... Treatmentof Myelomatosis SystemicTreatmentofKaposi'sSarcomaSystemicTreatmentof Soft Tissue Sarcomas 119 134 141 146 149 152 vi i CONTENTS VII SystemicTreatmentof Osteosarcomas ... Therapy of Indignant Disease I I1 I11 IV V VI Systemic IFN Therapy of Tumors-Screening Trials SystemicTreatmentof Leukemias SystemicTreatmentof Lymphomas., SystemicTreatment ... SystemicTreatmentof Malignant Melanoma IX SystemicTreatmentof Renal Cell Carcinoma X SystemicTreatmentof Lung Cancer XI SystemicTreatmentof Gastric Cancer XI1 Systemic Treatment...
... biopsy should be performed for diagnosis where other less invasive methods of biopsy have not been successful or are not possible B(DS) 1.2.8 Where there is evidence of distant metastases, biopsies ... assess the stage of the primary tumour (T-stage; see Appendix E) in NSCLC C(DS) 1.3.1.3 MRI should be performed, where necessary to assess the extent of disease, for patients with superior sulcus ... reviews of RCTs, or RCTs with a low risk of bias Meta-analyses, systematic reviews of RCTs, or RCTs with a high risk of bias High-quality systematic reviews of case–control or cohort studies High-quality...
... Patients with rectal cancer were analyzed separately Statistical analysis All statistical analyses were performed with a statistical software STATA Statistics/Data analysis (STATA Corp 2001 Stata Statistical ... This retrospective and comparative case series aimed to report results of acute GI and GU toxicities in patients with pelvic tumors treated with CRT versus IMRT techniques This is the first clinical ... toxicities when compared with conventional or CRT techniques but most of these studies are comparative case series or retrospective analyses with a small number of patients or with considerable...
... into the region as extensions of head and neck cancers [1,2] The skull base is also a common site of metastasis from distant tumors [3,4] Patients with skull base malignancies suffer greatly [5] ... patients were classified as having tumors of the skull base, of which 108 were benign Thirty-seven patients had 37 lesions that were classified as malignant skull base tumors Six patients who ... periods less than or equal to four weeks were eliminated from statistical consideration, thus leaving 31 patients for analysis For the purposes of this study, skull base lesions were defined as those...
... repetition of freeze-thaw cycles enhances the deleterious effects during cryosurgery 2.3.2 Vascular stasis The vascular stasis, under the classification of the delayed cell destruction, is a serious slowing ... (3.1) The heat source of perfusion term is shown as the second term on the right-hand side of Eq.(3.1) This term essentially assumes that blood enters the smallest vessels of the microcirculation ... a typical cryosurgical process, the undesired tissue undergoes liquid-solid and reverses phase transformation Successful cryosurgery means maximal destruction of cancerous cells while minimizing...
... http://www.wjso.com/content/6/1/123 successful laparoscopic operations the mean postoperative hospital stay was 12.7 days[71] Competing interests All these series proved that laparoscopic DP may benefit patients, since this procedure ... distant organs without specific symptoms at time of diagnosis Consequently, these tumors are associated with a lower resectability rate of only 10–12%, although surgical resec- Therefore, survival ... presence of regional nodal metastasis was associated with a poor survival (p = 0.006) [16] Farnell et al reviewed four prospective randomized trials comprising of 424 patients These studies showed...
... received salvage systemic therapy Despite treatment one patient died of progressive metastatic disease at months A second single lung metastasis patient died of a myocardial infarction at 11 months ... evidence of local or systemic disease No stage I lung cancer patient developed metastatic disease However, stage I lung cancer patients died of comorbid illnesses (1 secondary to progressive congestive ... the last treatment Two-sided Wilcoxon signed-ranks tests were used to assess statistical significance (α = 0.05) of post -treatment changes in forced expiratory volume in sec (FEV1), total lung...
... drugs within normal tissues, as these drugs are small enough to permeate across endothelial barriers of normal tissue microvasculature [61-64] In more recent years, slow sustained-drug release ... chemotherapy[9,10,28-31] Systemic chemotherapy consists of small molecule chemotherapy drugs[8,32] that are drugs of molecular weights (MW) less than kDa and diameters less than to nm These small molecule ... effectiveness ofsystemic chemotherapy in the treatmentof malignant brain tumors is based on my two recent observations[59,73,74] The first observation being that spherical nanoparticles smaller...
... statistical analyses were performed with a software program Statistics/Data analysis (STATA Corporation, Houston: University of Texas; 2000) Overall survival (OS), disease free survival (DFS), and local ... for OS, DFS and LC Relative risk of death was determined by Cox regression analysis [25] Comparison of categorical variables was performed using the chi-square (χ2) test Values of p lesser than ... coloanal anastomosis The 5-year local control in this group of patients was of 58.8%, suggesting that this strategy can compromise the local control Curiously, five patients in our study refused surgical...
... extent of contact and compression of critical neurological structures In most cases, the dose was prescribed to the isodose surface that encompassed the margin of the tumor Twelve collimator sizes ... structures In theory, inverse planning should allow for easily obtainable, optimized plans The appropriate measure (s) of plan optimization is still debated [9] Assessment of success in radiosurgery ... most LINAC and Gamma Knife systems use forward planning with user-selected arcs and beams The CyberKnife® radiosurgical system employs inverse planning algorithms based on specific constraints...
