the transfer of investment policy competences to the eu is supposed to give the eu the necessary legal basis to conclude international investment agreements as well as broader ptas in an international competition of systems
International Humanitarian Law and Human Rights Law Towards a New Merger in International Law
... merged in the contemporary corpus of IHL.38 The scope of the law of war was related to the other main branch of international law, the law of peace At the beginning of the 20th century, the generally ... discussion in this chapter The importance of the jurisprudence of the ICTY and ICTR for the scope of determining the content and applicability of FSH resides particularly in the denition of international ... achieved in this regard is largely based on the increasingly interplay between international human rights law, international humanitarian law, international criminal law, international refugee law and...
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The Role of Genetically Modified Organisms (GMOs) in Beverage Production
... mutagenesis, create signiÞcant changes in the genetic makeup of plants and animals due to the random recombination and sorting of thousands of genes As a result of intervention by people, the hybrid seed ... throughout the world bears little resemblance to teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in ... Examples of GM crops include insectresistant (Bt) corn, cotton, potato, and tomato; herbicide-tolerant soybeans, corn, rice, sugar beet, ßax, and canola; and virus-resistant squash, papaya, and potato...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... through the cell cycle (Fig 1) Cyclins B1 and B2 appear in S phase and accumulate in G2 and mitosis before disappearing at the transition from metaphase to anaphase Synthesis is controlled at the ... the Cdc2 promoter in vitro Lin-54 binds in EMSAs to a region in the upstream part as well as to the CHR of the Cdc2 promoter [86] Cyclin A and human cyclin B1 are class I and class II CDE ⁄ CHR-controlled ... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... was similar to that of the overall CTP synthesis reaction It was concluded that the effect of GTP was mainly to enhance the rate of chemical steps of the glutaminase reaction The nding that the ... of enzyme activity prior to injection j, tj)1 is the time between injection j)1 and j, [S]syr is the concentration of the injectant in the syringe Analysis of initial velocity data Analysis of ... where GTP is varied, since the heat evolved representing this activity is included in the baseline of the experiment Therefore, the assay only measures the rate increase due to the addition of GTP...
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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... l-serine binds to the cofactor at the active site, as is evident in the case of the double mutant enzyme This is monomeric in the apo-form, exists as an equilibrium mixture of monomers and dimers ... PLP binding properties The affinity of wild-type and mutant forms for the cofactor was measured to evaluate the impact of the mutations on the structure of the PLP binding site Because PLP binding ... Y55¢ interacts with the phosphate moiety of PLP; E57¢ is crucial in the binding of the l-serine hydroxyl group [15] and in the catalysis of the hydroxymethyltransferase reaction [16]; and Y65¢ interacts...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... number of other molecules such as casein kinase-2 and mitogen activated protein kinase (MAPK)-2 [23] as well as enzymes involved in the metabolism of glucose [24] It is difficult therefore to exclude ... phosphatidylinositol 3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced ... greater than that by insulin Since the activity of GS depends on the relative activities of GS kinases and PP1G, inhibiting GSK3 (one of the principal GS kinases) will shift the balance towards...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... were inserted into the tail veins, one for the administration of pentobarbital and one for the infusion of glucose A third catheter was placed intraperitoneally as an alternative means of glucose ... reflects increased glycogen utilization in an effort of the liver to establish euglycemia and reflects an overexpression of double mutant 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in the ... into the C6 position of glycogen in the ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead to increased 13C labeling at the triose level Such a mechanism can lead to...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... amine nucleophiles compared to water [13] In protease B of Streptomyces griseus an effective ligase was created by replacing the active-site serine by an alanine [14] In this case, the histidine ... positioning of the substrate in the active site with respect to the catalytic residues Transferase/hydrolase kinetics of the site-directed mutants From an analysis of the steady-state kinetic ... semisynthetic b-lactam antibiotics The Vs/Vh ratio was determined by measuring the initial rate of formation of antibiotic and hydrolysis product, using 15 mM of the acyl donor and 30 mM of the...
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The role of floating-rate bank loans in institutional portfolios pdf
... credit spread is the market-determined spread paid to the investor for taking on the credit risk (historically the normal range has been 3%–8%, depending on the riskiness of a loan) The credit spread ... Suisse, Moody’s, Ridgeworth Capital Data is historical and is not indicative of future results Russell Investments // Role of bank loans in a rising rate environment / p6 Bank loans in rising interest ... Treasury Yield Curve Rate 10-Year Treasury Yield Curve Rate Jan 11 Jan 10 Jan 09 Jan 08 Jan 07 Jan 06 Jan 05 Jan 04 Jan 03 Jan 02 Jan 01 Jan 00 Jan 99 Jan 98 Jan 97 Jan 96 Jan 95 Jan 94 Jan 93...
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Perceptions About Network Security: Survey of IT & IT security practitioners in the U.S. pptx
... the industry distribution for respondents who are employed by private and public sector organizations As can be seen, the largest sectors include financial services (including banking, insurance, ... that the cost of cyber attacks is increasing Reducing an organization’s vulnerability to such attacks through the combination of proper staffing, enabling technologies and training programs can ... annually: the Cost of a Data Breach and the Cost of Cyber Crime According to the findings, the average cost of one data breach for U.S organizations participating in the 2010 Ponemon Institute©...
