the molecular biology of sensory map plasticity in adult mammals
EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
... down its effect On the other side blocking the intracellular tyrosine-kinase domain could also inhibit the activation of the signaling pathways The latest way came into the front in past few years, ... Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications the growth rate of glioma cell lines so it was found to be involved in the progression of pri‐ mary brain tumors ... β1-integrins leads also to decreased motility, whereas inhibition of αv -in tegrin causes increased motility The integrin αvβ3 plays a central role in glioma invasion Increased expression of integrin...
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Báo cáo sinh học: "The molecular epidemiology of Stenotrophomonas maltophilia bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004" pot
... evidence of epidemiological relationships between strains and is an important tool in the investigation of the spread of infectious diseases [4] Such molecular fingerprinting methods to compare strains ... and interpretation of the clinical data All authors have read and approved the final manuscript We did not find the susceptibility tests performed helpful in distinguishing the strains or in choosing ... Line Cellulitis Pneumonia Line Line Febrile neutropenia Line-related abscess Line Line Line Line Line Line Line Line Line Line Line Line Y Y N N N N Y Y N N N Y N Y N N N N N N N Y N N Y Recovered...
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Báo cáo sinh học: " Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies" doc
... with inactivated viral vaccine provides significant protection in animals against challenge with certain corresponding pathogenic CoVs, in the case of SARS-CoV there remains the threat of introducing ... without administration of corticosteroids [44,45] Since then, the wealth of information that has emerged on SARS-CoV molecular and cellular biology, as updated in the preceding sections of this ... one SARS-CoV strain infection in one animal species or cell line in the development of a human vaccine The rapid development of an effective SARS-CoV vaccine depends upon continuing basic research...
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báo cáo hóa học:" Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies" pot
... with inactivated viral vaccine provides significant protection in animals against challenge with certain corresponding pathogenic CoVs, in the case of SARS-CoV there remains the threat of introducing ... without administration of corticosteroids [44,45] Since then, the wealth of information that has emerged on SARS-CoV molecular and cellular biology, as updated in the preceding sections of this ... one SARS-CoV strain infection in one animal species or cell line in the development of a human vaccine The rapid development of an effective SARS-CoV vaccine depends upon continuing basic research...
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Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt
... Determination of full-length cDNA sequences using the RACE method in both strains revealed the presence of a single point mutation in 1337 nucleotides of BmIVD In the sku mutant, the 1127th guanine ... wild-type BmIVD indicated that all the side chains in the loop connecting helices I and J are exposed on the surface of the monomer, pointing toward FAD or its neighbouring monomer in the tetramer ... Isoalloxazine ring of FAD is required for the formation of the core in the Hsp60assisted folding of medium chain acyl-CoA dehydrogenase subunit into the assembly competent conformation in mitochondria...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf
... cytokines, including IL-1b, TNF-a and IFN-c (B) Chemokines expressed in the joint recruit leukocytes into the joints In addition to functioning in cell trafficking, several chemokines have other biological ... concentrations of several chemokines Chemokines in the joints of patients Table Chemokines and chemokine receptors expressed in the joint of RA patients Systemic name CC chemokines CCL2 CCL3 ... et al Chemokines in the joints of patients CXC chemokines C and CX3C chemokines Interleukin-8 ⁄ CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... with the amino group of the main chain at Glu268 The oxygen of the main chain at Asp266 was bound to amino groups of main chain of Tyr269 and Ala270 by hydrogen bonds The interactions should maintain ... temperature indicates the stability of the structure of the protein The difference of the increments between the inactive temperature and the Tm should indicate that the mutations improved the stability ... surrounding residues of the depression, and the side chain of the mutated residue might restrain the mobility of the N-terminal region on the surface by interaction with the main chain of Lys26 by van...
