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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the KIND family of proteins, only KIND2 binds to MAP2 Pull-down assay (PD) of the endogenous MAP2 from cerebellar lysates of P21 ... domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and cloned into ... Center) and Dr J Miyazaki (Osaka University) for their kind gifts of the MAP2 cDNA and the pCAG expression vector, respectively The present study was supported by grants from the Japanese Ministry of...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... staining The sizes and positions of the molecular weight markers are indicated on the left side of each gel FEBS Journal 277 (2010) 148–162 ª 2009 The Authors Journal compilation ª 2009 FEBS 153 Manduca ... and the catalytic domain of active HP8 are marked with arrowheads The size and position of molecular weight standards are indicated on the left (B) The catalytic activity of activated HP8Xa (50 ... markers are indicated on the left of Spatzle-C108 (Fig 8A) Analysis of tryptic peptides ¨ from these bands by MS ⁄ MS and mascot software identified them as attacin-1, lysozyme, and cecropinA ⁄ B (Table...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... on one side of the b-sheet and two on the other side The rmsd of the heavy atoms (Ca, C, and N) of the protein core, when the NMR structures of both conformers are superimposed on the crystal ... sizes of the relative populations and possibly the rate of conformer interconversion are sensitive to the environment of the domain For the great majority of the residues in the minidomain, the ... between the HN of Thr358 and the Ha of His356 could be seen in both conformers (Fig 4; Fig S3) At the same time, the intensity of the NOE between the HN of Phe357 and the Ha of Lys354 in the open conformer...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
... view is from the top of the active site Water molecules are shown as red spheres The coloring of the chains is the same as in (A) Some of the residues surrounding the water cavity are shown Residues ... in the mutant First, there is an increase in the negative charge in the active site and, second, breaking the salt bridge would alter the quaternary structure of the protein and therefore the ... [14]) The sequences of the CMLE1s from members of the Rhizobiales, such as ArCMLE1 and AtCMLE1, are significantly shorter than the isofunctional enzymes from other bacteria (Fig 2) Expression of...
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structure and function of the arabic verb
... very indicative, in our opinion, of the adequacy and the basis of this orientation, on the one hand, and the destiny of linguistics, on the other hand Of course, these implications might be too ... constructions The frequency of WA, FA-, LA-, and Ø in front of QAD Frequency of the compound perfect The distribution and frequency of sawfa/saThe frequency of QAD, laʕalla, and rubbamaa The contextual ... representations, on the one hand, and their semantic interpretations, on the other hand VERBAL FORMS, CLAUSES, AND METHODOLOGY This chapter focuses, in particular, on the status and characteristics of these...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 1 pps
... understanding of the anatomy and function of the ear and the auditory nervous system, and it discusses the cause and treatment of hearing disorders Most books on hearing focus either on the anatomy ... accumulated about the function of the cochlea than of any other sensory organ C H A P T E R Anatomy of the Ear ABSTRACT 10 The ear consists of the outer ear, the middle ear and the inner ear The outer ... of the pinna and the ear canal The skin of the ear canal is innervated by four cranial nerves: the trigeminal; the facial; the glossopharyngeal; and the vagus nerves The middle ear consists of...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 2 ppsx
... ratio between the effective area of the tympanic membrane and the area of the stapes footplate, but the lever ratio of the middle ear bones also contributes The ratio of areas of the BOX 2.2 SOUND ... at the entrance of the ear canal compared with the sound pressure that is measured in the place of the head The effect of the head on the sound at the entrance of the ear canal is related to the ... remarkable in the light of the FIGURE 2.12 (A) Average displacements of the umbo, the head of the stapes and the lenticular process of the incus (B) The lever ratio at 124 dB SPL at the tympanic...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 4 potx
... in the ventral parts of the MGB of the thalamus, the nonclassical sensory pathways use the dorsal and medial division of the MGB as relay (Fig 5.10) [122] These divisions of the MGB receive their ... their input from the ICC and the ICX The posterior division of the MGB (PO) receives input from the ICC and projects to the AAF cortical area The neurons in the ventral portion of the auditory thalamus ... in the vertical plane is the dependence of the elevation on the spectrum of the sounds that reaches the ear canal This is a result of the outer ears and the shape of the head INTRODUCTION All...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 6 pot
... The caudal portion of the floor of the lateral recess is the (dorsal) surface of the dorsal cochlear nucleus and the rostral portion of the floor of the lateral recess is the dorsal surface of ... difference between the latency of the N1 of the AP and that of the response from the intracranial portion of the auditory nerve is the travel time in the auditory nerve from the ear to the recording ... the latency of the first peak in the dipole and the length is the relative strength of the dipoles Note the short distance between the two first dipoles (peak I and II of the ABR) and the third...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 7 pot
... and standard error of the mean are shown as a function of the intensity of the noise The TTS was measured 20 s after the end of the exposure In this study the noise exposure consisted of a band ... on the size of the hole in the tympanic membrane and the size of the middle-ear cavity 210 Section III Disorders of the Auditory System and Their Pathophysiology BOX 9.1 EFFECT OF A HOLE IN THE ... latency of the response to 1.5 kHz tones is shorter than the response to 0.5 kHz tones [182] The latency of the ipsilateral and the contralateral responses are similar The latency of the change in the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 8 docx
