... cancer is based on the size ofthe primary tumor and the degree of spreading to secondary sites in the body It determines the selection of therapy and assessment of prognosis The most widely used ... worldwide and Asia 1.1.2 Classifications ofbreastcarcinoma 1.1.3 Treatment of HR-positive breastcarcinoma 1.1.4 Treatment of HR-negative/ triple negative breastcarcinoma 1.2 Manganese Superoxide ... SUMMARY Breastcarcinoma is one ofthe most common malignancies among women worldwide and accounts for the leading cause of cancer-related deaths among Singaporean women Among the subtypes of breast...
... radiotherapy or afterwards in connection with the reported survey The measurement ofthe thyroid gland volume represents the main limitation of this small study On the background ofthe lack of ... doses of 10-80 Gy to the thyroid are reported to lead to dysfunction ofthe gland [11] The diversity of these figures illustrates that the threshold for thyroid radiation and development of hypothyroidism ... accelerator The dose plans were normalized to the mean dose to the planning target volume (PTV) The breast/ chest wall should receive a total dose of 50 Gy, and the regional lymph nodes 46-50 Gy Six of the...
... mgZn/kg based on the uniform distributionof these metals in the sediments ofthe lake The higher concentration in the northwest part ofthe lake is probably due to reverse flow ofthe polluted Pasig ... in the eastern side of Manila Bay The concentration profiles in the sea sediments show the decrease in lead and zinc concentrations in the sediments with the increase in the distance between the ... employed for the determination of total lead content before the instrumental analysis On the other hand, the concentration of dissolved fraction was determined for the filtrate samples with the same...
... leads to a decline ofthe filter ability ofthe constructed wetland The objective of this study is to survey the vertical and horizontal distributionofthe OM in sand bed ofthe experimental constructed ... Lower then 60 cm up to 100 cm, which is the bottom, the sand color returns to the original yellow Figure shows the average OM contents in the sand bed are linear reducing to the Ox direction In the ... direction, the average value of OM in each cross-section is highest at the depth 50 cm and lowest at the depth 80 cm This result is in line with the visual observation ofthe sand color and the root...
... levels of risk within the spectrum of risks associated with participants in the P-1 study Because ofthe importance of knowing whether or not the finding that tamoxifen reduces the incidence of tumors ... disease, they show that, at least during the duration ofthe P-1 study, the drug did not have a detrimental effect on the heart One ofthe original aims ofthe P-1 study was to determine whether ... assess the consistency ofthe effect of tamoxifen across the population, rates of invasive breast cancer were calculated for several subgroups of women When age, history of LCIS, history of atypical...
... greater than the rate of decomposition Therefore, the nature ofthe accumulated organic matter can then be used as a proxy to represent the composition ofthe former wetland communities at the site ... Despite the migration ofthe solar equator (the latitude where the sun’s rays hit the Earth perpendicular to the surface) between 23.5°N and 23.5°S latitudes over the course ofthe year, there ... impact the amount of solar energy that reaches the surface ofthe Earth (a) Eccentricity is the measure ofthe amount that the Earth’s orbit around the sun departs from a circle (b) Precession is the...
... findings in adult brain tissue of all three species Discussion Thedistributionof ADHs in the brain is of particular interest because of their implications in the metabolism of ethanol and retinoic ... absence of Adh4 mRNA in the stomach epithelia – the tissue with the best characterized Adh4 expression Taken together, our results demonstrate expression of ADH3 in most ofthe analyzed areas in the ... accordance with the literature [16–18] The difference in the expression levels in the liver ofthe ADH4–/– and wild-type mice (Fig 1C) might indicate that the transgenic manipulation at the ADH4 locus...
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health ofthe public The Institute acts under the responsibility given to the ... number of complexities, not the least of which is the need to understand the xi xii PREFACE basic biology ofbreast cancer The committee recognized the need for research on the natural history ofbreast ... councils ofthe National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members ofthe committee responsible for the report were chosen for their special...
... divisors of n, Ω(n) is the number of prime power divisors of n, π(x) is the number of primes ≤ x, τ (n) is the number of divisors of n P(s, t) is the set of positive integers composed of prime ... denote the sequence of Farey frac1 Q tions of order Q, and let N (Q) denote the number of distinct gaps between successive terms ofthe sequence Then Q2 (log Q)δ (log log Q)3/2 N (Q) Proof The ... author enjoyed the hospitality ofthe Institute of Mathematics and Informatics, Bulgarian Academy of Sciences Finally, the author acknowledges the referee for a thorough reading ofthe paper and...
... of adult zebrafish Panel shows thedistributionof fapb6 transcripts in the distal region ofthe intestine (A), liver (B), ovary (C) and the adrenal homolog ofthe fish kidney (D) Panel shows the ... in the distal region ofthe intestine, the tissue homologous to the mammalian ileum The presence of fabp6 transcripts suggests that Fabp6 may well play a role in the uptake of lipids from the ... separated [22] Thedistributionofthe hybridization signal for zebrafish fabp6 transcripts in the adrenal homolog ofthe kidney (Fig 6, 1D) is consistent with the structure ofthe adrenal homolog...
