the amount by which the contract is favourable or unfavourable for the acquirer when compared with market conditions
half year report 1999 good half-year results with a further increase in net income the holderbank group confirms its strength and flexibility in the face of rapidly changing market conditions
... dividend-bearing bearer share The half-year result was again very favorable and underscored the strength of the Group in the face of rapidly changing market conditions Once more the three major “Holderbank” ... demand for building ma- with the commissioning of the new ce- terials increased in all of “Holderbank’s” ment plant in Vietnam and a new kiln major European markets This is espe- line in the Philippines, ... developed surpris- ness in the Czech Republic to introduce ingly well in the first half of 1999 De- further reforms even exacerbated the mand for building materials in virtually recession there The economic...
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Báo cáo khoa học: Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis doc
... inactivation of phosphorylase is an essential component of the mechanism by which insulin stimulates glycogen synthesis and it can account for the stimulation of glycogen synthesis by insulin over ... phosphorylase a and glycogen synthase by a mutually exclusive mechanism [30] If the binding affinity of PTG is greater for phosphorylase a than for phosphorylase b, then dephosphorylation of phosphorylase ... mediating, the inactivation of phosphorylase by insulin? Acknowledgements This work was supported by Diabetes UK and by the Medical Research Council We thank Dr Morris Birnbaum for the gift of...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... values is exclusively displayed by the tetramer forms, and lowefficiency kinetics with high Km values is displayed by the dimer forms These observations strengthen the previous hypothesis that the ... whether the tetrameric and dimeric forms in Figs and exhibited low or high catalytic efficiency Therefore, the various incubated hTK1 forms from Figs and were analyzed for their kinetic behavior ... incubated with or without mm of the respective nucleotide or phosphate compound for h at °C, and stored for at least weeks at )80 °C before use for kinetic and molecular mass analyses The activity...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... cycle corresponding to the release of inorganic phosphate ([Pi]) is likely to correspond to the restoration of a high-affinity conformation for the transporter, which is supported by the restoration ... low-affinity conformation of drug binding sites in ABC multidrug efflux pumps is assumed to correspond to the outward-facing conformation The energy produced by the hydrolysis of ATP is harnessed for the ... although the binding data cannot unequivocally inform on the orientation of the sites, only their affinity for interaction with drugs The data presented here suggest that the ABCG2R482G isoform undergoes...
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Manhood Perfectly Restored, by Unknown This eBook is for the use of anyone anywhere at no cost and with almost no restrictions whatsoever. You may copy it, give it away or re-use it under the terms of the Project Gutenberg pptx
... honors conferred upon them by their country and their medical brethren, great as they were, could never half repay them for the good they rendered thoughtless youth and suffering manhood by their ... until the poor victim, driven too far, sinks into an early grave by disease or suicide, or is lost to the world and to all joys and friends behind the doors of an insane asylum He died of no disease ... LABORATORY, CIVIALE REMEDIAL AGENCY The above illustration originally appeared as the frontispiece, before the title page All our Doctors are Regular Graduates, and their Diplomas are Registered...
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The Healthy Life, Vol. V, Nos. 24-28, by Various This eBook is for the use of anyone anywhere at no cost and with almost no restrictions whatsoever. You may copy it, give it away or re-use it under the terms of the Project Gutenberg L ppt
... It is here that the work of the non- specialist comes in It is for him to compare the opposing views of the specialists, to reveal one in the light thrown by the other, to help into existence the ... adjusted up or down to raise or lower the kettle from the fire This knot is our old friend the two halfhitches Pass the loose end round the down cord, letting it come back under the up cord, then round ... spoons and forks and table knives are of the usual pattern, but the former can be had in aluminium and therefore much lighter than Britannia metal The camping-out valise is by all means the rucksack...
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the university of north carolina press opium war 1840-1842 barbarians in the celestial empire in the early part of the nineteenth century and the war by which they forced her gates mar 1998
... wait for the rains of the summer monsoon to sweep up from the Bay of Bengal But in fact there is activity here even at this time of the year For Ghazipur is one of the few places in the world ... chests the size of small footlockers That is the end of the process in this part of the factory; nothing more is done to the drug before it is shipped Exactly how much is turned out it is not ... but the bottom is not beyond the reach of an anchor The wind is muffled (not alwaysa typhoon at Hong Kong can be disastrous) on the west by Lantao, the other big island in the group, and on the...
