testing the integrity of the ventral visual processing pathway in alzheimer s disease
Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... gene in HD mouse brain This supports the hypothesis that the rate of transcription of CB1 in the striatum of symptomatic R6/2 mice is similar to the rate of transcription in regions of the brain ... expression of CB1 in the striatum vs the cortex or expression of CB1 in transgenic HD mice To test the hypothesis that expression of mutant huntingtin decreased CB1 transcription, we measured the ... levels of specific transcripts such as CB1 in striatal neurons Since it is known that the length of the CAG repeat affects the onset of HD in humans and in mice, we first confirmed that the rate of...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... which inhibit different steps in the complement cascade All of these regulatory proteins are produced in the human brain, but less is known about their CNS synthesis in other species [31] The status ... carries both of these transgenes and has been extensively used as a model for studying processes relating to the formation of SPs Aβ deposition occurs more rapidly in these mice than in the single ... liver is the main source of these proteins in peripheral blood, but they are also synthesized in other organs including the brain [31] Protein fragments generated during activation of the system...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... box plots The box represents the interquartile range that contains 50% of the values The whiskers extend from the box to the highest and lowest values The line across the box indicates the median ... brain area, methods of analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and O'Banion [17] In an immunohistochemical study they...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... Furthermore, global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved ... http://www.jneuroinflammation.com/content/3/1/30 kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52] Activation of these signaling cascades are linked to the synthesis and secretion of proinflammatory molecules and cytokines ... incidence among patient populations receiving statin treatment [117,118] Despite these promising findings, the use of statins in prospective clinical trials has yielded unsatisfactory results,...
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Báo cáo y học: "Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behçet''''s disease" docx
... boxy-terminal subunit of Sip1 (anti-Sip1 C-ter) antibodies in patients with Behçet 's disease (BD), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), vasculitis, inflammatory bowel disease ... C-ter in patients with distinct autoimmune diseases characterized by the presence of serum anti-endothelial cell antibodies such as BD, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), ... process involves apoptosis need further investigations Apoptosis of endothelial cells may be initially induced by inflammation or oxidative stress caused by intrinsic or extrinsic factors In this...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples ... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... and shown to increase Ab levels by six- to eightfold [4] These discoveries created intense interest in APP processing and paved the way for the development of more sophisticated ELISAs to selectively...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... proteins with either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies ... binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction and accelerates the translation rate of rapamycin-sensitive ... parallel, the corresponding stainings were weak in all of these areas as compared with the AD brain sections (data not shown) In AD brain, immunostainings with the antibody against p-eEF2 at Thr56 showed...
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báo cáo hóa học: "Effect of gait speed on gait rhythmicity in Parkinson''''s disease: variability of stride time and swing time respond differently" docx
... and stride-to-stride variability [22,39] The system measures the forces underneath the foot as a function of time The system consists of a pair of shoes and a recording unit Each shoe contains ... an increased fall risk in older adults in general, as well as in patients with PD [9-13], suggesting that this aspect of gait may have clinical utility as an aid in fall risk assessment More specifically, ... most serious complications of the gait disturbance in Parkinson 's disease (PD) [1-7] Beyond the acute trauma that they may cause, falls may lead to fear of falling, self-imposed restrictions in...
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Báo cáo y học: "The impact of provider-initiated (opt-out) HIV testing and counseling of patients with sexually transmitted infection in Cape Town, South Africa: a controlled trial" pot
... who tested for HIV as well as the proportion of patients offered testing There was also significantly less variation in the main outcomes across the intervention clinics, suggesting that the intervention ... effectiveness of the PITC intervention is in increasing the coverage of the offer of testing to 100% of new STI patients More than one-quarter of patients offered testing in the intervention group declined ... drop the offer of testing during busy periods For nurses to increase the offer of testing from 76%, as measured in this study, to 100% of new STI patients, they may require even more streamlined...
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báo cáo khoa học: " The impact of provider-initiated (opt-out) HIV testing and counseling of patients with sexually transmitted infection in Cape Town, South Africa: a controlled trial" doc
... who tested for HIV as well as the proportion of patients offered testing There was also significantly less variation in the main outcomes across the intervention clinics, suggesting that the intervention ... effectiveness of the PITC intervention is in increasing the coverage of the offer of testing to 100% of new STI patients More than one-quarter of patients offered testing in the intervention group declined ... drop the offer of testing during busy periods For nurses to increase the offer of testing from 76%, as measured in this study, to 100% of new STI patients, they may require even more streamlined...
