the cartesian coordinate system is formed by the
Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... proteinswithin the cell. We found this translocation to bedependent on the final amino acids of the receptorprotein. Similar to the other PDZ domain interactionsthat have been shown to be abolished by ... signal is impaired.We finally examined the effect of deletion of the components of the PDZ binding motif on the signal-ing properties of the receptor in Ca2+imagingexperiments. Truncation of the ... summary, when the interaction betweenMUPP1 and OR2AG1 is inhibited by over-expressing the interacting PDZ domains, the resulting response ofOR2AG1 to odorant is modified in that the rapiddecay...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... Fentonreaction with the iron metal at the active site. The presenceof iron is therefore a prerequisite for its effect and suggeststhat the absence of reactivity with the MnSOD mutants is due to the lack ... identified to distinguish between FeSOD andMnSOD [7]. The position of the glutamine residue, which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs (Q69) and the C ... a shift in the position of Y34 and a twist in the ring of the metal-binding H81. Thermostability is not a new phenomenonamongst SODs; those isolated from hyperthermophilicorganisms, for example,...
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Báo cáo khoa học: Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, a4 and the mammalian ortholog of yeast Tip41 (TIPRL) ppt
... Subsequently, the GST–PP2Aca:His–TIPRL complex was incubated withHis–a4 and the GST–PP2Aca:His–a4 complex wasincubated with His–TIPRL. Binding of His–TIPRL to the previously formed GST–PP2Aca:His–a4 ... order to test this hypothesis, in vitro assayswere performed in which the activity of PP2A coreenzyme (A and C subunits) was measured in the pres-ence of His–a4 or His–TIPRL using the phosphopep-tide ... PP2Ac is represented by a black bar for comparison. Numbers on the left of the gray bars indicate the first amino acid in the respective activationdomain-phosphatase catalytic subunit fusion. The...
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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt
... recruitment, due to the absence of the NTD. This might be overcome by the overexpression of cofactors. To test this hypothesis, weanalyzed the effects of two AR cofactors known tointeract with the AR LBD. ... observed. The important role of the NTD, which is absent in AR45, has been documented by severalstudies [40–42]. The hormone-dependent interactionbetween this region and the LBD of the AR is essen-tial ... primer specific for the extreme 5¢ region wasthen used together with a primer recognizing the 3¢ endof the AR coding part to amplify the complete codingregion of this novel AR form. The deduced amino...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... mutagenesis of the N-terminus of the V1aR; this revealed that a single residue(Arg46) located in the distal segment of this domain is critical for high affinity agonist binding but not antag-onist ... affinity agonist binding, by site-directed mutagenesis. The wildtype Arg46 was systematic-ally substituted by all the other 19 encoded amino acids.These receptor constructs were then characterized ... rescued by a chimeric construct in which the N-terminus of the OTR is replaced with the corresponding sequence of the V1aR [10]. The role of the N-terminus has beenaddressed recently by alanine-scanning...
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Báo cáo khoa học: The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters doc
... see[11,12]). At the renal epithelium, small peptides arereabsorbed from the glomerular filtrate into the cells by the subtypes PEPT1 and PEPT2. PEPT2 is alsoexpressed in other tissues, such as ... insertion of the correctcDNA was verified by sequencing. The pNKS-hPEPT1construct served as template for cRNA synthesis. Afterlinearizing the plasmids with NotI, cRNAs were synthesizedusing the mMESSAGE ... of vertebrates [1,2]. It is formed as a secondary product through the methylation of the dipeptide carnosine (b-alanyl-l-histidine) [3]. The reac-tion is catalysed by carnosine N-methyltransferase[3,4]....
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Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
... andobviously the isolated proteins are degraded by the protease. On the basis of these observations, we canexplain not only the protective effect exerted by HSP90 on the digestion of NOS isozymes, ... canprevent the degradation by calpain of both NOS by protecting the cleavage of the peptide bond close to the CaM binding site. This explains why both NOSare inactivated by calpain in the absence ... quantified as described in the Exper-imental procedures. The areas of the peaks were normalized on the basis of the amount of protein loaded on the column. The val-ues reported are the arithmetical mean...
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Metaphor, based on the association of similarity, is one of the two basic types of semantic transference that have been an interest for many linguistic researchers
... is thus a theory of the global distribution of the units of the grammar. The English grammatical rank scale recognized by Systemic Functional Grammar is as follows: In turn, each unit has their ... English Theme is the first element of a clause and providing what we call the departure for the starting point for the clause. By changing Theme we do not change the ideational meaning but the ... what is it that the participants are engaged in, in which the language is an essential component?+ The TENOR OF DISCOURSE concerns who is taking part, to the nature of the participants, their...
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![Tài liệu [ Team LiB ] Configuring Your Safe Senders List The Safe Senders list is part of the Junk E-mail pdf](https://media.store123doc.com/images/document/14/nu/js/small_jsx1390245650.jpg)
Tài liệu [ Team LiB ] Configuring Your Safe Senders List The Safe Senders list is part of the Junk E-mail pdf
... Safe Senders List The Safe Senders list is part of the Junk E-mail filters. If you choose to allow external content from addresses listed in your Safe Senders list, you need to check the configuration ... select Add Sender to Safe Senders List or Add the Domain @[domain-name] to Safe Senders List. The sender's fully qualified domain name is listed in the menu selection, as shown previously ... you need to check the configuration of the list. You can add addresses and domains to the Safe Senders list directly from an email message. Click on the InfoBar or right-click in any image...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... as the disease became less prevalent; however, the risk is still high for HCWs who work in settings in which the incidence of TB among patients is high. The precise risk for TB among HCWs in the ... developed at the University ofIllinois (Chicago, Illinois) from a strain originated at the Pasteur Institute. The Food andDrug Administration is considering another vaccine, which is produced by ConnaughtLaboratories, ... with the Advisory Council for the Elimination of Tuberculosisand the Advisory Committee on Immunization Practicesvi MMWR April 26, 1996Advisory Council for the Elimination of Tuberculosis (ACET)September...
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Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx
... tyrosines, by the PTK Lck, to be deduced.Experimental proceduresPeptide synthesisPeptides were made by manual solid-phase peptide synthesisusing the tBoc method [11], purified by RP-HPLC, ... sample. The analysis was repeated for fragment 5–6, the other high-yielding product of the (incomplete) trypsindigest in which the only ITAM Tyr was 1N. This procedurewas performed for all of the ... 2, and the farthest as 3. The two tyrosineswithin each ITAM are then further classified as N or C,reflecting their locations relative to the N-terminus andC-terminus (Fig. 1). Six synthetic...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... level of GR in the epithelia of the epididymis (Fig. 1 ). As the epididymis is rich in sulfoxidase, the oxidation of sulfhydryls in the sperm head and tailwould be mediated by this enzyme in a ... Thiol oxidation occursin the nuclei and the tail during the maturation process in the epididymis. The greater the extent of oxidation in nuclei, the more potent are the spermatozoa. In addition, ... prostate gland. The l ocalization ofGR, as evidenced by immunohistochemical techniques,reveals that it exists at high levels in the epithelia of the genital tract. In testis, GR is mainly localized...
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how the use of the diary form narrative is beneficial to the
... of the greatest benefits of the diarynarrative is that the reader is allowed see, and feel the emotional heartsand souls of the emotional characters. This is great because when acharacter is ... great and is trying hide something, the readerknows this, and therefore the reader knows everything that is happening; nothing is being hidden from the reader. An example of thishappening is when ... think forthemselves and they will not have to have the book, or someone in the book explain what they are reading to them. So in other words, if anewspaper is written in the book, the reader...
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