structure biosynthesis and application in drug research achilles heel of mycobacterium tuberculosis
Computational study of therapeutic targets and ADME associated proteins and application in drug design
... Sequence variation between protein’s drug- binding domain and those of the human proteins in the same family allows differential binding of a “rule -of- five” molecule; (3) Protein preferably has less than ... derived for facilitating the search of druggable proteins and for estimating the level of difficulty of their exploration, including (1) Protein is from one of the limited number of target families; ... methylation of genes, differential splicing of mRNAs, and differences in post-transcriptional processing of proteins such as protein folding, glycosylation, turnover and trafficking [63] Thus, in addition...
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Tài liệu Báo cáo khoa học: Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv pdf
... level of b-structures in different WhiB proteins, a thioflavin T (ThT)-binding assay was performed ThT shows strong fluorescence in the presence of crossed b-sheet structures [27,28] The binding of ... the amino acid immediately after the C-terminal cysteine of the CXXC motif is proline (Fig S6) In WhiB2 the absence of proline and therefore of the kink might not allow the protein to attain an ... in Mycobacterium tuberculosis Proc Natl Acad Sci USA 102, 12200–12205 Raghunand TR & Bishai WR (2006) Mapping essential domains of Mycobacterium smegmatis WhmD: insights into WhiB structure and...
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Báo cáo hóa học: " Research Article Adaptive Parameter Identification Based on Morlet Wavelet and Application in Gearbox Fault Feature Detection" pptx
... Processing, vol 41, no 12, pp 3397–3415, 1993 [12] L C Freudinger, R Lind, and M J Brenner, “Correlation filtering of modal dynamic using the Laplace wavelet,” in Proceedings of the 16th International ... method is effective in identifying parameters of impulse, including frequency, damping ratio, and the time index, and is especially sensitive to the cyclic period The gearbox application also demonstrates ... Zi, “Enhancement of signal denoising and multiple fault signatures detecting in rotating machinery using dual-tree complex wavelet transform,” Mechanical Systems and Signal Processing, vol 24, no...
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Research on operation mechanism and application in engineering of UNITANK process
... Materials Research Vol 937 371 372 Material Science and Environmental Engineering Advanced Materials Research Vol 937 373 374 Material Science and Environmental Engineering Material Science and Environmental ... Engineering Material Science and Environmental Engineering 10.4028/www.scientific.net/AMR.937 Research on Operation Mechanism and Application in Engineering of UNITANK Process 10.4028/www.scientific.net/AMR.937.370 ... UNITANK Process 10.4028/www.scientific.net/AMR.937.370 DOI References [2] Henze M, Gujer W, Mino T et al., in: Water Sci Technol, Issue1, Vol 39 (1999), pp.165-182 http://dx.doi.org/10.1016/S0273-1223(98)00829-4...
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Tài liệu The Early Detection Research Network: Investing in Translational Research on Biomarkers of Early Cancer and Cancer Risk docx
... studies; and • ncouraging collaboration and dissemination of information to ensure E progress and avoid fragmentation of effort EDRN is a leader in defining and using criteria for the validation of ... participating EDRN institutions across the country EDRN-supported statistical tools and informatics infrastructure make the sharing of samples, the developing of collaborations and the exchanging of information ... multidisciplinary, investigator-initiated projects with a strong administrative and data infrastructure In making cancer biomarkers of early detection and screening ready for large-scale clinical testing,...
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Tài liệu Lipases and Phospholipases in Drug Development pptx
... Sphingomyelinase Mechanism 85 Binding of Magnesium Ions 85 Binding of Substrate 85 Mechanism of Catalysis 86 Sphingomyelinase Assay 88 Sphingomyelinase Inhibitors 89 Sphingomyelinase–Membrane Interactions 89 ... Translocation of HSL 264 Mechanism 264 Involvement of Perilipins 266 Involvement of Lipotransin 268 Intrinsic Activity of HSL 270 Feedback Inhibition 270 Adipocyte Lipid-binding Protein 272 Expression of ... Sphingomyelinases (nSMase) 81 Mg2+-independent Neutral Sphingomyelinases 84 Alkaline Sphingomyelinase from the Intestinal Tract 85 Bacterial Sphingomyelinase-phospholipase C 85 Sphingomyelinase...
