... detected; in particular the cerebral and abdominal CT scans were inconspicuous Thus, the therapeutic indication for the definite treatment of these two injuries was established After the diagnostic ... imaging (MRI) ofthe skull on the sixth postoperative day These scans showed multiple lesions inthe brain stem, inthe cerebellum, and inthe cerebral hemispheres, which were consistent with ... soft and competent Deep vein thrombosis ofthe leg and any clotting inthe vena cava or inthe pelvic veins as possible causes were excluded by means of duplex ultrasonography Due to increasing...
... particular phase ofthe cell cycle, and was associated with an increase inthe sub-G1 (apoptotic) portion ofthe cell cycle We next investigated the effect of combining CDO withthe chemotherapeutic ... an increase in p21waf1 expression, loss of CDK function, and the generation of cells with senescence characteristics Inthe first part ofthe investigation, we determined the effect of continuous ... treated with drugs separately (Fig 3) Fig Effect of combining CDO with cytotoxic agents in HCT116 and GEO cells The numerical sum of BrdU incorporation into cultures containing CDO or any ofthe cytotoxic...
... alization started inthe eighties, at the time ofthe culmination of air-pollution disaster In that period, within the programme ofthe gene conservation of indigenous forest tree species inthe Krkonoše ... rooted cuttings ofthe 2nd generation The selection of individuals for further growing was performed on the basis ofthe complex evaluation of parent trees (the health status was the main criterion, ... outplanted inthe extreme mountain locality Černohorská rašelina) A description ofthe plots is shown in Table We studied the progenies of spruces coming from the area ofthe Černohorská rašelina locality,...
... ofthe intervention) and at final follow up (directly after the end ofthe intervention period) The intervention period consisted of one or more appointments withthe podiatrist during which the ... walking Patients were asked to score the average amount of foot pain they had experienced during walking inthe previous week using a NRS, where indicates no pain and 10 indicates severe pain The ... develop as a result of joint damage in combination with capsuloligamentous instability ofthe foot [41] The advantage of deformities is that they are recorded by clinical examination, in contrast to...
... practical to influence community-based practice When testing the effect of local opinion leaders inthe outpatient setting, the generalizability ofthe intervention is of utmost concern Thus, the focus ... trusted by their peers to evaluate medical innovations within the local context [68-70] Since they influence patterns of practice inthe community, their participation in any program of quality ... that included physician and nurse opinion leaders (as two ofthe 10 factors included inthe intervention) on management of patients with acute MI They demonstrated improvements in some of their...
... 0.60-0.94) The level of functioning was assessed by use ofthe split version ofthe Global Assessment of Functioning scale (GAF) [18] The GAF rating was carried out by the investigators, with a satisfactory ... non-responders with a higher degree of relapse, or in patients with more severe schizophrenia [5,12,19,20] The finding that the use of antipsychotics were mainly in accordance with guidelines up to the ... decline in global- or daily functioning, measured with GAF [9,21] This could be due to a type II error, at least in one ofthe studies, since this only included inpatients [9] The current finding...
... to the register may bias the findings On the other hand, the precision ofthe estimates inthe present study are limited due to the small sample size Finally, there was no decrease inthe incidence ... denominator population of patients with RA is not defined The aim ofthe present study was to investigate trends inthe incidence of primary THA and TKA in a well defined sample of patients with ... participated inthe design ofthe study and inthe analysis and interpretation of data JÅN participated inthe design ofthe study and performed the statistical analysis IFP participated inthe design of...
... group inthe follow-up study, due to inadequate pain-relieving effect These dogs were included inthe analysis ofthe results The largest weakness withthe present study is that it was non-blinded ... non-blinded during the last 18 months, with both the owner and the clinical investigator being aware ofthe treatment The results may therefore have been biased in a positive direction by the evaluators, ... two of these dropped out It is possible that the remaining dogs inthe control group had minimal pain signs and therefore represent a selection bias If so, the differences in pain between the...
... contributions ZM was involved inthe conception and design ofthe study, acquisition and interpretation ofthe data and drafting the manuscript; BA was involved inthe conception and design ofthe study, ... collected included demographics, the results ofthe cosyntropin stimulation test, the use of etomidate, the time interval between the etomidate administration and the cosyntropin stimulation test, the ... insufficiency when the cosyntropin stimulation test is performed within 24 hours ofthe administration of etomidate Competing interests The authors declare that they have no competing interests Authors' contributions...
... not increase In fact, the level of IL-8 was significantly lower at the later time point Thus, the institution of a low tidal volume strategy in patients with ALI may not worsen lung injury in these ... acceptance ofthe null hypothesis, namely that the institution of positive pressure ventilation is not associated with an increase in biomarkers of lung injury The total number of patients in this ... inthe spontaneously ventilating patients with ALI within the 6-hour period prior to endotracheal intubation The median levels ofthe biomarkers were all elevated several fold compared with the...
