39-42] It is not unlikely that the therapeutic benefits of imatinib in experimental ... antagonists The study protocol was approved by the ethics committee of the University of Giessen that conforms to the principles outlined in the Declaration of Helsinki Histology and mast cell ... we therefore investigated the lung tissues from idiopathic PAH (IPAH) patients and monocrotaline (MCT)-injected rats to determine total and perivascular MC count, and the degranulation of the...
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Báo cáo y học: "Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilatio" ppsx
... on the inspiratory port of the Fisher and Paykel humidification chamber Thus, NO was mixed with the bias flow gas of the oscillator and subsequently delivered to the neonate via the inspiratory ... study, we found that 61.1% of the responders responded within the first h after the initiation of INO and their response sustained to the end of the treatment and the remaining neonates showed ... conducted a study to evaluate whether INO would reduce the incidence of death or the need for ECMO in infants with hypoxic respiratory failure [9] HFOV was used in 55% of the infants The authors found...
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Báo cáo y học: "Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis" pptx
... reported [42] and it was hypothesised that the widespread use of antibiotics is the cause for this phenomenon There is also some evidence that fungal infections may worsen the outcome of acute pancreatitis, ... law for use of laboratory animals (BGB1.I S 1319) The study was approved by the Committee of Animal Care of the Regierungspräsidium Karlsruhe, Germany Animals were allowed free access to food and ... up to 20% to 85% [2,21,24,28,29] Due to major improvements in intensive-care management over the past decade, more patients survive the first phase of severe acute pancreatitis and therefore the...
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Báo cáo y học: " Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension" ppt
... intact and pharmacologically blocked ANS Materials and methods This investigation conforms to the Guide for the Care and Use of Laboratory Animals, published by the US National Institutes of Health ... oxygen cost Competing interests In the past five years, SR and WB have received honoraria for lectures from the manufacturer of iloprost From 2003 to 2004, the Department of Anaesthesiology of the ... out the animal experiments, performed the data acquisition and the statistical analysis, and wrote the manuscript PC wrote the software algorithms for the data analysis, participated in the statistical...
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báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... endarterectomy for thromboembolic PH) not cure the disease The present aim of treatment is to lengthen survival time, to ameliorate symptoms and to improve quality of life (QoL) However, treatments for ... from the Rasch analyses) were candidates for exclusion However, it was the aim to include a reasonable spread of items in terms of the degree of severity they represented The logit severity of the ... combined into four domains such that two domains had three levels and the other two domains had two levels The items were selected by re-analysis of the responses of 201 patients to the CAMPHOR...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... recognised to have a limited role in the management of PAH They also appear to be of limited benefit for RP in patients with SScl [19] In contrast, the prostanoids improve function and survival ... both the frequency and the severity of attacks [14] PDE type V inhibitors such as sildenafil inhibit the degradation of cGMP, which mediates the signalling of several endogenous vasodilators ... deposition and inhibition of NF-ΚB activation [5,12,13] Since there are commonalities in the pathophysiology of PAH and RP, particularly in the context of connective tissue disease, inhibition of the...
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Báo cáo y học: "Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters" doc
... introducer connected to an artery catheter was punctured into the right jugular vein and then into the right ventricle under pressure waveform monitoring After a period of stabilization, RVSP ... ligated, and 4% polyformaldehyde (pH 7.4) was instilled into the right lung through the trachea under constant pressure (20 cmH O) for 30 min, and then the right lung was removed and submersed in the ... temperature for paraffin embedding, sectioning and histological staining The remainder of the lung was dissected, and snap-frozen in liquid nitrogen, then stored at -80°C for biochemical analysis The...
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Báo cáo y học: " Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats" ppsx
... by the Animal Care and Use Committee of the Fourth Military Medical University and complied with the Declaration of the National Institutes of Health Guide for Care and Use of Xu et al Respiratory ... hypoxia-induced PVSR and pulmonary hypertension Therefore, we adopted b-E2 to explore the roles of p27kip1 and Skp-2 in the evolution of PVSR and HPH in vivo Further, we verified their effects on ... culture Petri dishes (JET BIOFIL inc, Canada) and allowed to grow for days Then the cells were undergone serum-starvation for 36 hours The media was then changed to containing 5% FBS phenol-red-free...
