stimulation of toll like receptors on lung carcinoma cells modulates cell survival and response to chemotherapy
Báo cáo y học: " Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes" pdf
... Stimulation of monocytes and bronchoalveolar cells with TLR ligands To assess ligand-induced TLR expression of monocytes and bronchoalveolar cells, 106 cells were cultured in a final volume of ... Expression and function of Toll- like receptor on T cells Cell Immunol 2005, 233:85-89 doi:10.1186/1465-9921-11-2 Cite this article as: Juarez et al.: Differential expression of Toll- like receptors on ... Following stimulation, one set of cultures from monocytes and bronchoalveolar cells was harvested and prepared for flow cytometry, and one set for mRNA extraction To assess TLR ligand-induced cytokine...
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Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt
... release of inflammatory mediators The family of Toll- like receptors (TLR) plays a key role in pathogen recognition and induction and regulation of the innate and adaptive immune response Airway ... expression of Toll- like Receptors (TLR) in stimulated primary small-airway-epithelial cells (SAEC) mRNA expression of Toll- like Receptors (TLR) in stimulated primary small-airway-epithelial cells ... antigens like LPS, the hyporesponsiveness of these epithelial cells to LPS stimulation [25,26] is assumed to provide a mechanism to dampen the inflammatory response to the constant LPS exposure and to...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... Microbial Non-Microbial Acute inflammation Innate Immunity Adaptive Immunity Toll- like receptors (TLRs) NOD -like receptors (NLRs) RIG -like receptors (RLRs) CD4 and CD8 T cells Antigen-specific B cells ... role of toll- like receptors in acute and chronic lung inflammation Journal of Inflammation 2010 7:57 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... Galanos C, Simon JC: Oligosaccharides of Hyaluronan activate dendritic cells via toll- like receptor J Exp Med 2002, 195(1):99-111 Tsan MF, Gao B: Endogenous ligands of Toll- like receptors J Leukoc...
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Báo cáo y học: "Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis" pps
... Authors' contributions CS contributed to the original idea, laboratory work, interpretation of data and manuscript writing AZ contributed to patient characterization, acquisition of data and statistics ... clearance of circulating opsonized material Activation of the classical complement pathway is considered one of the main physiological functions of CRP In contrast to IgG-mediated classical activation, ... activity and chronicity, today offers the best possibility to estimate renal disease and its response to therapy Biopsy is costly and is associated with considerable risks for the patient, however, and...
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Báo cáo khoa học: Effects of the antioxidant PycnogenolÒ on cellular redox systems in U1285 human lung carcinoma cells docx
... activity of both TrxR and GPx in cells by more than 50% compared to control cells, but the effect was less pronounced for GPx compared to TrxR (Fig 1) In contrary to the selenoenzymes TrxR and GPx, ... treatment at a concentration of 0.1 mm and incubation for an additional 48 h Then the cells were harvested and homogenized and the enzyme activity was measured Inhibition of enzyme activity of PycnoB ... treatment of cells for 48 h with PycnogenolÒ (25 lgÆmL)1) Polyclonal TrxR1 antibodies are known to generate more than one band due to the existence of several protein isoforms (B) TrxR1 (black bars) and...
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Báo cáo khoa học: " Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells" docx
... human lung carcinoma cells 25 Fig Flowcytometric detection of apoptosis of A549 cells treated with tetrandrine (TET) Cells were incubated with 30 μM of TET for 12 h and 24 h (A) Control, (B) TET 12 ... types of cancer Spatiotemporal control of the ERK signal pathway is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation and cell survival ... further analysis The concentration-dependent effect of TET on the inhibition of A549 cell proliferation The impact of TET on the viability and proliferation of A549 cells was determined using the...