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báo cáo khoa học: "The mechanisms by which polyamines accelerate tumor spread" pdf
... of polyamine synthesis by microbiota in the intestine with or without inhibitor-induced inhibition of polyamine Page of synthesis is reported to have favorable effects on cancer therapy [33,113-115] ... biosynthesis, with or without methylglyoxal-bis-guanylhydrazone (MGBG), an inhibitor of S-Adenosylmethionine (SAM) that is required for polyamine synthesis, successfully suppressed tumor growth ... polyamine synthesis is also accompanied by angiogenesis that is stimulated by cellular production of several factors, including vascular endothelial growth factor, which allow tumor tissues to grow...
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Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc
... Biological Laboratory (Woods Hole, MA, USA) We thank Andrew Gannon for help with the C intestinalis dissection Gene synthesis and analysis The ci0100132088 gene from the urochordate C intestinalis is now ... LBA is also a problem in metaphylogenies, but can be corrected for more easily, and a consensus is forming around the revised deuterostome phylogeny, with the urochordates actually being the sister ... described in the Experimental procedures Control (d); collagenase digestion (s) the volume of the catalytic gorge for C intestinalis ˚ AChE is 780 A3, whereas the volume of the gorge for ˚ T californica...
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Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt
... nucleolin This is probably due to the clustering of glutamic acid residues within the N-terminal region, preventing the formation of reasonably sized peptides for MS ⁄ MS analysis The calculated ... plus slides (VWR, Lutterworth, UK) For immunohistochemistry, sections were fixed for with )20 °C methanol and then blocked with 1% goat serum and 0.05% Tween in NaCl ⁄ Pi for 30 at room temperature ... act as a coreceptor for HIV, for example, the normal molecular function of cell surface nucleolin in any type of cell is still relatively unclear From the present study, we could hypothesize that...
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Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt
... Prof Ulrike Beisiegel and Prof Chica Schaller for discussion and providing the laboratory equipment and Susanne Hoppe for technical assistance This work was supported by the Deutsche Forschungsgemeinschaft ... identified by western blotting which was stained by the antiserum only in the absence of the peptides used for immunization 1722 Other proteins were also stained by the saturated antiserum (Fig 5B) The ... virions by cisternae derived from virus-modified trans-Golgi or endosomal membranes to form intracellular enveloped virions [7] The integrity of the p37 HKD motifs is required for the formation of the...
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Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
... this assembly is promoted by Vta1p (Fig 10B) Clearly, the RDF sequence at the end of the C-terminal helix is essential for ATPase activity, however, this requirement can be bypassed by the formation ... whereas the b domain is required for a Vps4p–Vps4p (i.e homotypic) interaction and for interaction with another component of the MVB sorting machinery, Vta1p ⁄ SBP1, both of which are important for ... Vps4p This is consistent with the results of our previous study in which we analysed the phenotypes that arise when the GAI sequence (also within the b domain) is deleted Also, like the GAI sequence,...
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Báo cáo khoa học: The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding ppt
... rearrangement of the ‘open’ and ‘closed’ forms of the ligand loop [19] Therefore, conformer A may be considered as the open form, albeit with the axial ligand still intact, with the main- and side-chain ... that of the wt protein (Fig 5B) Furthermore, in the absence of denaturant the second-order rate constant for peroxidase activity is some three times higher for the M100K variant than for the wt ... the dynamics in this region of the protein, which at cryo-temperatures leads to the visualization of two conformers On comparing the main-chain torsion angles and coordinates of the two conformers...
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High Remittance Costs in Africa: Is Building Regulatory Capacity for Microfinance Institutions the Answer? doc
... in the form of interest (or “float”) Part of the influence on cost structure in the by investing funds in the market before delive- remittance market is the level of competition ring them to the ... of the supervision of MFIs by the BCEAO and the Banking Commission, as referred to in section 44 of the Act for poor communities In any case, MFIs’ clients “MFIs' clients in majority are poor or ... commons or limited companies) has been adopted by the Board of Ministers of the WAEMU in 2007, as well as a corresponding order The law was passed by six of the eight WAEMU countries for the regulation...
