texture of igneous rocks is determined by

... Hydrogen peroxide, the product of the SOD reaction, is an inhibitor of SODs and an inactivator of FeSOD It is often used to distinguish between the two types of isoenzyme, particularly in conjunction ... equivalent in the enzymes, is contributed by the N domain of FeSODs (Q69) and the C domain of MnSODs (Q146) Exceptions to this scheme include the substitution of Gln by His in two MnSODs and some ... Comparison of E coli mononuclear superoxide dismutase molecular features (Top) Stereo view of the superposition of the backbone peptide chain of one subunit of FeSOD (black) and MnSOD (grey) of...

Ngày tải lên: 21/02/2014, 01:21

... mature part is weakened [15–17], resulting in a looser conformation of the proenzyme This is followed by intermolecular cleavage of the procathepsin B propeptide [14] However, initiation of the activation ... advantage of this inhibitor is the possibility of detecting the radioactively labelled proteins by autoradiography Samples of procathepsin B and cathepsin B were incubated in the presence of 125I-DCG-04 ... neutral pH Moreover, this conformational change, which is the only unimolecular step of the mechanism, is not accompanied by any larger structural changes, such as unfolding of the ‘hook’ domain,...

Ngày tải lên: 07/03/2014, 03:20

... diminished [Footnote 21: The "fatal habit of eating dirt" is described by Thomas Roughley in his _Planter's Guide_ (London 1823) pp 118-120.] The list of slaves at the beginning of 1794 is the ... colony from a distraught camp into a group of severely disciplined farms, owned by the London Company, administered by its officials, and operated partly by its servants, partly by its tenants ... forts lying within sight of each other: El Mina of the Dutch, and Cape Coast Castle of the English Each was commanded by a governor and garrisoned by a score or two of soldiers; and each with...

Ngày tải lên: 08/03/2014, 00:20

... levels of proteins were performed in the presence and absence of okadaic acid and/or MG132 By Western blot analysis of the whole cell extracts, TPH of molecular mass 53 kDa was localized side -by- side ... for proteolysis targeting The role of TPH phosphorylation is that it down regulates the TPH level in the cell by serving a tag for targeting for digestion by proteasomes This idea is based on ... phosphorylation is a prerequisite for proteasome digestion of nonneural TPH This phosphorylation enables the cell to severely down-regulate the enzyme level by means of stimulation of proteasome-driven...

Ngày tải lên: 08/03/2014, 16:20

... apoptosis [1,2] The existing evidence indicated that the cellular mechanisms of the anticancer effects of vanadium compounds were due to both inhibition of cellular proliferation and induction of ... apoptosis of HaCaT cells was mediated by c-fos and involved induction of total Bax and upregulation and accumulation of nCLU Furthermore, forced expression of nCLU sensitized HaCaT cells to apoptosis ... induction of HaCaT cell apoptosis by VOSO4 was promoted through the induction of both c-fos and nCLU, the expression of which was affected by Bcl-2 A Fos-mediated vanadium-induced apoptosis Overexpression...

Ngày tải lên: 16/03/2014, 02:20

... genes is coordinately regulated by iron limitation, as shown by the RT-PCR analysis, and there is overlapping of the desB translation termination triplet with the ATG of desC and also of desC ... TAgPuPuT [19] It is interesting that the )10 sequence is located inside the iron box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expression by binding of DmdR1 to ... extension analysis of the transcription start (TS) point of the S coelicolor desA promoter Comparison of the reaction sequences of the promoter region (T, G, C, A) with that of the primer extension...

