the interaction of antigens and superantigens with the human class ii major histocompatibility complex molecule hla dr1
Characterization of the interaction of EEN and its domains with ca2+ and proline rich domain
... the dimer by the FPLC because of the large molecular weight (Figure 4.1.3) In further, these polymers may accelerate the process of the EEN aggregation Therefore preventing the formation of the ... acids sequence of ΔBAR domain of EEN Green letters stands for the SH3 domain; Black letters stands for the random coil domain The ΔBar domain which consists of the SH3 domain and the random coil ... studies of the structures and functions of the EEN and its three domains Native PAGE, Circular Dichroism and NMR were used to exploit the interaction of Ca2+ with EEN and its domains 2-D NMR and ITC...
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STUDYING THE EFFECTIVENESS OF ANIMATION AND GRAPHICS WITH TEXT ON FOURTH, FIFTH AND SIXTH GRADERS potx
... through the cylinder As the rod is pulled out, air passes through the piston and fills the areas between the piston and the outlet valve As the rod is pushed in, the inlet valve closes and the piston ... through the outlet valve The movement of the handle, piston, an inlet valve and a cylinder creates a cause and effect which is self explanatory with the aid of animations and text as compared with ... FIGURES AND TABLES viii I INTRODUCTION Context of Study Effects of combining visuals with text Cognitive processes involved in learning Purpose of the Study Significance of the Study Statement of...
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Báo cáo y học: "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein" doc
... shown with the copy of α-4, tk and gC genes of HSV1 at 24 hours post-infection in cells with CTMP-7 expression being inhibited c Viral loads shown with the copy of α-4, tk and gC genes of HSV1 ... viral envelope and the exterior membrane facilitates egress of the enveloped virion from the nucleus via the cis-network and remains in the cisterna of perinuclear space The virion is then transported ... Co-immunoprecipitation of the VP26 and CTMP-7 interaction complex and immunoblot by anti-CTMP-7 antibody Vero cells transfected by VP26 and CTMP gene and labeled with 35S-methionine were lysed in RIPA buffer and...
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Báo cáo y học: "Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models" pot
... of exogenous and endogenous molecules In humans, CYP3A represents one of the most important subfamilies of the P450 superfamily CYP3A4 is the major P450 in the liver and intestine and has been ... protein binding of three compounds and their glucuronides, the unbound fraction of the glucuronide increased by factors of 2.2, 1.3 and 2.6 [39] For the purposes of the present study, the fraction ... 4:13 the prediction of the effect of ITZ and OH-ITZ CYP3A inhibition in the pharmacokinetics of MDZ and its metabolites The coupling was done such that the clearance of MDZ was affected by the...
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Báo cáo y học: "Baseline values from the electrocardiograms of children and adolescents with ADHD" docx
... T wave obscured the offset of the T wave, then the offset of the QT interval was defined as the intersection of the tangent to the midpoint of the downslope of the T wave and the isoelectric ... Frequencies of prolonged QTc intervals The frequency of prolonged QTc was determined using the Moss and Robinson criteria of > 460 ms and the regulatory criteria of > 500 ms With the criteria of a QTc ... trials For the cardiologist readings, the offset of a new QT interval was defined as the intersection of the line drawn along the downslopes of the T wave and the isoelectric line U waves were ignored,...
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Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot
... effects of ligand-activated RARa and RXRa on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-cisRA, on the promoter ... of RA treatment on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of over-expressing RARa and RXRa on the promoter activity of the hGnRH II gene in TE671 and ... formation of Complex A, indicating that the p65 subunit and members of the RAR family are involved in the DNA–protein Complex in TE671 cells Intriguingly, along with the abolition of Complex A...
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Báo cáo hóa học: "The toxicity of cadmium and resulting hazards for human health" ppt
... of osteomalacia and severe skeletal decalcification could be observed Criticism of this study came up because of the fact that the majority of the patient collective was made up of women in the ... transporting complexes, endocytosis of proteins Cd-MT, Cd-Protein Figure Handling of cadmium in human body Handling of cadmium in human body Figure legend text: Metabolism, storage and excretion of cadmium ... makes up for the major part of the cadmium body burden The amount of cadmium in the kidney tubulus cells increases during every person's life span A perturbance of the phosphor and calcium metabolism...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
... contrast, the LEW.1F strain is a low responder to immunization with CII [15] but is highly susceptible to MIRP On the other hand, the murine MIRP and CIA models are both dependent on B cells for the ... high scores However, the symptoms in these strains did not proceed in relapses as they did in the QD and B10.Q mice, and therefore resulted in a lower mean score than for the other strains (Fig ... of the cartilage were observed in sections from the nose, trachea, and larynx, and the degree of pathologic changes was correlated with clinical scores The inflammatory infiltrates consisted of...
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báo cáo khoa học: " Identification of genes differentially expressed during interaction of resistant and susceptible apple cultivars (Malus × domestica) with Erwinia amylovora" pdf
... putative function of the 32 genes Page of 10 tested by qPCR and their pattern of expression, we suggested in the figure a possible representation of involvement of these genes dureint the interaction ... markers The profile of expression of other ESTs will be verified in the future Conclusion The overall goal of this project was to characterize the genomic response of apple to fire blight These ... This burst is the result of the combined action of two hrp effectors of E amylovora HrpNEa and DspA/E [15] An increase in photosynthetic activity stimulates the production of ATP and sugar This...
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Báo cáo khoa học: " The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection" ppsx
... addressing the role of endosome proteases in the disassembly of HPV16 [24], the authors negated the role of cathepsin B and L in the HPV16 infectious process The differences between our studies and theirs ... absence of cathepsin B Lack of HPV16 Infection in the absence of cathepsin B HPV16 infection levels in cathepsin B and cathepsin L deficient (-/-) and wild type (+/+) MEF cells were analyzed and compared ... blocks the trafficking of HPV16 to caveosomes Ammonium Chloride blocks the trafficking of HPV16 to caveosomes Infection of 293 cells alone in the absence (A and C) or presence (B and D) of 20 mM of...