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Báo cáo y học: "Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages" docx
... O, Torp S, et al Differential expression of Toll- like receptor in human cells J Leukoc Biol 2001; 69(3): 474-81 17 Zarember KA, Godowski PJ Tissue expression of human Toll- like receptors and ... expression control of TLR5 by inflammatory cytokines may contribute to regulation of innate immunity in monocytes and neutrophils The effects of G-CSF and M-CSF on TLR expression in neutrophils and ... recognition receptors TLR2 and TLR4 on both neutrophils and monocytes GM-CSF treatment also increased expression of TLR2 and TLR4 on neutrophils and has previously been shown to enhance TLR ligand responses...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... cells in response to Loxoribine Consistent with basal expression data, there were Figure Figure Activation of Toll- like receptors TLR7 and TLR9 in IFNAR2-/- mice Activationof Toll- like receptors ... proliferation (Figure 5a) or IL-6 secretion (Figure 5b) in response to the TLR9 agonist in B cells from pristane-treated IFNAR2-/- mice Expression of Toll- like receptors TLR7 and TLR9 in IFNAR2-/- B cells ... dependent on IFNAR2 (Figure 4b) IFNAR2 is therefore required for the induction of TLR7 and TLR9 expression in B cells in response to IFN-α and for normal basal levels of B -cell TLR7 expression Toll- like...
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Báo cáo y học: " Gut flora enhance bacterial clearance in lung through toll-like receptors 4" docx
... adhesion molecule-1 (ICAM-1) on airway epithelial cells and contributes to inflammatory responses [24] Our data demonstrate that commensal depletion decreases MPO activity and NF-B activation but ... pneumoniainduced lung inflammation We hypothesized that commensal microflora in the gut could increase lung inflammatory reaction through the toll- like receptors (TLR4) We studied the effect of ... Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut -lung axis of inflammation J Immunol...
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Báo cáo y học: " Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis" ppsx
... found among healthy controls Figure TLR expression in response to tonsillar infection Altered Altered TLR expression in response to tonsillar infection Freshly isolated CD4+ and CD8+ T cells from ... K: Expression and function of Toll- like receptors in eosinophils: activation by Toll- like receptor ligand J Immunol 2003, 171:3977-3982 Dodson RE, Shapiro DJ: Regulation of pathways of mRNA destabilization ... the surgery) of GAS tonsillitis (small to substantially enlarged tonsils, positive cultivation test) The control group consisted of 21 patients who underwent tonsillectomy because of tonsillar hyperplasia...
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Báo cáo y học: "Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts" docx
... role of Toll- like receptors (TLRs) in mediating the synovial inflammatory response [5,6] TLRs belong to the pattern recognition receptor family and connect innate and adaptive immunoresponses Stimulation ... proliferation and activation has been considered the main cause of the secretion of proinflammatory cytokines and chemokines, the recruitment of inflammatory cells and the production of matrix ... T cells or to the stimulation of soluble factors derived from T cells, we incubated rat FLSs with pristane-primed T -cell conditioned medium (PIA group) or control T -cell conditioned medium (control...
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Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx
... function in that they elaborate cytokines to give warning of infection both near and far, and also contribute to the adaptive immune response, which is based on nonphagocytic lymphoid cells Natural ... marker of infection, and was used to identify the receptors that sense host invasion and transduce the essential signal across the membrane of the effector cells A remarkable new family of receptors, ... orphans None appears to be involved in development, and in Drosophila, among the nine ‘Tolls’ (paralogs of the original Toll protein) that are known to exist, only Toll itself has an immune function...
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Báo cáo hóa học: " Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4" potx
... rejection and strategies to prevent it Transplant Proc 2007, 39:667-672 26 Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R: Toll- like receptors control activation of adaptive immune responses ... cytoplasmic portion of TLR, which shows great similarity to that of the IL-1 receptor family and is termed Toll/ IL-1 (TIL) domain All TLRs possess a cytoplasmic toll IL-1 receptor (TIR) domain, and most ... terms of apoptosis, activation of TLRs in the myocardia may initiate either pro-apoptotic or anti-apoptotic mechanisms [24,29] Activation of TLR4 may trigger expression of cell survival and inflammatory...