Ngày tải lên: 16/03/2014, 11:20

... deletion of OXA1 decreased the rate of formation of all aminoglycerophospholipids The rate of PtdSer synthesis decreased to 80%, the rate of PtdEtn formation to 70% and that of PtdCho synthesis to ... effect of these two mutations acting on two different pathways Taken together, deletion of OXA1 affected synthesis of PtdEtn by Psd1p, but did not completely abolish the activity of this enzyme ... YRN2 YRN3 YRN12 BY4 741 Mata his3D1 leu2D0 met15D0 ura3D0 BY4 741 Mata his3D1 leu2D0 met15D0 ura3D0 afg3D::KanMX4 BY4 741 Mata his3D1 leu2D0 met15D0 ura3D0 psd1D::KanMX4 BY4 741 Mata his3D1 leu2D0 met15D0...

Ngày tải lên: 30/03/2014, 04:20

... by Corollary Theorem The k-base graph of a matroid of rank is connected The remainder of this paper is devoted to the proof of this theorem We consider a matroid M of rank on a ground set E of ... that cfi is a flat of rank and cefikl is a flat of rank on cefghijkl (the left-hand side of Figure 10) Note that the flat of rank is included in the flat of rank by submodularity Then a set, of size ... side of Figure 10) Similarly, any set of size consisting of one of cfi, one of ekl, and one of ghj is red It remains to show that this partition and the initial blue partition are connected By the...

Ngày tải lên: 08/08/2014, 12:22

... 1992:199-224 Portis JL: Genetic determinants of neurovirulence of murine oncornaviruses Adv Virus Res 2001, 56:3-38 Portis JL, Lynch WP: Dissecting the determinants of neuropathogenesis of the murine ... PH: Molecular basis of neurologic disorders induced by a mutant ts1, of Moloney murine leukemia virus In Molecular Neurovirology: Pathogenesis of Viral CNS Infections Edited by: Roos R Totowa: ... Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of...

Ngày tải lên: 13/08/2014, 01:20

... much distortion of the textual meaning of the source text By contrast, in translations between such distant languages as Vietnamese and English, this strategy leads to an enormous loss of original ... 4.2.2 Non - Linguistic Features (Cultural Features) In this part of the thesis, we just focus on some certain aspects of culture that cause loss of meaning during the translation of this work We will ... analysis of personal pronouns in English and in Vietnamese in the view of sociolinguistics to find out loss and gain in the process of translating personal pronouns According to her, sociolinguistic...

Ngày tải lên: 14/05/2016, 18:39

... Osako et al Enhancement of calpain autolysis by IST1 detected This result strongly suggests that 30 K is generated by proteolytic activity of mGFP–calpain 7–Strep itself, not by potentially contaminating ... Enhancement of calpain autolysis by IST1 Y Osako et al membranes [42] ALIX is recruited to plasma membranes by Gag proteins of HIV-1 and equine infectious anemia virus through binding of the V domain of ... in the case of mGFP–calpain 7C290S, suggesting that the degradation was caused by proteolytic activity of mGFP–calpain itself We refer to this issue later Effects of mutations of IST1 MIMs on...

Ngày tải lên: 18/02/2014, 04:20

... after dilution to lgỈmL)1 indicate that dissociation of the tetramer to the dimer is a slowly progressing process This is supported by the kinetic behaviour of the recombinant enzyme as shown in ... values is displayed by the dimer forms These observations strengthen the previous hypothesis that the dimer ⁄ tetramer interchange of TK1 with low ⁄ high catalytic efficiency is a fine-tuning mechanism ... regulation of TK1 ensures that the increase in TK1 activity coincides with an increase in the DNA synthesis rate and dNTP pools [10] TK1 is degraded to undetectable levels during mitosis by means of...

Ngày tải lên: 18/02/2014, 12:20

... This result is discussed in light of the possible biological function of this protein This study demonstrates the power of the SAIL approach in determining the structure of a larger protein by ... system Fig Comparison of 1H-13C constant-time HSQC NMR spectra of 0.6 mM of UL At3g16450.1 and 0.2 mM of SAIL At3g16450.1 (A) Full spectrum of UL At3g16450.1 (B) Full spectrum of SAIL At3g16450.1 ... energy refinement Comparison of NMR spectra of SAIL and UL At3g16450.1 Although the concentration of the SAIL protein was lower than that of the UL protein by a factor of three (SAIL, 0.2 mm;...