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Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf
... resulting from the occupancy of the first binding site [68] TTR is also involved in the transportation of retinol by forming a complex with the smaller retinolbinding protein (RBP) [69,70] The TTR–RBP–retinol ... these low -molecular- mass diffusible species can bind to lipid membranes In the model, binding to the lipid membrane disrupts the structure of the lipid rafts, thereby inducing changes in the membrane, ... ˚ H strand of the opposite dimer, creating a 50 A central channel that contains the two binding sites for thyroxine [81] The four binding sites for RBP are located on the surface of a TTR molecule...
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Báo cáo khoa học: The molecular basis of heme oxygenase deficiency in the pcd1 mutant of pea pot
... minimization of the resulting model The active site heme ligand in the model of the pea HO was derived from that found in the human enzyme Visual inspection of the model was performed using the ... cDNA sequences of PsHO1 indicating the location of intron-exon boundaries The position of the mutation in pcd1 causing premature chain termination is indicated Numbers refer to the first and last ... Overall fold of PsHO1 including position of the bound heme molecule (B) Close up of heme binding pocket An asterisk indicates the space above the plane of the heme molecule, that is present in plant,...
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molecular biology of the parathyroid - tally naveh-many
... 3’-UTR Binding Proteins and Their Function 61 Identification of the Minimal cis Acting Protein Binding Element in the PTH mRNA 3’-UTR 62 The Structure of the PTH cis Acting Element ... an increase of serum calcium through renal reabsorption and intestinal absorption, the latter is caused by the induction of the synthesis of the active form of vitamin D in the kidney Bone is the ... determined by comparing the sequence of the gene to the previously determined cDNA structure The location of intron A of the rat was determined by comparing the gene sequence with the sequence of...
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Báo cáo khoa học: " Variation in the molecular weight of Photobacterium damselae subsp. piscicida antigens when cultured under different conditions in vitro" pot
... eseht ni ecnatsissa rieht rof ,ylatI ,enidU 00133 ,81 on airehgnU elaiV ,enidU id atisrevinU ,elaminA enoizudorP alled ezneicS id otnemitrapiD ,izzartsellaB oflodoR rD dna innaZ ocraM rM knaht ot ... suhcrartneciD( iniznarb id ireis ied evittaeronummi de ehcisif ehcitsirettaraC A attoraM ,L sileinaD ,A aressaP ,A ingaM ,G ittegroiG ,G aihcseC ,E inilozzaM 42 239-729 ,15 ,5891 hsiF icS coS npJ lluB euqinhcet ... cificeps-noN rettolbsnart reffeoH a gnisu nim 07 rof V 06 gniylppa yb senarbmem esolullecortin otno derrefsnart erew airetcab elohw gniniatnoc sleG leg hcae rof sdradnats sa desu erew )ASU ,daR-oiB( srekram...
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Báo cáo khoa học: "Molecular dissection of the quantitative inheritance of wood property traits in loblolly pine" pps
... that the microfibrils of the S2 layer of the cell wall make with the longitudinal axis of the cell [20] Lower fibril angles (closer alignment with the axis of the cell) have a positive influence ... quantitative trait locus (QTL) mapping Our QTL mapping experiments have provided estimates of the number of genes controlling some of these traits, the relative proportion of phenotypic variance controlled ... fact segregates in the mapping population Thus, at least one parent of the mapping population must be heterozygous for as many of the QTLs that control a trait as possible Also, the phenotypic...
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Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx
... examined whether sIL-6R and IL-6 are involved in joint destruction in RA patients [13] The number of osteoclast-like multinucleated cells found in the synovial tissues derived from the knee joint ... differentiation In conclusion, control of the production of RANKL, of OPG and of other T-cell-derived cytokines in RA patients will provide a clue for strategies of the development of new treatment for inhibiting ... stimulated in RA patients, the mechanism of the joint destruction in RA patients remains to be elucidated The levels of monocyte/macrophage-derived cytokines such as IL-1 and IL-6, together with...