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FUTURE OF THE NUCLEAR SECURITY ENVIRONMENT IN 2015 pptx
... took part in their financing Practically all of the construction work was financed by the Kurchatov Institute, while installation of physical protection systems was carried out on the basis of ... monitoring is to raise the level of workplace discipline of staff and ensure that they follow the rules for handling nuclear materials, and to raise control over the aspects of the work and functioning ... It is also important to understand the reasons for the behavior of some states.43 So, on the one hand, there is a need to make the NPT regime more stringent, and on the other hand, the existing...
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Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx
... Mechanism of phosphoryl transfer Using [c-32P]ATP as phosphate donor, the mechanism of phosphoryl transfer during CTP synthesis by CMPK was studied Initially, using either dCDP or CDP as the ... in a high level of incorporation into DNA, but the level of labelled dTTP was very low [18] In organisms where NDK is present, the rate-limiting step in the synthesis of dNTPs ⁄ NTPs is not the ... introduced to the N-terminus of the recombinant proteins Tryptophans, coded by UGA codons in UMPK and AMPK, were mutated to UGG using the sitedirected mutagenesis method in order to express these...
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Báo cáo khoa học: Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism pdf
... Role of the time factor in signalling specificity: application to mitogenic and metabolic signalling by the insulin and insulin-like growth factor I receptor tyrosine kinases Glucose Metabolism and ... °C, during 10 min, in the presence of mm EDTA, the remnant inhibitory action was assayed on the TPO enzyme as described above The control activity of TPO was determined in the presence of inactivated ... performed in the presence of insulin The remnant inhibitory activity, after the treatments is the measure of stability Other details are given in the text TPO, thyroid peroxidase; PI, peroxidase inhibitor...
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báo cáo hóa học: " The role of cumulative physical work load in symptomatic knee osteoarthritis – a case-control study in Germany" potx
... questionnaire and observation ratings of 0.49 for frequency of lifting, carrying, and transferring 6–15 kg Concerning the frequency of lifting, carrying, and transferring 6–15 kg, the self-assessed and ... on the basis of the two-digit STBA job-title codes Cumulative exposure to kneeling/ squatting respectively to lifting/carrying was calculated up to the year of diagnosis (in cases) or to the ... exposure to kneeling and squatting as well as to lifting and carrying of loads and symptomatic knee osteoarthritis grade 2: definite osteophytes and possible narrowing of joint space; Subjects and...
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báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx
... recurrence and in 23 patients (95%) for local lymph node metastasis The evaluation of distant metastasis showed a rate of 50% overall concordance The subgroup analysis of distant metastases was also ... done The regions of distant metastasis noted were liver, distant lymph nodes, lungs, bones and intestinal wall The number of patients who had concordant findings for defining liver metastasis was ... It is an important limitation that the number of patients is small especially in the first group, the number of studies in the literature investigating the role of PET in the diagnosis of distant...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and synovial fibroblasts: a possible role as a ‘fine-tuning cytokine’ in inflammation ... interleukin 17 in inflammatory bowel disease Gut 2003, 52:65-70 Katz Y, Nadiv O, Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and ... (IL-17) in relation to other key cytokines in the pathogenesis of arthritis RANKL, receptor activator of NF-κB ligand; TNF, tumor necrosis factor inactivation of IL-17 [40] In line with the situation...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... chromatin in all seven patients, including those without anti-dsDNA antibodies [62] At least in part, the increase in anti-histone and anti-chromatin antibodies preceded the anti-dsDNA increase ... organs, such as the kidney, the joints, or the skin However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory ... two cytokines is not functional in active SLE Rather, the combined increase of both TNF and IFN-α might contribute to the pathogenesis of systemic autoimmunity Another hypothesis relates to prolonged...
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Báo cáo y học: "Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints" potx
... be assumed that HIF-1 exerts a compensatory protective role in the disease process rather than promoting the progression of the disease To further prove this hypothesis, we established two animal ... in most cases at the margins of the joint surface of all compartments (Figure 5b,d,f) Luxation of the patella was not observed The analysis of the synovial membrane using the scoring system of ... of data, the analysis and interpretation of data and drafted the manuscript DP participated in the study design and drafted the manuscript SO and KXK were involved in the acquisition of the data...
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Báo cáo y học: " Role of taurine on acid secretion in the rat stomach" ppsx
... plexus of the enteric nervous system in the stomach Taurinergic neurons in the muscle layer of the gastrointestinal (GI) tract might be involved in motility of the GI tract and the function of endocrine ... observations of CSAD- and taurine-positive cells in the stomach and taurine released from CSAD- and taurine-containing neurons, which is also consistent with the above hypothesis If peripheral taurine is ... taurine binds to GABA receptors [24-26] The purpose of the study was to determine if taurine also regulates gastric acid secretion via GABA receptors in the stomach Localization of taurine in the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25