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the effects of abl inhibitors on leukemia

Báo cáo y học:

Báo cáo y học: " Rac and Rho driving tumor invasion: who’s at the wheel" docx

Báo cáo khoa học

... cell-cell adhesion, where rounds of activation and de-activation of Rac at the contacting membrane lead to expansion of the contact zone between cells [22] Another example is the neuronal growth ... DOCK3, reduced the fraction of elongated (mesenchymal) cells Moreover, siRNA-mediated depletion of Rac1 itself also reduced the fraction of elongated cells, while conversely, inhibitors of ROCK or ... activation of RhoA for amoeboid motility There are three general conditions that we know of that contribute to the selection of the mesenchymal or amoeboid mode: MMP activity levels; rigidity of the...
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Tài liệu 80C51 family programmer’s guide and instruction set pptx

Tài liệu 80C51 family programmer’s guide and instruction set pptx

Điện - Điện tử

... of the incremented PC, opcode bits 7-5, and the second byte of the instruction The subroutine called must therefore start within the same 2k block of the program memory as the first byte of the ... in the Accumulator The INC A before the MOVC instruction is needed to “get around” the RET instruction above the table If several bytes of code separated the MOVC from the table, the corresponding ... at the end of the 8th bit time in mode 0, or at the beginning of the stop bit in the other modes Must be cleared by software RI SCON.0 Receive interrupt flag Set by hardware at the end of the...
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Tài liệu USAID/Haiti Maternal and Child Health and Family Planning Portfolio Review and Assessment pdf

Tài liệu USAID/Haiti Maternal and Child Health and Family Planning Portfolio Review and Assessment pdf

Sức khỏe trẻ em

... cases of complications to the hospital In interviews, the staff of the Pignon maternity claimed that these matrones are considered an integral part of the maternity team The review team was unable ... super matrones program, will further reinforce the impact of these community-based activities Abortion and Postabortion Care The performance of abortions is governed by the provisions of the Haitian ... the neonatal (less than one month of age) period was estimated at 38 percent in 2000 Three-quarters of neonatal deaths happen in the first week the highest risk of death is on the first day of...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Báo cáo khoa học

... positioned in the connecting loops Approximately onethird of all mutations in the BTK gene are missense and some of these reduce the stability of the protein This is exemplified by mutations in the ... transcription of the ITK gene and is key for the productive infection of HIV in these cells Accordingly, the inhibition of ITK activity compromises HIV infection, gene expression and replication [62] ... evaluated the effect of proteasome inhibitors on HIV infection and ⁄ or replication To determine whether the depletion of ITK could affect HIV replication, we treated activated peripheral blood mononuclear...
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Family Life, Reproductive Health, and Population Education: Key Elements of a Health-Promoting School docx

Family Life, Reproductive Health, and Population Education: Key Elements of a Health-Promoting School docx

Sức khỏe phụ nữ

... that the provision of sex education, including the provision of contraceptive services, encourages the initiation of sexual activity On the contrary, in some cases, sex education delayed the initiation ... UN, 1948) Most of these rights are also contained in the International Convention on Children’s Rights (CRC) In addition, the CRC WHO INFORMATION SERIES ON SCHOOL HEALTH CONVINCING OTHERS THAT FAMILY ... the completion of education, then education is likely to be interrupted or terminated, either because the mother is expelled from school or because the additional responsibilities and costs of...
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Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

Báo cáo khoa học

... and other nonconventional T cells [27] PLZF belongs to the BTB-zinc finger family of transcription factors and in the absence of PLZF, the numbers of mature iNKT cells is greatly reduced [28] The ... re-examination of the role of Ras in the development of these cells seems to be war1976 ranted With regards to transcriptional targets of the Itk pathway, although the spotlight has been on NFAT, other ... emanating from the TCR during T-cell selection [5–7] Furthermore, combined deletion of Itk and Rlk leads to a further reduction in the TCR signal strength, resulting in the conversion of negative...
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Báo cáo khoa học: The carbohydrate-binding module family 20 – diversity, structure, and function doc

Báo cáo khoa học: The carbohydrate-binding module family 20 – diversity, structure, and function doc

