the formation of shield volcanoes is favored by

... aorta The level of HSP90 and the type of NOS isoform present in rat brain and aorta were determined by immunoblotting (Fig 1) In brain, nNOS was the most preferentially expressed isoform, together ... to explore the relationship between the HSP90 to NOS ratio and the formation of calpainresistant heterocomplexes, we first studied, by immunoprecipitation analysis, the association of the two proteins ... in these digestion processes was demonstrated by the protective effect on both HSP90 and NOS degradation of the administration to the HSD-treated NMS animals of C.I.1 (Fig 5) In the brain of...

Ngày tải lên: 30/03/2014, 04:20

... is profoundly influenced by a single amino acid difference, i.e G252R, in a region within the catalytic domain This is the first evidence that this region is involved in the formation of the active ... characteristics when overexpressed in human 293-cells The main objective of the present work was to find an explanation for this phenomenon It is demonstrated that the formation of the active complex is ... Identification of the region causing different association characteristics The difference in association characteristics of the enzyme from the two sources was surprising because the sequence is extremely...

Ngày tải lên: 21/02/2014, 15:20

... advisory Q: What percentage of the current audit plan is comprised of advisory/consulting reviews? In our survey, 90% of respondents say that advisory comprises some portion of their audit plan, while ... one-dimensional view of the tness of controls within their organizations They want a holistic view that gives them a broad, yet balanced view of the risk and control environment, as well as of any emerging ... established itself as a strategic advisor to the business Leading trend 50%+ advisory 25%–50% advisory The key is to find the right balance between assurance and advisory when developing the internal...

Ngày tải lên: 15/03/2014, 23:20

... cluster expression of the des cluster is mediated by the DmdR1 regulator Results Deletion of the desA gene of S coelicolor blocks desferrioxamine biosynthesis The organization of the putative desferrioxamine ... cluster is expressed as a polycistronic 1116 transcript Expression of the four genes is coordinately regulated by iron limitation, as shown by the RT-PCR analysis, and there is overlapping of the ... [19] It is interesting that the )10 sequence is located inside the iron box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expression by binding of DmdR1 to the iron...

Ngày tải lên: 16/03/2014, 11:20

... that of Ca2+-CaM [10,11,25,26], and therefore adversely affects binding of CaM to the Ca2+-CaM-binding domain of nNOS CaM is not only essential for the operation of nNOS and the other NOS isoforms, ... of the two binding modes (Fig 4A,B) is adopted by the complex [30]: this is supported by small-angle X-ray scattering experiments [34] Cupiennin 1a conforms to all of these prerequisites It is ... of the target peptide This is shown in Fig 4B for the 20residue binding domain of the plasma membrane Ca2+ pump ⁄ Ca2+-CaM complex, where the first 12 residues of the peptide are encompassed by...

Ngày tải lên: 23/03/2014, 09:21

... 20 21 formation of storage oligosaccharides by transglycosylation using galactinol [O-a-d-Galp-(1 1)-l-myo-inositol] as the donor This relationship motivated the detailed analysis of the capacity ... and disaccharides as acceptors Furthermore, structural modelling of AglC using the three-dimensional structure of GalA [24] as the template and superimposition of an equilibrium mixture of a- ... complexes of GH27 were performed to illustrate the donor and acceptor specicity and the regioselectivity of AglC Results and Discussion Sequence similarity of AglC The amino acid sequence of AglC,...

Ngày tải lên: 29/03/2014, 21:20

... deletion of OXA1 decreased the rate of formation of all aminoglycerophospholipids The rate of PtdSer synthesis decreased to 80%, the rate of PtdEtn formation to 70% and that of PtdCho synthesis to ... affected First, is the supply of PtdSer to the mitochondria as a precursor for PtdEtn formation by Psd1p This process includes synthesis of PtdSer in the endoplasmic reticulum by the PtdSer synthase ... synthesis of PtdEtn by Psd1p, but did not completely abolish the activity of this enzyme Activity of Psd1p in vitro is impaired in oxa1D PtdEtn depletion in mitochondria and the decreased rate of...

Ngày tải lên: 30/03/2014, 04:20

... reflect the relative expression of the Aurora genes at the time of mitosis, the relationship of Aurora expression and response to GSK1070916 is still unclear In a subsequent analysis of the background ... polyploidy) This further underscores the significance of the general observation between polyploidy and resistance For these data, we hypothesize there is a selective growth advantage for the subpopulation ... recommended by the vendor The majority of the cell lines were used within months of acquisition and no re-authentication was performed For the DSMZ cell bank STR DNA typing is performed for authentication...

Ngày tải lên: 18/06/2014, 22:20

... reflect the relative expression of the Aurora genes at the time of mitosis, the relationship of Aurora expression and response to GSK1070916 is still unclear In a subsequent analysis of the background ... polyploidy) This further underscores the significance of the general observation between polyploidy and resistance For these data, we hypothesize there is a selective growth advantage for the subpopulation ... recommended by the vendor The majority of the cell lines were used within months of acquisition and no re-authentication was performed For the DSMZ cell bank STR DNA typing is performed for authentication...

Ngày tải lên: 20/06/2014, 04:20

... side of Figure 10) Note that the flat of rank is included in the flat of rank by submodularity Then a set, of size 3, consisting of one of cfi, one of ekl, and one of ghj must be a base because of the ... Base case of induction In this section, we show the base case of the induction in the proof of Theorem We show the connectivity of the 3-base graph of a matroid of rank and size In this section, ... Conjecture is true for o the matroids of rank To prove Theorem 2, it suffices to prove the next theorem by Corollary Theorem The k-base graph of a matroid of rank is connected The remainder of this paper...

