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Tài liệu Báo cáo khoa học: ATPase activity of magnesium chelatase subunit I is required to maintain subunit D in vivo ppt
... subunit, it is well-known that Mg2+ is required to perform the ATP hydrolysis In addition, kinetic analysis had shown binding of Mg2+ to this subunit [21] An integrin I domain, suggested to exist in ... to exist Acknowledgements Dr Salam Al-Karadaghi is acknowledged for fruitful discussions This work was made possible thanks to generous support from the Swedish Research Council, the Swedish Research ... subunit is essential for the function of this subunit as a chaperone and that binding of I to D is not enough to maintain the D subunit in the cell Our study suggests that ATP hydrolysis is important...
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Tài liệu Báo cáo khoa học: Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae pdf
... GAL4::NOP17, LEU2 lm GAL4::NOP53, LEU2 lm GAL1::ProtA, URA3, CEN4 YCp33GAL-A-NOP53 YCp111-His-NOP53 pRS313 pRS-GAL-His-NOP53 pGFP-N-FUS pGFP-N-NOP53 pRFP-NOP1 pGEX-NOP17 pET-NOP53 GAL1::ProtA-NOP53, ... NOP53::KANR MET15 his3D1 leu2D0 ura3D0 NOP53::KANR Dnop53, pGFP-N-FUS, pRS-GAL-His-NOP53 Dnop53, pGFP-N-FUS-NOP53 Dnop53, YCp33GAL-A-NOP53 NOP53, YCp33GAL-A NOP53, YCp33GAL-A-NOP53 L40-41 L40-61 ... GAL1::His-NOP53, LEU2, CEN4 pBluescript, HIS3, CEN6, ARSH4 GAL1::His-NOP53, HIS3, CEN4 MET25::GFP, CEN6, URA3 MET25::GFP- NOP53, URA3, CEN6 ADH1::RFP-NOP1, LEU2, lm GST::NOP17, AmpR His::NOP53,...
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Tài liệu Báo cáo Y học: Phosphorylation of initiation factor-2a is required for activation of internal translation initiation during cell differentiation ppt
... of Xenopus, Caenorhabditis elegans and Drosophila, the translation of subclasses of mRNAs is regulated However, during differentiation of mammalian cells, only a few individual mRNAs are known ... efficiently where there is an increase in eIF2a phosphorylation, under conditions of amino acid starvation and genotoxic stress, respectively [52,53] What is the mechanism underlying IRES-mediated ... mediated by eIF2a phosphorylation Another possibility could be that a mechanism exists that is similar to the translational regulation of GCN4 in yeast In this case, the induction of GCN4 translation...
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Báo cáo khoa học: YidC is required for the assembly of the MscL homopentameric pore potx
... structure is known [11,12] This allows analysis of targeting and membrane insertion of the monomer, as well as complex assembly and quality control Information about these late steps in IMP biogenesis ... IMP biogenesis is very scarce Using mutants compromised for SRP, Sec or YidC functioning, we found that the SRP is required for optimal targeting of MscL but the Sec translocon is not needed for ... reason for this discrepancy is not clear, but might be explained by the structural constraints of the respective mutants used for the assays The structure of MscL of E coli is unknown, but may...
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Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt
... this cell line does not show any detectable apoptosis after FasL treatment Using this system, we recently discovered that caspase-8-mediated cell-autonomous NF-jB activation is crucial for this ... activation Discussion In this study, we demonstrated that AP-1 activation is required for optimal IL-8 production upon FasL stimulation in HEK293 cells, and that JNK activation is required for ... NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta Mol Cell 21, 467–480 40 Itoh N & Nagata S (1993) A novel protein domain required for apoptosis Mutational analysis of...
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Báo cáo khoa học: "Does Size Matter – How Much Data is Required to Train a REG Algorithm?" potx
... controlled visual scenes for a given domain Since this is a time consuming exercise, it will not be surprising that such corpora are thin on the ground (and are often only available for English) An ... frequencies For our current evaluation experiments, this would hamper comparison across data sets, because it is difficult to it in a manner that is both consistent and meaningful Therefore we first experiment ... (Koolen and Krahmer, 2010) This corpus uses the same visual scenes and annotation scheme as the TUNA corpus, but with Dutch instead of English descriptions D-TUNA does not include locations as object...