Ngày tải lên: 18/02/2014, 14:20

... fraction of the Y17 kinase activity found in HeLa lysates C-YES is a 62 kDa nonreceptor tyrosine kinase of the Src family that is expressed in a wide range of tissues [24] The N-terminus of C-YES is ... and that this phosphorylation is independent of p27KIP1 The finding that Y17 phosphorylation is mediated by Src family kinases is completely novel and it is interesting to note how this fits in ... this context, Y17 phosphorylation is thought to be modulated by loss of the phosphatase CDC25A Our data suggest that Src kinases are candidates to provide the phosphorylation of CDK4 If this is...

Ngày tải lên: 18/02/2014, 18:20

... 4–9) is shown here The presence of both genes led to inhibition of transcription to 70% (lane 4), which was rescued by the addition of the TFIIIB fraction to almost 90% of the parent (lane 5) This ... antibodies to TRF AP was a recipient of a Senior Research Fellowship of the Council of Scientific and Industrial Research, Govt of India KPG is a senior scientist of the Indian National Science Academy ... reversed by supplementation of the TFIIIB fraction to almost 100% of original levels (lanes and 8) These results confirmed the role of TATATAA sequences in the sequestration of TFIIIB presumably by...

Ngày tải lên: 20/02/2014, 02:21

... ª 2005 FEBS H Seedorf et al Stereochemistry of F420H2 oxidase Fig MALDI-TOF-MS analysis of F420 and F420H2 for the determination of the stereospecificity of F420H2 oxidase (FprA) The insets show ... The natural isotopic distribution in F420 was calculated by the isotope pattern calculator provided by the University of Sheffield at the ChemPuter site (http://www.shef.ac.uk/ chemistry/chemputer/) ... spectrum of F420 formed from (5S)-[5-2H1]F420H2 by FprA-catalysed oxidation (c) is identical to the spectrum of [5-1H]F420 (a) The simulated stick spectrum (b, white) of (5S)-[5-2H1]F420H2 is for...

Ngày tải lên: 20/02/2014, 03:20

... transcription initiation, the usage of this TATA box was not observed in our studies Determination of the 5¢-end of mRNAs isolated from liver tissue and cloned by 5¢-RACE showed similar results ... start site of fgl2 mRNA (A) 5¢-RACE of fgl2 mRNA from macrophages Stars indicate the 5¢-terminus of 33 clones isolated after 5¢-RACE (B) Primer extension analysis of fgl2 mRNA The left side of the ... that a variety of tissues may express basal levels of a TF/factor VIIindependent procoagulant Indeed, constitutive expression of TF in some cells and tissues is known to play this role, such as...

Ngày tải lên: 20/02/2014, 11:20

... coordination sphere of Mn2+ [3] Binding of CO2 is not affected by the presence of cations, indicating that the interactions of Mn2+ and CO2 are independent of each other This agrees with observations ... This high binding affinity of PEP in the presence of Mn2+ appears common to PEPcarboxykinases A Kd of 0.6 lM has been determined for the dissociation of PEP from the enzyme–Mn2+–PEP complex of ... caused by the binding of substrate, is sensed by the P-pyridoxyl group, and allowed the acquisition of detailed and reliable information on the binding of several ligands and on the role of Mn2+...

Ngày tải lên: 21/02/2014, 01:21

... analysis of the regulation mechanism for the binding of a set of inner nuclear membrane proteins to chromatin is necessary for understanding the molecular mechanism of dissociation/ association of ... semiquantitatively by this method The effects of enzymes, inhibitors and other reagents on the cell cycle– dependent interaction could also be examined very easily by means of this method This method is applicable ... precise regulation of the cell-cycle dependent dissociation/association of these proteins and chromatin is important for the cell cycle In the case of LBR, binding to chromatin was shown by sperm...

Ngày tải lên: 22/02/2014, 04:20