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Báo cáo y học: " Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats" pps
... we transplanted the bone marrow cells into rats and, at the same time, left some cells and cultured them for 48 hours for analysis of CXCR4 expression in primary bone marrow cells In addition, ... Measurement of right ventricular hypertrophy The ventricles and septum of the animals were collected and the wet and dry ventricle and septal weight were obtained by drying them for 24 hours at 60°C Then ... centrifugation, the bone marrow cells were resuspended with medium and the number of the bone marrow cells was counted for transplantation Electroporation of CXCR4 shRNA plasmid into bone marrow cells...
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Báo cáo y học: " Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model" potx
... antiinflammatory effect [13] Therefore, we hypothesized that the antioxidant and anti-inflammatory effects of hydrogen-rich saline might prevent the progression of PH To test this hypothesis, we ... according to the Guide for the Care and Use of Laboratory Animals by the Chinese Academy of Sciences On day 22, rats were anesthetized with 10% chloral hydrate (0.4 ml/100 g body weight, i.p.) and ... reader and the concentrations were calculated according to the standard curve Experimental design Measurement of 8-OHdG, MDA and SOD in lung tissues and serum Rats were divided randomly into the...
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Báo cáo y học: " Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis" pot
... process through regulation of the secretion of cytokines; we analyzed the lung levels of the pro-inflammatory cytokines TNF-a and IL-1b A substantial increase in TNF-a and IL-1b formation was observed ... significant reduction of the oedema formation, tissue damage and reduced content of collagen Also, the treatment with AM reduced the loss of body weight and improved the survival of the mice In conclusion, ... suggested in animal models of intestinal bowel disease [17] Altogether, these observations raise the question of whether AM could play a role in the course of the inflammatory process associated...
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Báo cáo y học: " Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension" pot
... therapeutic benefit in these animal models and can be used for further investigation Additionally, TBC3711 can be used as a useful tool to further elucidate the role of ET system in recently found factors ... (STRIDE) [3,47] Collectively, these studies showed the benefits of selective ET-A receptor antagonism in the setting of human forms of PH Unfortunately, due to a pattern of idiosyncratic liver function ... ET-B receptors together with ET-A receptors mediate vasoconstriction and proliferation of vascular cells, but when expressed on endothelial cells the ET-B receptors cause vasodilatation and ET-1...
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Báo cáo y học: " Endothelial-like cells in chronic thromboembolic pulmonary hypertension: crosstalk with myofibroblast-like cells" pptx
... Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: Chaperone-Mediated Autophagy Regulation of Autophagy: Co-Regulators ... Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis B-cell CLL/lymphoma BCL2 NM_000633 0.000727 Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: ... Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Insulin-like growth factor (somatomedin C) IGF1 NM_000618 0.017282 Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis...
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Báo cáo y học: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice" ppt
... antiinflammatory effects of IL-6 IL-6 suppressed the generation of the proinflammatory cytokines IL-1 and TNF in macrophages exposed to lipopolysaccharide and attenuated the inflammatory response to intratracheally ... between the G(-174)C polymorphism of the IL-6 gene and the severity of PH in our patients with COPD This polymorphism influences the levels of circulating IL-6, suggesting a causal role for high circulating ... the Bradford method For standardization, serial dilutions of recombinant mouse IL-6 were assayed at the same time Lung immunohistochemical labeling of IL-6 and macrophages Paraffin sections of...
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Báo cáo y học: " Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease" ppsx
... therefore to immunohistochemically determine the expression of the three isoforms of NOS in the lungs of infants with secondary pulmonary hypertension since they will have been exposed to elevated ... alveolar macrophages and in the respiratory epithelium Expression of iNOS was found in the small pulmonary arteries, both media and endothelium, the respiratory epithelium, and in alveolar macrophages/alveolar ... lining cells There was significant upregulation of iNOS in endothelial cells of pulmonary hypertensive patients compared to control patients, but there were no differences between the cases and...
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Báo cáo y học: "Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosis" doc
... study and analysis and interpretation of histological, immunohistochemical and molecular data; DMA and ERP contributed to the acquisition of histologic and morphometric data and performed the statistical ... out the induction of the experimental scleroderma model and nasal tolerance and the immunofluorescence experiments, and drafted the manuscript; WRT contributed to conception and design of the ... Rheumatology Division of the School of Medicine of the University of Sóo Paulo (FMUSP), Sóo Paulo, SP, Brazil 2Department of Radiology, Discipline of Oncology of the School of Medicine of the University...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25