the role of non hla genes in the susceptibility to autoimmune disorders
Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... Stat 1-induced resistance to HSV-1 in vivo However, further studies are necessary to determine if chemokines and pro-inflammatory cytokines are also important contributors to Stat 1-dependent innate ... CyP's capacity to impair innate resistance to HSV-1 [56,57] Further study is needed to test this hypothesis Role of Stat in innate resistance to HSV-1 The biological functions of IFN-α/β and ... concluding that NK cells play no role in innate resistance to HSV-1 Likewise, we question the validity of comparisons of HSV-1 infection in mice that exhibit "high" or "low" natural cytotoxicity in...
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báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... Stat 1-induced resistance to HSV-1 in vivo However, further studies are necessary to determine if chemokines and pro-inflammatory cytokines are also important contributors to Stat 1-dependent innate ... CyP's capacity to impair innate resistance to HSV-1 [56,57] Further study is needed to test this hypothesis Role of Stat in innate resistance to HSV-1 The biological functions of IFN-α/β and ... concluding that NK cells play no role in innate resistance to HSV-1 Likewise, we question the validity of comparisons of HSV-1 infection in mice that exhibit "high" or "low" natural cytotoxicity in...
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Báo cáo khoa học: "the Role of Non-Timber Forest Products (NTFPs) in Livelihood Strategies and Household Economies in a Remote Upland Village in the Upper Ca River Basin, Nghe An, Vietnam" pdf
... costs The households can increase cash income by investing in livestock breeding due mainly to the low overhead associated with this activity (e.g low cost of caring for and transporting to market) ... among these households was the lowest of all groups, and they did not have the ability to invest in livestock or to follow another strategy Instead, they accepted work as employees to gain additional ... (23.3%) The roles of NTFPs in the livelihood strategies were considered a gap-filling supplement during the agricultural season and for diversifying sources of income The roles of NTFPs in Que...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... imaging technique (SENSE factor of 2) Imaging time of DWI was 90 s for 20 slices Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue On the other ... controls) Further study using larger numbers of patients is needed to establish the accuracy of ADC measurement in monitoring the effect of therapy for uterine cervical cancer For the diagnosis, McVeigh...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... with the model suggesting a transmembrane topology of CYPs with a single N-terminal membrane anchor and most of the remaining protein exposed to the cytosolic side [15,17,30,31] The intramitochondrial ... reduced to < 10% in the a ⁄ c mutant and < 3% in the a ⁄ b mutant, as compared to about 25% in the control strain We also tested the targeting to mitochondria of Su9-DHFR, in which the presequence of ... translocation of the cytosolic glutathione S-transferases to the mitochondrial matrix compartment, probably represent the targeting of noncanonical signal-containing proteins to the mitochondrial...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... lysine reduces the probability of forming the fully closed form of the protein The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine 120 in the ... proteins This was interpreted as a lack of fosfomycin binding to these mutant proteins [12] Binding of fosfomycin to either wild-type MurA or the K22 mutant proteins in the absence of UDPNAG is not ... concentration The dissociation constants, Kd values, enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... In line with this, alkaline hemin (ferriprotoporphyrin IX) has been shown to activate O2 to the hydroperoxide anion in the presence of NAD(P)H [150] with the immediate insertion of oxygen into ... oxygen into the benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives, ... BLM cofactor, other metals also bind strongly to the antibiotic [227] A key to the unique reactivity of the nonheme iron(II) site of BLM (Fig 5) toward O2 seems to reside in one of its equatorial...
