... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin ... replacement of R120 by lysine reduces the probability of forming the fully closed form ofthe protein The results obtained with the K22V/R120K double mutant protein point toward a central roleof arginine ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino...
... spillovers, ofnew large firms The positive spillovers include links with suppliers, increased consumer spending, the transfer of knowledge from one firm to another, andthe sharing of pools of workers ... well They include constraints on the supply of labor and other inputs, upward pressure on wages and rents, congestion of infrastructure, and (if fiscal incentives are provided to the locating ... recruitment The costs per job of incentive packages are generally measured in terms of gross new jobs at thenew firm The dollars of incentives are divided by the number of jobs During the recruitment...
... The motif present in DptF is GLDSV, indicating that this putative ACP domain is one ofthe few ACPs in which valine replaces isoleucine (I) or leucine (L) inthe conserved sequence To determine ... carrier proteins (ACPs) [14,15] The genes dptE and dptF are localized immediately upstream ofthe NRPSs of A21987C The resulting proteins DptE and DptF were predicted to be involved inthe lipidation ... Assay Fig In vitro phosphopantetheinylation of apo-DptF and apoAcpK Coomassie blue-stained SDS–PAGE gel (left) and in- gel fluorescence (right) ofthe fluoresceinyl-ACP (+) indicates the reaction...
... understand the meaning ofthe questions in this section Each session took 30 including instructions at the beginning, the listening comprehension task, and completion ofthe questionnaire The questionnaire ... placement inthe IEP was determined on the basis of an in- house placement test of listening, reading, and writing skills (reliability coefficients for the listening and reading sections of this ... the listening task so as not to bias any ofthe responses Results and Discussion To give the reader a better idea ofthe types of gestures the participants saw inthe lecture, discussion of the...
... businesses, the traditional target client group of savings banks By capturing and channelling more ofthe remittances into the financial system and intermediating the flow ofthe resources, savings ... disbursing of loans and collecting loan repayments Another promising track for savings banks is to invest their savings deposits in microfinance institutions by specialising 18 Microfinance Information ... countries andin Latin America and Asia, the figures also remain well below the average requirement ofthe banking system The microcredit schemes of savings banks Although savings banks are savings...
... University in St Louis andtheNew America Foundation in Washington, DC The College Savings Initiative is supported by the Lumina Foundation for Education andthe Bill & Melinda Gates Foundation The ... important for explaining wilt Inthe case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... for their youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this...
... rolein protein stability [8], and their involvement in interactions with cations offers new perspective inthe analysis ofthe contribution of ions as cofactors in protein folding [38] andin ... those observed for the wild-type, indicating the involvement of Glu53 and Asp287 inthe interaction with the cation (Fig 1E,F) The regain of aromatic chirality at 295 nm andinthe 260270 nm region ... [2] The solid lines through the mutants unfolding data points (lled symbols) are intended to guide the eye ofthe reader and not represent the tting ofthe data Reversibility points are indicated...
... ADAM10 and TACE are involved inthe shedding of APP, neither ADAM is involved inthe shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials and ... expressing ACE were transfected with the ASOs and then exposed to APMA andthe levels of soluble ACE inthe medium examined (Fig 5) APMA caused a twofold increase inthe shedding of ACE from the ... ADAM10 and TACE play a roleinthe a-secretase shedding of APP, neither protease was responsible for the shedding of ACE APMA stimulates the shedding of ACE but not APP The effect ofthe organomercurial...
... facility level in Zambia served inthe capacity of district managers of health programmes The finding that the nurses in Sudan were less involved in planning of activities (15.2% in polio andin measles) ... measles Roles of nurses and midwives in SIAs for polio and measles The involvement ofthe nurses and midwives in activities related to polio and measles SIAs is presented in Table In general, the ... midwives inthe expanded programme on immunization Study objectives The objectives of this study were to document the roles, functions and contribution of nurses and midwives inthe delivery of routine...
... part ofthe risk group Inthe case ofthe first LEs combination exposed at Table of breaking up with a boyfriend/girlfriend and failing a grade in school involves a sufficient impact to be part of ... between LEs on HRQoL by running similar models where the gender andthe interaction between gender and LCU scores were included and evaluating the significance ofthe interaction effect with a ... Spain Authors’ contributions JMV, LR, and JA participated inthe conception and design ofthe study EVO, SRF, GV and JAPV analyzed the data EVO, JMV, MH, MF, LR and JA participated inthe drafting...
... Engineering in providing services to the government, the public, andthe scientific and engineering communities The Council is administered jointly by both Academies andthe Institute of Medicine ... president ofthe National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... autonomous in its administration andinthe selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government The National Academy of Engineering...