... Paramount antitrust decision of 1948; and the advent of television in the 1950s The Paramount decision forced the majors to divest themselves of their extensive theatre (cinema) chains2 (see ... 51211) in the five counties of Southern California in 1999, and the median size of these establishments was just two employees The vast majority of these establishments comprise a cohort of independent ... expansion ofthe industry (and most notably by an increase in the number of small establishments) in the rest ofthe US Even so, Southern California remains the primary agglomeration in the country,...
... investigate the effect ofthe exact distributionofthe language inventory size on the nature ofthe degree distributionofthe consonants through a synthetic approach based on the principle of preferential ... consideration the β -distribution rather than just the mean value ofthe inventory size that can explain the negative slope ofthe first regime We look forward to the same as a part of our future work Rather, ... Figure 2: Degree distributionof PlaNet for the set VL The figure in the inner box is a magnified version of a portion ofthe original figure Degree Distributionof PlaNet The degree of a node u, denoted...
... order ofthe sum of two functions is not greater than the larger ofthe orders ofthe two summands, and if the orders ofthe summands and ofthe sum are all equal, then 21 the type ofthe sum ... greater than the larger ofthe types ofthe two summands In addition, if one ofthe two functions is of larger growth than the other, then the sum has the same order and type as the function of larger ... analogue of Rolle’s theorem Theorem (Gauss-Lucas Theorem [50, p 8],[57, Theorem 1.2.1]) If p(z) is a non-constant polynomial, then the zeros of p (z) belong in the convex hull ofthe zeros of p(z) The...
... SES ofthe younger female population ofthe practice Most of these measures are taken early during pregnancy and refer to the health, housing and SES ofthe mother prior to the birth ofthe ALSPAC ... income ofthe child and the quality to which they have access In terms ofthe second part ofthe explanation for the lack of gradient, we not find strong evidence that the quality ofthe GP to ... cohort of children born in one region ofthe UK in the early 1990s The cohort is the Avon Longitudinal Study of Parents and Children (ALSPAC) The advantages ofthe ALSPAC data are twofold First, the...
... for the development ofthe breast, paradoxically oestrogen is also involved in the development ofbreast cancer via the stimulation and proliferation ofbreast cancer cells15,16 In fact, the ... into the complicated origins ofbreast cancer I) THE COCKTAIL EFFECT Despite the theory ofthe role of oestrogen mimicking chemicals in breast cancer, it will be almost impossible to prove the ... doubled the risk ofbreast cancer for the daughters ofthe women who took it55 This shows how a hormone, when present at the wrong time (in this case during the development of baby girls in the womb)...
... Hellespont, ofthe Propontis, and ofthe Euxine, from the borders of Thessaly to the mouth ofthe Danube Of these we can only glance at the most important The colonies on the coast of Macedonia ... upon it the duty of inspecting the lives and occupations ofthe citizens All archons became members of it at the expiration of their year of office Solon laid only the foundation ofthe Athenian ... abandoned the defence ofthe walls, and took refuge at the altar of Athena (Minerva) They were induced by the archon Megacles, one ofthe illustrious family ofthe Alcmaeonidae, to quit the altar on the...
... in Rn Proof of Theorem 4.1 The ubiquity version of Theorem 4.2 An auxiluary lemma 4.3 Proof of Theorem Proof of Theorem Proof of Theorem Proof of Theorem Various generalizations 8.1 Theorem for ... completes the proof of Theorem 10 in the case that G is finite C.3 Proof of Theorem 10: G = ∞ The proof of Theorem 10 in the case that G is infinite follows the same strategy as the proof when G ... < ψ(Q)/Q Proof of Theorem modulo Theorem This is trivial Given the hypotheses of Theorem 7, the hypotheses of Theorem are clearly satisfied Fix an interval I ⊆ I0 By Theorem 7, there exist constants...
... tissue-specific patterns ofdistribution On the basis ofthedistributionof fabp10b transcripts in many tissues of adult zebrafish, compared with the limited distributionof zebrafish fabp10a transcripts, ... coding region of a gene results in a novel function for that protein of benefit to the organism As such, the process of neofunctionalization leads to the retention of both copies ofthe duplicated ... in the same clade (bootstrap value of 56 ⁄ 100) The single copy ofthe fabp10 gene found in the Tetraodon genome sequence database may indicate that the genome of this fish has lost one of the...
... that would generally place the burden of proof ofthe efficiency effects of any restraints of internet retailing on the manufacturers (regardless ofthe market share ofthe manufacturer) Such a ... reduce the value ofthe product to the customer 50 The “image” of a brand is therefore an integral part ofthe product, and determines the willingness to pay of consumers Manufacturers of luxury ... distribution than they are in the case of any other distribution channel Distribution over the internet should therefore not be treated differently as to the legality of vertical restraints when the Vertical...