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báo cáo hóa học: " Toll-like receptors in cerebral ischemic inflammatory injury" pdf
... immunity of the central nervous system in chronic pain: the role of Toll- like receptors Cell Mol Life Sci 2007, 64:1128-1136 69 Tsan MF, Gao B: Endogenous ligands of Toll- like receptors J Leukoc ... initiate only minor IL-6 responses to all but TLR3 stimulation [12] TLR signaling The TLRs signal through common intracellular pathways leading to transcription factor activation and the generation of ... phosphorylation of IKKa/b, activation of the transcription factors NF-B, interferon-b promoter-binding protein (IRF)1, and IRF7, and generation of the pro-inflammatory cytokines IL-6 and TNF-a, among...
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Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection" doc
... endothelial cells in all tonsil sections and a subset of T cells ([44], Table 1) A polyclonal antibody directed against interleukin-8 (IL-8) was used to evaluate the activation status of epithelial cells ... http://www.virologyj.com/content/3/1/25 Figure Epithelial damage and repair in ex vivo tonsil organ culture and HIV infection of tonsil cells Epithelial damage and repair in ex vivo tonsil organ culture and HIV ... of co-receptor expression on tonsil cell suspensions provided valuable information relating to lymphocyte populations [51] but, by gating on populations of single cells of defined size, this study...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... factor-β and IL-10 In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro family (mer, tyro and axl) downregulate inflammatory cytokines, IL-12 and TNFα during ingestion, and ... necrotic cells and stimulation of Toll- like receptor by DNA HMGB proteins provide a new paradigm for how cell death may be linked to innate immune responses HMGB1 is a transcriptional regulator that ... apoptotic cells [44] C3b/bi associates with phosphatidyserine on apoptotic cells and binds to C3 and C4 complement receptors on macrophages, facilitating apoptotic cell clearance [45] These observations...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... expression of toll- like receptors and in rheumatoid arthritis synovium is increased and costimulation of toll- like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells ... S, Kyburz D: Overexpression of toll- like receptors and in synovial tissue from patients with early rheumatoid arthritis: toll- like receptor expression in early and longstanding arthritis Arthritis ... hematoxylin and eosin Arrow indicates inflammatory cell influx and chondrocyte cell death Image taken from [21] Reproduced with permission of John Wiley and Sons cells) as well as TLR ligands of microbial...
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Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-B pathway doc
... analysis and interpretation of data C-ML has made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data HC has given final approval of the ... Barber R, Horton J, Carison D: Alteration in the cardiac inflammatory response to burn trauma in mice lacking a functiona; tolllike receptor gene Shock 2008, 30:740-746 Shyu KG: Cellular and molecular ... modulation of TLR4 expression in cardiomyocytes Our data also demonstrated that functional consequence of TLR4 up-regulation by stretch resulted in adhesion of monocytes TLR4 Shyu et al Journal of...
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Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf
... Toll- like receptor-4 mediates vascular inflammation and insulin resistance in diet induced obesity Cir Res 2007, 100:1589-1596 Song MJ, Kim KH, Yoon JM, Kim JB: Activation of toll- like receptor ... microbial endotoxin, LPS (TLR4 agonist), triggers the host’s innate immune and inflammatory responses leading to the upregulation of pathways relating to insulin resistance and dyslipidemia One possible ... al.: Loss of function mutation in tolllike receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice Journal of Inflammation 2011 8:2...
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Báo cáo y học: "Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice" docx
... Toll- like receptor-4 mediates vascular inflammation and insulin resistance in diet induced obesity Cir Res 2007, 100:1589-1596 Song MJ, Kim KH, Yoon JM, Kim JB: Activation of toll- like receptor ... microbial endotoxin, LPS (TLR4 agonist), triggers the host’s innate immune and inflammatory responses leading to the upregulation of pathways relating to insulin resistance and dyslipidemia One possible ... al.: Loss of function mutation in tolllike receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice Journal of Inflammation 2011 8:2...
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