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Báo cáo y học: "Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocyte" pot
... to the complex homeostatic signalling pathway known as the unfolded protein response (UPR) The UPR system is involved in balancing the load of newly synthesized proteins with the capacity of the ... reported the role of GS in counteracting the IL-1β-mediated increase of inducible nitric oxide synthase (iNOS) and the decrease of heme oxygenase, and indicated that the influence of GS and CS ... would allow both the inclusion of more samples to be analyzed and the performance of time-course or doseresponse experiments) As a proof of the act, in this work (and based on their previously...
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Báo cáo y học: " Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27kip1" ppsx
... measurement and data analysis SM conceived the study idea and participated in the laboratory measurement and drafted the manuscript 16 17 YD, SA, and IM participated in the design of the study ... FBS and antibiotics The cells were further incubated for 24 h under normal or hypoxic conditions with or without 10 µM BPS The cells were harvested with trypsinEDTA and fixed using 70% ethanol The ... 8-Br-cAMP The cells were then harvested and resuspended in protein lysis buffer (150 mM of NaCl, 20 mM of Tris-HCl, 1% NP-40, 10 mM of EDTA, 10% glycerol, mM of PMSF, 10 µg/ml of aprotinin, µg/ml of...
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Báo cáo y học: " Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe)" potx
... × 106 of these H9 or CEM-SS cells were either mock infected or infected with 2.0 × 103 TCID50 of HIV-1LAI or IIIB The HIV-1 LAI strain carries a wild type vpr gene; the vpr gene in the IIIB strain ... 36°C with overproduced Hsf1 (Fig 3B) Together, results of these experiments suggest that Hsf is the key cellular regulator of heat shock-mediated suppression of the Vpr activities Page of 14 ... Analysis of hsp16 expression in S pombe Q1649 strain, in which the hsp16 gene is tagged with GFP and is under the control of its native promoter [35], demonstrated that both the wild type Vpr and the...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2
... al 1990) 2.5 HLA Sequence-Based Typing The HLA genotype at the classical HLA loci HLA- A, -B, -C and -DRB1 was determined for each sample by sequence-based typing For the HLA- A, -B and -C genes, ... temperature The interface containing mononuclear cells was collected and rinsed twice with 10ml of RPMI medium To infect the cell pellets with EBV, the 2ml of a cell culture medium (RPMI with 10% FCS and ... blood donors The archived samples were genotyped at classical HLA loci (HLA- A, -B, -DRB1) and screened to see if they carried homozygous HLA alleles at either loci (HLA- A, -B) or loci (HLA- A, -B,...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 3
... Disequilibrium and Haplotype Map of the Chromosome 6p and the Major Histocompatibility Complex To characterize the genetic variation and patterns of linkage disequilibrium (LD) of the human chromosome 6p and ... 33.4Mb) and at this resolution, no strong LD block is seen across the class I loci HLA- A, -B, and –C, nor the highly polymorphic class II locus HLA- DRB1 The more invariant HLA- DRA, -DMA and -DMB ... between HLA- C and HLA- B alleles as compared to HLA- A or HLA- DRB1 Each HLA- C allele has a dominant HLA- B partner with an r2 value of at least 0.1, a reflection of the close proximity between the loci...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4
... However, there is a noticeable difference in the rate of decay of LD across the different sub-regions of the MHC The class I, class III and extended class II segments show a level of LD similar to the ... al 2002) The haplotype block characteristics mirror the pattern of stronger and longer LD in the extended class I region, and weaker LD in the class II segment The stark contrast of the haplotype ... the MHC is described in each of the sub-regions: extended class I, class I, class III, class II and extended class II as defined in a recent review (Horton et al 2004) The sub-regions exhibit distinct...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 5
... At the HLA- DRB Locus HLA- DR haplotypes may be broadly classified into major haplotypes, DR1, DR8, DR51, DR52 and DR53 All of these haplotypes carry the DRB1, DRB9 and DRA loci, but vary in the ... Figure 3.19 Extent of EHH of Common HLA Alleles This figure summarizes the extent of EHH for all common alleles at the HLA loci (A,B,C and DRB1) The top table indicates the segments of high EHH for ... into the MHC class III region At the HLA- B locus, all HLA- B alleles have strong homozygosity (EHH>=0.8) that reaches past the MICA locus (31.48Mb) and the HCP5 gene (31.54Mb) Consequently, each HLA- B...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 6
... segments in the Class II region, covering the HLA- DR and DQB1 loci These haplotypes also show high symmetry within the Class III region; in fact more than half of the entire Class III region is ... section of this thesis A2-B46-DR9 also shares long segments of symmetry with the PGF (A3-B7 -DR15 ) haplotype spanning 400kb across the MHC These fall within the Class I and Class III regions, and ... Haplotypes of HLA Homozygous Samples The inclusion of HLA homozygous individuals in the genotyped samples provides robustness to the description of the CEHs in the population Three of the four...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 7
... panel with both haplotypes of each individual shown together with the linked HLA- B allele Half of the samples are homozygous leading to the telomeric edge of the 4.5kb interval with the other ... Location of the Hotspot Telomeric to HLA- F This figure shows the location of the hotspot mapped to a region telomeric to the HLA- F locus The genotypes of the 19 re-sequenced samples used to define the ... by Cullen and co-workers is indicated by the red bar at the top of the chart EHH values of HLA haplotypes decay of across this interval This interval also coincides with the breaks of HLA- A02 ancestral...
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