structure function relationships in airway disease analysis by computed tomographic imaging
Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships docx
... identified to be involved in the interdomain interaction [16] However, no further conclusions could be made on the interdomain interaction by NMR unless structure of the b-domain of hGIF could ... growth-inhibitory activity, it does play an important role in modulating the stability of the metal–thiolate cluster and conformation of the b-domain by domain–domain interactions, thus altering zinc ... was suggested to provide an interacting interface for protein–protein interactions [12–14] The other structural feature found in the predicted structure of the b-domain of hGIF was the hydrogenbond...
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Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx
... the crystal structures, indicating that binding of acetyl CoA may induce changes in the protein conformation in solution Berthold et al [4] published crystal structures of OfODC in complex with ... the functional dimer The main chain oxygen of G421 and the side-chain carboxyl oxygen of E54 interact with the amino pyrimidine moiety of ThDP (Fig 3); these are highly conserved interactions in ... Determination of protein concentration The protein concentrations of samples containing absorbing ligands, such as ThDP, ADP, CoA or acetyl CoA, were determined by the Bradford assay [23] using...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure–function relationships ppt
... N-terminus and the in uences of this change on binding to TH and on the functions of transthyretin, including that of proteolysis Structure of transthyretin 3D structure of human transthyretin The ... and retinol-binding protein Science 268, 1039–1041 65 Naylor HM & Newcomer ME (1999) The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction ... for retinol via binding to RBP In blood, the transport of retinol is mediated by RBP [56] Liver is the site of RBP synthesis, and the secretion of RBP into the blood is initiated by the binding...
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Báo cáo khoa học: Studies on structure–function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway ppt
... suggesting a similar catalytic mechanism Differences in tetramer packing, several amino acid exchanges in the substrate binding pocket and the diverse constitution of the C-terminal helix covering ... quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 14 Hallmann, G & Hagle, H (1963) Benzofuranderivate: Trypta¨ min-, Serotonin- und Melatonin-Analoga Liebigs ... (at saturating Mg2+ concentration), pointing to a two-step mechanism of cofactor binding (Fig inset) [27] The calculated maximum rate constant of reconstitution is % 0.03 s)1 and thus in the range...
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Báo cáo khoa học: Structure–cytotoxicity relationships in bovine seminal ribonuclease: new insights from heat and chemical denaturation studies on variants ppt
... monomers, DS0(Tm), were determined by integrating the curve obtained by dividing the heat capacity curve by the absolute temperature All of the experimental procedures for obtaining significant amounts ... Stability–activity relationships in a cytotoxic dimeric ribonuclease monomers, the entropy changes, DS0(Tm), were determined by integrating the curve obtained by dividing the heat capacity curve by the absolute ... form in which the chains swap their N-termini (MxM) This phenomenon was later found in many proteins, and is now well known under the name of ‘3D domain swapping’ In most cases, the swapping is...
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Báo cáo khóa học: The structure–function relationship in the clostripain family of peptidases potx
... clostripain The molecular modelling, in conjunction with sequence analysis studies, indicates the P1 specicity determining residue as Asp229 and locates possible calciumbinding sites involved in the ... (specicity-determining, experimentally determined for caspase and gingipain, predicted for clostripain) The caspase and gingipain structures shown (1bmq [32] and 1cvr [35], respectively) both contain inhibitors ... using a molar extinction coefcient of 11.4 Lặcm)1ặmmol)1 determined in M urea The protein concentration was determined by the method of Lowry [21]; no dye interference is observed in protein...
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Báo cáo khoa học: Protein tyrosine phosphatases: structure–function relationships ppt
... contains a short b sheet formed by the N-terminal bA and C-terminal bN strands, which is not encountered in PTP1B but that is present in the structures of kinase interaction motif (KIM)-containing ... domains, thus representing a novel phosphotyrosinebinding domain [26] Recently, the crystal structure of the YopH PTP domain in complex with a phosphopeptide revealed a second substrate-binding ... protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands J Med Chem 46, 3437–3440 Hunter T (1989) Protein-tyrosine...