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Tài liệu From Burden to “Best Buys”: Reducing the Economic Impact of Non-Communicable Diseases in Low- and Middle-Income Countries pdf
... needed to mitigate this impact It brings together findings from two recently completed studies that can inform international policy dialogue, including the UN High-Level Meeting on NCDs Their findings ... country income category) The total burden is lowest in the low-income countries, in part because the value of lost earnings in this group is low and in part because the total population of this ... gaps in our understanding of how to mitigate these challenges by highlighting recent findings about the social costs of NCDs and the resource needs for managing these conditions Specifically, the...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... determined as part of the investigation into the shielding from solvent of the electrostatic interaction between Asp113 and His210 With increasing NaCl, the maximum activity decreased, while the ... among serine proteases The close position of His210 to Asp113 guides us to a new way of thinking about the functional role of the former ionizable aromatic amino acid The pH optimum mechanism in API ... Amino–aromatic interactions in proteins FEBS Lett 203, 139–143 19 Chakrabarti, P & Samanta, U (1995) CH/, p interaction in the packing of the adenine ring in protein structures Advan Protein...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... concept in the adaptation strategies of enzymes to low temperatures As in the previous study [16], our interest is focused to the vicinity of the active site of the psychrophilic alkaline phosphatase ... strain TAB5 We particularly attempted to investigate the functional importance of the Gly pair, located in the vicinity of the active site of the cold adapted enzyme and to study its potential role ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... is GLDSV, indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence To determine whether DptF is the putative ... with the N-terminal tryptophan of the nonribosomally synthesized peptide is necessary Here, we report the results of a steady-state kinetic analysis of DptE The aim of this kinetic study was to ... bioselectivity of these antibiotics [9,10] It remains to be clarified whether all of the fatty acids activated by DptE can be incorporated into the final product or whether there is an interfering specificity...
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Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc
... effect of integrating the two genomic datasets into a single set via the sum of the kernel-similarity matrices Finally, we predicted a global network for all the genes of P aeruginosa In the inference ... cross-validation step, the known enzyme genes were randomly divided into two sets: the training set and the test set, in the proportion of nine to one First, we used the training dataset for a learning process ... Several of these high-scoring genes may be functionally related to PA1586 and PA0447 Taking into account the first three digits of the EC numbers, we assigned the high-scoring genes to each missing...
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Báo cáo khoa học: Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome docx
... the timing of the insertion of intron in the fabp1a gene Linkage group assignment of zebrafish fabp1a, fabp1b and fabp10 genes using radiation hybrid mapping The fabp1a gene was assigned to linkage ... D88¢ The interaction of amino acid D88¢ is due to crystal packing from a symmetry-related molecule and is of lesser importance [34] Variations in the residues involved in the binding at site of the ... concentration in the intestine increases sharply by three- to four-fold within 24 h of birth and increases another two-fold during the suckling period In hepatocytes, FABP1 mRNA is induced during the first...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... antigen-dependency To evaluate the OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the ... known to retain the specificity and affinity to antigen in itself [7,20] At least for these antibodies, the role of the VL domain might be to increase the affinity by supporting the VH domain The ... induction, two glutamine permease terminators (tHP) [15] were incorporated upstream and downstream of the spFv coding sequence To insert the terminator into the SapI site upstream of the lac promoter,...
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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
... keywords, all the inections of the verb are also considered Therefore, the initial query is expanded into: QUERY(Q209): paper AND clip AND (invented OR ) inventor OR invent OR invents) QUERY(Q258): ... Where did the ukulele originate ?, the expected answer type is L OCATION In the paragraph the ukulele introduced from Portugal into the Hawaiian islands contains two named entities of the category ... pull a sled in the Iditarod ?, since the denition of WordNet sense of noun harness contains the bigram pull cart and both sled and cart are forms of vehicles, the alternation of the pair of keywords...
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Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... (1979), the situational conditions of gift-giving may differ according to characteristics of the gift-giving occasion, whether the presentation of the gift is public, private, or anonymous, and whether ... uniqueness of the product; (6) time spent; (7) the store from which the gift is purchased (p.21) These results were the same if comparing between male and female behavior is the interesting finding of ... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content of the message which only emphasizes the benefits of the...
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The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... apart from financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase in the probability of attending college Further, when net worth is included in the model, ... factors, economic factors may also be important for explaining wilt In the case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either ... choose either of the latter two responses are defined as ―certain‖ youth, and there are 333 youth in the final weighted sample of certain youth Youth who respond that their chances of attending a...
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Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf
... levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear receptor that sequesters ... overexpression [29,30] The aim of the present study was to provide a better understanding of the contribution of Glc6P to the metabolic effects of glucokinase overexpression in hepatocytes and to test for ... also determines the cell content of Fru2,6P2, an allosteric activator of phosphofructokinase-1 [37], and is implicated in the control of gene expression of various enzymes involved in either glycolysis...
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