tất cả các loại đường đều cho phản ứng khử khi được chuyển về đường đơn
CÂU HỎI TRẮC NGHIỆM HÓA HỌC VÀ CHUYỂN HÓA GLUCID pptx
... chung cho tất loại đường có carbon A Đúng B Sai 162 Tính khử monosaccarid việc định lượng chất đường vì: A Chỉ có đơn đường cho phản ứng khử B Cả đơn đường đường đôi cho phản ứng khử C Tất loại đường ... đường đôi cho phản ứng khử C Tất loại đường cho phản ứng khử D Tất loại đường cho phản ứng khử chuyển đường đơn E Tất câu sai 163 Glucose fructose bị khử tạo thành Sorbitol A Đúng B Sai 164 Liên ... 81 Chất tính khử A Saccarose B Lactose C Mantose D Galactose E Mannose 81 Phản ứng Molish dùng để nhận định: A Các chất Protid B Các chất acid amin C Các chất có nhóm aldehyd D Các chất có nhóm...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... allosteric inhibitors have also failed The ATP competitive inhibitors appear to be the target of choice [33] 5.2 The ATP binding site ATP binds within a deep cleft formed between the two lobes...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
... organisms, including mammals Checkpoint proteins accumulate at unattached kinetochores in prometaphase, but disappear from kinetochores later in mitosis or meiosis upon microtubule attachment and tension ... Mad2 translocates into the nucleus and is guided to unattached kinetochores by Mad1 (Chen et al 1999) Recruiting Mad2 to kinetochores is the only known function of Mad1 to date From early mitosis ... recruiting Mad1 and Mad2 to the kinetochores in Xenopus egg extracts (Sharp-Baker and Chen 2001) Immunodepletion of Bub1 abolishes the spindle checkpoint and the kinetochore binding of the checkpoint...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... Willheim M, Raderer M & Chott A (2006) Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma Leukemia 20, 313–318 Rigby S, Huang Y, Streubel B, Chott A, Du MQ, Turner ... src family of protein-tyrosine kinases Nature 361, 226–233 Thomas JD, Sideras P, Smith CIE, Vorechovsky I, Chapman V & Paul WE (1993) Colocalization of X-linked agammaglobulinemia and X-linked ... HJ, Hinkula J, van Dijk-Hard I, Dilber MS, Wahren B, Christensson B, Mohamed AJ & Smith CI (2003) Choosing CCR5 or Rev siRNA in HIV-1 Nat Biotechnol 21, 230–231 Yu L, Mohamed AJ, Simonson OE, Vargas...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2, DKIND1 + 2, DRasN, DGEF, KIND1 or ... quantify dendrite growth and branching, 15 neurons transfected with each construct were randomly chosen for each experiment, and EGFP fluorescent images of their dendrites were analyzed with neurolucida...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... 2: versatile plant blue-light receptors Trends Plant Sci 7, 204–210 Christensen SK, Dagenais N, Chory J & Weigel D (2000) Regulation of auxin response by the protein kinase PINOID Cell 100, 469–478 ... part of the jasmonate signal transduction pathway in Arabidopsis Plant Cell 19, 805–818 35 Yoo SD, Cho YH, Tena G, Xiong Y & Sheen J (2008) Dual control of nuclear EIN3 by bifurcate MAPK cascades...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... stimulus, Bax is translocated to the mitochondria [43] and induces mitochondrial dysfunction, characterized by the formation of large pores in the mitochondrial membrane [44] Stimulation of the ... the intrinsic (also called ‘mitochondrial’ or ‘Bcl-2-regulated’) pathway [20] The intrinsic pathway is characterized by the permeabilization of the outer mitochondrial membrane and the release ... [35] Following a proapoptotic stimulus, however, Bim is localized to the mitochondria, where it initiates the mitochondrial cell death pathway by directly activating Bax ⁄ Bak [36] Bim expression...
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Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc
... (B–D) FLIM analysis of the interaction between cerulean–GAPDH and citrine–GAPDH in living CHO- K1 cells CHOK1 cells were transfected with plasmids encoding cerulean–GAPDH (CG) and citrine– GAPDH ... very weak background signals (below 5% of donor fluorescence intensity) due to autofluorescence of CHO- K1 cells were observed (data not shown) Chi-square values of the fitting were between 1.0 and ... secondary antibody Chimeric proteins, GAPDH–citrine and PGK– cerulean, were transiently expressed in CHO- K1 cells by DNA transfection, using the lipofection method Forty hours after transfection, fluorescence...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... proapoptotic BH3-only protein family, which induce permeabilization of the outer mitochondrial membrane Release of mitochondrial cytochrome c triggers assembly of a caspase-9activating complex and subsequent ... reductase escaping the endoplasmic reticulum insertion pathway and relocating to the outer mitochondrial membrane [36] Myristoylation has also been implicated in the regulation of apoptosis Although ... after caspase cleavage [32] In the case of Bid, the myristoylated fragment relocates to the mitochondrial membrane, where it induces oligomerization of Bak and subsequent cytochrome c release...
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Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf
... Contribution of hydrophobic interactions to protein stability Nature 333, 784–786 27 Matthews BW, Nicholson H & Becktel WJ (1987) Enhanced protein thermostability from site-directed mutations that ... sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Nucleic Acids Res 22, 4673–4680 Gouet P, Courcelle E, Stuart DI & Metoz F (1999) ESPript:...