Ngày tải lên: 08/08/2014, 12:22

... Vpu The inability of the triple cysteine mutant to inhibit virus release was therefore not due to gross mislocalization or misfolding of the protein Our results suggest that the formation of cysteine-linked ... none of these mutations affected BST-2 function supports the notion that the loss of activity seen for the triple cysteine mutant is due to the lack of protein dimerization rather than caused by ... (N65,92Q) The presence of the desired mutations and the absence of additional mutations were verified for each construct by sequence analysis Antisera Anti-BST-2 antiserum was elicited in rabbits by...

Ngày tải lên: 12/08/2014, 23:22

... Comparison of the lamps in turbid water samples The inactivation effects of the lamps on turbid water with the excystation and the cell culture methods were compared Fig shows that, concerning the ... Inactivation effect of the lamps using the cell culture method 3) Comparison of the evaluation methods used The experiment results (Fig 6) show that the sensitivity to UV was highest when the cell culture ... that the level of inactivity achieved with the low-pressure mercury lamp rose primarily corresponding to the UV dose delivered However, the gradient of the change in inactivity varied in the case...

Ngày tải lên: 05/09/2013, 09:08

... weight is much less than that of Pt which is similar to the XRD result of FePt foils prepared by cold deformation [20] The Pt peaks in the as-prepared samples are broad due to the small size of the ... i.e., the transformation of the disordered fcc to the ordered fct phase, there will be a sharp peak in the range from 367°C – 440°C with the full width at half maximum of 56°C – 120°C on the heat ... to remove the nanoparticles from the electrode The time of ultrasound was 0.2 s for all samples The temperature during the reaction was room temperature The volume of the electrolysis cell was...

Ngày tải lên: 13/02/2014, 03:20

... that the association of the Qcr9p subunit with the bc1 complex precedes the binding of ISP In fact, the direct absence of ISP (DISP), or the block of its insertion into the bc1 complex due to the ... possible role of this chaperone in the stabilization of the core structure of the bc1 complex can be excluded on the basis of the existence of the 500 kDa bc1 sub-complex also in the DBCS1 deletion ... that the binding of ISP and Qcr10p is subsequent to that of Bcs1p Previous studies have suggested that the insertion of ISP into the bc1 complex would replace the bound Bcs1p on the basis of the...

Ngày tải lên: 18/02/2014, 08:20

... the microsomal fraction by only 20%, despite the presence of ATPMg It is shown below that this is due to loss of the inhibitory effect of ATP-Mg, consequent to the removal of a heat-stable cofactor ... observe the stimulation of glucuronate formation by xenobiotics in cell-free systems is an important step towards the identification of the detailed mechanisms by which these compounds act and of the ... test whether the enzymes catalysing the formation of glucuronate and glucuronate 1-phosphate were present in the lumen of the ER (or had their catalytic site oriented towards the lumen of this organelle),...

Ngày tải lên: 19/02/2014, 07:20

... show that the data fit well with the individual determination of flux control coefficients by PFK, PK and LDH The role of the las operon is discussed on the basis of the distribution of flux control ... enhance the activity of the PTS system and thereby result in further increases in hexose phosphate pools The decreased LDH activity may contribute further to this effect by causing an accumulation of ... was supported by the Danish Dairy Research Foundation (Danish Dairy Board), the Danish Research Agency and the Danish Center for Advance Food Studies (LMC) 2301 Control analysis of the las operon...

Ngày tải lên: 19/02/2014, 17:20

... Letter of the bishop of Vienne to the Roman senate upon this Council, 139 The cause of the Bishop of Rome is not that of one bishop, but of the Episcopate itself, 140 Words of Ennodius, bishop of ... and the decline of Arian in the West, 123 Letter of St Avitus, bishop of Vienne, to Clovis on his baptism, 124 He recognises the vast importance of the professing the Catholic faith by Clovis, ... beginning of his dignity to the See of the Apostle Peter For the newly-elected pontiff acknowledges in his letter that Peter is the chief of the Apostles and the Rock of the Faith: that the keys of the...

Ngày tải lên: 21/02/2014, 11:20

... profile of the polypeptide The hot-spot threshold (HST) was defined as the average of the a3v of the 20 natural amino acids weighted by their frequencies in the SwissProt database [22] A segment of the ... reported, such as the average a4v in each hot-spot, the area of the aggregation profile above the HST, the total area (the HST being the zero axis) and the area above the HST of each profile peak ... inside the window and the average is assigned to the central residue of the window The smoothed expected values for every position of the polypeptide chain provide the final profile, which is directly...

Ngày tải lên: 06/03/2014, 00:20

... contraction This bird is the only feathered polygamist we have The females are greatly in excess of the males, and the latter are usually attended by three or four of the former As soon as the other birds ... eagerly our ears[16] drink them in! The first utterance, and the spell of winter is thoroughly broken, and the remembrance of it afar off One of the most graceful of warriors is the robin I know few ... hear their piping in the meadow, in the pasture, on the hillside Walk in the woods, and the dry leaves rustle with the whir of their wings, the air is vocal with their cheery call In excess of...

Ngày tải lên: 06/03/2014, 13:20

... facilitate the removal of the rest of the propeptide from the interacting procathepsin B molecules Fully active mature cathepsin B molecules then enter the cycle and process the majority of the intact ... [23] The major advantage of this inhibitor is the possibility of detecting the radioactively labelled proteins by autoradiography Samples of procathepsin B and cathepsin B were incubated in the ... towards the N-terminus of the mature enzyme in the direction opposite to that of substrate binding, thereby serving as a linker between the ‘hook’ domain and the N-terminus of the mature enzyme This...

Ngày tải lên: 07/03/2014, 03:20