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Báo cáo y học: " New approaches to the modulation of inflammatory processes in airway disease models" pdf
... demonstrating an improved therapeutic ratio over Fluticasone These findings were supported by the findings of Dr D Bundschuh (Byk Gulden, Konstanz, Germany) who, in a range of in vitro and in vivo ... group Gastrointestinal side effects in Cilomilast treated patients were generally self-limited and mild to moderate in intensity In a separate study in the clinic, Dr J Kelly (GlaxoSmithKline, UK) ... tyrosine kinase as a possible target for intervention in the treatment of asthma lyn kinase has been shown to be a signal transduction intermediate involved in the production of various cytokines...
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Structure function relationships of variegin a novel class of thrombin inhibitors
... Savignin Monobin Amblin Boophilin Hemalin • • • Slow, tight-binding, competitive inhibition N-terminal Kazal domain inhibits active site canonically C-terminal Kazal domain binds to exosite-I (Steiner ... Exosites binding not determined Chimadanin Cysteine-rich domain of ~ kDa Containing a 26-residues segment with conserved cysteines and disulfide linkages Domain typically repeated in tandem • • Inhibits ... Similar to hirudin but Cterminus binds to exosite-II Slow, tight-binding, competitive inhibition N-terminal Kunitz domain inhibits active site noncanonically C-terminal Kunitz domain binds to exosite-I...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc
... occur at a protein site different from the active site, and thermostabilization is the result of a protein conformational change induced by the binding event Residues involved in the structural ... converted into rates Kinetic parameters were obtained from nonlinear ts of initial rate data to Eqn (1) using the SIGMAPLOT program (SPSS Inc., Chicago, IL, USA), 1ị where v is the initial rate, ... remaining active CcStP against time were linear, suggesting that inactivation can be approximated by a pseudo rst-order model The half-life of the holophosphorylase was 60 at pH 7.0 The inactivation...
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Báo cáo y học: " Fetal death due to upper airway compromise complicated by thyroid storm in a mother with uncontrolled Graves’ disease: a case report" pps
... was not followed regularly by an obstetrician during her pregnancy and was fine in the second trimester despite some mild respiratory problems However, at the beginning of the third trimester, ... [6,7] According to one study, there is evidence that pregnancy in some way precipitated thyrotoxicosis In our case, since the patient continued to use her antithyroid medications in the first ... presence of Pemberton’s sign in this patient is also convincing evidence in favor of obstruction of venous and lymphatic drainage as a more likely cause of this patient’s upper airway edema before pregnancy...
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Báo cáo y học: " Inhaled salmeterol and/or fluticasone alters structure/function in a murine model of allergic airways disease" potx
... statistically insignificant increases in inflammation (Figure 2), epithelial damage (Figure 4), or mucus production (Figure 7), we think that an increase in mucus containing cells or mucus within the airway, ... worsens airways hyperresponsiveness, possibly by upregulating either aspects of the inflammatory response or mucin containing cells and exacerbating distal airway closure thus, providing a potential ... thickening, was essentially abrogated (Figures 4, 6, and 7) and correspondingly, methacholine responsiveness was returned to (or remained at) baseline levels (Figure 5) These findings are in keeping...
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Báo cáo y học: "Segment-orientated analysis of two-dimensional strain and strain rate as assessed by velocity vector imaging in patients with acute myocardial infarction"
... Int J Med Sci 2011, ability by the deformation indices two-dimensional strain (2DS) and strain rate (SR), might be an alternative approach in clinical routine Tissue Doppler Imaging (TDI) ... 2-vessel disease was achieved by serial PCI of the remaining diseased coronary arteries according to hemodynamic relevance and morphology of the stenosis during the further clinical course Basic clinical ... circumferential strain and strain rate by 2DST in normo-, hypo-, akinetic and dyskinetic segments of post-infarct patients 8-13, 30-37, which were not reliably accessible by TDI Radial strain also allowed...
