that the digital audio player is good for the ears people may become deaf if they play music too loud
Báo cáo khoa học: Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity docx
... product dissociation, this internal proton relay system can be reloaded, leading to protonation of His106, such that the enzyme is ready for the next substrate turnover In this mechanism, His106 plays ... but before EPSP undergoes transformation to the product [18,19] This species is formed very rapidly (within a few milliseconds) and disappears when all substrate has been consumed The formation ... that abrogates the required water structure Therefore, we propose a mechanism in which a proton is relocated from the N(1)–C(2) O locus of the = isoalloxazine ring to the imidazole ring of His106,...
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Tài liệu THE MEDICAID EXPANSION IS GOOD MEDICINE FOR MISSOURI pptx
... referred for urgent care one time this year, was charged $90 for that visit and is still paying off that bill She is ineligible for Medicaid because her income is above Missouri’s eligibility limit for ... whether Missouri moves forward with the expansion is up to the legislature There are many factors that policymakers must consider in deciding whether to implement the ACA’s Medicaid expansion The ... for assistance with analysis of U.S Census data Finally, the author thanks the Missouri Foundation for Health for providing grant funding for health policy analysis, including the work on this...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... proposed that the WD protein acts as a copperspecific pump that mediates the export of copper from the cytosol, similar to the P-type ATPase [14] On the basis of the fact that MREs mediate the transcriptional ... in the transcriptional regulation of WD gene Previous studies report that MREa is also the most crucial MRE for transcription of the MT gene and that there is a relationship between the distance ... Ku-80 proteins The exact reason for this lack of difference is not clearly understood and further characterization is required The Ku proteins have been shown to be components of the mammalian...
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Báo cáo khoa học: The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis pot
... finger, the TUDOR domain, the ATrich interaction domain (ARID) and the zinc finger motif [11–13] Recent studies revealed that the JmjCcontaining proteins are histone demethylases and that the JmjC ... tested for their lethal phases and phenotypes during pupal stages Of the control flies that contain the either FLAG–mjmj (line 35) transgene or the hsp70–GAL4 driver under the background of the djmj ... results were obtained for the Df(3L)AC1 chromosome, which lacks a djmj locus in the genome These results suggest the involvement of dJmj in the establishment and ⁄ or maintenance of the closed chromatin...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... novo synthesis, it might be involved in the stearic acid incorporation after the de novo synthesis of this lipid (i.e the second hypothesis) According to this hypothesis, previously raised for mammals ... in the de novo synthesis of a given phospholipid, including PI Hence, the rate of synthesis and the amount of CDP-DAG molecules that were used as substrate for PI synthesis appeared to be the ... different subdomains of the endoplasmic reticulum (ER) where the two enzymes may be localized) results in different fatty acid compositions of PS and PI The other is that, after its synthesis,...
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Báo cáo sinh học: " A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis" pptx
... particles suggests the hypothesis that there is a requirement for the processing threshold of the core protein precursors to be achieved before morphogenesis can proceed Taken together, the data we ... progression to the formation of intracellular mature virus If the activity of the I7L proteinase is blocked, viral morphogenesis arrests prior to core condensation If the activity of G1L proteinase is blocked, ... Traktman for the vTetR virus strain and for helpful discussions, Tove' Bolken and Dr Marika Hedengren-Olcott for helpful discussions, and Dr Michael Nesson for the electron microscopy analysis This...
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báo cáo hóa học:" A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis" potx
... particles suggests the hypothesis that there is a requirement for the processing threshold of the core protein precursors to be achieved before morphogenesis can proceed Taken together, the data we ... progression to the formation of intracellular mature virus If the activity of the I7L proteinase is blocked, viral morphogenesis arrests prior to core condensation If the activity of G1L proteinase is blocked, ... Traktman for the vTetR virus strain and for helpful discussions, Tove' Bolken and Dr Marika Hedengren-Olcott for helpful discussions, and Dr Michael Nesson for the electron microscopy analysis This...
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báo cáo khoa học: " A var2 leaf variegation suppressor locus, SUPPRESSOR OF VARIEGATION3, encodes a putative chloroplast translation elongation factor that is important for chloroplast development in the cold" docx
... TAG-11 is smaller than svr3 single mutants and displays some variegation at later development stages This is true for both alleles of svr3, indicating that it is specific for the SVR3 locus, rather ... Below-threshold activities, on the other hand, are not sufficient for chloroplast biogenesis and condition the formation of non-pigmented plastids Our working hypothesis is that the green sectors of var2 ... though the svr7-1 single mutant is resistant to cold treatment, the svr3-1 svr7-1 double mutant is susceptible to it inasmuch that the double mutant shows a chlorosis phenotype similar to that of the...
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Báo cáo y học: "Good night, sleep tight: the time is ripe for critical care providers to wake up and focus on sleep" pps
... Care Vol 12 No Friese Competing interests The author declares that they have no competing interests References Bourne RS, Mills GH, Minelli C: Melatonin therapy to improve nocturnal sleep in critically ... LM: Quantity and quality of sleep in the surgical intensive care unit: are our patients sleeping? J Trauma 2007, 63:1210-1214 Aurell J, Elmqvist D: Sleep in the surgical intensive care unit: continuous ... recovery from illness and injury: A review of theory, current practice, and future directions Crit Care Med 2008, 36:697-705 Weinhouse GL, Schwab RJ: Sleep in the critically ill patient Sleep 2006,...