... various mesenchymal tissues: superiority of synovium as a cell source Arthritis Rheum 2005, 52:2521-2529 Shirasawa S, Sekiya I, Sakaguchi Y, Yagishita K, Ichinose S, Muneta T: In vitro chondrogenesis ... that transplanted MSCs not increase, and a higher number of MSCs can provide better results for cartilage regeneration In the present study we chose a dose of 108 cells/ml MSC suspension for ... Intercellular adhesion molecule (ICAM-1) expression in human synovial mesenchymal stem cells (MSCs) minute and 10 minutes after plating on glass slides ICAM-1-positive cells are shown as light shading,...
... no analysis of prognostic factors associated with neither progression of cases initially diagnosed as plasmacytoma into myeloma nor an assessment of local disease control The current manuscript ... [38] Statistical analysis was performed using SPSS version 17.0 (SPSPSS Inc., Chicago, IL) Chi-square test was used to make correlations between categorical variables Overall and disease-specific ... the treatment outcomes of patients initially diagnosed with plasmacytoma Furthermore, the study seeks to compare clinical parameters in cases of plasmacytoma not progressing to systemic disease...
... Metastasis NSCLC 68 No No 61 F SOB Metastasis Renal 182 10 59 M None Metastasis NSCLC 38 No 11 65 M SOB Metastasis Mesothelioma 324 Yes 12 23 F None Metastasis Colon 39 No 13 49 M Cough Metastasis ... Metastasis Renal 58 No 14 46 M SOB Metastasis Colon 141 No 15 81 F Cough Metastasis NSCLC 50 No 16 71 M SOB Metastasis NSCLC 78 No 17 82 F None Metastasis NSCLC 23 No 18 51 F SOB Metastasis Breast ... SOB Metastasis Sarcoma 179 No 79 M SOB Primary NSCLC 137 No 71 F Cough Primary NSCLC 221 No 65 F SOB Primary NSCLC 68 No 13 M None Metastasis Sarcoma 44 No 76 F Cough Metastasis NSCLC 41 Yes 69...
... radiosurgery to spinal lesions Neurosurgery 2001, 49:838-846 Gerszten PC, Ozhasoglu C, Burton SA, Kalnicki S, Welch WC: Feasibility of frameless single-fraction stereotactic radiosurgery for spinal ... 10 months after radiation treatment showed stable soft-tissue asymmetry in the mediastinum, with no evidence of recurrent or metastatic disease (Figure 8) At his oneyear follow-up visit, the ... dyspnea on exertion but was otherwise asymptomatic Discussion IGRT has emerged as a method of improving radiation treatment accuracy for tumors near the spinal cord Three forms of IGRT for this...
... concentration of compound 85070 For comparison, stiffness responses to relaxing agonists (10 μM isoproterenol or mM db-cAMP) are shown Stiffness responses are normalized to respective baseline stiffness of ... decreases Compound 85070 also decreased the stiffness of serotonin-stimulated rat ASM cells, as well as histamine-stimulated human ASM cells (data not shown) Conclusions To accelerate discovery, screening, ... the seven scaffolds which showed activity in the FP assay as small molecule analogs of pHSP20, only a small subset of compounds belonging to two scaffolds caused appreciable decreases in cell stiffness...
... questions need to be answered As the pro-coagulant state in the alveolar space begins in the early phases of ALI, how can it be assessed in order to initiate heparin administration as rapidly as ... syndrome with different possible causes and origins, but also involves patients with complex conditions: ‘standard’ care has to be defined in detail in such situations, and rigorous control of ... control of physiological variables as well as therapeutic modalities is of the outmost importance [9] The use oftreatment bundles’ could be a further necessary step in the direction of optimal...
... the book is structured mostly as a series of critical discussions centering on four questions: What is social phobia? What is its nature? What causes it? And what kinds of treatments are likely ... frustrations of submissive social phobic individuals, stoking their insecurities Emotional expressivity (e.g of affection but especially anger) is circumscribed Passive/aggressive gestures of omission or ... position of authority, among others Second, several detailed descriptions of cases of ereutophobia (blushing phobia) and discussions of related conceptual issues were published Notable is a Swiss...
... proinflammatory state, as measured by leucocytosis or monocyte activation, is associated with AF, although the mechanism is not clear [2325] AF is sometimes the first sign of sepsis [4] A genetic predisposition ... haemodynamically stable patients [128,129] These studies have been described in three meta-analyses; rate control showed less adverse events and less hospitalisations [9,89,130] These meta-analyses, however, ... Conclusion A rational treatment protocol could therefore consist of several steps First, treatmentof predisposing factors is necessary Second, a short attempt at magnesium supplementation can...
... prevalence of obesity in this study of outpatients was related to the use of antipsychotics, but less so lithium or anticonvulsants Of those persons prescribed no psychotropics, less than 10% were obese, ... hepatitis accompanied by hallmarks of a hypersensitivity syndrome [57] Risperidone may cause transient increases in aminotransferases as well as cholestatic hepatitis [57], but hepatic disease does ... hemodialysis (HD) and should be administered in a single post-dialysis dose of 300–600 mg Lithium levels should be checked pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case...
... scars Essentially, the physician inserts a needle and sweeps it back and forth repeatedly to free the skin from the underlying scar tissue Normally, the dissection plane of subcision is rather superficial: ... it is a subdermal dissection performed successfully in the treatmentof acne scars In this novel technique, we perform a deeper dissection plane and it is designed in order to remove adhesions ... is not a lack of tissue secondary to trauma as for example the suffering of sub-cutaneous adipose tissue, it would be sufficient to eliminate the single adhesion without reopening the entire scar...