... drafting the manuscript SK, MB, and LB participated in coordinating the study and inthe interpretation of data and were involved in drafting the manuscript JP was involved inthe interpretation of ... the sealed envelope technique Treatment inthe intensive care unit (ICU) and inthe intermediate care unit was at the discretion ofthe physicians and nurses in charge Withthe exception ofthe ... associated with higher plasma lactate and glucose levels and increased insulin needs in comparison withthe phosphodiesterase III inhibitor milrinone The use of adrenaline – in contrast to milrinone...
... findings of CTs conducted before inclusion ofthe patients inthe study The CT findings on inclusion were regarded to be the worst ofthe hospital stay; the prognostic value of such CT findings ... [CSF]): infection ofthe CNS with a positive culture inthe CSF eSOFA pre: value ofthe Sepsis related Organ-Failure Assessment (SOFA) score before the beginning ofthe barbiturate coma fSOFA maximum: ... to the BTF Guidelines Nevertheless, these findings should be interpreted with caution because ofthe imbalance in CT characteristics and the different dosages employed inthe two arms of the...
... participated inthe conception and design ofthe study, inthe development and conduct of analyses, and in drafting the manuscript MDW participated in drafting the manuscript JFD participated inthe clinical ... population The use of severity scoring systems in clinical trials may require training and validation ofthe training to ensure proper collection of severity of illness information Helps to ensure the ... percentage of patients inthe ≤2 subgroup experienced 'any bleeding' and 'any bleeding during the infusion' compared with DrotAA patients inthe ≥3 subgroup A lower percentage of DrotAA patients in the...
... investigating the incidence and clinical significance of hypernatremia occurring during the course ofthe ICU stay in a large series of patients with severe TBI The study shows that, inthe immediate ... of continuous-infusion hypertonic saline [54] In that study, hypertonic saline use increased the risk of hypernatremia, increased the number of infection days, increased the hospital length of ... balance the competing desire of finding the best model (in terms of maximizing the likelihood) with model parsimony (only including those covariates that significantly contribute to the model) For the...
... prior to the occurrence of MODS, so the sharp decrease inthe number and function of EPCs inthe progression of MODS may be one ofthe main pathogenic factors of MODS Inthe present study, the migratory, ... factors of MODS inthe present study The mechanisms for the decrease inthe number and function of EPCs inthe progression of MODS still remain to be determined Another limitation ofthe present ... magnitude of changes was greater and the timing point ofthe increase was earlier (24 hours after endotoxemia) Inthe control group, the number of EPCs in peripheral circulation and inthe bone...
... poverty. Their policy process is looking at the health systems and their problems and tackling them accordingly within the confines ofthe country’s economic status and income which ... When assessing which ofthe key functions inthe health system that seems to have fallen short of their potential, the questions often lie withthe planning, management and the operation ofthe health system. Many health systems have fallen short of its potential due ... of an organization. According to Reinke, the core of planning is the analysis of alternative means of achieving established 67 goals ranked in order of priority inthe ...
... injection of VX was performed by pinching a bit of skin between the fingers to form a fold and the needle was inserted into the skin at the bottom ofthe fold where the loose skin meets the body ... Another finding was that the death rate was found to correlate withthe occurrence of cardiac arrhythmias, withthe frequency of mortality increasing with abnormal cardiac rhythm Only 20% ofthe ... for the subcutaneous injection ofthe nerve agent inthe lateral-ventral region ofthe animal i.e at the side ofthe animal’s body between the thoracic and abdominal area The subcutaneous injection...
... while other studies did not control for the effects of race [5,6] This could explain some ofthe contradictory results between investigations, making the findings ofthe present study more meaningful ... (Tables to 5) The SIR is a comparison ofthe incidence of second primary tumors among study patients (observed) withthe incidence ofthe same tumors inthe general population of California males ... on the etiology and development of these tumors Melanoma and breast cancer are more common in women than men, implicating the role of female hormones and further strengthening the argument of...
... subsites indicate the location within the substrate binding tunnel of Pc_Cel7D interacting with carbohydrates [30] The hydrophobic B-face ofthe sugar thus makes a number of nonpolar contacts withthe ... 4A) The glucosyl unit inthe +1 site continues to make good stacking interactions with Trp373, although it now lies more directly against the six-membered ring ofthe indole O2 maintains the ... look at the available structural data on binding inthe +1 and +2 sites in these enzymes (Fig 4C) The nonreducing end ofthe disaccharide in each ofthe available complex structures is inthe +1...