... increase the sensitivity and frequency selectivity of the ear (cf Chapter 3) The widening of the tuning of the basilar membrane broadens the “slices” of the spectrum of broad band sounds from which the ... MRIs are used both as a comparison between other methods and as the definitive proof of the presence of a tumor MRI scans are thus used as the standard with which all other tests are compared ... MEASURE OF COCHLEAR HYDROPS The ratio between the amplitude of the SP and the AP components are used as indication of cochlear hydrops In response to clicks, the SP appears before the AP and the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 9 pdf
... tinnitus and abnormal perception of sounds such as hyperacusis and phonophobia) are some of the most diverse and complex disorders of the auditory system and their causes are often obscure Often ... maxima are determined on the basis of the output of 16 band-pass filters The output of the six band-pass filters with the largest amplitudes is coded in the impulses that are applied to the electrodes ... III Disorders of the Auditory System and Their Pathophysiology spectral bands of the visual spectrum The three kinds of photo pigment that are present in the cones of the retina in the human eye...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
... table and the test statistics of these were used to form an estimate of their distribution under the null hypothesis, to which the observed test statistic can be compared Additional data files The ... assignments of the proteins used in the analysis Additional data file contains the sequences of the proteins used in the analysis of the assignments The sequences assignments file in the used in ... subset of 14 samples representing distinct non-redundant organs was chosen out of the complete dataset The tissues are listed in Figure The use of different cut-offs within the range of 0.025...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
... factor function The combined results of these studies have expanded our current understanding of the expression and function of the PRL family of enzymes as well as of the role these important ... 2G) Equivalent levels of expression were noted in the villous epithelium, crypt epithelium, and muscularis mucosae of the duodenum and jejunum and in the Brunner’s glands of the duodenum PRL-2 was ... 3D) and kidney (Figure 3F) Figure Moderate expression of PRL-1 mRNA and strong expression of PRL-2 mRNA in the glandular epithelia of the prostate (A,B), urothelia of the bladder (C,D), and glomeruli...
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Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
... associated with the deletion of multiple chromosomal regions including chromosomes 5q, 17p, and 18q Such chromosome loss is often suggestive of the deletion or loss of function of TSGs The candidate ... points On the day of the assay, 10 µl of WST1 was added to each well, and the cells were incubated for a further hr at 37ºC, 5% CO2, in a humidified incubator Absorbance readings of each well ... especially my parents and my husband, as well as my friends for their love and support throughout my stay in Singapore TABLE OF CONTENTS TABLE OF CONTENTS ACKNOWLEDGMENTS i TABLE OF CONTENTS...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... survival The effects of changes in the magnitude of each of these traits on the others (e.g increased offspring size may be traded off against a reduction in offspring number), and their relationship ... size and temperature The metabolic theory of ecology uses these scaling relations to make and test THE METABOLIC THEORY OF ECOLOGY predictions about the effects of energy and materials on the ... empirical and theoretical work in biological oceanography and limnology that relates the structure, function and biotic composition of these systems to the body sizes of the organisms present and the...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... density of each experimental point Therefore, according to the RSDM analysis [21], most of the 15N–1H vectors of the TTF-1 HD core move at the rate of the overall rotational correlation frequency, and ... residues and hence does not conflict with the global interpretation of the data With the exclusion of the N-terminal octapeptidyl and C-terminal nonapeptidyl fragments of Glu17, Leu34 and Lys46, the ... blank slots in the correspondence of residues 29 and 42 are for prolines The se values of Ser27 and Gln50 are not reported, because they were not optimized by MF analysis The extension of TTF-1 HD...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... and kidney To compare the amounts of the two variants expressed in the testis, we performed the PCR using the primers ‘d’ and ‘c’, where the cDNAs for both Noxo1b and Noxo1c are amplified as the ... cells; and the organizers p47phox and Noxo1 are capable of enhancing the superoxide production by Nox3 via the interaction of their SH3 domains with p22phox [25– 27] Although the SH3 domain of Noxo1 ... between the pair of primers (Fig 2A) The lengths of the PCR products of Noxo1b and Noxo1c were 225 and 240 bp, respectively To delineate the difference in the two products, we subjected the PCR...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... above, the determination of the subunit composition of the nAChRs involved has been hindered by the lack of selective ligands and imperfect correlations between the characteristics of native and ... activation states of the nAChR At the Table Comparison of a common motif in loop II of a4/7-conotoxins and their activity on oocyte-expressed a7 and a3b2 nAChRs The length/ hydrophobicity of the amino ... domain of each subunit contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... denote the five residues of one of the three sides of sbwAFP or six residues of one of two sides of TmAFP The strands that make up the three, parallel b-sheets of the protein are designated PB1, PB2 ... Tyr (TmAFP) and the TH activity of the protein was measured The top of the panel shows the protein with the TXT face oriented towards the viewer, while the bottom shows the effect of mutations ... shown in Fig 4B The overlap emphasizes the similarity of the b-strand along the TXT face of TmAFP Even though the number of residues is approximately half, the disulphide core of TmAFP and resultant...
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