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Luận văn ellipsis in english an analysis of errors made by secondary school students = phân tích lỗi thường gặp của học sinh THPT trong việc sử dụng phép tỉnh lược trong tiếng anh
... exercises indicate that students' errors belong to two main types: interlingual and intralingual errors The interlingual errors are caused by mother tongue interference The causes of intralingual ... phenomenon in language learning process Based on the analysis of errors done by linguists and researchers, there are two main types of errors in language learning They are interlingual errors caused by ... of language in performance 18 1.3.3 Error analysis According to Carl James in "Errors in language learning and use", error analysis is defined as "the process of determining the incidence, nature,...
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Tài liệu Computer and Internet Use by Children and Adolescents in 2001: Statistical Analysis Report pptx
... or radio Make purchases Phone calls Taking a course on-line Other Find government information1 Find health information1 Find a job1 Online banking1 Trading stocks1 See footnotes at end of table ... or radio Make purchases Phone calls Taking a course on-line Other Find government information1 Find health information1 Find a job1 Online banking1 Trading stocks1 See footnotes at end of table ... or radio Make purchases Phone calls Taking a course on-line Other Find government information1 Find health information1 Find a job1 Online banking1 Trading stocks1 See footnotes at end of table...
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Tài liệu Novel Strategies in Ischemic Heart Disease Edited by Umashankar Lakshmanadoss pdf
... cardiovascular disease in the Indian subcontinent Indian J Med Res 2006; 124:235 [8] Critchley J, Liu J, Zhao D, et al Explaining the increase in coronary heart disease mortality in Beijing between ... heart disease With increasing life expectancy and increasing prevalence of the disease, patients with ischemic heart disease are being taken care of by various health care providers I sincerely ... populations involved In India, CAD may not be largely explained by traditional risk factors [7] In China, risk factor trends complement tracking of event rates For example, the dramatic increase in CAD...
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Tài liệu Báo cáo khoa học: "Identifying Linguistic Structure in a Quantitative Analysis of Dialect Pronunciation" docx
... differences, since there was high correlation between differences obtained only by using vowels and by using complete transcriptions (r = 0.936) Two ways of aggregate analysis also resulted in comparable ... presented in the traditional dialectological atlases (Stojkov, 2002) The most incoherent area is the An interesting discussion on the normalization by length can be found in Heeringa et al (2006) In ... underlying linguistic structure in the aggregate analysis The method and the obtained results will be presented in more detail 4.1 Method From the aligned pairs of word pronunciations all non-matching...
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Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc
... thus suggesting other factors influencing the DNA strand breaks The increasingly detailed map of human DNA will certainly bring new insight into the possible links between DNA secondary structure ... prepared disomic budding yeast [43] Rapid development in proteomics enabled analysis of protein levels in budding yeast cells Interestingly, using the model disomic cell lines, Torres et al [43] ... with diseases affecting the brain [65] In particular, the percentage of aneuploid cells is higher in brains from patients 16 Aneuploidy in Health and Disease with Alzheimer disease (AD) than in...
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Báo cáo khoa học: Structure ⁄function analysis of spinalin, a spine protein of Hydra nematocysts doc
... only background staining intensity FESEM analysis using protein A–gold confirms the localization of spinalin predominantly on the spines of the desmoneme tubule (Fig 1C) Interestingly, the tubule ... by the rotary shadowing technique was performed as described [21] Reduction and alkylation of spinalin was performed by incubating the protein in 10 mm dithiothreitol followed by incubation in ... 560 mM NaCl Proteins were detected by Coomassie staining (A) or samples were analyzed by western blotting using spinalin antibody (B) Visualization of nonreduced aggregated spinalin (D) and reduced...
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Báo cáo khoa học: Structure–function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin pot
... Schuler and W Peti ¨ The actin binding domain of spinophilin A B C Fig Recombinant proteins containing N-terminal fragments of rat spinophilin are active in F-actin binding (A) Cosedimentation assays ... spinophilin and neurabin contain N-terminal filamentous actin (F-actin) binding, PP1 binding, PDZ and C-terminal coiled-coil domains In addition, neurabin, but not spinophilin, contains a sterile a ... The actin binding domain of spinophilin H Schuler and W Peti ¨ Fig Spinophilin F-actin binding domain constructs can crosslink and cap actin polymers Polymers of actin, marked with rhodamine–phalloidin,...
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