the strategy of conquest the interaction of herpes simplex virus with its host
báo cáo hóa học: " A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells" pot
... Quantitation of herpes simplex virus type DNA in cells of cerebrospinal fluid of patients with herpes simplex virus encephalitis Neurology 1997, 48:1341-1346 Trifilo MJ, Lane TE: Adenovirus-mediated ... members of the herpesvirus family including human herpesvirus 6, HSV-1, and HSV-2 can elicit damaging CNS inflammation [2,32] Acute HSV -1 infection or the reactivation of latent virus in the trigeminal ... drafted the manuscript VSC participated in the performance of the in vivo viral infections and the isolation of CNS cells MM participated in the preparation of viral stocks and determination of viral...
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Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx
... transcripts of herpes simplex virus: RNA in search of function Virology 1992, 191:1-8 Lee LY, Schaffer PA: A virus with a mutation in the ICP4-binding site in the L/ST promoter of herpes simplex virus ... inoculated with × 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG...
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Báo cáo khoa học: Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry potx
... process of penetration begins The latter, depending on the host cell type and the mode of entry [4,5], may require fusion of the virion envelope with the plasma membrane or with the membrane of an ... key feature of alphaherpesviruses [1] During this period, hosts are still capable of spreading infection to other humans via asymptomatic shedding of the virions Reactivation of the virus can be ... toward the nuclear membrane for uncoating and the release of viral DNA into the nucleus Transcription, replication of viral DNA and assembly of progeny capsids take place within the host nucleus The...
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Báo cáo sinh học: " Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection" pptx
... gamma herpesvirus 68 It will be of interest to determine how widespread this effect is among different virus infections or whether it is unique to viruses that persist in the host, such as the herpesviruses ... infections are usually cleared from the primary site of infection by the host immune response [1], but some viruses can persist at other sites in a latent form Herpes simplex virus (HSV), for example, ... number of neurological diseases have been associated with HSV infection [30], and these could be associated with these long-term inflammatory responses In addition, the possibility of other types of...
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Báo cáo sinh học: " Detection, quantification and genotyping of Herpes Simplex Virus in cervicovaginal secretions by real-time PCR: a cross sectional survey" potx
... regions with no other base changes within 20 nucleotides (i.e within the likely probe binding area) of the potential typing SNP These SNPs were then submitted for primer-probe design using either ... reduce the risk of transmission of genital herpes N Engl J Med 2004, 350:11-20 Wald A, Zeh J, Barnum G, Davis LG, Corey L: Suppression of subclinical shedding of herpes simplex virus type with ... monitoring the effectiveness of any current intervention, determining the efficacy of drugs, assessing drug resistance and are useful research tools in the study of the epidemiology of transmission The...
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Báo cáo hóa học: " Involvement of intracellular free Ca2+ in enhanced release of herpes simplex virus by hydrogen peroxide" ppt
... ciated of1 2O2 on the amount of cell-free virus and cell-assoEffect virus Effect of H2O2 on the amount of cell-free virus and cell-associated virus FI cells were infected with HSV-1 at an MOI of ... only, the increase of cell-free virus would be accompanied by the decrease of cell-associated virus, but the amount of cell-associated virus was not altered This suggested that the total amount of ... value by the treatment with H2O2 (Fig 3A) The amounts of cell-free virus in the presence of 50 μM BAPTA and 50 μM quin-2 were 250 % and 230 % of the control, respectively, indicating that the H2O2-mediated...
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báo cáo hóa học:" Detection, quantification and genotyping of Herpes Simplex Virus in cervicovaginal secretions by real-time PCR: a cross sectional survey" pdf
... regions with no other base changes within 20 nucleotides (i.e within the likely probe binding area) of the potential typing SNP These SNPs were then submitted for primer-probe design using either ... reduce the risk of transmission of genital herpes N Engl J Med 2004, 350:11-20 Wald A, Zeh J, Barnum G, Davis LG, Corey L: Suppression of subclinical shedding of herpes simplex virus type with ... monitoring the effectiveness of any current intervention, determining the efficacy of drugs, assessing drug resistance and are useful research tools in the study of the epidemiology of transmission The...
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Báo cáo sinh học: "A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma" ppsx
... use with PET limits the direct comparison of the presented data to our results Bioluminescent activity of the fusion constructs containing firefly Luc was reduced to 22 – 63% of the activity of ... after GCV therapy) of tumor volumes and integrated light intensity units within a region of interest (ROI) including all tumors were plotted against each other (Figure 5) Within the weeks of GCV ... mouse prior to sacrifice The tumor was cut in the middle and placed with the cut side facing the CCD camera One part of the tumor was obviously hemorrhagic while the other part looked vital Photon...
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Báo cáo sinh học: " The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment" docx
... Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells J Virol 1979, 29:677-697 Foster TP, Kousoulas KG: Genetic analysis of the role of herpes ... for the UL11 functions of herpes simplex virus type cytoplasmic virion envelopment Journal of virology 2007, 81(7):3097-3108 McMillan TN, Johnson DC: Cytoplasmic domain of herpes simplex virus ... cercopithecine herpesvirus and 2, but not in varicella zoster (VZV) or pseurodabies virus (PRV) (not shown) Mutagenesis of the Y residue of a YXXΦ(YTKI) motif within gK domain IV, shown to lie in the...