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Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt
... emulsions of TO, 1-mono-oleoyl-2-O-mono-oleylglycerol or cholesterol oleate [18,20] Briefly, labelled and nonlabelled lipid substrates and phosphatidylcholine ⁄ phosphatidylinositol (3 : 1) in cyclohexane ... between HSL and sonicated phospholipid vesicles Phosphatidylcholine vesicles were prepared as described in [15] In brief, phosphatidylcholine was evaporated under nitrogen to remove the solvent ... phospholipid vesicles, followed by penetration of the membrane, mimics what happens in vivo as HSL is anchored to the lipid droplet to hydrolyse acylglycerols Even though PKA-phosphorylated HSL was found...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... unpublished data) Gene disruption studies demonstrate that JNK is required for the release of mitochondrial proapoptotic molecules (including cytochrome c) and apoptosis in response to UV radiation ... dissociation of Bax from 14-3-3 proteins, leading to apoptosis [50] Because translocation of Bax to mitochondria was observed in AG1478-treated PC-9 cells (K Takeuchi & F Ito, unpublished data), AG1478 ... may exert its apoptotic actions, at least in part, by promoting the translocation of Bax to mitochondria Some reports have shown that the activation of the Fas ⁄ FasL system may be one of the...
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Tài liệu Báo cáo khoa học: Hypoxia downregulates farnesoid X receptor via a hypoxia-inducible factor-independent but p38 mitogen-activated protein kinase-dependent pathway doc
... treatment of cholestasis [13] In different types of clinical situations, liver ischemia may occur and cause or contribute to hepatobiliary dysfunction, which is most often of the cholestatic type ... expression under hypoxia should be primarily restored to avoid the progress of cholestatic liver disorders, as cholestasis results either from an impairment of bile secretion or from an obstruction ... usually very low; however, it is induced in patients with cholestasis and cirrhosis [54] Thus, the basolateral MRPs upregulated during severe cholestasis may act as an alternative export system to...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... 1A1 with impaired mitochondrial targeting showed vastly reduced mitochondrial ERND activity Our results on ERND activity of mitochondriatargeted CYP1A1 supported by mitochondrial FDX1 + FDXR ... NADPH FDR& FDX nmoles/HCHO/min/mg nmoles/HCHO/min/mg A N B V Sepuri et al Micro Mito Fig Mitochondrial CYP2E1 activity in wild-type and FDXR-depleted yeast strains Mitochondrial and microsomal ... rat liver mitochondrial enzymes, yeast mitochondrial CYP1A1 shows high ERND activity and mitochondrial CYP2E1 exhibits high NDMA-d activity The activities of both microsomal and mitochondrial enzymes...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... 4204–4213 18 Schricker R, Angermayr M, Strobel G, Klinke S, Korber D & Bandlow W (2002) Redundant mitochondrial targeting signals in yeast adenylate kinase J Biol Chem 277, 28757–28764 19 LaRonde-LeBlanc ... cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p Cell 91, 221–230 Dale GE, Schonfeld HJ, Langen H & Stieger M (1994) ¨ Increased solubility of trimethoprim-resistant type S1 ... G, Zollner A, Angermayr M & Bandlow W (2002) Competition of spontaneous protein folding and mitochondrial import causes dual subcellular location of major adenylate kinase Mol Biol Cell 13, 1439–...
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Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt
... of Phe133, and from O4 to the backbone N and the side chain of Thr131, with the ribose moiety anchored by two hydrogen bonds, one from 2¢-OH to the side chain of Asp70, and one from the backbone ... the lack of GTP activation [8] A comparison of UMPKs from U parvum, E coli and S solfataricus, chosen to represent mycoplasma, bacteria and archaea, showed that they all shared the same fold ... Egeblad-Welin et al glycol) 400 as cryoprotectant, and data were collected at ID14-eh4 at the European synchotron radiation facility (ESRF), Grenoble, France The data were indexed, scaled and merged using...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... Arterioscler Thromb Vasc Biol 25, 2673–2678 Mangin P, Yap CL, Nonne C, Sturgeon SA, Goncalves I, Yuan Y, Schoenwaelder SM, Wright CE, Lanza F & Jackson SP (2006) Thrombin overcomes the thrombosis defect ... platelet ADP receptor function in dynamic thrombus stabilization Blood 108, 3045–3052 21 Jackson SP, Schoenwaelder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE, Kenche V, Anderson KE, Dopheide SM, ... effects of thrombin-induced Ca2+ signaling Eur J Biochem 249, 547–555 45 Goncalves I, Hughan SC, Schoenwaelder SM, Yap CL, Yuan Y & Jackson SP (2003) Integrin aIIbb3-dependent calcium signals regulate...
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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
... lysate Due to the commercial availability of suitable quantities of HeLa nuclear pellets, these were chosen as the starting material for a purification of CDK4 Y17 kinases Purification of C-YES as a ... phosphate gradient (Fig 2C) Fractions 38–49 and a sample of the input were precipitated using deoxycholate and trichloroacetic acid, and the proteins were separated using SDS ⁄ PAGE A major protein ... gradient of 10–500 mm phosphate buffer and 500 lL fractions were collected 2.5 lL of sodium deoxycholate (2%, w ⁄ v) was added to 250 lL samples of selected fractions and the samples were incubated...
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Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt
... and sphingolipids remain to be further defined Skin epidermis contains abundant lipids, including cholesterol, fatty acids and Cer, each of which plays a critical role in water retention and epidermal ... protein kinase and phosphatidylinositol 3-kinase-mediated phosphorylation This pathway results in cholangiocarcinoma cell growth CerK has also been reported to act as an upstream modulator of cystolic ... accordance with the Guide for the Care and Use of Laboratory Animals (Hokkaido University Graduate School of Medicine, Japan) Animals were housed in plastic cages with metal lids at a temperature...
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