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Báo cáo khoa học: Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase a is required for Src activation doc
... [45] This hypothesis was confirmed in a study showing that the catalytic site of LAR-D2 is required for binding to the insulin receptor, a known LAR substrate [46] The interaction is decreased when ... Arg554 residue is essential for the catalytic activity of RPTPa-D2 Catalytic activity of the RPTPa D2 domain is required for Src binding and activation It is well known that the membrane distal domains ... We discovered an R554H mutation in the KNRY motif of RPTPa-D2 in a screen for disease-related mutations in RPTPs Whereas this mutation appears not to be linked to disease, we observed that this...
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WORKING PAPER NO. 192 IS THE EUROPEAN CENTRAL BANK (AND THE UNITED STATES FEDERAL RESERVE) PREDICTABLE? pptx
... 10-ene-01 NO 0.01 0.07 0.05 0.05 Issing ("Fed decision has no impact on the ECB") Communication 20-feb-01 NO 0.12 0.03 0.09 0.09 Welteke ("inflation risks have not vanished") Communication 23-feb-01 NO ... 6-sep-01 NO -0.03 -0.07 NAPM-ISM (non manufacturing) -0.12 Partly unexpected cut Market Meeting Economic data Economic data Economic data Meeting Meeting Economic data Economic data 7-sep-01 NO -0.12 ... 14-oct-99 NO 0.02 0.08 0.06 0.07 MB (inflation risks rising) and Issing (strong growth) Communication 25-oct-99 NO 0.06 0.07 0.07 0.06 German CPI Economic data 29-oct-99 NO 0.05 0.10 0.10 0.11 Issing,...
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Báo cáo khoa học: Knock-out of the chloroplast-encoded PSI-J subunit of photosystem I in Nicotiana tabacum PSI-J is required for efficient electron transfer and stable accumulation of photosystem I pot
... plants disrupted in the psaJ gene and subjected to immunoblot analysis An antibody originally raised A Plants devoid of PSI-J are fully viable and fertile but display a clear phenotype When plants ... marinus (PROMA)] Amino-acid residues involved in Chl binding [W (Trp), E (Glu) and H (His)] are indicated with green arrows Note that the histidine residue is only conserved in cyanobacteria, in agreement ... it is known that PSI-E is in contact with the C-terminus of the PSI-F subunit [5] Changes in binding or amounts of any of the stromal subunits of PSI were not detected in our immunoblot analysis;...
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Báo cáo khoa học: Multi-tasking of nonstructural gene products is required for bean yellow dwarf geminivirus transcriptional regulation potx
... virion sense-strand and initiates DNA synthesis from the 5¢-terminus As DNA synthesis progresses, the virion sense-strand is displaced and eventually is recircularized and religated by Rep [1,4–6] ... regulation of BeYDV CP expression was examined The discovery of an unconventional mechanism of translational initiation is discussed Results Comparison of Pc and Pv promoter strengths in NT-1 cells ... detail, whether V2 is expressed from a smaller monocistronic transcript, or as the downstream cistron of a larger polycistronic transcription unit, a northern blot was performed on NT-1 cells bombarded...
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Báo cáo khoa học: The b domain is required for Vps4p oligomerization into a functionally active ATPase potx
... This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study GAI as well as GST-tagged ... Healthcare Novagen Clontech Clontech Clontech [31] [30] [30] [30] [30] [30] [30] [30] [30] This study This study This study This study This study This study This study This study This study This study ... two-hybrid assay [25], and this mutant forms a 10–122358 mer in the presence of ATP [24,27], it is not clear whether this is due to stabilization of a complex that is normally transiently formed...
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Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf
... the hydrolysis of mca-GlyProGlyPhe-dnp, a synthetic substrate, is decreased up to approximately 400-fold when Tyr612 is replaced with Phe [17] The proposed role of Tyr612 of TOP is to stabilize ... hydrogen bond donation This role is similar to that of other amino acid residues in peptidases, such as His231 in thermolysin [17,18] However, modeling suggests that Tyr612 of TOP is several angstroms ... which lie close to Y605, caused no significant change in activity towards mcaBk It is notable that Y612F and Y605F caused a modest and no change, respectively, towards this same substrate Substitution...