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Tài liệu The Centrality of Money, Credit, and Financial Intermediation in Marx’s Crisis Theory: An Interpretation of Marx’s Methodology pptx
... of Theories of Surplus Value Marx presents the same basic analysis, but the language he uses there makes it harder to misunderstand the theoretical status of the abstract forms of crisis in SCP ... is not a theory of the causes of crisis in capitalism or of capitalism s laws of motion A complete theory of crisis requires the analysis of the general laws and tendencies inherent in the specific ... crisis in SCP: It can therefore be said that the crisis in its first form is the metamorphosis of the commodity itself, the falling asunder of purchase and sale The crisis in its second form is...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... cm)1 Assessment of aggregation using thioflavin T binding and electron microscopy The kinetics of fibril formation was determined using a continuous ThT assay [49] Solutions of Ab isolated by SEC ... peptides accumulate in inclusion bodies, and that Ab(L1–40) is the dominant protein in the inclusion bodies In contrast, the major protein in the Ab(M1–42) inclusions was not Ab, but was the small ... containing m urea Mass spectrometry, amino acid analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... to establish a baseline of cognitive functioning, assess the magnitude and rate of change in patients who have had previous testing, or assess behavioral expressions of treatment response In addition, ... illustrates an approach toward scan interpretation that integrates the visual and quantifying information present in clinical PET scans Visual Assessment Systematic visual examination of a clinical ... screenings are brief in- office assessments of cognition that provide information regarding cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE,...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... dyshomeostasis in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of extracellular metals and a decrease in the ... increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase in Ab production promotes excess Cu transport out of the cell, ... kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 (GSK3) GSK3 has recently been implicated as a critical kinase involved in...
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The Handbook of Alzheimer’s Disease and Other Dementias doc
... class of drugs approved by the FDA for treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease ... Wernicke–Korsakoff syndrome Alzheimer s disease Frontotemporal and Parkinsonian dementias Huntington s disease Neuronal ceroid lipofuscinosis Multiple infarct dementia “Binswanger s disease “Small vessel ... Alzheimer s disease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists, graduate students, and allied health professionals including nurses, social...
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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot
... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... investigated the levels of different MMPs in plasma of AD patients [30] The increased levels of several MMPs in the CSF of individuals with increased risk for AD, as observed in the current study, ... the PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests were used because normal distribution could not be assumed in the groups...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The findings obtained in the present study lead to a proposed working hypothesis: in the absence of calpain 3, CARP ... muscle [30], was not assessed as a substrate The structure of CARP comprises several ankyrin-like repeats, PEST motifs (i.e regions of protein instability rich in proline, glutamic acid, serine ... and the M line, are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase...
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Báo cáo Y học: Structural study on lipid A and the O-specific polysaccharide of the lipopolysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn’s disease ppt
... nonreducing terminus of the OPS chain Taking these observations into account, the structure of the OPS moiety was deduced to be that shown in Fig 5C In the Bacteroides group, the structure of the ... was used as a matrix The sample was ionized with KeV Xe atoms, and the ions were accelerated through 10 KeV Argon was used as the collision gas RESULTS AND DISCUSSION Analysis of LPS As shown in ... signals were mainly observed, and the corresponding sugars were designated as a and b in order of 1H chemical shift The 1H signals were assigned using DQF-COSY, TOCSY and ROESY spectra, and the...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... expressing the short B-cell epitope of amyloid within the HA of influenza virus The HA and NA glycoproteins of influenza A viruses contain the major antigenic determinants of the virus responsible ... samples was determined by the Bio-Rad protein assay (Bio-RAD, CA) and the purity of the samples was analyzed by SDS-PAGE (Bio-RAD, CA) The protein bands were visualized by coomassie blue staining ... performed in vitro assessment using HI [29] and neurotoxicity [24,32] assays routinely used in our laboratories These analyses showed that chimeric virus maintained the ability to induce the production...
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báo cáo hóa học: " The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients" pptx
... in these patients and delineate the underlying mechanisms of this disease In the present study, we extended previous work utilizing the same kinematic and kinetic biomechanical measures to assess ... changes that occur further up in the kinetic chain at the hip joint The Page of increase in the range of motion of the ankle during stance was accompanied by a decrease in range of motion of the ... patients in this study were combined into one group for analysis regardless of medication type Because the focus of this study was not to evaluate the effects of one medication versus another, the...
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