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Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... depletion with anti-asialo GM1 did not decrease the duration of survival of HSV-1 infected scid mice (Fig 6B) Rather, treatment with control IgG or anti-asialo GM1 increased the duration of survival of ... herpes simplex virus Curr Top Microbiol Immunol 1992, 179:89-110 Engler H, Zawatzky R, Kirchner H, Armerding D: Experimental infection of inbred mice with herpes simplex virus IV Comparison of ... Johnson D: Herpes simplex virus turns off the TAP to evade host immunity Nature 1995, 375:411-415 Tomazin R, van Schoot NE, Goldsmith K, Jugovic P, Sempe P, Fruh K, Johnson DC: Herpes simplex virus...
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Báo cáo hóa học: " The product of the Herpes simplex virus 1 UL7 gene interacts with a mitochondrial protein, adenine nucleotide translocator 2" pot
... http://www.virologyj.com/content/5/1/125 On the other hand, mutant viruses in which the UL7 homologous genes of other alphaherpesviruses pseudorabies virus (PRV) and bovine herpesvirus (BHV-1) have been constructed ... of the mutated HSV-BAC (pMT102) into rabbit skin cells Line 8, a schematic diagram of the repaired virus MT103 The rescue of MT102 by cotransfection of its DNA was the same as that used for the ... Proteins of purified Epstein-Barr virus Proc Natl Acad Sci USA 2004, 101:16286-16291 Patel AH, MacLean JB: The product of the UL6 gene of herpes simplex virus type is associated with virus capsids...
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báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... depletion with anti-asialo GM1 did not decrease the duration of survival of HSV-1 infected scid mice (Fig 6B) Rather, treatment with control IgG or anti-asialo GM1 increased the duration of survival of ... herpes simplex virus Curr Top Microbiol Immunol 1992, 179:89-110 Engler H, Zawatzky R, Kirchner H, Armerding D: Experimental infection of inbred mice with herpes simplex virus IV Comparison of ... Johnson D: Herpes simplex virus turns off the TAP to evade host immunity Nature 1995, 375:411-415 Tomazin R, van Schoot NE, Goldsmith K, Jugovic P, Sempe P, Fruh K, Johnson DC: Herpes simplex virus...
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Involvement of p63 in the herpes simplex virus-1-induced demise of corneal cells Research ppt
... shutoff of host protein synthesis in cells infected with Herpes simplex viruses Acta Virol 2001, 45:269-277 38 Wysocka J, Herr W: The Herpes simplex virus VP16-induced complex: the makings of ... activity of the p63 isoforms via the induction of their posttranslational modifications [36-44] The virion-associated host shutoff protein [(vhs), also known as UL41], which causes the degradation of ... cells were infected with the KOS strain of HSV1 at an MOI of 10 and maintained for 24 h in the absence or in the presence of Acyclovir (ACG) To determine the dependence of the TAp63γ expression...
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Báo cáo khoa học: " Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case of low pathogenicity" docx
... inform the decision regarding whether to institute antiviral therapy and help in determining the pathogenicity of the virus, we measured the PLI in four consecutive critically ill patients with ... on the number of quadrants with radiographic opacities), the ratio of arterial oxygen tension to fractional inspired oxygen, the level of positive end-expiratory pressure and the compliance, the ... at the discretion of the treating physician Aciclovir was withheld in the other two patients because it was presumed that the pulmonary infiltrates were not caused by HSV-1, on the basis of a...
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A microscopic examination of the interaction between antibodies, dengue virus and monocytes
... the transport of dengue between population centres of the world are the major contributors to the re-emergence of the disease [Gubler, 1998] With increased air travel and exchange of viruses across ... destruction of cities changed the landscape and places abandoned the colonial system [Halstead, 2006] Movement of troops during war aided the dispersal of the DENVs between population centres of the ... summarizes the known functions of the different viral proteins 28 (a) (b) Figure 1-8 Structure and proteome of DENV (a) Structure of whole virus showing each monomer of the E protein with domains...
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Báo cáo y học: " Analysis of a new strain of Euphorbia mosaic virus with distinct replication specificity unveils a lineage of begomoviruses with short Rep sequences in the DNA-B intergenic region" pdf
... shared with CpGMV at 90% of nucleotide identity Two additional observations support the hypothesis of intermolecular recombination: (1) The absence of a G-box element within the CR of the DNA-A ... inducing its degradation [55] Several DNA viruses (i.e., herpesviruses, adenoviruses, ascoviruses and polyomaviruses) encode miRNAs which participate in the regulation of some processes of the viral ... 103° 30’00’’ W) In the four cases the plants were co-infected with either PHYVV or PepGMV The complete sequence of the DNA-A and DNA-B genomic components of the unidentified begomovirus was obtained...
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Báo cáo y học: " The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site" ppt
... normalized the ratio of the p66 RT and p51 RT subunit content in most mutant viruses, suggesting near normal proteolytic processing and stability of RT p66 in these mutant viruses (Fig 2B) The impact of ... antibodies The positions of molecular size markers are shown to the left of each panel Arrows to the right of each panel indicate the positions and molecular masses of immunoreactive viral proteins The ... spread (data not shown), thereby validating the compensatory nature of the T477A substitution in the context of the F440V p51↓RNH cleavage site mutation Interestingly, the T477A substitution also...
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Báo cáo sinh học: " Macrophages and cytokines in the early defence against herpes simplex virus" potx
... nerves The two types of herpes simplex virus confer the genera Simplexvirus and -2, which were formally designated by the International Committee on Taxonomy of Viruses as Human herpesvirus (HHV) ... characterized the substances involved in the previously described interference of one virus with the replication of another unrelated virus, and the interfering activity of inactivated influenza virus with ... adapted to the human host and environment Thus, herpesviruses are capable of coping with the human immune defence in a balanced manner generally without serious threads to the life of the host Infection...
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