the neuroendocrine system and rheumatoid arthritis focus on the hypothalamic pituitary adrenal axis
Báo cáo y học: "Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability" ppt
... application of an extreme stress sol production and then returning to the original state Figure shows a simulation of the response of the HPA axis to a short stress The initial condition of the HPA axis ... research on HPA axis function in chronic diseases has been hampered by the complexity of the numerous systems affected by the HPA axis, such as the immune and neuroendocrine systems, the lack ... response to stress The increased concentration of cortisol induced the synthesis of GR and the inhibition of pituitary ACTH When stress was applied for long periods, GR synthesis continued and...
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Báo cáo y học: "Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis" pdf
... vivo [25] Thus, the role of the cannabinoid receptor system in bone remodelling and aspects of pathological conditions such as periarticular bony erosions in RA and subchondral bony sclerosis in ... implicated in the induction of osteoclast differentiation and bone resorption [49], and all of our patients had bone -on- bone changes somewhere within their arthritic knees, reflecting the severity ... and histology scoring, and contributed to the writing of the manuscript AJR contributed to the writing of the manuscript VC designed research and significantly contributed to the writing of the...
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The Six Driving Forces That Affect Your Business Plan _ And How to Focus on the Best One for Your Company’s Needs
... FOCUS TO CLARIFY YOUR MISSION Once we had the sales force’s attention, we moved on to the mission Clearly the interpretation of the mission by each camp was further distorting and inflaming the ... up-front with the customer in a one -on- one relationship pays great dividends in the long term People and businesses pay premium prices to have their needs legitimized, their concerns heard, and their ... specific store, and are shipped out in the afternoon The product enters the store and is immediately on the shelf The production-to-consumer sequence is short, controlled, and efficient Another example...
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" ppsx
... replacement therapy on disease progression and bone mineral density in rheumatoid arthritis J Rheumatol 2003, 30:1456-1463 Carlsten H: Immune responses and bone loss: the estrogen connection Immunol ... Belgium), and Wyeth (Madison, NJ, USA) Authors' contributions The QUEST-RA Study was designed and conducted by TS and TPincus All authors participated in data collection concerning their clinical ... Effect of pregnancy on the onset and course of rheumatoid arthritis Ann Rheum Dis 1953, 12:227-229 Brennan P, Bankhead C, Silman A, Symmons D: Oral contraceptives and rheumatoid arthritis: results...
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Báo cáo y học: "Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis" doc
... fragments from the heparin column, and Centriprep (Amicon, Beverly, MA, USA) concentration of the 250 mM NaCl fraction [15] Electrophoresis One-dimensional (1D) and two-dimensional (2D) electrophoresis ... interactions between chondrocytes and their insoluble extracellular matrix Based upon their potential roles in the pathogenesis of arthritis, the species described in this study also constitute candidate ... to ~170-kDa bands decreased in the gelatin-bead FT fraction in comparison with the starting material (Fig 2, top panel) Furthermore, the average intensity of the ~170-kDa band in the FT was 61.5...
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Báo cáo y học: "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction" potx
... hyaluronan concentration is determined by the production volume of hyaluronan, the elimination volume of hyaluronan from the joint, and the total volume of joint fluid The production of hyaluronan ... osteoarthritis hyaluronidase-1, -2, and -3 in the synovium synthase-1, 2, and -3 and (OA) levels of the messages (RA) Relative expressionand rheumatoid arthritis for hyaluronanof knees in 2, and ... for hyaluronidase-1 and hyaluronidase-3 message expression The expression of the message for hyaluronidase-2 was significantly greater (400% of the control value), while the expression of messages...
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Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx
... of bone destruction (Fig and see Supplementary material) These results indicate that NFAT5 and Fbx3 could be correlated not only with the proliferation but also with the activation and invasion ... likely play a critical role in maintaining the long-term activation of RA-SF and thereby contribute to matrix degradation In addition to the expression of these anti-apoptotic molecules, RA-SF show ... lines and inhibits cell proliferation when overexpressed [31,32] On the other hand, RNASE mediates the antiviral and antiproliferative roles of interferons and is induced during growth inhibition...
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Báo cáo y học: "Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study" docx
... design of the study and to the interpretation of the results LP had the main responsibility for the genetic analyses and contributed to the analysis and interpretation of the results LA and LK were ... work and contributed to the interpretation of results and the writing of the manuscript CB contributed to the design of the study, to the collection of the data, to statistical analysis and to the ... received their questionnaire in connection with inclusion into the study at each study centre (i.e in connection with the time point of the RA diagnosis), whereas the controls received their questionnaires...
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Báo cáo y học: "What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register" ppt
... for the probable phenomenon that the more severe the disease, the more intensive the therapy The question can conversely be turned on its head, and the data can be used to address questions of ... activity in their joints while they are off treatment Persistence is the opposite of remission There are problems in the literature regarding the definition of remission and the resolution of IP ... affect the severity of the disease and genes that affect the handling of the drug Then there are psychosocial factors such as adherence to and expectations of therapy outcome Finally, there are...
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Báo cáo y học: "Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis" pot
... protein and APRIL in arthritic joints of patients with inflammatory arthritis Arthritis Rheum 2003, 48:982-992 30 Ronnblom L, Alm GV: Systemic lupus erythematosus and the type I interferon system Arthritis ... depicts the cytokine level, and the unbroken line depicts the B-cell frequency (b) Two patients with rheumatoid arthritis (RA) (R17 and R3) representing the relation of B-cell frequency (left y -axis) ... http:/ /arthritis- research.com/content/8/6/R167 Figure Correlations of BAFF (B-cell activation factor of the tumour necrosis factor family) and APRIL (a proliferation-inducing ligand) (a) Negative correlaligand) tion of the...