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Báo cáo khoa học: In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities pdf
... and, moreover, that this phosphorylation is performed by PKA A comparison of CNBP primary structures from a variety of species revealed that the amino acid sequence for PKA phosphorylation is evolutionarily ... influence the affinities of La or CNBP for the 5¢ UTR, and the alternative binding of these proteins may lead, either alone or together with additional factors, to differential effects on the translation ... °C for before being transferred to ice, and then subjected to 15% native PAGE in Tris-Borate-EDTA 1· Gels were dried and autoradiography visualized by using GP-Storage Phosphor Screen and storm...
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Báo cáo khoa học: Mechanism of the ring contraction process in vitamin B12 biosynthesis by the anaerobe Propionibacterium shermanii under aerobic conditions docx
... Ring contraction mechanism of vitamin B12 Fig The mechanisms of the ring contraction process in the biosynthesis of vitamin B12 postulated on the basis of the isolation of factor IV from the anaerobe ... of the 13C18O-amide (C27) oxygen in the ring A show that the mechanism of the ring contraction process in P shermanii is the same irrespective of the presence or absence of oxygen In other words, ... experiments [5] to confirm the mechanism of the anaerobic ring contraction process in P shermanii for comparison with the result of the aerobic feeding experiments 3476 Results and Discussion Aerobic...
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Báo cáo khoa học: The transmembrane domain of subunitbof theEscherichia coli F1FOATP synthase is sufficient for H + -translocating activity together with subunitsaandc doc
... involved in the transient storage of energy [26] Due to the tension, which is built up during catalysis, stator resistance was shown to be at least balanced with the torque produced by the rotor [27] ... preformed ac subcomplexes Previous studies dealing with the reconstitution of chloroform/methanol extracted subunit c revealed the necessity for the addition of detergent to the sample prior ... level Neither the subunit b dimer [8] or the ab2 stator subcomplex [13], nor subunit a together with the ring of c subunits [14] or the subunit c ring alone [13], can be held responsible for F1...
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Báo cáo khoa học: The highly conserved extracellular peptide, DSYG(893–896), is a critical structure for sodium pump function docx
... R A Farley for the generous gift of the vectors YhNa1 and GhNb1 This work was supported by the Deutsche Forschungsgemeinschaft, Sche 397/5-1 and 397/5-2 S B was supported through the Graduiertenkolleg ... the Tyr895fiTrp mutant is considerably reduced when compared to the abundance of the wild-type enzyme and the other mutants Comparison of the signals for the wild-type and the Tyr895fiCys and Tyr895fiPhe ... chimeric constructs formed by replacing the 26 amino acids of the rat a3 subunit (Asn886)Ala911) with the corresponding region from either the gastric (Gln905-Val930) or the distal (Asn908-Ala933)...
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... mechanisms for the hydrolysis of ApA with different optimum pH and different orientations for the dinucleotide within the active site [19] The ability of R121K and R121Q variants to interact with ... considering the intensity at the wavelength of the emission maximum of the wild-type protein for excitation at 275 nm as 1.0 fluorescence emission Thus, the fluorescence emission of R121K coincided with ... reasonable agreement with the value of 1.34 reported for the wild-type protein [37] The far-UV CD spectra of both mutant variants were indistinguishable from that already reported for the natural fungal...
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Creativity Thinking Or the ability to connect to what is outside the box when you are inside it
... on the assumption that neither technology nor end use is a foundation for management policy They are limitations The foundations have to be customer values and customer decisions on the distribution ... “seeing”: there is no boundary Thirty spokes coverage upon a single hub; It is on the hole in the centre that the use of the cart hinges We make a vessel from a lump of clay; It is the empty space within ... Consultancy Lumiknows 18 How does it to with the Innovation Entrepreneurship? Red Ocean Strategy Blue Ocean Strategy Search for the market instead of in the market is a key to success in today’s Innovation...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25