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Báo cáo khoa học: Kinetic and mechanistic characterization of Mycobacterium tuberculosis glutamyl–tRNA synthetase and determination of its oligomeric structure in solution pptx
... the discriminating behaviour of Mt-GluRS in E coli Studies on Tt-GluRS indicated that discriminating and nondiscriminating GluRS can be distinguished on the basis of the presence of a specic ... mm and the pH from 7.5 to 6.5 in 20 vol at a ow-rate of mLặmin)1; (g) concentration of the GluRS-containing fractions by ultraltration to $ 20 mgặmL)1 and mL; and and (h) dialysis against L of ... Analysis of the kinetics of proteolysis of Mt- and Ec-GluRS Fig S9 Minimal models of the proteolytic events leading to fragments M1M5 of Mt-GluRS and E1-E3 of Ec-GluRS Fig S10 DLS analysis of GluRS...
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Reproductive System Structure, Development and Function in Cephalopods with a New General Scale for Maturity Stages pot
... their eggs in rigid capsules, capsule glands and albumin glands are present in a complex of pallial glands These differ in their origin and function (Chukchin, 1984) Oviductal glands in octopus ... accessory glands are different in origin, and form egg coverings at spawning A mucous secretion is formed by pallial, pedal and hypobranchial glands in different species of this class In mollusks ... females, this involves formation of additional oocyte coverings and the process of transferring oocytes into the organs from which spawning will take place In males this involves formation of spermatophores...
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Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx
... polymorphisms in CYP2D6 can significantly affect the activity of the enzyme, and therefore serve as an important guideline for determining the dose of antidepressant drugs and preventing drug- induced ... 53% and 50%, respectively, by the addition of 10 lm quinidine, a CYP2D6 specific inhibitor (Note that a concentration of lm quinidine is generally sufficient to inhibit CYP2D6 in a system using ... mitochondrial targeting signal domain of CYP2D6, a series of constructs were generated with N-terminal truncations and point mutations in the putative mitochondrial targeting signal and used for in vitro...
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pharmacokinetics and metabolism in drug design
... EF EM Average amount of drug in the body over a dosing interval Maximum amount of drug in the body over a dosing interval Minimum amount of drug in the body over a dosing interval Area under plasma ... volume of the series Methods and Principles in Medicinal Chemistry focuses on the impact of pharmacokinetics and metabolism in Drug Design Pharmacokinetics is the study of the kinetics of absorption, ... measurements and analysis are adequate for understanding a single drug in a single species in a number of different situations since both protein binding and the resultant unbound fraction are approximately...
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báo cáo hóa học:" Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients" pdf
... avenue for targeting Ovarian cancer is the 8th leading cause of cancer in women in the US and the leading cause of death from gynaecological malignancy in the western world [15] Cancer of the ovary ... state In NTera2 cells, differentiation status is confirmed by decreases in expression of Oct4 and Nanog and increases in expression of Afp, Ncam1 and Eno3 2102Ep cells alter expression of these ... phenotype In undifferentiated cells, this involves decreased expression of miRNA biosynthesis genes, increased expression of mature miRNAs and expression of miRNAs clustering along chromosomes 14 and...
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Báo cáo nghiên cứu khoa học: " CHARACTERIZATION OF PROTEASE FROM ASPERGILLUS ORYZAE SURFACE CULTURE AND APPLICATION IN FISH SAUCE PROCESSING" pps
... The procedure in the sample S1 seems to be satisfied for both purposes: inhibiting the contaminated and pathogenic micro-organisms in fish and maintaining the protease acitivity during the fermentation ... was 65.45% and the purified degree was 3.03 This purified protease was used for determination of Km, Vmax and applied in fish sauce processing 2.3 Determination of kinetic parameters Km and Vmax ... The application of this enzyme with a suitable procedure of salt addition in fish sauce processing accelerated fish proteolysis and increased the free amino nitrogen content Our research continued...