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Báo cáo khoa học: The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis pot
... modified histones Antibody to H3 was used as a loading control This material is available as part of the online article from http://www.blackwell-synergy.com Please note: Blackwell Publishing is not ... that is required for heart development, by counteracting the function of ANF activators Nkx2.5 and GATA4 [26] As jmj is widely expressed and is required for the correct development of various tissues, ... Drosophila jumonji N Sasai et al band is a nonspecific protein that is cross-reactive with the antibody It should be noted that this cross-reactive 120 kDa band is undetectable in extracts from flies...
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NO COUNTRY IS AN ISLAND docx
... Genocide Convention, but this legislation did not itself criminalise genocide in Australian law and no legislation had been passed since that time to so Despite the absence of relevant legislation, ... said, ‘I not believe the argument is whether this is legal or not legal; it is just that it is wrong’.40 The Shadow Attorney-General, Robert McClelland, stated in similar vein, ‘The Prime Minister ... pillars to collapse The decision to split from the government on this issue, Mr Rudd emphasised, was not ‘the product of mindless anti-Americanism: it is the product of an analysis which concludes that...
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Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf
... is giving novel molecular mechanistic insight is adenocarcinoma of the oesophagus [2] This cancer is one of the fastest rising cancers in the west, is taking the place of squamous cell carcinoma ... because it is well characterized with regards to its apoptotic pathway, is p53-null (which is not required for DCA-induced death) (Fig 5), does not express endogenous SEP53 protein (data not shown), ... particular bile acid was not associated with disease state as determined by one-way anova (data not shown and published in the PhD thesis of J Darragh, University of Dundee) Although no difference in...
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Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... are known to couple to both Gq/11 and Gi/o and stimulate phosphoinositide turnover although their other potential downstream signalling targets have not been fully established [12] In this study ... [4] This suggests either that duodenase is present in both cell types, or that each site produces distinct enzymes that are nonetheless highly similar structurally, functionally and immunologically ... structurally, functionally and immunologically Lungworm infection in sheep is known to involve a pronounced mastocytosis [24], and sMCP-1 is upregulated in mast cells recruited to sites of allergic lung...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... of cell motility, immunoprecipitation and immunoblotting Immunoprecipitation and immunoblotting Cell lysates were prepared with lysis buffer (50 mM Tris/ HCl, pH 7.4, 1% Nonidet P-40, 150 mM NaCl, ... experiments FAK is required for LPA-induced cell motility FAK signaling is modulated by expression of an endogenous FAK inhibitor, FRNK, which is expressed as an independent protein and consists of the ... PAK1 is required for LPA-induced A2058 cell motility Discussion PAKs play an important role in a variety of cellular functions including cell morphogenesis, motility, survival, angiogenesis and...
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Báo cáo khoa học: Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system potx
... activated transcription It is important to note that Sc pombe TFIIA was not included in the reactions, and human TFIIA had no effect on the results However, we not know whether human TFIIA can ... TFIIF is also composed of two subunits, a (CAA22493) and b (NP595082) Sc pombe TFIIFa contains 490 amino acids and shares 33% amino acid sequence identity with its S cerevisiae homolog However, no ... has 301 amino Ó FEBS 2004 acids and displays 27% amino acid sequence identity with human TFIIFb and 37% identity with S cerevisiae TFIIFb The Sc pombe Tfb1 subunit of TFIIH has 457 amino acids...
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Báo cáo sinh học: " A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis" pptx
... anti-I7L antisera As expected, the I7L enzyme from the inducible mutant was detected in the core sample, as was the wild type virus (data not shown) The morphogenesis of vtetOI7L under nonpermissive ... the virus (Fig 4, panels A-C), which were indistinguishable from cells infected with wild type virus (not shown) However, in the absence of TET, no mature virions were observed in any of the ... blocked, viral morphogenesis arrests prior to core condensation If the activity of G1L proteinase is blocked, viral morphogenesis arrests at a stage subsequent to this but still prior to complete...
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Báo cáo hóa học: " The YPLGVG sequence of the Nipah virus matrix protein is required for budding" pdf
... identified), where x is any amino acid and Ø is any aromatic amino acid [30-32] Until the identification of the novel FPIV sequence in SV5 M [38], paramyxoviruses were not known to utilize L-domains ... (Fig 3B) Martin-Serrano and co-workers, as well as others, previously observed this phenotype in cells expressing VP40 [41,48,49] This cellular morphology was not observed when the native overlapping ... expressing NiV M P93A displayed a somewhat intermediate phenotype with less pronounced filamentous structures and this phenotype also corresponded to the partial buddingdefective phenotype (Fig 4) Together,...
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