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Báo cáo y học: "Elucidating the molecular characteristics of organogenesis in human embryos" potx
... differences in the role of the transcription factor Pax6 in the specification of the neurectoderm - the ectodermal cells that will develop into the animal’s nervous system They determined that ... determine whether these findings implicate important species-specific differences in the regulation of organ development Charting the loss of pluripotency Fang et al also took advantage of the ... dataset they gener ated to compare the gene-expression profile of human embryos with that of human embryonic stem cells (hESCs) maintained in culture They found that approxi mately 20% of the genes...
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Báo cáo y học: " Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage" ppt
... antiretroviral therapy since their binding to HIV-1 LTR in a sequence specific manner is associated with the repression of LTR activity [97,98] Interestingly, zinc-finger protein can influence the chromatin ... resulting in persistent infection of monocytic cells [137] HIV-1 infection first results in a decrease of Bcl-2 and thioredoxin, permitting an initial boost of replication Then, as the synthesis ... http://www.retrovirology.com/content/7/1/32 via the P38-MAPK pathway and is involved in the reactivation of latently infected macrophages [91] The zinc-finger protein OKT18, which is produced during HIV-1 infection of macrophages,...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
... common in HIV-2 than in HIV-1 infection Still, little is known about the role of humoral immunity in the evolution of the HIV-2 env gene In the present study we analyze, for the first time, the molecular ... is the main driver of the rapid intra-host evolution of the C2 and C3 regions in HIV-2 [15,25,58,60,64-66] Indeed, we found that most of the amino acids under selection are located in C2, including ... below), in the envelope complex of HIV-2 differs substantially from that of HIV-1 Glycans on HIV-1 envelope protein play an important role in the folding of the glycoproteins, in infection and in...
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Molecular biology of the lung and kidney of the african lungfish, protopterus annectens, during three phases of aestivation cystic fibrosis transmembrane conductance regulator, gulonolactone oxidase and p53
... studied the differential gene expression in the liver of P annectens at the end of the induction phase and the beginning of the maintenance phase Their results confirmed the importance of reconstruction ... the mRNA expression of these cftr isoforms in the lungs of P annectens during the induction, maintenance and arousal phases of aestivation The hypothesis tested was that the mRNA expression of ... expressed in the lung of P annectens, suggesting that noncoding DNA may not be the only reason to explain the huge genome of P annectens The predominant isoform of Cftr from the lungs of P annectens...
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The role of ORF3 protein in the molecular pathogenesis of porcine circovirus 2 infection
... the genome The sequence to the 3’ of the stem-loop structure contains the hexamer repeats CGGCAG which act as the binding site for the Rep proteins The numbering of the nucleotide begins in the ... expedites the spread of the virus by inducing the early release of the virus from the infected cells Further, in PCV2 infected mice, the ORF3 induced apoptosis also aids in recruiting macrophages ... Our findings on the molecular activity of ORF3 have also led us to speculate other potential uses for the protein In the third part of the thesis, the role of ORF3 mediated apoptosis in the egress...
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Developing miniemulsion polymerization for use in the molecular imprinting of protein with nanoparticles
... development of a new strategy and technique for the molecular imprinting of protein macromolecules The main considerations include (1) the compatibility of the imprinting system with the template protein ... Minoura, 2001) In their investigation, instead of imprinting the entire protein molecule, they imprinted just a small peptide fraction of the protein This short peptide is the epitope of the 16 ... surfactant-induced denaturation of globular proteins and the formation of proteinsurfactant complexes is as shown in Figure 2.5 The initial step involves the binding of the surfactant head group to the...
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Molecular analysis of the breeding biology of the asian arowana (scleropages formosus)
... and long fins of the RG1 and the intense colouration of the MG One of the shortfalls of the hybrid is the large variation of phenotypes produced in their offsprings which is common in hybridisation ... possibility of kinselection occurring in the pond where kins are helping each other in parental care The grey bar indicates the k value of the thief with the genetic father where the white 18 ... Figure 12: The breeding cycle of the Asian arowana in the farm The graph shows the total production in terms of number of batches（dotted line）and number of offspring (solid line) for the three...
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