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Đề tài:what qualities and skill are needs for the manage people in a company? what is the importance of good human resources?
... 2.Listen, listen, listen and then speak • 3.Accommodate to the person you are talking to • 4.Take into account that you can be wrong • 5.Leave the space for others to think • 6.Timing is the ... Qualified employees will be promoted if the manager has time to improve his public capacity Give your employees the knowledge and experience of themselves so that they can learn and develop further ... identification and recognition of the values and needs of the communication object This is the basis of the importance of communication, handling conflict and negotiation 4)Communications • The...
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LUẬN MẪU LỚP 12 Discuss the view that tolerance is essential for peace and harmony in any community or country
... differences in certain localities, yet they can hardly be attributed to the general uprising of the races against one another In fact, the goodwill that prevails among the different races of people ... contributed to the development of a new nation, which has become the envy of many countries The racial unity among the people is the main factor that has contributed to the progress of the country ... in the future Their leaders have met at various times, in the course of history, to discuss peace and to find a way of removing the causes of war It is this urge that led to the creation of the...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... protein for MS analysis of the myristoylation site, we used 293T cells as the expression system, as the presence of the SV40 large T antigen in these cells enhances their resistance to apoptosis Apoptosis ... of apoptosis, further demonstrating that the myristoylation mutant was functionally impaired Discussion JSP1 and its relative DUSP15 are unique among members of the PTP family in that they contain ... JSP1-wt than those cells that remained attached to the culture dish Furthermore, cells expressing the JSP1-G2A mutant remained attached to the dish despite the fact that the mutant protein was...
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Tài liệu Protest Fee Schedule for Thunder Cars: Protestor must verify with the INEX inspector that the proper tools are available to check protested items ppt
... used for this bar is (1”x 1/2” x 0.120” wall) The length for the sedan is 14 3/4” and the coupe is 13 1/2” (with an angle at the one end) The distance this bar should be from the B-Pillar is 25” ... the minimum tread depth If this rule is violated on two different occasions at the same event or two tires on the car at the same time, then that driver will be disqualified If the wear bar is ... CRANKCASE BREATHER: The only locations that the crankcase may have a breather is under the carburetors at the stock outlet or in the oil fill cap This breather may not be evacuated through the exhaust...
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Tài liệu Báo cáo khoa học: Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae pdf
... unpublished This study This study [44] This study [45] This study [28] [28] This study although by this time the levels of the protein are very low (Fig 2D) The fusion Protein A–Nop53p is functional, ... processing [35–37] The finding 4458 that the depletion of Nop53p leads to the accumulation of 7S pre-rRNA indicates that Nop53p could mediate the signal for the processing of this pre-rRNA to the exosome ... of the pre-rRNAs 27S and 7S The finding that depletion of Nop53p affects more strongly the late processing reactions responsible for the formation of the mature 5.8S rRNA, indicates that this...
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Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx
... characteristics when overexpressed in human 293-cells The main objective of the present work was to find an explanation for this phenomenon It is demonstrated that the formation of the active complex is ... influenced by a single amino acid difference, i.e G252R, in a region within the catalytic domain This is the first evidence that this region is involved in the formation of the active complex MATERIALS ... comparison shows that there is a cluster of amino-acid differences in the C-terminal part of the enzyme (Fig 2A) where 13 of 44 amino acids are different Therefore, chimeric enzymes with the N-terminal...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... and the development of endo-H resistance [13,18], nevertheless failed to identify the role, if any, that glycosylation plays in HFE localization and function We established for the first time that ... between HFE and TfR1 in that they are mediated by the a3 domain of HFE, as opposed to the a1/a2 superstructure [33] An emerging model, therefore, is that TfR2 competes with TfR1 for FEBS Journal 277 ... response We propose that glycosylation is important for the folding of HFE and is essential for transport and exit of the protein from the ER The importance of glycosylation is cumulative, however,...
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Báo cáo khoa học: The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity pot
... is designed such that the ATG codon is attached to the 5¢-terminus of the gene encoding Tma-CD Primer is designed such that the TGA codon is attached to the 3¢-terminus of the gene encoding For ... cases, the conformation of the metal binding site is probably slightly changed, so that it becomes unfavorable for binding of Mg2+ but is kept favorable for binding of Mn2+ The finding that the D13-R4-D12 ... that the conformation of the active site is not significantly changed on removal of the HBD Because the HBD is important for substrate binding, the HBD may affect the interaction between the enzyme...
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Báo cáo khoa học: YidC is required for the assembly of the MscL homopentameric pore potx
... the earlier study [13], is located adjacent to the centre of the pore-forming TM1 It is therefore conceivable that even a slight perturbation of the conformation of MscL, for example due to the ... impact on the level of the MscL–HA complex, suggesting that the Sec translocon is dispensable for the oligomerization of the MscL subunits Discussion We have analysed the requirements for targeting, ... is equal to that of the non-depleted IMVs This indicates that YidC is required for assembly of the MscL complex (Fig 5) To investigate the role of the Sec translocon in formation of the MscL–HA...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008