Báo cáo khoa học

... phosphorylation [129] Hence, the effects of in planta expression of SBDs are dependent both on the used SBD construct and on the genetic background of the host plant The above studies clearly demonstrate ... whether the measured thermodynamic ngerprint of GA SBD is representative of other CBM20s or whether variations of this scheme exist within this diverse CBM family The effects of CBM binding on ... protein concentration units [82,83] Conversely, if the SBD concentration is kept constant and the starch concentration is varied, Kd is reported in units of starch suspension concentration, typically...
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family therapy concepts, process and practice

family therapy concepts, process and practice

Đại cương

... throughout the production of the first edition of this book and to Deborah Egleton for her support with the production of the second edition The second edition of this book was completed at the Psychology ... sole criterion for judging the merit of one formulation over another Because of its emphasis on the socially constructed nature of problem and exception formulations and the choice of usefulness ... idiosyncrasies rather than on the idealized views (or mutual projections) which formed the basis of their relationship during the initial period of infatuation Coming to terms with the dissolution of the...
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The Impact of ParentalInvolvement  Parental Supportand Family Education on PupilAchievements and Adjustment A Literature Review

The Impact of ParentalInvolvement Parental Supportand Family Education on PupilAchievements and Adjustment A Literature Review

Hóa học - Dầu khí

... non-manual occupations; the proportion of children taking only GCE examinations; the proportion of children in the class taking only CSE exams and the proportion of children in the class from the previous ... explore the effects of provision on children’s attainment and adjustment Of particular interest here is the impact of parental involvement in interaction with professional provision The idea of a ... negative responses from others (Kohl et al, p 503) In their exploration of the impact on these factors on involvement, Kohl et al developed a conception which attempted to go beyond the common ‘quantity’...
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Báo cáo hóa học:

Báo cáo hóa học: "The Pediatric Quality of Life Inventory™ (PedsQL™) family impact module: reliability and validity of the Brazilian version" pdf

Điện - Điện tử

... administration needs further investigation In the present study, there was no report by the parents/guardians of any lack of comprehension regarding the questions Conclusion The Brazilian version of the ... cross-cultural adaptation, the group of specialists stated that the concept of the impact of childhood cancer on the quality of life of the families used for development of the original instrument ... understanding the questionnaire A synthesisversion was developed (T3) as a result of this process The third step consisted of a backtranslation of the synthesis-version (T3) by a professional, bilingual...
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báo cáo hóa học:

báo cáo hóa học:" Research Article Strong Convergence of a New Iterative Method for Infinite Family of Generalized Equilibrium and Fixed-Point Problems of Nonexpansive Mappings in Hilbert Spaces" pptx

Hóa học - Dầu khí

... strong convergence theorems for the iterative scheme to the solution of the quadratic minimization problem x∈F under suitable hypotheses on F n F T1 T2 · · · TN Ax, x − x, u 1.5 and the additional ... prove that the scheme strongly converges to the unique solution x∗ of the variational inequality: A − γf x∗ , x − x∗ ≥ 0, ∀x ∈ F T , 1.8 which is the optimality condition for the minimization problem: ... ∀n ≥ 1.25 The proof method of the main result of this paper is different with ones of others in the literatures and our result extends and improves the ones of Colao et al and some others 6 Fixed...
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Báo cáo hóa học:

Báo cáo hóa học: "Research Article Some Characterizations for a Family of Nonexpansive Mappings and Convergence of a Generated Sequence to Their Common Fixed Poin" pdf

Hóa học - Dầu khí

... common fixed points of a family of nonexpansive mappings by the notion of Mosco convergence and prove strong convergence theorems for nonexpansive mappings and semigroups in a uniformly convex ... onto a nonempty closed convex subset K of E Moreover, if E has the Kadec-Klee property, the convergence is in the strong topology On the other hand, Ibaraki et al 20 proved the following theorem ... if E has the Kadec-Klee property, the convergence is in the strong topology Kimura 21 obtained the further generalization of this theorem by using the Bregman projection; see also 22 Theorem...
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Báo cáo toán học:

Báo cáo toán học: "On a new family of generalized Stirling and Bell numbers" pps

Báo cáo khoa học

... version of [40, Theorem 7.1] for the particular words w = (UD)n (in [40, Theorem 7.1], the summand sk in the exponent is missing) Conclusion In this paper, a thorough discussion of the family of ... completes the proof the electronic journal of combinatorics 18 (2011), #P77 14 Remark 3.10 During the proof of the theorem, we considered the cases s = and s = explicitly using generating function techniques ... i.e., the exponential generating function of the generalized Bell numbers From the proof of Theorem 3.9, we obtain the following explicit formulas for the generating functions Ls;h (x, y) the electronic...
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family therapy concepts process and practice phần 1 ppsx

family therapy concepts process and practice phần 1 ppsx

Quản trị kinh doanh

... throughout the production of the first edition of this book and to Deborah Egleton for her support with the production of the second edition The second edition of this book was completed at the Psychology ... sole criterion for judging the merit of one formulation over another Because of its emphasis on the socially constructed nature of problem and exception formulations and the choice of usefulness ... idiosyncrasies rather than on the idealized views (or mutual projections) which formed the basis of their relationship during the initial period of infatuation Coming to terms with the dissolution of the...
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family therapy concepts process and practice phần 2 potx

family therapy concepts process and practice phần 2 potx

Quản trị kinh doanh

... supportive the responses of members of these three systems, the better the adjustment of the individual In response to the process of ‘coming out’ families undergo a process of destabilisation They ... awareness of the young person’s sexual orientation, to absorbing the impact of this realisation and 44 CENTRAL CONCEPTS IN FAMILY THERAPY adjusting to it Resolution and integration of the reality of the ... psychotherapeutic approaches and research traditions Detailed consideration is given to the unique contribution of Gregory Bateson to the emergence of family therapy The scope and goals of family therapy...
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family therapy concepts process and practice phần 3 potx

family therapy concepts process and practice phần 3 potx

Quản trị kinh doanh

... the accuracy of predictions entailed by construct systems Within this process, the clients are the experts on the content of their own construct systems and the types of situations in which they ... point of not discussing the contents of these meetings with children or other family members Over the course of therapy, the impact of this intervention of the beliefs and behaviour of the family ... in which they wish their construct systems to make accurate predications The therapist, on the other hand is an expert on the processes of facilitating the articulation of constructs and designing...
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family therapy concepts process and practice phần 4 potx

family therapy concepts process and practice phần 4 potx

Quản trị kinh doanh

... experiential family therapy: (1) the authenticity of the therapeutic alliance; and (2) the depth of clients’ emotional experiencing within therapy The more authentic the relationship between the therapist ... initiative, the therapist places the primary responsibility for the content, process, and pacing of therapy sessions on the family These two interventions maximise the opportunities for confronting ... respond to the reality of their spouses rather than to their projections In problematic relationships, partners either completely conform to the demands of each other’s projections or not conform...
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family therapy concepts process and practice phần 5 pps

family therapy concepts process and practice phần 5 pps

Quản trị kinh doanh

... facilitate the development of relapse management plans; and frame the process of disengagement as the conclusion of an episode in an ongoing relationship rather than the end of the relationship THE ... stay? Then the therapist helps the family construct an understanding of the change process by reviewing with them the problem, the formulation, their progress through the treatment programme and the ... Sixth, ask about the pros and cons of these courses of action Seventh, frame a therapeutic dilemma that outlines the costs of maintaining the status quo and the costs of circumventing the blocks When...
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family therapy concepts process and practice phần 6 docx

family therapy concepts process and practice phần 6 docx

Quản trị kinh doanh

... building on exceptions the overall aim is to help clients first separate out the problem from the person; identify the effects of the problem on the person; identify and amplify situations in which the ... out of four of these conditions are met the prognosis is fair Where less than three of these conditions are met, it is unlikely that even the most skilful professional team would be able to offer ... enlisting the aid of the family therapy agency to help the family reduce the risk of further violence, so that the child may be returned to the custody of the parents The parents may acknowledge their...
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family therapy concepts process and practice phần 7 pps

family therapy concepts process and practice phần 7 pps

Quản trị kinh doanh

... relationship with her mother and a conflictual relationship with her father, which is ongoing The relationship maps from these relationships affect her relationship with Michael The accumulation of ... depending on the customer and the context of the referral With cases where the parents are the customer, the parents and child may find it useful to see family therapy as a way of helping everyone in the ... parents and children Sessions addressing these issue are the core of family therapy in cases where the main contract focuses on the reduction of conduct problems It is less confusing for clients if...
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