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Báo cáo y học: "The relationship between cancer and rheumatoid arthritis: still a large research agenda" ppsx
... Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and ... meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis Arthritis Res Ther 2008, 10:R45 Chakravarty EF, Genovese MC: Associations between rheumatoid arthritis and malignancy ... C, Klareskog L: Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis Arthritis Rheum 2006, 54:692-701 Baron JA, Sandler RS, Bresalier RS,...
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Báo cáo y học: "Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis" pptx
... homology with IL-4, and it stimulates proliferation and differentiation of B cells and induces IgE and IgM production The role played by these genes in RA susceptibility and severity is not clearly ... approaches We stratified the study subjects according to the genotype of one gene and performed the analysis of the other gene on different strata using the Mantel-Haenszel test Deviation from independence ... either individually or in combination Competing interests The authors declare that they have no competing interests Authors' contributions AGW conceived and designed the study All authors contributed...
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Báo cáo y học: "κ The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis" ppsx
... discussion, we first provide some background on the generation of Th17 cells, which are the main producers of IL-17 We then discuss the biologic effects of Th17 and IL-17 in the context of RA, and the ... metalloproteases, cathepsin G and elastase, leading to destruction of the extracelluar matrix and cartilage, and further bone erosion [113] IL-17 and IL-6 block matrix synthesis by articular chondrocytes; ... and concomitantly decreases OPG expression in osteoblasts, causing enhanced formation of osteoclasts and bone erosion Neutrophils also contribute to bone and cartilage degradation by secretion...
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Báo cáo y học: "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" potx
... replacement therapy on disease progression and bone mineral density in rheumatoid arthritis J Rheumatol 2003, 30:1456-1463 Carlsten H: Immune responses and bone loss: the estrogen connection Immunol ... Belgium), and Wyeth (Madison, NJ, USA) Authors' contributions The QUEST-RA Study was designed and conducted by TS and TPincus All authors participated in data collection concerning their clinical ... Effect of pregnancy on the onset and course of rheumatoid arthritis Ann Rheum Dis 1953, 12:227-229 Brennan P, Bankhead C, Silman A, Symmons D: Oral contraceptives and rheumatoid arthritis: results...
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Báo cáo y học: " Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis" ppt
... interpretation of data and in drafting and revising the article RHS participated in the concept and design, analysis and interpretation of data, and drafting and revising the article Acknowledgements The ... Competing interests The authors declare that they have no competing interests Authors' contributions BR and SG participated in the concept and design and acquisition of data RW and MF participated ... installed at the forefront of the innate immunity cascade in RA [30] Riepl et al Arthritis Research & Therapy 2010, 12:R110 http:/ /arthritis- research.com/content/12/3/R110 Conclusions In conclusion,...
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Báo cáo y học: "Citrullination, a possible functional link between susceptibility genes and rheumatoid arthritis" ppsx
... more closely conserved to PAD4 sequences of other species (two of the three positions conserved) than the nonsusceptible haplotype (one of the three positions conserved) Interestingly, the fourth ... citrullination and RA Their study, however, leaves open some intriguing research questions What are the effects of the amino acid substitutions on the enzymatic function of PAD? What are the effects on ... lead to an amino acid substitution, is at a 100% conserved position Only one of the three amino acid substitutions leads to a change in the electrostatic character of the residue This SNP (padi4_89)...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
... but the consequence to the individual may be considerable With conventional NSAIDs, there is the risk of major harm through gastrointestinal ulceration, perforation, and bleeding These events consume ... usually of months' duration or longer, and required long-term treatment with anti-inflammatory drugs or other analgesics for the control of pain Further details of inclusion and exclusion criteria ... medication throughout the study, and if randomisation blind was broken, the patient was removed from the study Discontinuation Details of discontinuations are shown in Table All-cause and lack-of-efficacy...
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Báo cáo y học: "Natural killer T cells and rheumatoid arthritis: friend or foe" ppt
... inflammation A particularly fascinating and novel aspect of the current report is the notion that Vαi NKT cells may actively contribute to synovial inflammation by residing in a niche where they are ... elucidated Taken together, the data illustrate the multifaceted roles of Vαi NKT cells in autoimmune diseases, particularly RA, and underline the important and non redundant role of these innate-like ... warrants further investigation [15] Likewise, the precise mechanism(s) by which Vαi NKT cells are attracted to synovial tissue and the reason(s) why they get activated locally in the K/BXN serum transfer...
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Báo cáo y học: "Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens" ppt
... conversion of DHEA, ASD, and testosterone in synovial tissue of patients with RA and OA We functionally tested hormone conversion in mixed synovial cells of RA and OA patients and tried to find the ... detect spontaneously released estrogens and testosterone, we superfused standardized synovial tissue slices and measured hormone concentrations in the superfusate R944 Arthritis Research & Therapy ... Discussion This study demonstrated three important new aspects of hormone conversion in primary synovial cells and synovial tissue of long-standing RA and OA patients in the advanced phase of the...
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Báo cáo y học: "Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis" pps
... functional implications of this observation are unclear and require further examination to include other TLR agonists and DC activation conditions In particular we now wish to examine the cross-regulation ... citation purposes) A further novel observation was the reduced CD62L expression on both DC subsets in PsA PB and RA PB Reduced CD62L expression on RA PB CD3+ and CD19+ lymphocytes, monocytes and ... healthy control PB mDCs and PB pDCs, respectively RA SF and PsA SF contain mDCs and pDCs The aforementioned data strongly suggest that DC subset distribution in inflammatory arthritis is abnormal and...
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