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Báo cáo lâm nghiệp: "Reconstruction of crown length of Norway spruce (Picea abies (L.) Karst.) and Silver fir (Abies alba Mill.) – technique, establishment of sample methods and application in forest growth analysis Peter SPATHELF" ppt
... exceeded if a determined crown ratio is intended to be maintained (Fig 10) The increase of competition leads to a decreasing ih/chb ratio for both species In the case of increasing competition, ... height increment and change of the height to crown base (ih/chb) in function of the competition status based on Hegyi’s index Figure Development of crown ratio (cr) of thinned and unthinned Norway ... Norway spruce and Silver fir up to 10 years since thinning With the exception of thinned Silver fir all trees are declining in crown ratio, the unthinned trees more than the thinned ones rate)...
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Báo cáo y học: "Investigating the complementary value of discrete choice experiments for the evaluation of barriers and facilitators in implementation research: a questionnaire survey" pptx
... consists of five stages: identifying the attributes of interest, assigning levels to the attributes, presenting profiles to individuals which involve different levels of the attributes, obtaining ... acquisition, and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intellectual content All authors have read and approved the final submitted ... contributions to the conception and design of the study, the analysis and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intellec- Patients...
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báo cáo khoa học: " Exploring the role of organizational policies and procedures in promoting research utilization in registered nurses" potx
... Use of nursing practice research findings Nursing Research 1987, 36:344-349 Michel Y, Sneed NV: Dissemination and use of research h findings in nursing practice Journal of Professional Nursing ... Buckwalter K: Infusing research into practice to promote quality care Nursing Research 1994, 43:307-318 Ketefian S: Application of selected nursing research findings into nursing practice Nursing Research ... Such strategies included increasing the reading activity of nurses, teaching research critique and appraisal skills, and offering a variety of educational programs targeted at the individual [9]...
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báo cáo khoa học: " Investigating the complementary value of discrete choice experiments for the evaluation of barriers and facilitators in implementation research: a questionnaire survey" pot
... consists of five stages: identifying the attributes of interest, assigning levels to the attributes, presenting profiles to individuals which involve different levels of the attributes, obtaining ... acquisition, and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intellectual content All authors have read and approved the final submitted ... contributions to the conception and design of the study, the analysis and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intellec- Patients...
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Biointormatics of targeted therapeutics and applications in drug discovery
... Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery x Bioinformatics of Targeted Therapeutics and Applications in Drug Discovery List of Tables Chapter Table Statistics of ... have been injected into drug discovery, in the hope of finding new drugs Statistics show that R&D expenditures in pharmaceutical industry has been growing at an annual growth of 13% since 1970, ... highly desired Drug combinations are already standard treatments of many diseases including cancer, diabetes, viral and bacterial infections And the high efficacy of existing drug combinations shows...
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Alternative gate dielectrics and application in nanocrystal memory
... discussed Finally, investigation of trap energy levels in Ge nanocrystal memory structures and their effect on the device charging and discharging kinetics were also carried out by monitoring the ... floating gate memory during programming by F-N tunneling 19 Figure 2.4 Schematic diagram showing uniform F-N tunneling of electrons from the substrate to the floating gate during programming of ... 2.3: Energy band diagram of a floating gate memory during programming by F-N tunneling 19 In Fig 2.3, Ec and Ev are the conduction and valence bands respectively, Eg is the energy band gap (1.1eV...
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Fabrication of tungsten oxide nanostructured films using anodic porous alumina and application in gas sensing
... Wong Kin Mun for working together in CICFAR and reducing the stress of working on the project by having meals and breaks together; Parents Mr and Mrs See for providing strong moral support and ... presence of oxidizing or reducing gases by means of changes in the conductivity of the sensing layer The theory of MOX gas sensing is described in further detail here Pure and perfectly crystalline ... course of this project: Supervisors A/Prof Chim Wai Kin and A/Prof John Thong for patience, guidance and invaluable suggestions throughout the course of the project, and for imparting many life application...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25