... curves for the growth indices ofthe ’young’ (< 60 years) andthe ’old’ (> 65 years) rings (cambial age) Inthe final stage, the curve ofthe growth indices IC0 was modelled according to the available ... III and IV) The case of July appears somewhat disconcerting because the related parameters andthe from years y, y- and y- on the hand, and years y- and y- on the other, can be given opposing ... structure and on the rooting ofthe trees owing to the impermeability ofthe subsoil Ofthe recent dendroecological studies that demonstrate a long-term increase inthe wood production rate of forest...
... ubiquitination of various target proteins, andthe intracellular domain ofthe Notch receptor (involved inthe maintenance of cells in an undifferentiated state), both of which notably contain ankyrin repeat ... vascularity and inflammatory signalling pathways Inthe present review we focus on current knowledge ofthe regulation ofthe HIF pathway, and then consider the potential roleof hypoxia inthe pathogenesis ... in RA, and this may yield further insight into the links between hypoxia, angiogenesis, inflammatory cell trafficking and matrix breakdown in RA Competing interests The authors declare that they...
... cyclin E in all invasive carcinomas andinthe subgroup of IDC This may be due to the early stage ofthe disease The major limitation of this study is the small size ofthe study group Further ... positive staining in less than 5% of nuclei); low staining = moderate to strong positive staining in 5% to 50% of nuclei; high staining = moderate to strong positive staining in more than 50% of nuclei ... follow up of more than 36 months There were 59 infiltrating ductal carcinomas (not otherwise specified and variants) and infiltrating lobular carcinomas The infiltrating ductal carcinoma group included...
... at the start of night prolongation, or 12 wk, an important roleinthe possibility ofthe buds to attain a deeper stage of dormancy Only the 12 wk old plants of northern origin had no flushing ... the chilling requirement to break winter dormancy in Scots pine has been stressed (e.g., Wareing, 1951; Vegis, 1965; Sarvas, 1974) Inthe following,I will use the working definition of dormancy ... (Fig 2) The same was true for the higher temperature 25/15°C compared with 25/5°C Dormancy breaking treatments ofand wk had a dramatic influence, hastening the tilushing rate, especially in the...
... ubiquitination of various target proteins, andthe intracellular domain ofthe Notch receptor (involved inthe maintenance of cells in an undifferentiated state), both of which notably contain ankyrin repeat ... vascularity and inflammatory signalling pathways Inthe present review we focus on current knowledge ofthe regulation ofthe HIF pathway, and then consider the potential roleof hypoxia inthe pathogenesis ... in RA, and this may yield further insight into the links between hypoxia, angiogenesis, inflammatory cell trafficking and matrix breakdown in RA Competing interests The authors declare that they...
... Figure Lack of HPV16 Infection inthe absence of cathepsin B Lack of HPV16 Infection inthe absence of cathepsin B HPV16 infection levels in cathepsin B and cathepsin L deficient (-/-) and wild ... cathepsin B or cathepsin L protease, Figure Cathepsin B and L treatment of HPV16 increases binding Cathepsin B and L treatment of HPV16 increases binding Reporter virus binding was compared in ... cathepsin L enhanced infectivity by cleaving and removing a highly glycosylated mucin domain inthe Ebolavirus glycoprotein and resulted in increased binding suggesting that cathepsins are indeed...
... [66] The binding of PTN with syndecan-3 induces neurite outgrowth of embryonic neurons [67] Heparitinase, which cleaves the heparin sulfate chain and disrupts the binding of PTN, inhibits PTN-induced ... tips It binds to the FGFR2b on the epithelial cells and transmits a signal to induce the initiation ofthe lung bud [17-22] Recombinant FGF10 alone can induce budding inthe lung epithelial explants ... and ciliated epithelial cells inthe adult lung [11] HFH-4 induces the expression of βtubulin IV inthe pseudoglandular stage, and promotes the differentiation of ciliated epithelial cells Other...
... evaluated immunohistochemistry, and participated inthe design ofthe study and drafting ofthe manuscript The data presented in this manuscript are part ofthe doctoral thesis of SA 12 13 14 15 16 17 ... with the results of a previous study involving the chemical (Triton X-100) ablation ofthe murine tracheal epithelium [3] Removal ofthe airway epithelium also led to a significant reduction inthe ... response following cholinergic stimulation, as shown in this andin an earlier study [11] These data clearly indicate that the release of epithelial ACh is not involved inthe 5-HT-induced bronchoconstrictor...